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Regeneration of rat corpora cavernosa tissue by transplantation of CD133＋ cells derived from human bone marrow and placement of biodegradable gel sponge sheet

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Asian Journal of Andrology 2017年第2期19卷 203-207页

作者： Shogo Inoue Katsutoshi Miyamoto Shunsuke Shinmei Koichi Shoji Jun Teishima Kazuhiro Sentani wataru yasui Akio Matsubara Department of Urology Hiroshima University Institute of Biomedical and Health Sciences Hiroshima Japan Department of Molecular Pathology Hiroshima University Institute of Biomedical and Health Sciences Hiroshima Japan

The objective is to develop an easier technique for regenerating corpora cavernosa tissue through transplantation of human bone marrow-derived CD133＋ cells into a rat corpora cavernosa defect model. We excised 2 mm× 2 mm squares of the right corpora cavernosa of twenty-three 8-week-old male nude rats. AIginate gel sponge sheets supplemented with 1 × 10^4 CD133＋ cells were then placed over the excised area of nine rats. Functional and histological evaluations were carried out 8 weeks later. The mean intracavernous pressure/mean arterial pressure ratio for the nine rats （0.34258 ± 0.0831） was significantly higher than that for eight rats with only the excision （0.0580±0.0831, P = 0.0238） and similar to that for five rats for which the penis was exposed, and there was no excision （0.37228±0.1051, P = 0.8266）. Immunohistochemical analysis revealed that the nine fully treated rats had venous sinus-like structures and quantitative reverse transcription polymerase chain reaction analysis of extracts from their alginate gel sponge sheets revealed that the amounts of mRNA encoding the nerve growth factor （NGF）, and vascular endothelial growth factor （VEGF） were significantly higher than those for rats treated with alginate gel sheets without cell supplementation （NGF： P= 0.0309; VEGF： P〈 0.0001）. These findings show that transplantation of CD133＋ cells accelerates functional and histological recovery in the corpora cavernosa defect model.

关键词： alginate gel sponge sheet CD133+ cell corpora cavernosa

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Clinicopathological features of minute pharyngeal lesions diagnosed by narrow-band imaging endoscopy and biopsy

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World Journal of Gastroenterology 2012年第44期18卷 6468-6474页

作者： Takashi Kumamoto Kazuhiro Sentani Shiro Oka Shinji Tanaka wataru yasui Kumamoto Gastrointestinal Clinic Hiroshima 730-0051Japan Department of Molecular Pathology Hiroshima University Graduate School of Biomedical SciencesHiroshima 734-8551Japan Department of Endoscopy Hiroshima University HospitalHiroshima 734-8551Japan

AIM:To evaluate the utility of magnified narrow-band imaging(NBI) endoscopy for diagnosing and treating minute pharyngeal ***:Magnified NBI gastrointestinal examinations were performed by the first author.A magnification hood was attached to the tip of the endoscope for quick *** of the examinations were performed under *** NBI examinations were performed for all of the pharyngeal lesions that had noticeable brownish areas under unmagnified NBI observation,and an intrapapillary capillary loop(IPCL) classification was made.A total of 93 consecutive pharyngeal lesions were diagnosed as IPCL type Ⅳ and were suspected to represent ***-two lesions of approximately 1 mm in diameter were biopsied in the clinic,and 17 lesions with larger diameters were resected by endoscopic submucosal dissection(ESD) at the Hiroshima University *** addition to the histological diagnoses,the lesion diameters were microscopically measured in 45 of the 62 *** of the 62 biopsied patients received endoscopic follow ***:Minute pharyngeal lesions were diagnosed in 93 of approximately 3000 patients receiving magnified NBI examinations at the *** the 93 patients with IPCL type Ⅳ lesions,80 were men,and 13 were ***-six were drinkers,and 57 were *** had esophageal ***-one lesions were located on the posterior hypopharyngeal wall,and 72 lesions were located on the posterior oropharyngeal *** 93 lesions were flat and showed similar findings in the magnified and unmagnified NBI *** almost all of the IPCL type Ⅳ lesions showed faint redness when examined under white light,it was difficult to diagnose the lesions using only this technique because the contrast was weaker than that achieved in the NBI *** the 93 lesions,only 3 had diameters greater than 2.1 ***-two lesions of approximately 1 mm were biopsied in the clinic,whereas 17 larger lesions were tre

