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Vertical graphene on flexible substrate,overcoming limits of crack-based resistive strain sensors

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npj Flexible Electronics 2022年第1期6卷 28-35页

作者： Hong Ryeol Na Hyun Joo Lee jae Ho Jeon Han-Jin Kim Sahng-Kyoon Jerng Sanjib Baran Roy Seung-Hyun chun Sunghun Lee Yong Ju Yun Department of Physics and Astronomy Sejong UniversitySeoul 05006Korea Graduate School of Energy and Environment(KU-KIST Green School) Korea UniversitySeoul 02841Korea Center for Energy Materials Research Korea Institute of Science and TechnologySeoul 02792Korea Graphene Research Institute Sejong UniversitySeoul 05006Korea

Resistive strain sensors(RSS)with ultrasensitivity have attracted much attention as multifunctional ***,since most ultrasensitive RSS are designed by cracked conductive metals,the sensing performance is severely degraded due to accumulated structural deformation with consecutive *** overcome such limitation,newly designed structures have been suggested,but the development of mechanosensors exhibiting superior stability and ultrasensitivity still remains a ***,we demonstrate that vertical graphene(VG)RSS with high sensitivity(gauge factor greater than 5000),remarkable durability(>10,000 cycles),and extraordinary resilience can serve multifunctional *** find that well-defined cracks on tufted network structure result in highly reversible resistance variation,especially revivable status even after broken current path,confirmed by microscopic in situ *** VG integrated with a wireless sensing system exhibits excellent timbre recognition *** findings provide inspirable insights for mechanosensing system,making VG a promising component for future practicable flexible sensor technologies.

关键词： strain durability Vertical

Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virusinduced oxidative stress

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Acta Pharmaceutica Sinica B 2023年第1期13卷 174-191页

作者： Eun-Bin Kwon Wei Li Young Soo Kim Buyun Kim Hwan-Suck chung Younghoon Go Hyun-Jeong Ko jae-Hyoung Song Young Ho Kim chun Whan Choi Jang-Gi Choi Korean Medicine(KM)Application Center Korea Institute of Oriental MedicineDaegu 41062Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Natural Product Research Team BiocenterGyeonggido Business and Science AcceleratorGyeonggi-Do 16229Republic of Korea Laboratory of Microbiology and Immunology College of PharmacyKangwon National UniversityChuncheon 24341Republic of Korea

The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral ***,neuraminidase(NA)inhibitors are commonly used antiviral drugs approved by the US Food and Drug Administration(FDA)for the prevention and treatment of ***,we show that vitisin B(VB)inhibits NA activity and suppresses H1N1 viral replication in MDCK and A549 *** oxygen species(ROS),which frequently occur during viral infection,increase virus replication by activating the NF-κB signaling pathway,downmodulating glucose-6-phosphate dehydrogenase(G6PD)expression,and decreasing the expression of nuclear factor erythroid2-related factor 2(Nrf2)antioxidant response *** decreased virus-induced ROS generation by increasing G6PD expression and Nrf2 activity,and inhibiting NF-κB translocation to the nucleus through IKK *** addition,VB reduced body weight loss,increased survival,decreased viral replication and the inflammatory response in the lungs of influenza A virus(IAV)-infected *** together,our results indicate that VB is a promising therapeutic candidate against IAV infection,complements existing drug limitations targeting viral *** modulated the intracellular ROS by G6PD,Nrf2 antioxidant response pathway,and NF-κB signaling *** results demonstrate the feasibility of a multi-targeting drug strategy,providing new approaches for drug discovery against IAV infection.

关键词： Influenza Vitisin B Vitis vinifera L. Neuraminidase Reactive oxygen species NF-κB Multi-targeting Nrf2 G6PD

Impact of homeobox genes in gastrointestinal cancer

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World Journal of Gastroenterology 2016年第37期22卷 8247-8256页

作者： Moon Kyung Joo Jong-jae Park Hoon Jai chun Division of Gastroenterology Department of Internal Medicine Korea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Digestive Disease and Nutrition Korea University College of Medicine

