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光学学报 2003年第S1期23卷 5-6页

作者： Kazunori Tanaka Kaoru Okuno Tomoyuki Hattori Kiyoaki Moriuchi Hiroshi Hayami wataru Katsurashima Yoshikyo Tamekuni Yokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 JapanYokohama R&D Laboratories Sumitomo Electric Industries Ltd. 1 Taya-cho Sakae-ku Yokohama 244-8588 Japan

A non-halogen highly flame-retardant 0.9mm optical fiber and 2.0mm simplex optical cord, which are harmonized with the ecosystem, have been developed. The characteristics of them are presented in this paper.

关键词： of test Development of Non-Halogen Flame Retardant Optical Fiber and Optical Fiber Cord been have

Post-colonoscopy colorectal cancer rate in the era of highdefinition colonoscopy

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World Journal of Gastroenterology 2017年第42期23卷 7609-7617页

作者： Mineo Iwatate Tomoyuki Kitagawa Yasumi Katayama Naohiko Tokutomi Shinichi Ban Santa Hattori Noriaki Hasuike wataru Sano Yasushi Sano Masaya Tamano Gastrointestinal Center and Institute of Minimally-Invasive Endoscopic Care Sano Hospital Department of Gastroenterology Dokkyo Medical University Koshigaya Hospital Department of Pathology Dokkyo Medical University Koshigaya Hospital

AIM To investigate the post-colonoscopy colorectal cancer(PCCRC) rate for high-definition(HD) colonoscopy compared with that for standard-definition colonoscopy reported *** Using medical records at Sano Hospital(SH) and Dokkyo Medical University Koshigaya Hospital(DMUKH), we retrospectively obtained data on consecutive patients diagnosed as having CRC between January 2010 andDecember 2015. The definition of PCCRC was diagnosis of CRC between 7 and 36 mo after initial high-definition colonoscopy that had detected no cancer, and patients were divided into a PCCRC group and a non-PCCRC group. The primary outcome was the rate of PCCRC for HD colonoscopy. The secondary outcomes were factors associated with PCCRC and possible reason for occurrence of early and advanced *** Among 892 CRC patients, 11 were diagnosed as having PCCRC and 881 had non-PCCRC. The PCCRC rate was 1.7%(8/471) at SH and 0.7%(3/421) at DMUKH. In comparison with the non-PCCRC group, the PCCRC group had a significantly higher preponderance of smaller tumors(39 mm vs 19 mm, P = 0.002), a shallower invasion depth(T1 rate, 25.4% vs 63.6%, P = 0.01), a non-polypoid macroscopic appearance(39.0% vs 85.7%, P = 0.02) and an earlier stage(59.7% vs 90.9%, P = 0.03). Possible reasons for PCCRC were "missed or new" in 9 patients(82%), "incomplete resection" in 1(9%), and "inadequate examination'" in 1(9%). Among 9 "missed or new" PCCRC, the leading cause was non-polypoid shape for early PCCRC and blinded location for advanced *** The PCCRC rate for HD colonoscopy was 0.7%-1.7%, being lower than that for standard-definition colonoscopy(1.8%-9.0%) reported previously employing the same methodology.

关键词： Post-colonoscopy colorectal cancer Highdefinition Post-colonoscopy colorectal cancer rate Associated factor Possible explanation

Emergency balloon-occluded retrograde transvenous obliteration of ruptured gastric varices

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World Journal of Gastroenterology 2013年第31期19卷 5125-5130页

作者： Tetsuo Sonomura wataru Ono Morio Sato Shinya Sahara Kouhei Nakata Hiroki Sanda Nobuyuki Kawai Hiroki Minamiguchi Motoki Nakai Kazushi Kishi Department of Radiology Wakayama Medical University Wakayama 641-8510 Japan Department of Gastroenterology Kishiwada Tokushukai Hospital Kishiwada 596-8522 Japan Department of Radiology Kishiwada Tokushukai Hospital Kishiwada 596-8522 Japan

