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Hypophysitis induced by anti-programmed cell death protein 1 immunotherapy in non-small cell lung cancer:Three case reports

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World Journal of Clinical Cases 2022年第30期10卷 11049-11058页

作者： Yun Zheng chen-Yu Zhu Jing Lin wang-shan chen Yu-Jie wang Hong-Ye Fu Qiong Zhao Zhejiang University School of Medicine Zhejiang UniversityHangzhou 310030Zhejiang ProvinceChina Department of Thoracic Oncology Shulan(Hangzhou)Hospital affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310000Zhejiang ProvinceChina Zhejiang Chinese Medical University Hangzhou 311402Zhejiang ProvinceChina

BACKGROUND Hypophysitis induced by programmed cell death 1 protein(PD-1)immune checkpoint inhibitors is rare and poorly *** report three patients with non-small cell lung cancer who developed hypophysitis after anti-PD-1 *** SUMMARY Both case 1 and case 2 presented with common symptoms of fatigue,nausea,and ***,case 3 showed rare acute severe symptoms such as hoarse voice,bucking,and difficulty in breathing even when *** two cycles of immunotherapy in case 3,the above severe symptoms and pituitary gland enlargement were found on magnetic resonance imaging at the onset of *** symptoms were relieved after 10 d of steroid *** 3 was the first patient with these specific symptoms,which provided a new insight into the diagnosis of *** addition,we found that the clinical prognosis of patients with hypophysitis was related to the dose of steroid *** 3 was treated with high-dose hormone therapy and her pituitary-corticotropic axis dysfunction returned to normal after more than 6 mo of steroid *** 1 and 2 were treated with the low-dose hormone,and dysfunction of the pituitary-corticotropic axis was still present after up to 7 mo of steroid *** The clinical symptoms described in this study provide a valuable reference for the diagnosis and treatment of immune-related hypophysitis.

关键词： Programmed cell death protein 1 Immunotherapy Hypophysitis Lung cancer Case reports

Oxidative-damage effect of Fe3O4 nanoparticles on mouse hepatic and brain cells in vivo

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Frontiers in Biology 2013年第5期8卷 549-555页

作者： Yongli wang Nian QIN shan chen Jingyun ZHAO Xu YANG Hubei Key Laboratory of Genetic Regulation and Integrative Biology College of Life Science Central China Normal University Wuhan 430079 China

To assess the biological safety of Fe3O4 nanoparticles （NPs）, the oxidative-damage effect of these NPs was studied. Twenty-five Kunming mice were exposed to Fe3O4 NPs by intraperitoneai injection daily for 1 week at doses of 0, 10, 20, and 40 ***1. Five Kunming mice were also injected with 40 *** 1 ordinary Fe3O4 particles under the same physiological conditions. Biomarkers of reactive oxygen species （ROS）, glutathione （GSH）, and malondialdehyde （MDA） in the hepatic and brain tissues were detected. Results showed that no significant difference in oxidative damage existed at concentrations lower than 10 *** i for NPs compared with the control group. Fe3O4 NP concentration had obvious dose-effect relationships （P〈 0.05 or P 〈 0.01） with ROS level, GSH content, and MDA content in mouse hepatic and brain tissues at〉20 *** 1 concentrations. To some extent, ordinary Fe3O4 particles with *** -1 concentration also affected hepatic and brain tissues in mice. The biological effect was similar to Fe3O4 NPs at 10 mg. kg-1 concentration. Thus, Fe3O4 NPs had significant damage effects on the antioxidant defense system in the hepatic and brain tissues of mice, whereas ordinary Fe3O4 had less influence than Fe3O4 NPs at the same concentration.

