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World Journal of Gastroenterology 2005年第26期11卷 4013-4017页

作者： Yoshiharu Motoo Hisatsugu Mouri Koushiro Ohtsubo Yasushi Yamaguchi hiroyuki watanabe Norio Sawabu Department of Internal Medicine and Medical Oncology Cancer Research Institute Kanazawa University Kanazawa Japan

AIM:Ribavirin (RBV) shows a strong antiviral effect on hepatitis C virus when used in combination with interferon. However, RBV-induced anemia is a major problem in this therapy. It would be of great clinical importance to ameliorate the anemia without reducing the RBV dose. We report here that, Ninjinyoeito (NYT), a herbal medicine can reduce the RBV-induced anemia. METHODS: Twenty-three patients with chronic hepatitis C were treated with interferon alpha 2b plus RBV with (NYT group) or without (control group) NYT by a randomized selection. Eighteen patients completed the treatment schedule, and hemato-biochemical and virological effects were evaluated. RESULTS: There was no significant difference in biochemical and virological responses between the two groups. However, anemia was significantly reduced in the NYT group compared with the control group. The maximal decrease of Hb in the NYT group (2.59±1.10 g/dL) was significantly (P= 0.026) smaller than that in the control group (3.71±0.97 g/dL). There was no significant difference in serum glutathione peroxidase activity, serum RBV concentration, and Thl/Th2 balance between the two groups. There was no specific adverse effect in NYT administration. CONCLUSION: These results suggest that NYT could be used as a supportive remedy to reduce the RBV-induced anemia in the treatment of chronic hepatitis C.

关键词： Chronic hepatitis C Ribavirin Interferon Herbal medicine Anemia

Effect of educational intervention on attitudes toward the concept of criminal responsibility

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World Journal of Psychiatry 2017年第4期7卷 197-206页

作者： Akihiro Shiina Tomihisa Niitsu Aiko Sato Soichiro Omiya Takako Nagata Aika Tomoto hiroyuki watanabe Yoshito Igarashi Masaomi Iyo Division of Medical Treatment and Rehabilitation Chiba University Center for Forensic Mental Health Department of Psychiatry Graduate School of Medicine Chiba University Social Psychiatry and Mental Health Faculty of Medicine University of Tsukuba Ministry of Health Labour and Welfare Division of Law and Psy-chiatry Chiba University Center for Forensic Mental Health

AIM To evaluate the effect of educational intervention on individuals' knowledge of and attitudes toward forensic mental *** We conducted a questionnaire regarding attitudes toward various ideas about forensic mental health. The respondents attended a 1-h seminar regarding forensic mental health after answering the questionnaire. On completion of the seminar, the respondents answered another questionnaire containing many of the same questions as contained in the pre-seminar *** A total of 86 individuals attended the seminar, and 78 responded to the questionnaire. Only 13(18.8%) participants were supportive of the concept of criminal responsibility initially, and there was a statistically significant increase in those who became more supportive after the seminar, with 22(33%) being supportive after the seminar(Wilcoxon signed-rank test, P < 0.001). Logistic regression analysis revealed that participants who were skeptical about forensic mental systems and those with fewer opportunities to see media reports regarding psychiatry were likely to become supportive of criminal responsibility after the *** These results suggest that public attitudes toward criminal responsibility and mental health can be influenced via educational interventions.

关键词： Forensic psychiatry Criminal responsibility Psychiatry,Law and Ethics Public policy Education in psychiatry Anti-stigma in psychiatry

一种模糊推理机的VLSI实现:单片专家系统

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计算机科学 1989年第4期16卷 59-64页

作者： Masaki Togai hiroyuki watanabe 石桥林

我们给出了一种能处理不确定性和近似推理的推理机制的VLSI实现。为了有效和实时应用,设计是以模糊集合论中的“极大极小运算”为基础的,这种推理机制能处理不精确和不确定的知识,从而能获取专家知识并模拟其推理过程。我们采用定制CMO... 详细信息

我们给出了一种能处理不确定性和近似推理的推理机制的VLSI实现。为了有效和实时应用,设计是以模糊集合论中的“极大极小运算”为基础的,这种推理机制能处理不精确和不确定的知识,从而能获取专家知识并模拟其推理过程。我们采用定制CMOS技术实现了这种推理机制,并突出了简洁性、可扩充性和效率。定时模拟表明这种推理机每秒能完成约80,000次模糊逻辑推理。这类推理机的潜在应用包括指挥与控制领域中的实时决策和机器人系统的自适应命令生成等。

