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华泽兰内生真菌Aspergillus puniceus次级代谢产物及其抗三阴性乳腺癌活性和作用机制

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华中师范大学学报（自然科学版） 2024年第2期58卷 206-213页

作者：魏敏陈莲陈剑锋金桂兰徐帮王倩邹坤程凡刘呈雄三峡大学生物与制药学院天然产物研究与利用湖北省重点实验室湖北宜昌443002 宜昌市第一人民医院三峡大学附属人民医院湖北宜昌443002 宜昌人福药业有限责任公司湖北宜昌443002

从华泽兰根部分离得到一株内生真菌Aspergillus puniceus.采用正相硅胶柱色谱、Sephadex LH-20凝胶柱色谱及半制备高效液相色谱等方法,从该菌株的发酵液中分离得到8个结构类似的口山酮类化合物,通过现代波谱技术分别鉴定为3′,4′-hydro... 详细信息

从华泽兰根部分离得到一株内生真菌Aspergillus puniceus.采用正相硅胶柱色谱、Sephadex LH-20凝胶柱色谱及半制备高效液相色谱等方法,从该菌株的发酵液中分离得到8个结构类似的口山酮类化合物,通过现代波谱技术分别鉴定为3′,4′-hydrogenated austocystins A(1)、austocystin M(2)、austocystin F(3)、austocystin D(4)、austocystin B(5)、austocystin K(6)、austocystin A(7)、austocystin H(8).MTT结果显示化合物5对三阴性乳腺癌MDA-MB-231细胞具有较好的选择性细胞毒活性(IC_(50)为1.28μmol·L^(-1)).另外,流式细胞术检测化合物5作用于MDA-MB-231细胞后凋亡率的变化,相比于对照组,最高总凋亡率为69.7%.同时,AO/EB双荧光染色也证明化合物5能够诱导MDA-MB-231的细胞凋亡.JC-1线粒体膜电位检测进一步显示化合物5能够通过线粒体途径诱导三阴性乳腺癌MDA-MB-231的细胞凋亡.

关键词：华泽兰 Aspergillus puniceus 次级代谢产物口山酮三阴性乳腺癌凋亡

Additive manufacturing of Ti-6Al-4V alloy by hybrid plasma-arc deposition and microrolling:Grain morphology,microstructure,and tensile properties

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Science China(Technological Sciences) 2022年第4期65卷 849-857页

作者： CHENG Kui ZHANG MingBo SONG Hao LIU Xinwang fan ZiTian wang guilan ZHANG HaiOu State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

To address the problems of coarse columnar grains,inhomogeneous microstructure,and anisotropic mechanical properties of Ti-6Al-4V manufactured by wire and arc additive manufacturing(WAAM)and hybrid additive manufacturing with plasma-arc deposition,synchronous microrolling(HDMR)was examined in this *** leads to significant grain refinement and isotropy *** additive manufacturing alloys show typical columnar grains,while the microrolled ones show a transition from columnar to equiaxed grains with the fraction depending on the microrolling *** microrolling-induced formation of equiaxed grains is caused by both dendrite fragmentation and priorβrecrystallization in the subsequent ***,the rolling force required for good grain refinement in HDMR is much lower than that in WAAM with subsequent cold *** characteristics are present near the grain boundaries due to the recrystallizedαlamellae *** width of the basketweaveαlamellae decreases with the increasing microrolling *** yield strength and ultimate tensile strength of HDMR samples increase with a decrease in elongation *** study shows that HDMR can effectively refine grains and improve the tensile properties of titanium alloys,providing a broad prospect for the rapid formation of large titanium alloy parts.

关键词： titanium alloy additive manufacturing grain refinement microstructure tensile property

IDL: Evaluating software quality based on PageRank algorithm

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The Journal of China Universities of Posts and Telecommunications 2020年第1期27卷 10-25页

作者： Zhou Guoqiang fan Yi Zhang Shuai wang Yilun Li Peng Dai guilan School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China Southwest China Institute of Electronic Technology Chengdu 610036China Institute of Information Technology Tsinghua UniversityBeijing 100084China

In the traditional method, the software quality is measured by various metrics of the software, such as decoupling level(DL), which can be used to predict software defect. However, DL, which treats all the files equally, has not taken file importance into consideration. Therefore, a novel software quality metric, named as improved decoupling level(IDL), based on the importance of documents was proposed. First, the PageRank algorithm was used to calculate the importance of files to obtain the weights of the dependencies, and then defect prediction models was established by combining the software scale, dependencies, scores and software defects to assess the software quality. Compared to most existing module-based software quality evaluation methods, IDL has similar or even superior performance in the prediction of software quality. The results indicate that IDL measures the importance of each file in the software more accurately by combining the PageRank algorithm in DL, which indirectly reflects the quality of software by predicting the bug information in software and improves the accuracy of prediction result of software bug information.