关键词： Fe3O4 nanoparticle (NP) ordinary Fe3O4 particle oxidative damage reactive oxygen species (ROS) glutathione (GSH) malondialdehyde (MDA)

Comparison of Near Infrared Spectroscopy Models for Determining Protein and Amylose Contents Between Calibration Samples of Recombinant Inbred Lines and Conventional Varieties of Rice

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Agricultural Sciences in China 2007年第8期6卷 941-948页

作者： ZHANG Hong-jiang WU Jin-hong LUO Li-jun LI Ying YANG Hua YU Xin-qiao wang Xiao-shan chen Liang MEI Han-wei shanghai Agrobiological Gene Center Shanghai 201106 P.R.China

The near infrared spectra of 178 recombinant inbred lines （RILs） from the cross of Ⅱ-32B/Yuezaoxian 6 （YZX6） and 511 varieties in rice were acquired. A total of 80 RILs and 96 cultivars were selected as modeling samples by comparing the spectra similarity primarily. Three partial least square （PLS） regression models were developed, based on the RILs （RIL-model）, the varieties （Var-model） and their mixture （Mix-model）, for protein content （PC） and amylose content （AC）, respectively. Cross validation and outer prediction showed that the models were largely influenced by the range and distribution of modeling samples. The regression model of PC based on the cultivars and the model of AC based on RILs had higher coefficient of determination （r^2 ≥ 0.9） and lower root mean square error of cross validation （RMSECVs）. The disadvantages of RIL samples for PC model and variety samples for AC model were probably caused by the narrow range of variance. Aberrant predictions were obtained for outer sample with PC or AC outside the range or within the distribution gap of modeling samples. The Mix-models gave more reliable prediction as the distribution of RIL and variety modeling samples were complementary to each other.

关键词： Oryza sativa L. protein content amylose content NIR spectroscopy RILs varieties

Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai shan Guoliang Li Xuechun chen Wen Zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

交通伤患儿创面鲍氏不动杆菌耐药性及其与抗生素使用的相关性分析

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中华烧伤杂志 2017年第7期33卷 404-409页

作者：刘珊王晨傅跃先重庆医科大学附属儿童医院烧伤整形外科 400014

目的了解交通伤患儿创面鲍氏不动杆菌的耐药性及其与抗生素使用的相关性。方法收集笔者单位2010年1月-2015年12月收治的226例交通伤患儿的创面分泌物，采用API细菌鉴定板条及全自动微生物鉴定系统进行菌株鉴定，通过K—B纸片扩散法测定... 详细信息

目的了解交通伤患儿创面鲍氏不动杆菌的耐药性及其与抗生素使用的相关性。方法收集笔者单位2010年1月-2015年12月收治的226例交通伤患儿的创面分泌物，采用API细菌鉴定板条及全自动微生物鉴定系统进行菌株鉴定，通过K—B纸片扩散法测定检出菌株对阿莫西林／棒酸、哌拉西林／他唑巴坦、亚胺培南等18种抗生素的耐药性。统计各年度患儿创面病原菌检出情况。检出鲍氏不动杆菌对18种抗生素的耐药情况。将鲍氏不动杆菌检出阳性的46例患儿，根据鲍氏不动杆菌对亚胺培南是否100％耐药分为耐亚胺培南组19例和非耐亚胺培南组25例（2例患儿排除），比较2组患JESt面鲍氏不动杆菌对18种抗生素的耐药情况。统计鲍氏不动杆菌检出阳性患儿抗生素使用情况，比较2组患儿抗生素使用强度。对数据进行Fisher确切概率法检验、独立样本≠检验、校正t检验。结果（1）2010--2015年患儿创面病原菌检出率分别为95．6％（43／45）、89．8％（53／59）、81．3％（148／182）、81．1％（107／132）、81．6％（120／147）、77．5％（62／80），呈逐年递减的趋势。共检出665株、75种病原菌，检出率居前5位的病原菌从高到低依次为鲍氏不动杆菌、铜绿假单胞菌、阴沟肠杆菌、表皮葡萄球菌、大肠杆菌。（2）鲍氏不动杆菌对阿莫西林／棒酸、头孢唑林、氨曲南、哌拉西林100％耐药，对多黏菌素100％敏感，对其他13种抗生素总体耐药率均高于50％。2010--2015年各年度患儿创面鲍氏不动杆菌对哌拉西林的耐药率均较哌拉西林／他唑巴坦高。（3）除亚胺培南、阿莫西林／棒酸、头孢唑林、氨曲南、哌拉西林、多黏菌素外，耐亚胺培南组患儿创面鲍氏不动杆菌对其他12种抗生素的耐药率均显著高于非耐亚胺培南组（P值均小于O．01），且该组患儿创面鲍氏不动杆菌对碳青霉烯类、氨基糖苷类、喹诺酮类等3类以上抗生素均100％耐药，属于多药耐药鲍氏不动杆菌。（4）鲍氏不动杆菌检出阳性的46例患儿共使用32种抗生素，其中使用强度前10位的抗生素从高到低分别为头孢哌酮／舒巴坦、哌拉西林／他唑巴坦、头孢唑林、亚胺培南、头孢唑肟、阿莫西林／克拉维酸、头孢他啶、头孢吡肟、阿莫西林／舒巴坦、头孢美唑。（5）21种抗生素因使用量小，未列入进行比较。其他11种抗生素中，2组患儿仅甲硝唑使用强度差异有统计学意义（t=-3．104，P〈0．05）。2组患儿抗生素总体使用强度比较，差异无统计学意义（t=0．368，P〉0．05）。结论鲍氏不动杆菌是交通伤患儿创面主要病原菌之一，耐药率高，高强度使用抗生素可能诱导其产生耐药性。本研究中使用强度居前列的抗生素与鲍氏不动杆菌的耐药抗生素一致，提示抗生素使用的规范性有所欠缺。