AIM: To evaluate the effectiveness and safety of emergency balloon-occluded retrograde transvenous obliteration(BRTO) for ruptured gastric ***: Emergency BRTO was performed in 17 patients with gastric varices and gastrorenal or gastrocaval shunts within 24 h of hematemesis and/or tarry *** gastric varices were confirmed by endoscopy,and the gastrorenal or gastrocaval shunts were identified by contrast-enhanced computed tomography(CE-CT).A 6-Fr balloon catheter(Cobra type) was inserted into the gastrorenal shunt via the right internal jugular vein,or into the gastrocaval shunt via the right femoral vein,depending on the varices drainage *** sclerosant,5% ethanolamine oleate iopamidol,was injected into the gastric varices through the catheter during balloon *** patients with incom plete thrombosis of the varices after the first BRTO,a second BRTO was performed the following *** were followed up by endoscopy and CE-CT at 1 d,1 wk,and 1,3 and 6 mo after the procedure,and every 6 mo ***: Complete thrombosis of the gastric varices was not achieved with the first BRTO in 7/17 patients because of large gastric *** patients underwent a second BRTO on the next day,and additional sclerosant was injected through the *** thrombosis which led to disappearance of the varices was achieved in 16/17 patients,while the remaining patient had incomplete thrombosis of the *** of the patients experienced rebleeding or recurrence of the gastric varices after a median follow-up of 1130 d(range 8-2739 d).No major complications occurred after the ***,esophageal varices worsened in 5/17 patients after a mean follow-up of 8.6 ***: Emergency BRTO is an effective and safe treatment for ruptured gastric varices.

关键词： Emergency balloon-occluded retrograde transvenous obliteration Gastric varices Bleeding Portal hypertension Ethanolamine oleate

Rectal angiolipoma diagnosed after surgical resection: A case report

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World Journal of Gastroenterology 2007年第3期13卷 467-469页

作者： Mitsuru ishizuka Hitoshi Nagata Kazutoshi Takagi Toru Horie Akihito Abe Keiichi Kubota Department of Gastroenterological Surgery Dokkyo University School of Medicine Tochigi Japan

Angiolipoma is a common benign tumor with a char- acteristic vascular component that usually occurs in subcutaneous tissue. Although lipomas are frequently encountered at colonoscopy as submucosal tumors, an- giolipomas are rarely found in the gastrointestinal tract including the large intestine. Here we report a 77-year old Japanese man who underwent transanal resection of a tumor that was diagnosed tentatively as a leiomyoma. Histologically, the tumor consisted of mature fat cells and blood vessels. Immunohistochemically, the tumor cells were negative for c-kit and HMB-45, which are consis- tently expressed in tumors such as gastrointestinal stro- mal tumor and angiomyolipoma. The tumor was there- fore diagnosed as an angiolipoma. This is thought to be the first case report of a surgically resected angiolipoma of the rectum.

关键词： Angiolipoma Angiomyolipoma Gastrointestinal stromal tumor

High-spin states of ^(125)Sb:Particle-core excitation coupling

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Science China(Physics,Mechanics & Astronomy) 2003年第4期46卷 390-397页

作者：刘忠张玉虎马英君 Y.Sasaki K.Yamada H.Oshima H.Yokose M.ishizuka T.Komatsubara K.Furuno Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics and Tandem Accelerator Center University of TsukubaIbaraki 305-0006Japan

Excited states of125Sb have been studied using in-beam γ spectroscopy techniques via the124Sn(7Li, α2n) reaction at a beam energy of 32 MeV. A high-spin level scheme including 21 new γ-transitions and 14 new excited states have been established. Three isomers have been identified at 1970, 2110 and 2471 keV and the ranges of their half-lives have been estimated from the delayed coincidence data. The level structure of125Sb is discussed in terms of particle-core excitation coupling. With the help of empirical shell model calculations the three isomers are proposed to have three-quasiparticle πg7/2?v(h 11/2 s 1/2)5?, πg7/2?v(h 11/2 d 3/2)7? and πg7/2?v(h 11 2/2 )10 + configurations, respectively.