关键词：专家系统推理机制模糊集合 VLSI

胰腺癌组织中基质金属蛋白酶-7(MMP7)的表达(英文)

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癌症 2000年第6期19卷 521-523页

作者：胡育新李平刘宝姝 watanabe hiroyuki Sawabu Norio 上海长海医院肿瘤科上海200433 日本金泽大学癌症研究所内科部

目的：有研究表明基质金属蛋白酶-７（ｍａｔｒｉｘ　ｍｅｔａｌｌｏｐｒｏｔｅｉｎａｓｅ　７，ＭＭＰ７）与部分人肿瘤的浸润和转移有一定关系。本研究旨在探讨胰腺癌组织中ＭＭＰ７的表达及其在本病发展过程中的作用。材料与方法：... 详细信息

目的：有研究表明基质金属蛋白酶-７（ｍａｔｒｉｘ　ｍｅｔａｌｌｏｐｒｏｔｅｉｎａｓｅ　７，ＭＭＰ７）与部分人肿瘤的浸润和转移有一定关系。本研究旨在探讨胰腺癌组织中ＭＭＰ７的表达及其在本病发展过程中的作用。材料与方法：用免疫组化染色方法检测了５１例胰腺癌石蜡包埋组织（其中２２例为早期病变，２９例为晚期病变）中ＭＭＰ７的表达。结果：５１例胰腺癌组织中３５例（６８.６％）显示有ＭＭＰ７表达。而且，晚期胰腺癌ＭＭＰ７表达的阳性率（７９.３％，２３／２９）比早期（５４.５％，１２／２２）高，两组比较差异显著（Ｐ＜０.０５）。结论：胰腺癌组织中ＭＭＰ７的表达与肿瘤进展有一定关系，可被视为一种反映胰腺癌生物侵袭性的有价值的标志物。

关键词：胰腺肿瘤基质金属蛋白酶-7 MMP7 免疫组织化学

Vibration Signal Analysis for Detecting Early-Stage Lumbar Spondylolysis Using Synthetic Bone

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Journal of Biomedical Science and Engineering 2018年第12期11卷 338-347页

作者： hiroyuki watanabe Naohiro Tahara Rina Sakai Naonobu Takahira Suguru Torii Atsuhiko Matsunaga Department of Rehabilitation School of Allied Health Sciences Kitasato University Sagamihara Japan Osada Hospital Yokohama Japan Department of Medical Engineering and Technology School of Allied Health Sciences Kitasato University Sagamihara Japan Faculty of Sports Science Waseda University Tokorozawa Japan

Bone fractures can be detected by analyzing vibration signals following bone stimulation. This method can also be applied to detect stress fractures, such as spondylolysis. The aim of this study was to investigate whether vibration signal analysis can be used to detect lumbar spondylolysis in synthetic bone. Four synthetic spondylolysis models of the fifth lumbar vertebra (Sawbones, product No. SAW1352-10: Malmö, Sweden) were prepared, with the following conditions: intact, unilateral defect, and bilateral defect. Unilateral defects were created by making an incision of either half the diameter (50% incision) or the entire diameter (100% incision) in length through the pars interarticularis or pedicle. Bilateral defects were created by making an additional incision of half the diameter in length on the opposite side of the defected pars interarticularis or pedicle (50% + 100% incision). Hammering was performed five times on each spinous process of the fixed synthetic bones and vibration signals were measured using an accelerometer attached to the contralateral side of the hammer. Signals were analyzed using fast Fourier transform. The parameters analyzed included the mean power frequency, first power minimum frequency (the minimum value between the first and second peaks), spectral areas of low and high frequency bands, and the relative ratio between the spectral areas of low and high frequency bands. The relative ratio was significantly lower in the 50%, 100%, and 50% + 100% incision conditions compared to the intact condition (p < 0.01), suggesting the potential utility of vibration signal analysis in diagnosing lumbar spondylolysis.

关键词： Vibration Signal Spondylolysis Synthetic Bone Lumbar Vertebra

Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia

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Neural Regeneration Research 2025年第6期20卷 1705-1706页

作者： Kazuki watanabe Atsuhiko Hattori Department of Immunobiology Institute of Development Aging and CancerTohoku UniversitySendaiMiyagiJapan Department of Sport and Wellness College of Sport and WellnessRikkyo UniversityNiizaSaitamaJapan

Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian *** hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.