关键词：儿童鲍氏不动杆菌抗菌药耐药创面

特质、深描和理解——解读《文化的解释》的路径

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中南民族大学学报（人文社会科学版） 2006年第6期26卷 38-42页

作者：王成善北京师范大学高等教育研究所北京100875

《文化的解释》是美国著名人类学家克利福德.格尔茨的扛鼎之作,也是阐释人类学理论流派的奠基之作。在当代,阐释人类学理论流派是自符号人类学和认知人类学以来,被认为是文化人类学在文化批判和文化研究上影响力最为卓著的一个流派。本... 详细信息

《文化的解释》是美国著名人类学家克利福德.格尔茨的扛鼎之作,也是阐释人类学理论流派的奠基之作。在当代,阐释人类学理论流派是自符号人类学和认知人类学以来,被认为是文化人类学在文化批判和文化研究上影响力最为卓著的一个流派。本文通过对《文化的解释》的解读,试析出阐释人类学理论的路径,指出文化特质是阐释人类学理论的突破口,深描是阐释人类学理论采用的主要方法,尊重地方性文化是理解的主要内涵。

关键词：《文化的解释》阐释人类学特质深描理解

Graphene Aerogel Composites with Self‑Organized Nanowires‑Packed Honeycomb Structure for Highly Efficient Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 533-547页

作者： Xiao You Huiying Ouyang Ruixiang Deng Qiuqi Zhang Zhenzhong Xing Xiaowu chen Qingliang shan Jinshan Yang Shaoming Dong State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Key Laboratory of Inorganic Coating Materials CAS Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Structural Ceramics and Composites Engineering Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210People’s Republic of China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China University of Chinese Academy of Sciences Beijing 100039People’s Republic of China

With vigorous developments in nanotechnology,the elaborate regulation of microstructure shows attractive potential in the design of electromagnetic wave ***,a hierarchical porous structure and composite heterogeneous interface are constructed successfully to optimize the electromagnetic loss *** macro–micro-synergistic graphene aerogel formed by the ice template‑assisted 3D printing strategy is cut by silicon carbide nanowires(SiC_(nws))grown in situ,while boron nitride(BN)interfacial structure is introduced on graphene *** unique composite structure forces multiple scattering of incident EMWs,ensuring the combined effects of interfacial polarization,conduction networks,and magnetic-dielectric ***,the as-prepared composites present a minimum reflection loss value of−37.8 dB and a wide effective absorption bandwidth(EAB)of 9.2 GHz(from 8.8 to 18.0 GHz)at 2.5 ***,relying on the intrinsic high-temperature resistance of SiC_(nws) and BN,the EAB also remains above 5.0 GHz after annealing in air environment at 600℃ for 10 h.

关键词： Hierarchical porous structure Interface High-temperature resistance Graphene aerogel composites Electromagnetic wave absorption

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui shan Shiyu chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

Coupling asymmetry of electrical synapses is set by Ca2+ signals and mediates network-neurons' asynchrony in hypothalamic suprachiasmatic nucleus

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Coupling asymmetry of electrical synapses is set by Ca2+ sig...