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Mobile stroke care expedites intravenous thrombolysis and endovascular thrombectomy

Stroke & Vascular Neurology 2022年第3期7卷 209-214页

作者： Matthew T Bender Thomas K Mattingly Redi Rahmani Diana Proper Walter A Burnett Jason L Burgett Joshua LEsperance Jeremy T Cushman webster.h pilcher.cur.is g benesch Adam g Kelly Tarun Bhalla Department of Neurosurgery University of Rochester Medical CenterRochesterNew YorkUSA Department of Emergency Medicine University of Rochester Medical CenterRochesterNew YorkUSA Department of Neurology University of Rochester Medical CenterRochesterNew YorkUSA

Background The number of mobile stroke programmes has increased with evidence,showing they expedite intravenous *** questions include whether time savings extend to patients eligible for endovascular therapy and impact clinical *** Our mobile stroke unit(MSU),based at an academic medical centre in upstate New York,launched in October *** reviewed prospective observational data sets over 26 months to identify MSU and non-MSU emergency medical service(EMS)patients who underwent intravenous thrombolysis or endovascular thrombectomy for comparison of angiographic and clinical *** Over 568 days in service,the MSU was dispatched 1489 times(2.6/day)and transported 300 patients(20%of dispatches).Intravenous tissue plasminogen activator(tPA)was administered to 57 MSU patients and the average time from 911 call-to tPA was 42.5 min(±9.2),while EMS transported 73 patients who received tPA at 99.4 min(±35.7)(phours to 4.5 hours since last known well and would likely have been outside the window with EMS *** thrombectomy was performed on 21 MSU patients with an average 911 call-to groin puncture time of 99.9 min(±18.1),while EMS transported 54 patients who underwent endovascular thrombectomy(ET)at 133.0 min(±37.0)(p=0.0002).There was no difference between MSU and traditional EMS in modified Rankin score at 90-day clinic follow-up for patients undergoing intravenous thrombolysis or endovascular thrombectomy,whether assessed as a dichotomous or ordinal *** Mobile stroke care expedited both intravenous thrombolysis and endovascular *** is an ongoing need to show improved functional outcomes with MSU care.

关键词： intravenous throm endovascular

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Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment:evidence from a laboratory life-history trade-offs selection study

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Infectious Diseases of Poverty 2017年第1期6卷 988-998页

作者： Poppy h.L.Lamberton Christina L.Faust Joanne P.webster Institute for Biodiversity Animal Healthand Comparative Medicine&Wellcome Centre for Molecular ParasitologyCollege of MedicalVeterinary&Life SciencesUniversity of GlasgowG128QQGlasgowUK London Centre for Neglected Tropical Disease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonSt Mary’s CampusW21PGLondonUK Centre for Endemic Emerging and Exotic DiseasesThe Royal Veterinary CollegeUniversity of LondonLondon AL97TAUK

Background:Mass drug administration of praziquantel is the World health Organization’s endorsed control strategy for schistosomiasis.A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence and intensity levels,although‘hotspots’*** drug treatments place strong selective pressures on parasites,which may affect life-history traits that impact transmission *** drug treatment responses and the evolution of such traits can help inform on how to minimise the risk of drug resistance developing,maximise sustainable control programme success,and improve diagnostic ***:We performed a four-generation Schistosoma mansoni praziquantel selection experiment in mice and *** used three *** lines:a praziquantel-resistant isolate(R),a praziquantel-susceptible isolate(S),and a coinfected line(RS),under three treatment regimens:untreated,25 mg/kg praziquantel,or 50 mg/kg *** traits,including parasite adult-worm establishment,survival,reproduction(fecundity),and associated morbidity,were recorded in mice across all four *** variables were tested in a series of generalized linear mixed effects models to determine which factors had a significant influence on parasite life-history traits in definitive hosts under different selection ***:Praziquantel pressure significantly reduced adult-worm burdens across all generations and isolates,including within ***,previous drug treatment resulted in an increase in adult-worm establishment with increasing generation from P1 to *** highest worm numbers were in the co-infected RS *** treatment decreased adult-worm burden,but had a larger negative impact on the mean daily number of miracidia,a proxy for fecundity,across all three parasite ***:Our predicted cost of resistance was not supported by the traits we measured within the murine host.