关键词： Biopsy Minute pharyngeal lesions Narrow-band imaging

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Scaffolds based therapy for osteochondral lesions of the talus:A systematic review

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World Journal of Orthopedics 2017年第10期8卷 798-808页

作者： Yoshiharu Shimozono Youichi yasui Andrew W Ross wataru Miyamoto John G Kennedy Hospital for Special Surgery New York Department of Orthopaedic Surgery Teikyo University School of Medicine Department of Orthopaedic Surgery Kyoto University Graduate School of Medicine

AIM To clarify the effectiveness of scaffold-based therapy for osteochondral lesions of the talus(OLT). METHODS A systematic search of MEDLINE and EMBASE databases was performed during August 2016 and updated in January 2017. Included studies were evaluated with regard to the level of evidence(LOE) and quality of evidence(QOE) using the Modified Coleman Methodology Score. Variable reporting outcome data, clinical outcomes, and the percentage of patients who returned to sport at previous level were also evaluated. RESULTS Twenty-eight studies for a total of 897 ankles were included; 96% were either LOE Ⅲ or Ⅳ. Studies were designated as either of poor or fair quality. There were 30 treatment groups reporting six different scaffold repair techniques: 13 matrix-induced autologous chondrocyte transplantation(MACT), nine bone marrow derived cell transplantation(BMDCT), four autologous matrixinduced chondrogeneis(AMIC), and four studies of other techniques. The categories of general demographics(93%) and patient-reported outcome data(85%) were well reported. Study design(73%), imaging data(73%), clinical variables(49%), and patient history(30%) were also included. The weighted mean American Orthopaedic Foot and Ankle Society(AOFAS) score at final follow-up was: 86.7 in MACT, 88.2 in BMDCT, and 82.3 in AMIC. Eight studies reported that a weighted mean of 68.3% ofpatients returned to a previous level of sport activity. CONCLUSION Scaffold-based therapy for OLT may produce favorable clinical outcomes, but low LOE, poor QOE, and variability of the data have confounded the effectiveness of this treatment.

关键词： Scaffold Ankle Talar osteochondral lesion Systematic review Cartilage

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Modeling and measurement of curing properties of photocurable polymer containing magnetic particles and microcapsules

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Microsystems & Nanoengineering 2017年第1期3卷 175-183页

作者： Masato yasui Koji Ikuta Laboratory for Cell Signaling Dynamics RIKEN Quantitative Biology Center6-2-3 FuruedaiSuitaOsaka 565-0874Japan Graduate School of Information Science and Technology The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8685Japan

In microstereolithography,three-dimensional microstructures are created by scanning an ultraviolet laser on a photocurable resin and stacking several such layers to form the desired *** mixing different types of particles in the resin,the formed microstructures exhibit various physical *** example,the magnetism and density of the microstructure can be controlled by adding magnetic particles and microcapsules to the *** method has been used to fabricate magnetic *** such functional resins are useful,the incorporated magnetic particles and microcapsules can affect the fabrication resolution,making it difficult to fabricate microstructures with high ***,it is necessary to understand the effects of such microparticles and microcapsules on the fabrication *** this study,we propose a simple model of curing resins containing magnetic particles and microcapsules to explain the effects of the magnetic particles and *** proposed model can explain the observed curing characteristics of a resin that contains particles for all concentrations as well as for different types of magnetic particles and ***,using the proposed model,we discuss how to improve the characteristics of resins containing microparticles to realize the high-resolution fabrication of three-dimensional microstructures with desirable material properties.