Homeobox genes, including HOX and non-HOX genes, have been identified to be expressed aberrantly in solid tumors. In gastrointestinal(GI) cancers, most studies have focused on the function of non-HOX genes including caudal-related homeobox transcription factor 1(CDX1) and CDX2. CDX2 is a crucial factor in the development of pre-cancerous lesions such as Barrett's esophagus or intestinal metaplasia in the stomach, and its tumor suppressive role has been investigated in colorectal cancers. Recently, several HOX genes were reported to have specific roles in GI cancers; for example, HOXA13 in esophageal squamous cell cancer and HOXB7 in stomach and colorectal cancers. HOXD10 is upregulated in colorectal cancer while it is silenced epigenetically in gastric cancer. Thus, it is essential to examine the differential expression pattern of various homeobox genes in specific tumor types or cell lineages, and understand their underlying mechanisms. In this review, we summarize the available research on homeobox genes and present their potential value for the prediction of prognosis in GI cancers.

关键词： Homeobox genes HOX genes Caudalrelated homeobox transcription factor 2 Gastrointestinal cancers HOXB7

Proton pump inhibitor: The dual role in gastric cancer

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World Journal of Gastroenterology 2019年第17期25卷 2058-2070页

作者： Moon Kyung Joo Jong-jae Park Hoon Jai chun Division of Gastroenterology Department of Internal MedicineKorea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of Medicine

Proton pump inhibitors(PPIs) are one of the most frequently used medications for upper gastrointestinal diseases. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Helicobacter pylori eradication. However, the effects of PPIs on the development of pre-malignant conditions such as atrophic gastritis or intestinal metaplasia are not fully known, suggesting the need for comprehensive and confirmative studies are needed in the future. Meanwhile,several experimental studies have demonstrated the effects of PPIs in reducing chemoresistance in gastric cancer cells by modulating the acidic microenvironment, cancer stemness and signal transducer and activator of transcription 3(STAT3) signaling pathway. The inhibitory effects of PPIs on STAT3 activity may overcome drug resistance and enhance the efficacy of conventional or targeted chemotherapeutic agents. Taken together, PPIs may"play dual role" in gastric carcinogenesis and treatment of gastric cancer.

关键词： Proton pump inhibitor Gastric cancer Drug resistance Signal transducer and activator of transcription 3

Single omental metastasis of renal cell carcinoma after radical nephrectomy:A case report

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世界临床病例杂志 2023年第25期11卷 5994-5999页

作者： jae-Wook chung Jun-Koo Kang Eun Hye Lee So Young chun Yun-Sok Ha Jun Nyung Lee Tae-Hwan Kim Tae Gyun Kwon Ghil Suk Yoon Department of Urology Kyungpook National University HospitalDaegu 41404South Korea Department of Urology School of MedicineKyungpook National UniversityDaegu 41404South Korea Biomedical Research Institute Kyungpook National UniversityDaegu 41404South Korea Joint Institute for Regenerative Medicine Kyungpook National UniversityDaegu 41404South Korea Department of Pathology Kyungpook National University HospitalDaegu 41404South Korea Department of Pathology School of MedicineKyungpook National UniversityDaegu 41404South Korea

BACKGROUND Renal cell carcinoma(RCC)is the third most common malignancy in the genitourinary *** lungs,bone,lymph nodes,liver,and brain are common metastatic sites of ***,there is limited literature on single omental metastasis of *** SUMMARY We present the case of a 44-year-old man with single omental metastasis of RCC after laparoscopic radical *** diagnosis of the resected left kidney revealed pT3a clear cell RCC(Fuhrman grade III).At 6 mo postoperatively,abdominal computed tomography revealed a 12-mm enhancing nodule in the left lower *** 7 mo after initial operation,laparoscopic removal of the left omental nodule was *** pathological results indicated metastatic clear cell ***,the patient is being treated with adjuvant *** Omental metastasis of RCC owing to laparoscopic radical nephrectomy is *** should be aware of the diverse nature of RCC.