关键词： Schistosoma mansoni Biomphalaria Mouse Praziquantel Resistance Establishment Survival Fecundity Trade-offs

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Fundamental motor skills,screen-time,and physical activity in preschoolers

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Journal of Sport and health Science 2019年第2期8卷 114-121页

作者： E.Kipling webster Corby K.Martin Amanda E.Staiano School ofKinesiology Louisiana State University Pennington Biomedical Research Center Louisiana State University

Purpose: To examine the associations among preschoolers fundamental motor skills, screen-time, physical activity(PA), and sedentary behavior(SB).Methods: Children ages 3à4 years were enrolled in a prospective observational trial of PA. Trained assessors conducted the Test of gross Motor Development-3 rd edition(TgMD-3), and the Movement Assessment Battery for Children-2 nd edition, and parent-reported child screen-time and sociodemographic information. Children wore an accelerometer for 7 days to examine SB and total PA(TPA). TPA was further characterized as moderateto-vigorous PA(MVPA) or vigorous PA(VPA). Mixed linear models were calculated, controlling for age(for TgMD-3), sex, household income, and accelerometer wear time(for accelerometry models), with childcare center as a random effect. The primary analysis reported on the cross-sectional baseline data of 126 children with complete fundamental motor skill and screen-time data; a subanalysis included 88 children with complete accelerometry ***: Children were 3.4 § 0.5 years of age(54% girls; 46% white, 42% African American, 12% other). A total of 48% lived in households at or below the federal poverty level. Children engaged in 5.1 § 3.6 h/day of screen-time. Children's screen-time was inversely related to the Movement Assessment Battery for Children-2 nd edition, manual dexterity skills percentile(b(SE) = ?1.7(0.8), p = 0.049). In the accelerometry subsample,children engaged in 5.9 § 0.9 h/day of TPA of which 1.7 § 0.6 h/day was MVPA. Boys engaged in more MVPA and VPA and less SB compared with girls(all p higher TgMD-3, total score(b(SE) = 0.4(0.2), p = 0.017) and locomotor score(b(SE) = 0.7(0.3), p = 0.018) were associated with more VPA but not with TPA or MVPA. Screen-time and television in the bedroom were not related to SB, TPA, MVPA, or ***: Children's motor skills were positively related to VPA but inversely related to screen-time. Further inquiry into the implications of

关键词： Fundamental motor skills Physical activity Preschool Screen-time

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The Language of Early Childhood: Volume 4

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丛书名： Collected Works of M.A.K. halliday

2004年

作者： M.A.K. halliday Jonathan J. webster

ISBN: (数字)9781847144041

ISBN: (纸本)9780826458704

For nearly half a century, Professor M. A. K. halliday has been enriching the discipline of linguistics with his keen insights into the social semiotic phenomenon we call language. This ten-volume series presents the seminal works of Professor halliday. This fourth volume contains sixteen papers that look at the development of early childhood language. They are presented in three parts: infancy and protolanguage; the transition from child tongue to mother tongue; and early language and learning. The sociolinguistic account of the early development of the mother tongue presented by Professor halliday is based on his intensive study of the language of one particular child, Nigel, for the period from nine- to eighteen months.

关键词： Language acquisition.

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测定淬火槽对流强度的热流速仪探头的优化设计(英文)

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金属热处理 2002年第7期27卷 39-44页

作者： h.M.Tensi A.haas K.Lainer g.E.Totten g.M.webster Department of Materials and Processing Technical University of MunichDepartment of Materials and ProcessingTechnical University of MunichDepartment of Materials and ProcessingTechnical University of MunichThe Dow Chemical CompanyTarrytownThe Dow Ch

淬火槽中复杂的液流形态会明显影响淬硬结果 ,因此开发一套结构紧凑的液流测量装置就显得很重要了。一个典型的淬火过程包括把已奥氏体化了的钢浸没在淬火槽中 ,这一过程势必影响液流的循环 ,使其形成不均匀的液流和热波动 ,由此而引起... 详细信息

淬火槽中复杂的液流形态会明显影响淬硬结果 ,因此开发一套结构紧凑的液流测量装置就显得很重要了。一个典型的淬火过程包括把已奥氏体化了的钢浸没在淬火槽中 ,这一过程势必影响液流的循环 ,使其形成不均匀的液流和热波动 ,由此而引起传热变化 ,导致零件的不均匀淬火。

关键词：测定淬火槽对流强度热流速仪探头优化设计

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工业淬火槽中的液流传感器—文献综述(英文)

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金属热处理 2002年第5期27卷 27-32页

作者： g.E.Totten 1,h.M.Tensi 2,and g.M.webster 1 (1 The Dow Chemical Company,Tarrytown,NY USA 2 Technical University of Munich,Munich,germany) The Dow Chemical Company 美国 Tarrytown Technical University of Munich 德国 Munich

造成淬火后工件硬度不均匀、热应力增加、畸变和开裂 ,主要是因为淬火槽内整个淬火区的液流不均匀。在淬火过程中 ,液流是控制淬火烈度的关键。因此 ,如何测量在淬火过程发生的液流特性很重要。迄今为止 ,市场上还没有一种可用于热处理... 详细信息

造成淬火后工件硬度不均匀、热应力增加、畸变和开裂 ,主要是因为淬火槽内整个淬火区的液流不均匀。在淬火过程中 ,液流是控制淬火烈度的关键。因此 ,如何测量在淬火过程发生的液流特性很重要。迄今为止 ,市场上还没有一种可用于热处理生产设备的设计合理、具有足够灵敏度并经久耐用的液流传感器。本文对不同传感器的各种测量原理进行了概括 ,并描述了几种最近开发的可用于淬火槽中测量液流传感器。