关键词： Magnetic particles Microcapsules Microstereolithography Photocurable model Photocurable polymer Resin

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Systematic review of bone marrow stimulation for osteochondral lesion of talus-evaluation for level and quality of clinical studies

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World Journal of Orthopedics 2017年第12期8卷 956-963页

作者： Youichi yasui Laura Ramponi Dexter Seow Eoghan T Hurley wataru Miyamoto Yoshiharu Shimozono John G Kennedy 2~(nd) Department of Orthopaedic Surgery Teikyo University School of Medicine Hospital for Special Surgery New York 2~(nd) Rizzoli Orthopaedic Institute 2~(nd) Royal College of Surgeons in Ireland Department of Orthopaedic Surgery Teikyo University School of Medicine

AIM To clarify the quality of the studies indicating lesion size and/or containment as prognostic indicators of bone marrow stimulation(BMS) for osteochondral lesions of the talus(OLT). METHODS Two reviewers searched the Pub Med/MEDLINE and EMBASE databases using specific terms on March 2015 in accordance with the Preferred Reporting Items for Systemic Reviews and Meta-Analyses guidelines. Predetermined variables were extracted for all the included studies. Level of evidence(LOE) was determined using previously published criteria by the Journal of Bone and Joint Surgery and methodological quality of evidence (MQOE) was evaluated using the Modified Coleman Methodology Score. RESULTS This review included 22 studies. Overall, 21 of the 22(95.5%) included studies were level Ⅳ or level Ⅲ evidences. The remaining study was a level Ⅱ evidence. MQOE analysis revealed 14 of the 22(63.6%) included studies having fair quality, 7(31.8%) studies having poor quality and only 1 study having excellent quality. CONCLUSION The evidence supporting the use of lesion size and containment as prognostic indicators of BMS for OLTs has been shown to be of low quality.

关键词： Osteochondral lesion of talus Arthroscopy Bone marrow stimulation Systematic review

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Landscape gradient of autumn photosynthetic decline in Abies sachalinensis seedlings

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Journal of Forestry Research 2023年第1期34卷 187-195页

作者： Tetsuto Sugai wataru Ishizuka Toshihiro Watanabe Hokkaido Research Center Forestry and Forest Products Research InstituteHitsujigaoka 7Sapporo 062-8516Japan Plant Nutrition Laboratory Research Faculty of AgricultureHokkaido UniversitySapporo 060-8689Japan Forest Research Institute Hokkaido Research OrganizationBibaiHokkaido 079-0198Japan

Understanding what environmental factors are genetically linked to a phenologic al event is critical for predicting responses to climate *** synthetic phenology often varies among a species of evergreen conifers due to local ***,few empirical studies have revealed relevant relationships between climatic factors in provenance environments and photosynthetic *** study evaluated the effects of environmental conditions of the growing site and seed source provenance on the seasonal changes in maximal photochemical quantum yield of photo systemⅡ(Fv/Fm)in a common garden experiment with 2-year-old seedlings of Sakhalin fir(Abies sachalinensis),a representative species with local adaptation,from four seed source provenances.A logistic model was constructed to explain the seasonal variation of Fv/Fmfrom July to October and the relationships between the estimated model parameters and representative factors featuring provenance environments were *** landscape gradient of the detected model parameters responsible for the provenance environments was visualized in a map of the distribution *** lowest temperature was the most plausible factor in the growing environment to explain the seasonal changes of Fv/*** the representative meteorological factors of provenance environments,the lowest temperatures in July showed significant relationships with two model parameters,explaining the lower limit of Fv/Fmand the higher sensitivity of autumn Fv/*** estimated spatial maps of model parameters consistently showed that the higher the lowest temperature in July in the provenance environment,the lower the Fv/Fmin October and the greater the decrease in the autumn Fv/***,the lowest summer temperature could be associated with the local adaptation of autumn photosynthetic phenology in ***.