关键词： decoupling level(DL) PageRank improved decoupling level(IDL) software architecture software matrix software quality

Selective nitrogen doping on carbon cloth to enhance the performance of zinc anode

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Chinese Chemical Letters 2021年第3期32卷 1095-1100页

作者： Lei wang guilan fan Jiuding Liu Le Zhang Meng Yu Zhenhua Yan fangyi Cheng Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityTianjin 300071China

Metallic zinc is attractive anode material of rechargeable aqueous Zn-based batteries due to its ambient stability,high volumetric capacity,and abundant ***,Zn anodes suffer from issues such as low coulombic efficiency(CE),large polarization and dendrite ***,uniform Zn electrodeposition is reported on carbon substrates by selective nitrogen *** experimental and theoretical investigations demonstrate that pyrrolic and pyridinic nitrogen doped in carbon play beneficial effect as zinc-philic sites to direct nucleation and growth of metallic Zn,while negligible effect is observed for graphite nitrogen in Zn *** carbon cloth with modified amount of doped pyrrolic and pyridinic nitrogen stabilizes Zn plating/stripping with 99.3%CE after 300 cycles and significantly increases the deliverable capacity at high depth of charge and discharge compared to undoped carbon substrate and Zn *** work provides a better understanding of heteroatom doping effect in design and preparation of stable 3 D carbon-supported zinc anode.

关键词： Zinc Batteries Nitrogen doping Carbon substrate Electrodeposition

糖尿病视网膜病变病人个人掌控感与希望水平及家庭关怀度的相关性

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循证护理 2024年第10期10卷 1803-1807页

作者：张悦黎琴黄艳潘凯丽吴帆王桂兰王康美广西中医药大学护理学院广西530001 广西中医药大学附属瑞康医院

目的:探讨糖尿病视网膜病变病人个人掌控感与希望水平及家庭关怀度的相关性。方法:选取2023年4月—8月在广西南宁市某三级甲等医院眼科和内分泌科就诊的糖尿病视网膜病变病人,应用一般人口学资料调查表、个人掌控感量表(PMS)、希望水平... 详细信息

目的:探讨糖尿病视网膜病变病人个人掌控感与希望水平及家庭关怀度的相关性。方法:选取2023年4月—8月在广西南宁市某三级甲等医院眼科和内分泌科就诊的糖尿病视网膜病变病人,应用一般人口学资料调查表、个人掌控感量表(PMS)、希望水平量表(HHI)和家庭关怀度指数量表(APGAR)进行调查,采用Pearson相关性分析对糖尿病视网膜病变病人PMS评分与HHI、APGAR评分的关系进行分析。采用多重线性回归分析糖尿病视网膜病变病人PMS评分的影响因素。结果:116例糖尿病视网膜病变病人PMS评分为(18.76±2.78)分。Pearson相关性分析显示,糖尿病视网膜病变病人PMS评分与HHI、APGAR评分均呈正相关(P<0.001)。多重线性回归分析结果显示,性别、文化程度、糖尿病病程、HHI和APGAR是糖尿病视网膜病变病人PMS的影响因素(P<0.05)。结论:糖尿病视网膜病变病人个人掌控感处于较低水平,医护人员应重视其个人掌控感,以影响因素为切入点制定针对性干预措施,增强其个人掌控感水平,促进病人的身心健康,减缓疾病的进展。

关键词：糖尿病视网膜病变个人掌控感希望水平家庭关怀度影响因素护理

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Defect passivation and electrical conductivity enhancement in perovskite solar cells using functionalized graphene quantum dots

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Materials Futures 2022年第4期1卷 121-132页

作者： Yichuan Rui zuoming Jin Xinyi fan Weitao Li Bin Li Tianpeng Li Yuanqiang wang Liang wang Jia Liang College of Chemistry and Chemical Engineering Shanghai University of Engineering ScienceShanghai 201620People’s Republic of China Institute of Nanochemistry and Nanobiology School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444People’s Republic of China Department of Materials Science Fudan University220 Handan RoadShanghai 200433People’s Republic of China