关键词：工业淬火槽液流传感器测量原理

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弹簧钢淬火残余应力模拟(英文)

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金属热处理 2003年第11期28卷 47-52页

作者： g.Sánchez Sarmiento M.Castro g.E.Totten L.harvis g.webster M.F.Cabré Universidad de Buenos Aires Facultad de IngenieríaUniversidad de Buenos AiresFacultad de IngenieríaDow Chemical Co.Tenaxol Inc.Dow Chemical Co.Universidad del Salvador Buenos AiresArgentinaBuenos AiresArgentinaTarrytownN YUSAMilwakeeWisconsinUSATarrytownN YUSABuenos AiresArgentina

对AISI 5 16 0h弹簧钢圆柱试样在不同温度的 2 5 %水溶性聚 (亚烷基 )二醇UCONhT淬火液和Arco5 2 1淬火油中淬火产生的残余应力及畸变进行了对比性研究。试棒的直径分2 0 5 6mm (0 81inches)和13 4 5mm (0 5 3inches)两种。先用I... 详细信息

对AISI 5 16 0h弹簧钢圆柱试样在不同温度的 2 5 %水溶性聚 (亚烷基 )二醇UCONhT淬火液和Arco5 2 1淬火油中淬火产生的残余应力及畸变进行了对比性研究。试棒的直径分2 0 5 6mm (0 81inches)和13 4 5mm (0 5 3inches)两种。先用INC PhATRAN代码计算出试样随时间变化的传热系数 ,并用ABAQUS/标准有限元软件估算热处理过程中的残余应力和畸变。在试样中心放置热电偶 ,测出冷却曲线 ,根据所测的冷却曲线 ,用INC PhATRAN解决了伴随相变时的逆向热传导问题。试验了这两种淬火介质 ,力图将热处理畸变和开裂减少到最少 ,并得出了颇有价值的结论。

关键词：弹簧钢淬火残余应力数值模拟

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The Quantification of Intra-Fractional Tumour Motion Errors in Lung Stereotactic Ablative Radiotherapy Patients

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第2期6卷 105-110页

作者： Ibrahem h. Kanbayti Qamar ghafoor gareth webster Saddig Jastaniah Diagnostic Radiology Department King Abdulaziz University Jeddah KSA Queen Elizabieth hospital Oncology Center Birmingham UK Batterjee Medical College Jeddah KSA

This work aims at quantifying intra-fractional motion errors and evaluating the appropriateness of a Planning Target Volume (PTV) margin for Queen Elizabeth (QE) hospital’s patients. Intra-fractional motion errors were quantified for 29 patients who underwent lung Stereotactic Ablative Radiotherapy (SABR) treatment at the cancer centre of QE hospital. One hundred thirty post-Cone Beam Computed Tomography (CBCT) scans were collected to calculate these errors. In terms of the adequacy of a PTV margin, the intra-fractional motion errors that were calculated are combined with other geometric errors which were taken from historical audit studies. Then, the combined outcome was compared with the common PTV margin that is delineated by most United Kingdom (UK) oncology centres. The findings of this study showed that the systematic component of intra-fractional motion error is equal to 0.08, 0.08 and 0.08 cm in right/left, superior/anterior and anterior/posterior directions, respectively, While the random component of this error is equal to 0.11, 0.13 and 0.14 cm. In addition to that, a PTV margin of 0.5 cm is the appropriate margin for QE hospital’s patients and this volume is compatible with the common PTV margin that is delineated by the most UK oncology centres. This work concluded that A PTV margin of 0.5 cm is the suitable volume for lung SABR patients at QE hospital.

关键词： SABR geometric Errors Lung Cancer

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Studies in Chinese language /

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丛书名： The collected works of M.A.K. halliday

2005年

作者： M.A.K. halliday edited by Jonathan webster.

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宠物鸟h3N8亚型流行性感冒病毒NA基因分子特征性分析

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病毒学报 2005年第2期21卷 145-149页

作者：张云刘明于康震 Robert g.webster St.Jude Children’s Research hospital 中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点开放实验室哈尔滨150001

虽然流行性感冒(流感)病毒的自然宿主是野生水禽类,作为宠物的雀形目鸟(Passeriformes)不代表流感病毒主要储存库[1-4,6,7],但Stallknecht和Shane 1988年对21 318份鸟的样品分析后发现,雀形目鸟中流感病毒的分离率占2.9%,表明雀形目鸟... 详细信息

虽然流行性感冒(流感)病毒的自然宿主是野生水禽类,作为宠物的雀形目鸟(Passeriformes)不代表流感病毒主要储存库[1-4,6,7],但Stallknecht和Shane 1988年对21 318份鸟的样品分析后发现,雀形目鸟中流感病毒的分离率占2.9%,表明雀形目鸟在流感病毒储存库中起着一定的作用.

关键词：流感病毒亚型流行性感冒病毒分子特征分离率自然宿主宠物 NA基因野生水禽禽类

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