关键词： in-beam γ spectroscopy isomer particle-core coupling

Clinicopathological features of minute pharyngeal lesions diagnosed by narrow-band imaging endoscopy and biopsy

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World Journal of Gastroenterology 2012年第44期18卷 6468-6474页

作者： Takashi Kumamoto Kazuhiro Sentani Shiro Oka Shinji Tanaka wataru Yasui Kumamoto Gastrointestinal Clinic Hiroshima 730-0051Japan Department of Molecular Pathology Hiroshima University Graduate School of Biomedical SciencesHiroshima 734-8551Japan Department of Endoscopy Hiroshima University HospitalHiroshima 734-8551Japan

AIM:To evaluate the utility of magnified narrow-band imaging(NBI) endoscopy for diagnosing and treating minute pharyngeal ***:Magnified NBI gastrointestinal examinations were performed by the first author.A magnification hood was attached to the tip of the endoscope for quick *** of the examinations were performed under *** NBI examinations were performed for all of the pharyngeal lesions that had noticeable brownish areas under unmagnified NBI observation,and an intrapapillary capillary loop(IPCL) classification was made.A total of 93 consecutive pharyngeal lesions were diagnosed as IPCL type Ⅳ and were suspected to represent ***-two lesions of approximately 1 mm in diameter were biopsied in the clinic,and 17 lesions with larger diameters were resected by endoscopic submucosal dissection(ESD) at the Hiroshima University *** addition to the histological diagnoses,the lesion diameters were microscopically measured in 45 of the 62 *** of the 62 biopsied patients received endoscopic follow ***:Minute pharyngeal lesions were diagnosed in 93 of approximately 3000 patients receiving magnified NBI examinations at the *** the 93 patients with IPCL type Ⅳ lesions,80 were men,and 13 were ***-six were drinkers,and 57 were *** had esophageal ***-one lesions were located on the posterior hypopharyngeal wall,and 72 lesions were located on the posterior oropharyngeal *** 93 lesions were flat and showed similar findings in the magnified and unmagnified NBI *** almost all of the IPCL type Ⅳ lesions showed faint redness when examined under white light,it was difficult to diagnose the lesions using only this technique because the contrast was weaker than that achieved in the NBI *** the 93 lesions,only 3 had diameters greater than 2.1 ***-two lesions of approximately 1 mm were biopsied in the clinic,whereas 17 larger lesions were tre

关键词： Biopsy Minute pharyngeal lesions Narrow-band imaging

Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface

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International Journal of Oral Science 2018年第3期10卷 174-181页

作者： Hidemichi Kihara David M.Kim Masazumi Nagai Toshiki Nojiri Shigemi Nagai Chia-Yu Chen Cliff Lee wataru Hatakeyama Hisatomo Kondo John Da Silva Harvard School of Dental Medicine BostonMAUSA School of Dental Medicine Iwate Medical UniversityIwateJapan University of California San FranciscoCAUSA

Epithelial attachment via the basal lamina on the tooth surface provides an important structural defence mechanism against bacterial invasion in combating periodontal disease. However, when considering dental implants, strong epithelial attachment does not exist throughout the titanium-soft tissue interface, making soft tissues more susceptible to peri-implant disease. This study introduced a novel synthetic peptide(A10) to enhance epithelial attachment. A10 was identified from a bacterial peptide display library and synthesized. A10 and protease-activated receptor 4-activating peptide(PAR4-AP, positive control) were immobilized on commercially pure titanium. The peptide-treated titanium showed high epithelial cell migration ability during incubation in platelet-rich plasma. We confirmed the development of dense and expanded BL(stained by Ln5) with pericellular junctions(stained by ZO1) on the peptide-treated titanium surface. In an adhesion assay of epithelial cells on A10-treated titanium, PAR4-AP-treated titanium, bovine root and non-treated titanium, A10-treated titanium and PAR4-AP-treated titanium showed significantly stronger adhesion than non-treated titanium. PAR4-AP-treated titanium showed significantly higher inflammatory cytokine release than non-treated titanium. There was no significant difference in inflammatory cytokine release between A10-treated and non-treated titanium. These results indicated that A10 could induce the adhesion and migration of epithelial cells with low inflammatory cytokine release. This novel peptide has a potentially useful application that could improve clinical outcomes with titanium implants and abutments by reducing or preventing peri-implant disease.