关键词： Metastasis Omentum Renal cell carcinoma Radical nephrectomy Case report

Down-scaled regional ocean modeling system (ROMS) for high-resolution coastal hydrodynamics in Korea

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Acta Oceanologica Sinica 2013年第9期32卷 50-61页

作者： LIM Hak-Soo KIM Chang S PARK Kwang-Soon SHIM jae Seol chun Insik Korea Institute of Ocean Science and Technology Konkuk University

A down-scaled operational oceanographic system is developed for the coastal waters of Korea using a re- gional ocean modeling system （ROMS）. The operational oceanographic modeling system consists of at- mospheric and hydrodynamic models. The hydrodynamic model, ROMS, is coupled with wave, sediment transport, and water quality modules. The system forecasts the predicted results twice a day on a 72 h basis, including sea surface elevation, currents, temperature, salinity, storm surge height, and wave information for the coastal waters of Korea. The predicted results are exported to the web-GIS-based coastal informa- tion system for real-time dissemination to the public and validation with real-time monitoring data using visualization technologies. The ROMS is two-way coupled with a simulating waves nearshore model, SWAN, for the hydrodynamics and waves, nested with the meteorological model, WRE for the atmospheric surface forcing, and externally nested with the eutrophication model, CE-QUAL-ICM, for the water quality. The op- erational model, ROMS, was calibrated with the tidal surface observed with a tide-gage and verified with current data observed by bottom-mounted ADCP or AWAC near the coastal waters of Korea. To validate the predicted results, we used real-time monitoring data derived from remote buoy system, HF-radar, and geostationary ocean color imager （GOCI）. This down-scaled operational coastal forecasting system will be used as a part of the Korea operational oceanographic system （KOOS） with other operational oceanographic systems.

关键词： down-scaled operational oceanographic system regional ocean modeling system wave coupledmodel real-time monitoring system

How to reduce and manage the hepatic arterial complications in living and deceased donor liver transplantation?

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 284-287页

作者： Deok-Bog Moon Min-jae Kim Gil-chun Park Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Hepatic artery(HA)reconstruction in liver transplantation(LT),particularly in living donor liver transplantation(LDLT)is nerve-wracking job due to the smallest and shortest vascular *** diameter of donor HA in Asian people is less than 3 mm in more than three quarters of the donors(1).After introduction of microvascular techniques for HA reconstruction in LDLT,the incidence of arterial complications has decreased significantly(2).

关键词： arterial donor liver

TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells

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Cellular & Molecular Immunology 2021年第9期18卷 2262-2274页

作者： Xiaoping Xie Lele Zhu Zuliang Jie Yanchuan Li Meidi Gu Xiaofei Zhou Hui wang jae-Hoon Chang chun-Jung Ko Xuhong Cheng Shao-Cong Sun Department of Immunology The University of Texas MD Anderson Cancer Center7455 Fannin StreetBox 902HoustonTX77030USA Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyXuzhou Medical University209 Tongshan RoadXuzhou221004JiangsuChina College of Pharmacy Yeungnam UniversityGyeongsan712-749Republic of Korea MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences HoustonTX77030USA

Generation and maintenance of antigen-specific effector and memory T cells are central events in immune responses against *** show that TNF receptor-associated factor 2(TRAF2)maintains a survival signaling axis in effector and memory CD8 T cells required for immune responses against *** signaling axis involves activation of Tpl2 and its downstream kinase ERK by NF-κB-inducing kinase(NIK)and degradation of the proapoptotic factor *** mediates Tpl2 activation by stimulating the phosphorylation and degradation of the Tpl2 inhibitor ***,while NIK is required for Tpl2-ERK signaling under normal conditions,uncontrolled NIK activation due to loss of its negative regulator,TRAF2,causes constitutive degradation of p105 and Tpl2,leading to severe defects in ERK activation and effector/memory CD8 T cell ***,TRAF2 controls a previously unappreciated signaling axis mediating effector/memory CD8 T cell survival and protective immunity.

关键词： T cell survival Effector and memory CD8 T cells Protective immunity Bacterial infection TRAF2 NIK Tpl2

Surface and Through Curing Studies by ATR

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光学学报 2003年第S1期23卷 108-109页

作者： chun Kee Ann jae Myoung Ryu Dae Sung Lee Luvantix Co. Ltd. 403-2 Moknae Danwon Ansan Kyoungki Republic of KoreaLuvantix Co. Ltd. 403-2 Moknae Danwon Ansan Kyoungki Republic of KoreaLuvantix Co. Ltd. 403-2 Moknae Danwon Ansan Kyoungki Republic of Korea

The degrees of surface and through cure of UV curable acrylate-based pigmented systems were studied by using ATR(Attenuated Total Reflection) spectroscopy. This paper describes curing investigations of ink coating lay... 详细信息

关键词： Surface and Through Curing Studies by ATR UV on by RAU were of into