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A novel bio‑active microsphere for meniscus regeneration via inducing cell migration and chondrocyte differentiation

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Bio-Design and Manufacturing 2021年第2期4卷 203-221页

作者： Hongyao Xu He Huang Xiangjie Zou Pengcheng Xia warren a.l.s.foon Jinwen Wang Department of sports Medicine and Joint surgery Nanjing First HospitalNanjing Medical University68 Changle RoadNanjing 210006JiangsuChina

Abstract Meniscus injury is a common disease in *** it was not treated in time,it leads to osteoarthritis which brings unbearable pain and heavy economic burden to the *** present,meniscectomy and meniscus suture are widely used in the treatment for meniscus ***,It is not ideal for poor self-healing ability of *** recruitment of endogenous stem cells is an attractive option for wounded meniscus *** reduced high-mobility group box 1 protein(HMGB1)can accelerate the regeneration of multiple tissues by endogenous stem cell activation,migration and ***(KGN)has shown to induce the chondrogenesis of the stem ***,no study has explored such effects of HMGB1 and KGN in wounded meniscus ***,in order to improve the regeneration of meniscus,we intend to use a novel bioactive microsphere which was developed by combining fully reduced high mobility group box 1(frHMGB1)and kartogenin(KGN)with alginate gel which slowly release high concentrations of HMGB1 and KGN to activate rat bone marrow stem cells(BMsCs)and promote cell *** results showed that this HMGB1–KGN microsphere released and kept high concentrations of HMGB1 and KGN in the wound area for more than 2 *** vitro experimental results showed that the HMGB1–KGN microsphere can promote cell proliferation via recruiting rat bone marrow stem cells(BMsCs)and activating the BMsCs from G_(0) to G_(Alert) stage as evidenced by cell migration testing and 5-bromo-2′-deoxyuridine(BrdU)incorporation *** vivo results indicated that this HMGB-KGN microsphere can recruit GFP-labeled BMsCs from tail vein to wounded meniscus and induce these GFP-labeled BMsCs to differentiate into *** results demonstrated that the HMGB1–KGN-containing bioactive microsphere induced cell migration in vitro and recruited the cells to wound area to promote wounded rat meniscus healing in vivo.

关键词： Fully reduced HMGB1(frHMGB1) Kartogenin Alginate microsphere Cell migration Meniscus regeneration

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Is aggregated oviposition by the blow flies lucilia sericata and Phormia regina （Diptera： Calliphoridae） really pheromone-mediated？

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Insect science 2015年第5期22卷 651-660页

作者： Bekka s. Brodie warren H. l. Wong sherah Vanlaerhoven Gerhard Gries simon Fraser University Dept. of Biological Sciences Burnaby BC V5A 1S6 Canada and University of Windsor Windsor ON N9B3P4 Canada

When female blow flies lucilia sericata and Phormia regina （Diptera： Cal- liphoridae） oviposit in aggregations on carrion, even-aged larval offspring reportedly de- velop faster, and fewer are parasitized or preyed upon. The benefits of aggregated ovipo- sition equally affect con- and heterospecific larvae sharing a resource. The benefits imply that female blow flies engage in coordinated, pheromone-mediated oviposition behavior. Yet, repeated attempts to identify oviposition pheromones have failed invoking doubt that they exist. simply by regurgitating and feeding on carrion, flies may produce attractive semiochemicals. If flies were to aggregate in response to feeding flies rather than oviposit- ing flies, then the semiochemical cue（s） may be associated with the salivary gland. Working with l. sericata and P.. regina and using liver as a surrogate oviposition medium, we test the hypotheses, and present data in their support, that （i） gravid or nongravid females ovipositing and/or feeding on liver enhance its attractiveness to gravid and nongravid fe- males; （ii） females respond to semiochemicals from feeding heterospecific females; （iii） females respond equally well to semiochemicals from feeding con- and heterospecific females; （iv） macerated head tissues of females applied to liver enhance its attractiveness; and （v） females in direct contact with and feeding on liver, but not when next to yet physically separated from liver, enhance attraction of flies. We conclude that oviposition site-seeking females do not respond to an oviposition pheromone. Instead, they appear to coopt semiochemicals associated with feeding flies as resource indicators, taking chances that resources are suitable for oviposition, and that ovipositing flies are present.