关键词： metabolism primarily agent

新型淀粉样蛋白成像PET显像剂18F-FPYBF-2的生物分布和辐射剂量:首次在人体中的测定评估

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中华核医学与分子影像杂志 2018年第9期38卷 646-647页

作者：李雪娜 Ryuichi Nishii Tatsuya Higashi Shinya Kagawa Chio Okuyama Yoshihiko Kishibe Masaaki Takahashi Tomoko Okina Norio Suzuki Hiroshi Hasegawa Yasuhiro Nagahama Koichi Ishizu Naoya Oishi hiroyuki Kimura hiroyuki watanabe Masahiro Ono Hideo Saji Hiroshi Yamauchi 中国医科大学附属第一医院核医学科 Shiga Medical Center Research Institute Dept.of Molecular Imaging and Theranostics National Institute of Radiological Sciences (NIRS)National Institutes for Quantum and Radiological Science and Technology( QST)

目的近年来,苯并呋喃衍生物5-(5-(2-(2-(2-18F-氟乙氧基)乙氧基)乙氧基)苯并呋喃-2-基)-N-甲基吡啶-2-胺(18F-FPYBF-2)被证实是淀粉样蛋白成像的显像剂。已发现18F-FPYBF-2PET/CT是评估阿尔茨海默病（AD）有用且可靠的诊断工具（Higashi... 详细信息

目的近年来,苯并呋喃衍生物5-(5-(2-(2-(2-18F-氟乙氧基)乙氧基)乙氧基)苯并呋喃-2-基)-N-甲基吡啶-2-胺(18F-FPYBF-2)被证实是淀粉样蛋白成像的显像剂。已发现18F-FPYBF-2PET/CT是评估阿尔茨海默病（AD）有用且可靠的诊断工具（Higashi等,Ann Nucl Med,https://***/10.1007/s12149-018-1236-1,2018）。该研究首次在健康志愿者中评估诊断剂量18F-FPYBF-2的生物分布和辐射。方法 4名健康志愿者[男3名,女1名;平均年龄（40±17）岁,年龄范围25～56岁]行18FFPYBF-2 PET/CT显像,以评估辐射暴露和药代动力学。注射后0～10 min进行身体（胸部和腹部）的动态PET/CT显像,在注射18F-FPYBF-2后进行6次15 min的全身静态显像。重建PET和CT图像数据后,通过拟合动态显像和全身显像的感兴趣体积数据来估量个体器官时间-活度曲线。用OLINDA/EXM 2.0软件判定全身有效剂量（ED）。结果动态PET显像示肝胆系统和肾是18F-FPYBF-2清除的主要途径。肝脏、胆囊、胃和肾脏呈放射性高摄取,其次是肠和膀胱。成人剂量学模型估测的ED为（8.48±1.25）μSv/MBq。男性和女性中较高吸收剂量的器官为:肝脏[（28.98±12.49）和（36.21±15. 64）μGy/MBq],大脑[（20.93±4.56）和（23.05±5.03）μGy/MBq],成骨细胞[（9.67±1.67）和（10.29±1.70）μGy/MBq],小肠[（9.12±2.61）和（11.12±3.15）μGy/MBq]和肾脏[（7.81±2.62）和（8.71±2.90）μGy/MBq]。结论成人剂量学模型的ED与用于淀粉样蛋白PET显像的其他药物所致ED相似。18F-FPYBF-2作为评估AD的诊断工具,其诊断剂量185～370 MBq对患者而言是可耐受的。

关键词：阿尔茨海默病淀粉样蛋白显像健康志愿者正电子发射断层显像术生物分布辐射剂量测定 OLINDA/EXM

泰国东北部—坤坎(Khon Kaen)公共市场所售的可吃昆虫名录

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海南大学学报（自然科学版） 1990年第2期8卷 89-89页

作者： hiroyuki watanabe Rojchai Satrawaha 陈家悦日本京都大学农学院热带农业部坤坎大学科学院生物学部

瓦拉阿史瓦柏提(Varaasvapati)等[1975年]在其所著的《泰国东北部的可吃昆虫》一书中,描述了作为食物的各种昆虫,其中包括椿象、红娘华和螳螂。继此之后,芒格空典(Mungkorndin)[1981年]发表了《森林作为泰国村社食物的来源》一文,文中... 详细信息