关键词： PAR OBA Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface AP

Systematic review of bone marrow stimulation for osteochondral lesion of talus-evaluation for level and quality of clinical studies

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World Journal of Orthopedics 2017年第12期8卷 956-963页

作者： Youichi Yasui Laura Ramponi Dexter Seow Eoghan T Hurley wataru Miyamoto Yoshiharu Shimozono John G Kennedy 2~(nd) Department of Orthopaedic Surgery Teikyo University School of Medicine Hospital for Special Surgery New York 2~(nd) Rizzoli Orthopaedic Institute 2~(nd) Royal College of Surgeons in Ireland Department of Orthopaedic Surgery Teikyo University School of Medicine

AIM To clarify the quality of the studies indicating lesion size and/or containment as prognostic indicators of bone marrow stimulation(BMS) for osteochondral lesions of the talus(OLT). METHODS Two reviewers searched the Pub Med/MEDLINE and EMBASE databases using specific terms on March 2015 in accordance with the Preferred Reporting Items for Systemic Reviews and Meta-Analyses guidelines. Predetermined variables were extracted for all the included studies. Level of evidence(LOE) was determined using previously published criteria by the Journal of Bone and Joint Surgery and methodological quality of evidence (MQOE) was evaluated using the Modified Coleman Methodology Score. RESULTS This review included 22 studies. Overall, 21 of the 22(95.5%) included studies were level Ⅳ or level Ⅲ evidences. The remaining study was a level Ⅱ evidence. MQOE analysis revealed 14 of the 22(63.6%) included studies having fair quality, 7(31.8%) studies having poor quality and only 1 study having excellent quality. CONCLUSION The evidence supporting the use of lesion size and containment as prognostic indicators of BMS for OLTs has been shown to be of low quality.

关键词： Osteochondral lesion of talus Arthroscopy Bone marrow stimulation Systematic review

Carotenoid productivity in human intestinal bacteria Eubacterium limosum and Leuconostoc mesenteroides with functional analysis of their carotenoid biosynthesis genes

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Engineering Microbiology 2024年第2期4卷 1-11页

作者： wataru Matsumoto Miho Takemura Haruka Nanaura Yuta Ami Takashi Maoka Kazutoshi Shindo Shin Kurihara Norihiko Misawa Research Institute for Bioresources and Biotechnology Ishikawa Prefectural University1-308SuematsuNonoich-shi 921-8836Japan Department of Science and Technology on Food Safety Kinki University930 NishimitaniKinokawaWakayama 649-6493Japan Research Institute for Production Development Shimogamo-morimotochoSakyo-kuKyoto 606-0805Japan Department of Food and Nutrition Japan Women’s UniversityMejirodaiBunkyo-kuTokyo 112-8681Japan

The human intestinal microbiota that comprise over 1,000 species thrive in dark and anaerobic *** are recognized for the production of diverse low-molecular-weight metabolites crucial to human health and ***,low-molecular-weight pigments known for their antioxidative activity,are delivered to humans through oral ***,it remains unclear whether human intestinal bacteria biosynthesize carotenoids as part of the in-situ *** this study,we investigated carotenoid synthesis genes in vari-ous human gut and probiotic *** a result,novel candidates,the crtM and crtN genes,were identified in the carbon monoxide-utilizing gut anaerobe Eubacterium limosum and the lactic acid bacterium Leuconostoc mesenteroides *** gene candidates were isolated,introduced into Escherichia coli,which synthesized a carotenoid substrate,and cultured *** analysis of the resulting carotenoids re-vealed that the crtM and crtN gene candidates of *** and *** mediate the production of 4,4′-diaponeurosporene through 15-cis-4,4′-*** of the crtE-homologous genes in these bacteria indicated their non-functionality for C40-carotenoid *** and ***,along with the known carotenogenic lactic acid bacterium Lactiplantibacillus plantarum,were observed to produce no carotenoids under strictly anaerobic *** two lactic acid bacteria synthesized detectable levels of 4,4′-diaponeurosporene under semi-aerobic *** findings highlight that the obligate anaerobe ***-sum retains aerobically functional C30-carotenoid biosynthesis genes,potentially with no immediate self-utility,suggesting an evolutionary direction in carotenoid biosynthesis.(229 words)

关键词： C_(30)carotenoid biosynthesis Obligate anaerobe Human gut bacterium Eubacterium limosum Leuconostoc mesenteroides Lactiplantibacillus plantarum