关键词： blow flies carrion egg-laying site pheromone saliva semiochemical

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Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective

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World Journal of Gastroenterology 2017年第4期23卷 638-645页

作者： Kumar Pallav Daniel Riche warren l May Patrick sanchez Nitin K Gupta Division of Digestive Diseases University of Mississippi Medical Center Department of Pharmacy Practice University of Mississippi Medical Center

AIMTo identify the predictors of vitamin D deficiency in patients with and without inflammatory bowel disease (IBD).METHODsPatients with ulcerative colitis (UC) or Crohn’s disease (CD) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were identified. After thorough chart review, we identified patients with biopsy proven IBD who had also been tested for serum 25-hydroxyvitamin D [25(OH)D] concentration. We compared these patients to a previously studied cohort of healthy controls who also had vitamin D concentration checked. logistic regression analysis was performed to determine the association between vitamin d deficiency and UC, CD, race, age, gender and body mass index (BMI).REsUlTsWe identified 237 patients with confirmed IBD. Of these, only 211 had a serum 25(OH)D concentrations available in the medical record. The group of healthy controls consisted of 98 individuals with available serum 25(OH)D concentration. 43% of IBD patients were African American (AA). Patients with CD were more likely to have vitamin D concentration checked. Bivariate analysis showed that AA (51% vs 21%, P = 0.00001), subjects with BMI >30 kg/msup>2sup> (39% vs 23% P = 0.01) and CD (40% vs 26%, P = 0.04) were more likely to be vitamin D deficient than vitamin D sufficient. Those with Age > 65 were more likely to be vitamin D sufficient (46% vs 15%, P = 0.04). Multiple regression showed that only BMI > 30 kg/msup>2sup> and AA race are associated with vitamin D *** > 30 kg/msup>2sup> and AA race are predictive of vitamin D deficiency. Gender, age and diagnosis of IBD are not predictive of vitamin D deficiency.

关键词： Vitamin D deficiency Inflammatory bowel disease Body mass index Ulcerative colitis Crohn’ s disease African American

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A novel algorithm for describing population level trends in body weight

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Health 2012年第12期4卷 1514-1521页

作者： Azadeh Alimadad Carrie Matteson warren l. Hare Ozge Karanfil Diane T. Finegood Department of Biomedical Physiology & Kinesiology Simon Fraser University Burnaby Canada Faculty of Health sciences Simon Fraser University Burnaby Canada Modeling of Complex social systems Program Simon Fraser University Burnaby Canada sloan school of Management MIT Cambridge USA

Modeling population trends and predicting the impact of interventions to address obesity requires algorithms for predicting body weight status in the future. Predictions can be based on statistical consideration of different risk factors, or be an extrapolation of past and current trends. Despite the well known correlation between previous and future weight, individual weight history has not been used to predict future trends. We developed a novel population-level model to examine trends of different classes of body weight considering individual body weight histories from the National longitudinal survey of Youth (NlsY79). A subset of data used to assess the predictive ability of our proposed model with actual data. Our results confirm the importance of weight history in determining future weight status. Over 80% of individuals in a specific weight category (normal, overweight, obese) will stay in the same weight category after two years (except overweight females). The length of body weight stability was also found to be important. The probability of remaining normal weight increased with longer prior periods of being at a normal weight over 18 years (0.834 to 0.893). We demonstrate that an individual’s most probable weight class in the future is consistent with their maximal historical weight class.