关键词： Phenology Local adaptation Genetic cline Lowest temperature

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Phase transition in Pd_(40)Ni_(10)Cu_(30)P_(20) bulk metallic glass under HP & HT

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Science China(Physics,Mechanics & Astronomy) 2005年第6期48卷 716-722页

作者： Utsumi wataru Okada Taku Synchrotron Radiation Research Center Japan Atomic Energy Research Institute 1-1-1 Kout Mikasuki Sayo Hyogo 679-5148 Japan

The phase transitions in Pd40Ni10Cu30P20 bulk metallic glass (BMG) have been studied under high pressure and high temperature (HP & HT) by X-ray diffraction measurements with synchrotron radiation source. We found that the BMG underwent a phase transitions of amorphous-crystalline-amorphous at 10 GPa upon heating. The parallel experiments were carried out at 7 GPa, while we did not observe the amorphous-crystalline-amorphous transitions by increasing temperature. Quenching the melted BMG at 7 GPa, it was found that the phase crystallized from the melt differed from the primary phase crystallized from the starting amorphous solid upon heating, suggesting there existed a distinct mechanism in two cases.

关键词： phase transition, Pd40Ni10Cu30P20, high pressure and high temperature.

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Full polarimetric PALSAR-based land cover monitoring in Cambodia for implementation of REDD policies

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International Journal of Digital Earth 2013年第3期6卷 255-275页

作者： Ram Avtar wataru Takeuchi Haruo Sawada Institute of Industrial Science The University of TokyoTokyoJapan

Forest cover monitoring plays an important role in the implementation of climate change mitigation policies such as Kyoto protocol and Reducing Emissions from Deforestation and Forest Degradation(REDD).In this study,we have monitored land cover using the PALSAR(Phased Array type L-band Synthetic Aperture Radar)full polarimetric data based on incoherent target *** classification technique has been applied on CloudePottier decomposition,FreemanDurden three component,and Yamaguchi four component decomposition for accurate mapping of different types of land cover *** on confusion matrix derived from the predicted and defined pixels,the evergreen and sparsely deciduous forests have shown high producer’s accuracy by FreemanDurden three component and Yamaguchi four component classifica*** overall accuracy of Maximum Likelihood Classification by Yamaguchi four component is 94.1%with 0.93 kappa coefficient as compared to the 90.3%with 0.88 kappa coefficient by FreemanDurden three component and 89.7%with 0.88 kappa coefficient by CloudePottier *** accuracy of classification in a forested area using full polarimetric PALSAR data may have been because of high penetration of L-band *** content of this study could be useful for the forest cover mapping during cloudy days needed for proper implementation of REDD policies in Cambodia.

关键词： global climate change REDD PALSAR forest cover mapping

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Essentials of Proteolytic Machineries in Chloroplasts

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Molecular Plant 2017年第1期10卷 4-19页

作者： Kenji Nishimura Yusuke Kato wataru Sakamoto Institute of Plant Science and Resources Okayama University 2-20-1 Chuo Kurashiki Okayama 710-0046 Japan

Plastids are unique organelles that can alter their structure and function in response to environmental and developmental stimuli. Chloroplasts are one type of plastid and are the sites for various metabolic pro- cesses, including photosynthesis. For optimal photosynthetic activity, the chloroplast proteome must be properly shaped and maintained through regulated proteolysis and protein quality control mechanisms. Enzymatic functions and activities are conferred by protein maturation processes involving consecutive proteolytic reactions. Protein abundances are optimized by the balanced protein synthesis and degrada- tion, which is depending on the metabolic status. Malfunctioning proteins are promptly degraded. Twenty chloroplast proteolytic machineries have been characterized to date. Specifically, processing peptidases and energy-driven processive proteases are the major players in chloroplast proteome biogenesis, remod- eling, and maintenance. Recently identified putative proteases are potential regulators of photosynthetic functions. Here we provide an updated, comprehensive overview of chloroplast protein degradation ma- chineries and discuss their importance for photosynthesis. Wherever possible, we also provide structural insights into chloroplast proteases that implement regulated proteolysis of substrate proteins/peptides.

关键词： chloroplast biogenesis protease protein homeostasis

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Corticosteroid and nucleoside analogue for hepatitis B virus-related acute liver failure

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World Journal of Gastroenterology 2015年第36期21卷 10485-10486页

作者： Keiichi Fujiwara Shin yasui Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of MedicineChiba University

The early introduction of combination therapy of high-dose corticosteroid and nucleoside analogue is beneficial for the rescue of severe acute exacerbation of chronic hepatitis B.

关键词： Chronic hepatitis B Exacerbation Acute liver failu

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