Organic–inorganic halide perovskites have been intensively investigated as potential photovoltaic materials due to their exceptional optoelectronic properties and their successful applications in perovskite solar cells(PSCs).However,a large number of defect states still exist in the PSCs so far and are detrimental to their power conversion efficiencies(PCEs)and ***,an effective strategy of incorporating single-crystalline graphene quantum dots(GQDs)into the perovskite films is proposed to passivate the defect ***,the GQD-modified perovskite films exhibit purer phase structure,higher quality of morphology,and higher electrical conductivity when compared with the control perovskite *** of the advantages caused by the incorporation of the GQDs lead to fast carrier separation and transport,long carrier lifetime,and low nonradiative recombination in the PSCs based on the GQD-modified perovskite *** a result,this kind of PSC displays an increase in all photovoltaic parameters,and its PCE shows an enhancement of more than 20%when compared with the control ***,this novel PSC is demonstrated to have long-term stability and resistibility against heat and *** findings provide an insight into how to passivate the defect states and enhance the electrical conductivities in the perovskites and pave the way for their further exploration to achieve higher photovoltaic performances.

关键词： perovskite solar cells graphene quantum dots defect passivation

老年维持性血液透析患者透析中低血压的危险因素分析

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中华肾脏病杂志 2023年第2期39卷 101-111页

作者：曹虎男刘玉秀樊蕊孔凌王芳吕桂兰南京大学医学院南京210093 东部战区总医院重症医学科南京210002 东部战区总医院国家肾脏疾病临床医学研究中心南京210002

目的基于纵向多维数据分析老年维持性血液透析(maintenance hemodialysis,MHD)患者发生透析中低血压(intradialytic hypotension,IDH)的危险因素。方法本研究为单中心、回顾性观察性研究,回顾分析东部战区总医院国家肾脏疾病临床研究中... 详细信息

目的基于纵向多维数据分析老年维持性血液透析(maintenance hemodialysis,MHD)患者发生透析中低血压(intradialytic hypotension,IDH)的危险因素。方法本研究为单中心、回顾性观察性研究,回顾分析东部战区总医院国家肾脏疾病临床研究中心血液净化中心2017年4月3日至2021年12月31日的MHD患者资料。以肾脏疾病结果质量倡议所定义的IDH为结局指标,借助广义估计方程进行单因素回归筛选变量后,结合专业知识行多因素回归以探索IDH发生的独立影响因素。以卡方统计量减自由度评价各因素对IDH发生的重要性,敏感性分析通过对缺失数据行2项5重插补实现。结果共纳入156例老年MHD患者,其中男性91例(58.3%),纳入透析数据记录2681例次。2017—2021年各年度IDH发生率波动于8.3%~13.2%,2017—2021年期间IDH总体发生率为11.0%。多因素回归结果显示,透析前收缩压处于140~159 mmHg(1 mmHg=0.133 kPa,以90~139 mmHg为参照:OR=0.482,95%CI 0.273~0.851,P=0.012)、透析前舒张压≥90 mmHg(以60~89 mmHg为参照,90~99 mmHg:OR=4.081,95%CI 2.132~7.809,P48 g/L:OR=2.692,95%CI 1.102~6.577,P=0.030)、C反应蛋白≥8 mg/L(以<8 mg/L为参照:OR=1.787,95%CI 1.216~2.628,P=0.003)、透析模式为血液透析滤过(以血液透析为参照:OR=2.256,95%CI 1.395~3.648,P=0.001)、实际超滤量/干体重(每增加1%,OR=1.539,95%CI 1.139~2.080,P=0.005)、超滤率(每增加100 ml/h,OR=1.641,95%CI 1.389~1.939,P<0.001)与IDH发生独立相关。重要性分析显示与IDH发生最相关的前三项相关因素为超滤率(χ^(2)-df=32.798)、透析前舒张压(χ^(2)-df=20.757)和白蛋白(χ^(2)-df=19.971),敏感性分析结果表现稳健。结论老年MHD患者IDH发生的独立危险因素分别为超滤率升高、透析前舒张压较高(≥90 mmHg)、白蛋白较低(<34 g/L)、透析模式为HDF、C反应蛋白较高(≥8 mg/L)以及实际超滤量/干体重升高,而透析前较高的收缩压(140~159 mmHg)为保护因素。