关键词： Body Weight Modeling Obesity

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Free bisphenol A(BPA),BPA-Glucuronide(BPA-G),and total BPA concentrations in maternal serum and urine during pregnancy and umbilical cord blood at delivery

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Emerging Contaminants 2019年第1期5卷 279-287页

作者： warren G.Foster Cariton Kubwabo Ivana Kosarac sandra Gregorovich Garima Aryal Kaela Coleman Department of Obstetrics&Gynaecology McMaster UniversityHamiltonOntarioL8S 4K1Canada Environmental Health science and Research Bureau Health CanadaOttawaOntarioK1A 0K9Canada Tobacco Control Directorate Health CanadaOttawaOntarioK1A 0K9Canada

While adult exposure to total bisphenol A(BPA)has been well documented,developmental exposure to BPA and fetal exposure to the bioactive form(free BPA)remains poorly ***,pregnant women(n?199)between 28 and 35 weeks of pregnancy were invited to participate in this *** serum free of hemolysis(n?189)and urine(n?112)were collected at third trimester and delivery along with umbilical cord blood(UCB)at *** BPA,BPA mono-glucuronide(BPA-G)and total BPA concentrations were measured using gas chromatography coupled with tandem mass *** concentrations of free BPA were quantifiable above the method detection limit(MDl?0.026 ng/ml)in approximately 34%of serum samples in the third trimester and 21%of samples at delivery whereas BPA-G and total BPA were quantified in 43 and 70%of third trimester and delivery samples,*** geometric mean of free BPA,BPA-G and total BPA concentrations in maternal serum during the third trimester and at delivery were 0.62 ng/l andl,0.09 and 0.28 ng/ml,and 0.24 and 0.31 ng/ml,*** mean urinary concentrations of free BPA,BPA-G,and total BPA(MDl?0.027 ng/ml)in the third trimester and delivery samples were 0.07 and 0.06 ng/ml,0.36 and 0.09 ng/ml,and 0.36 and 0.09 ng/ml,*** the UCB,the geometric means for free BPA,BPA-G,and total BPA concentrations were 0.05,0.08 and 0.10 ng/ml,*** results suggest that,in our study population,free BPA concentrations were low compared to other Canadian cohorts.

关键词： Bisphenol A Free BPA Conjugated BPA Pregnancy Exposure Fetal development Cord blood

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监测浸金过程氰化物消耗的研究——氰离子电极性能的评价

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黄金 1997年第10期18卷 35-39页

作者：李希明 D.C.Wright l.J.warren 中国科学院化工冶金研究所 DivisionofMineralProductsCsIRO Australia

为寻找有效的监测手段以降低氰化浸金的试剂消耗,评价了两种商业电极“Kegold”和“Orion”氰离子电极的性能,对电极响应和氰离子浓度变化进行线性关联,研究了溶液pH和温度变化对电极响应的影响,并比较了两种电极的测量误差。研究表明,... 详细信息

为寻找有效的监测手段以降低氰化浸金的试剂消耗,评价了两种商业电极“Kegold”和“Orion”氰离子电极的性能,对电极响应和氰离子浓度变化进行线性关联,研究了溶液pH和温度变化对电极响应的影响,并比较了两种电极的测量误差。研究表明,用氰离子电极监测氰化物浓度变化是可行的。在深入研究干扰因素影响的基础上,优化工作条件能进一步改善其测量精确度。

关键词：浸金氰离子电极氰化物炼金测量误差

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氰化浸金过程氰化物消耗的监测——硫、砷离子对氰离子电极行为的影响

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黄金 1999年第10期20卷 30-34页

作者：李希明 D.C.Wright l.J.warren 国家经贸委黄金管理局 DivisionofMineralProducts.CsRO

讨论了两类氰离子电极的工作原理，列举了可能的干扰反应，并在此基础上探讨了硫、砷离子对工作电极的影响。实验结果表明，二价硫离子对测量有严重干扰，三价砷则无不良影响。化学分析证实，氰离子电极能正确响应元素硫、Ｓ２Ｏ２－３... 详细信息

