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Ovarian aging:mechanisms and intervention strategies

Medical Review 2022年第6期2卷 590-610页

作者： Zhengmao Zhu wanxue xu Lin Liu Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Department of Genetics and Cell Biology College of Life ScienceNankai University94 Weijing RoadTianjin 300071China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijingChina Tianjin Union Medical Center Institute of Translational MedicineNankai UniversityTianjin 300000China

Ovarian reserve is essential for fertility and influences healthy aging in *** maternal age correlates with the progressive loss of both the quantity and quality of *** molecular mechanisms and various contributing factors underlying ovarian aging have been *** this review,we highlight some of critical factors that impact oocyte quantity and quality during *** cell and follicle reserve at birth de-termines reproductive lifespan and timing the menopause in female *** diminishing ovarian reserve leads to premature ovarian aging or *** oocyte quality with increasing age could result from chromosomal cohesion deterioration and misaligned chromosomes,telomere shortening,DNA damage and associated genetic mutations,oxidative stress,mitochondrial dysfunction and epigenetic *** also discuss the intervention strategies to delay ovarian *** the efficacy of senotherapies by antioxidants against reproductive aging and mitochondrial therapy are *** oocytes and ovarioids could be rejuvenated from pluripotent stem cells or somatic *** propose directions for future *** couples increasingly begin delaying parenthood in life worldwide,understanding the molecular mechanisms during female reproductive aging and potential intervention strategies could benefit women in making earlier choices about their reproductive health.

关键词： mitochondrial therapy oocyte quality oocyte quantity ovarian aging ovarioids senotherapy

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Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers

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Signal Transduction and Targeted Therapy 2019年第1期4卷 116-126页

作者： wanxue xu Mengyao xu Longlong Wang Wei Zhou Rong Xiang Yi Shi Yunshan Zhang Yongjun Piao School of Medicine Nankai UniversityTianjinChina Tianjin Key Laboratory of Human Development and Reproductive Regulation Nankai University Affiliated Hospital of Obstetrics and GynecologyTianjinChina Reproductive Medical Center Nankai University Affiliated Hospital of Obstetrics and GynecologyTianjinChina

Cervical cancer is the leading cause of death among women with cancer ***,we performed an integrative analysis of Illumina HumanMethylation450K and RNA-seq data from TCGA to identify cervical cancer-specific DNA methylation *** first identified differentially methylated and expressed genes and examined the correlation between DNA methylation and gene *** DNA methylation profiles of 12 types of cancers,including cervical cancer,were used to generate a candidate set,and machine-learning techniques were adopted to define the final cervical cancer-specific markers in the candidate ***,we assessed the protein levels of marker genes by immunohistochemistry by using tissue arrays containing 93 human cervical squamous cell carcinoma samples and cancer-adjacent normal *** methylation was negatively correlated with the local regulation of gene *** the distant regulation of gene expression,the methylation of hypermethylated genes was more likely to be negatively correlated with gene expression,while the methylation of hypomethylated genes was more likely to be positively correlated with gene ***,we identified four cervical cancer-specific methylation markers,cg07211381(RAB3C),cg12205729(GABRA2),cg20708961(ZNF257),and cg26490054(SLC5A8),with 96.2%sensitivity and 95.2%specificity by using the tenfold cross-validation of TCGA *** four markers could distinguish tumors from normal tissues with a 94.2,100,100,and 100%AUC in four independent validation sets from the GEO ***,our study demonstrates the potential use of methylation markers in cervical cancer diagnosis and may boost the development of new epigenetic therapies.

关键词： cervical diagnosis specificity

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长链酯酰辅酶A合成酶4介导铁死亡的发生机制

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畜牧兽医学报 2024年第9期55卷 3792-3801页

作者：付红玉李玥崔晗李玖芝许琬雪王曦樊瑞锋山东农业大学动物医学院泰安271017

铁死亡(ferroptosis)是一种铁和脂质过氧化依赖性的程序性死亡方式,触发铁死亡的必要条件是细胞内活性氧物质堆积到致死量。由脂质过氧化反应产生的脂质活性氧会作用于细胞膜上的脂质分子,导致脂质过氧化和膜损伤,因此脂质过氧化是铁死... 详细信息

铁死亡(ferroptosis)是一种铁和脂质过氧化依赖性的程序性死亡方式,触发铁死亡的必要条件是细胞内活性氧物质堆积到致死量。由脂质过氧化反应产生的脂质活性氧会作用于细胞膜上的脂质分子,导致脂质过氧化和膜损伤,因此脂质过氧化是铁死亡的显著特征。长链酯酰辅酶A合成酶4(long-chain acyl-CoA synthetase 4,ACSL4)在调节脂质代谢方面具有关键作用,其主要功能是将多不饱和脂肪酸酯化并插入膜磷脂中,从而加速脂质过氧化的发生并推动铁死亡。ACSL4介导的铁死亡主要受到转录、转录后和翻译后水平上的调控影响,在脂质过氧化依赖性的疾病中发挥着重要作用。本文旨在介绍铁死亡的发生机制,重点阐述了ACSL4受到的上游调控从而介导铁死亡的机制,为研究ACSL4介导铁死亡机制提供理论依据。

关键词： ACSL4 铁死亡脂质过氧化上游调控机制

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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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微(纳米)塑料单独及联合重金属暴露所致动物毒性研究进展

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中国兽医学报 2024年第4期44卷 863-870页

作者：李玖芝付红玉许琬雪陈雪微李玥崔晗樊瑞锋山东农业大学动物医学院山东泰安271017

近年来,随着人口的增长和城市化的推进,人们对塑料产品的需求和使用量持续增加。废弃塑料分解过程可以产生粒径大小不一的微塑料(microplastics,MPs)并进一步分解为纳米塑料(nanoplastics,NPs)。由于难以彻底降解,MPs/NPs污染已成为威... 详细信息

近年来,随着人口的增长和城市化的推进,人们对塑料产品的需求和使用量持续增加。废弃塑料分解过程可以产生粒径大小不一的微塑料(microplastics,MPs)并进一步分解为纳米塑料(nanoplastics,NPs)。由于难以彻底降解,MPs/NPs污染已成为威胁环境的重要因素之一。MPs/NPs具有较强的吸附能力,容易与其他环境污染物结合并富集于动物体内。重金属是广泛存在且长期滞留的环境污染物,MPs/NPs与重金属吸附结合后,通过食物链影响人类和动物的健康。通过对MPs/NPs的污染现状、暴露途径和动物毒性的综述,讨论MPs/NPs与重金属联合暴露导致的毒性作用,以期对MPs/NPs的动物毒性机制与解毒机制研究提供思路。

关键词：微塑料纳米塑料重金属联合暴露毒性效应

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-Fu xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia Rui Mao Xiang Cao Yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Enantio-divergent C–H borylation with two different ligands from a single chiral source

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Science China Chemistry 2025年第1期 226-232页

作者： Rongrong Du Senmiao xu State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University of Chinese Academy of Sciences

Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

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A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng xu xu Zhang Peiyu Wang Bao Yang Bingjun Yang Juan Yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

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Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua xu Miao Yu Yuhang Song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

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