关键词：肾透析低血压老年人危险因素

用户视角下农业科学数据描述信息的“结构-效用”研究

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农业图书情报学报 2022年第10期34卷 57-69页

作者：范智萱王健撒旭张贵兰中国农业科学院农业信息研究所北京100081 中国科学技术信息研究所北京100038

[目的 /意义]研究并提出科学数据描述信息的内容结构与其描述效用的对应关系,为科学数据描述的理论研究提供新的视角,为数字环境下农业科学数据的最优描述提供参考。[方法 /过程]对47名农业领域硕博研究生被试的科学数据搜索与相关性判... 详细信息

[目的 /意义]研究并提出科学数据描述信息的内容结构与其描述效用的对应关系,为科学数据描述的理论研究提供新的视角,为数字环境下农业科学数据的最优描述提供参考。[方法 /过程]对47名农业领域硕博研究生被试的科学数据搜索与相关性判断行为进行准实验观察。首先,通过半结构化访谈获取被试相关性判断过程中使用的农业科学数据描述项集合及其使用特征;其次,分析高信心水平下用户的描述项使用路径;最后采用多元回归方法分析描述项对判断信心的预测能力。[结果 /结论]研究得到了11类42项农业科学数据描述项,确定了来源、数据内容、使用与评价、数据产生信息是具备高效用的描述项,得到了高效用描述项组合,初步分析了用户数据素养和数据利用目的对描述项效用的影响。研究成果为科学数据元数据等具体的描述实践提供了理论依据。

关键词：科学数据数据描述元数据信息效用眼动追踪

妊娠期高血压患者血清SFRP5、miR-124-3p表达及临床意义

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中华内分泌外科杂志 2022年第6期16卷 693-697页

作者：聂桂兰范徐妃王春茶于辉兰范俊霞金华市妇幼保健院产科金华321000 金华市中心医院产科金华321000

目的探究妊娠期高血压疾病(HDCP)患者血清分泌型卷曲相关蛋白5(SFRP5)、miR-124-3p表达水平及临床意义。方法选取金华市妇幼保健院2019年1月至2022年2月确诊的98例HDCP患者为观察组,其中包括妊娠期高血压(GH)组41例,轻度子痫前期(PE)32... 详细信息

目的探究妊娠期高血压疾病(HDCP)患者血清分泌型卷曲相关蛋白5(SFRP5)、miR-124-3p表达水平及临床意义。方法选取金华市妇幼保健院2019年1月至2022年2月确诊的98例HDCP患者为观察组,其中包括妊娠期高血压(GH)组41例,轻度子痫前期(PE)32例,重度PE 25例,另选取同期的80名健康体检者作为对照组。采用酶联免疫吸附法(ELISA)检测SFRP5水平,实时荧光定量法(qRT-PCR)检测miR-124-3p表达水平。分析SFRP5、miR-124-3p水平与HDCP患者临床病理指标的关系,采用Pearson法分析SFRP5与miR-124-3p的相关性。HDCP的危险因素探究利用多因素Logistic回归。结果与对照组相比,观察组血清SFRP5表达水平[(33.78±5.21)vs(43.34±8.56)ng/L]下调,而miR-124-3p水平[(2.16±0.41)vs(1.01±0.17)]上调,且观察组血清SFRP5水平随着疾病程度加重而降低[(38.43±6.37)vs(33.18±5.14)vs(26.94±3.38)ng/L],而miR-124-3p水平随疾病程度加重而升高[(1.62±0.24)(2.19±0.43)(3.01±0.69)],其差异均具有统计学意义(P0.05)。生物信息学TargetScan网站显示,SFRP5和miR-124-3p存在结合位点。Pearson相关性分析结果显示,SFRP5和miR-124-3p呈负相关(r=-0.610,P<0.05)。回归分析显示,SFRP5是妊娠期孕妇发生HDCP的保护因素,miR-124-3p是危险因素(P<0.05)。结论HDCP患者血清SFRP5、miR-124-3p水平呈异常表达,且和疾病的程度存在一定的关系,二者均调控HDCP的发生和发展。

关键词：妊娠期高血压子痫前期分泌型卷曲相关蛋白5 miR-124-3p