讨论了两类氰离子电极的工作原理，列举了可能的干扰反应，并在此基础上探讨了硫、砷离子对工作电极的影响。实验结果表明，二价硫离子对测量有严重干扰，三价砷则无不良影响。化学分析证实，氰离子电极能正确响应元素硫、Ｓ２Ｏ２－３、ＳＯ２－３、ＳＣＮ－和ＯＣＮ－存在时溶液氰离子浓度的变化。除元素硫之外，其它干扰离子通常在浸金过程中含量都很低，故其影响可不予考虑。

关键词：氰化物监测氰离子电极硫化物氰化浸金

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Discrete-time dynamic graphical games:model-free reinforcement learning solution

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Control Theory and Technology 2015年第1期13卷 55-69页

作者： Mohammed I.ABOUHEAF Frank l.lEWIs Magdi s.MAHMOUD Dariusz G.MIKUlsKI systems Engineering Department King Fahd University of Petroleum & Mineral UTA Research Institute University of Texas at ArlingtonFort Worth Texas U.S.A. state Key laboratory of synthetical Automation for Process Industries Northeastern University Ground Vehicle Robotics (GVR) U.S. Army TARDEC Warren MI U.S.A.

This paper introduces a model-free reinforcement learning technique that is used to solve a class of dynamic games known as dynamic graphical games. The graphical game results from to make all the agents synchronize to the state of a command multi-agent dynamical systems, where pinning control is used generator or a leader agent. Novel coupled Bellman equations and Hamiltonian functions are developed for the dynamic graphical games. The Hamiltonian mechanics are used to derive the necessary conditions for optimality. The solution for the dynamic graphical game is given in terms of the solution to a set of coupled Hamilton-Jacobi-Bellman equations developed herein. Nash equilibrium solution for the graphical game is given in terms of the solution to the underlying coupled Hamilton-Jacobi-Bellman equations. An online model-free policy iteration algorithm is developed to learn the Nash solution for the dynamic graphical game. This algorithm does not require any knowledge of the agents＇ dynamics. A proof of convergence for this multi-agent learning algorithm is given under mild assumption about the inter-connectivity properties of the graph. A gradient descent technique with critic network structures is used to implement the policy iteration algorithm to solve the graphical game online in real-time.

关键词： Dynamic graphical games Nash equilibrium discrete mechanics optimal control model-free reinforcementlearning policy iteration

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高粱对禾谷炭疽病菌的抗性

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园艺与种苗 1984年第2期 8-11页

作者： A.s.Ferreira H.l.warren 郑培绩高淑芝

由禾谷炭疽病菌(Colletotrichumgraminicola,又称禾生刺盘孢菌或禾谷毛盘孢菌)所引起的高粱炭疽病,经常危害甜高粱和粒用高粱。这种菌引起叶片枯萎、茎部腐烂和穗部枯萎,在大部分干旱地区限制了高粱的生产,严重时感病栽培品种减产达50... 详细信息

由禾谷炭疽病菌(Colletotrichumgraminicola,又称禾生刺盘孢菌或禾谷毛盘孢菌)所引起的高粱炭疽病,经常危害甜高粱和粒用高粱。这种菌引起叶片枯萎、茎部腐烂和穗部枯萎,在大部分干旱地区限制了高粱的生产,严重时感病栽培品种减产达50％以上。幼苗接种后,待叶部炭疽病症状充分表现时,可评价抗病的高粱种质。虽然在温室内,用禾谷炭疽

关键词：炭疽病菌苗龄秧龄分生抱子高粱

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美国建筑照明法规近期发展概况

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中国照明电器 2008年第6期 35-35,24页

作者： Willard l. warren 赵阳

引言如今的能源法规发生着怎样的变化?为制订AsHRAE/IEsNA 90.1-2010版能效标准,AsHRAE/IEsNA 90.1照明专委会于2007年10月11～13日在芝加哥召开大会.

关键词：建筑照明能源法规发展概况美国能效标准芝加哥

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