瓦拉阿史瓦柏提(Varaasvapati)等[1975年]在其所著的《泰国东北部的可吃昆虫》一书中,描述了作为食物的各种昆虫,其中包括椿象、红娘华和螳螂。继此之后,芒格空典(Mungkorndin)[1981年]发表了《森林作为泰国村社食物的来源》一文,文中讨论了泰国全国的可吃植物和动物。此外,山格普拉都布(Sangpradub)[1982年]发现在泰国东北部可吃的无脊椎动物中计有44％是属于昆虫。我们发现泰国东北部的一个主要城市——坤坎在公共市场上有作为食物出售的各种昆虫。本文描述这些昆虫的15种的价格、出售季节和其它详情。

关键词： Khon Kaen 红娘华普拉文中瓦拉第二作者蛋白质来源饲养方法蒸熟近缘

Interplay between epidermal stem cell dynamics and dermal deformation

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npj Computational Materials 2018年第1期4卷 280-288页

作者： Yasuaki Kobayashi Yusuke Yasugahira hiroyuki Kitahata Mika watanabe Ken Natsuga Masaharu Nagayama Center for Simulation Sciences Ochanomizu UniversityTokyo 112-8620Japan Graduate School of Science Hokkaido UniversitySapporo 060-0810Japan Department of Physics Chiba UniversityChiba 263-8502Japan Department of Dermatology Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan Research Institute for Electronic Science Hokkaido UniversitySapporo 060-0812Japan

Tissue growth is a driving force of morphological changes in living *** the buckling instability is known to play a crutial role for initiating spatial pattern formations in such growing systems,little is known about the rationale for succeeding morphological changes beyond this *** mammalian skin,the dermis has many protrusions toward the epidermis,and the epidermal stem cells are typically found on the tips of these *** the initial instability may well be explained by the buckling involving the dermis and the basal layer,which contains proliferative cells,it does not dictate the direction of these protrusions,nor the spatial patterning of epidermal stem *** we introduce a particle-based model of self-replicating cells on a deformable substrate composed of the dermis and the basement membrane,and investigate the relationship between dermal deformation and epidermal stem cell pattering on *** show that our model reproduces the formation of dermal protrusions directing from the dermis to the epidermis,and preferential epidermal stem cell distributions on the tips of the dermal protrusions,which the basic buckling mechanism fails to *** argue that cell-type-dependent adhesion strengths of the cells to the basement membrane are crucial factors influencing these patterns.

关键词： buckling rational initiating

Isolation and characterization ofβ-transducin repeat-containing protein ligands screened using a high-throughput screening system

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Oncology Research 2023年第5期31卷 645-654页

作者： XINTONG LIU EMIKO SANADA JIANG LI XIAOMENG LI hiroyuki OSADA NOBUMOTO watanabe Chemical Resource Development Research Unit RIKEN CSRSWakoSaitama351-0198Japan Department of RIKEN Molecular and Chemical Somatology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyokuTokyo113-8510Japan Bioprobe Application Research Unit RIKEN CSRSWakoSaitama351-0198Japan Chemical Biology Research Group RIKEN CSRSWakoSaitama351-0198Japan Guangdong Engineering Research Center of Oral Restoration and Reconstruction Affiliated Stomatology Hospital of Guangzhou Medical UniversityGuangzhou510180China KingMed School of Laboratory Medicine Guangzhou Medical UniversityGuangzhou510182China Department of Pharmaceutical Sciences University of ShizuokaSuruga-kuShizuoka422-8526Japan

β-transducin repeat-containing protein(β-TrCP)is an F-box protein subunit of the E3 Skp1-Cullin-F box(SCF)type ubiquitin-ligase complex,and provides the substrate specificity for the *** find potent ligands ofβ-TrCP useful for the proteolysis targeting chimera(PROTAC)system usingβ-TrCP in the future,we developed a high-throughput screening system for small moleculeβ-TrCP *** screened the chemical library utilizing the system and obtained several hit *** effects of the hit compounds on in vitro ubiquitination activity of SCFβ-TrCP1 and on downstream signaling pathways were *** compounds NPD5943,NPL62020-01,and NPL42040-01 inhibited the TNFα-induced degradation of IκBαand its phosphorylated ***,they inhibited the activation of the transcription activity of NF-κB,indicating the effective inhibition ofβ-TrCP by the hit compounds in ***,we performed an in silico analysis of the hit compounds to determine the important moieties of the hit *** groups of NPL62020-01 and NPL42040-01 and hydroxyl groups of NPD5943 created hydrogen bonds withβ-TrCP similar to those created by intrinsic target phosphopeptides ofβ-*** findings enhance our knowledge of useful small molecule ligands ofβ-TrCP and the importance of residues that can be ligands ofβ-TrCP.

关键词： Ubiquitin F-box protein Chemical biology