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针灸治“神”理论在心身病中的应用

世界中医药 2024年第17期19卷 2631-2635页

作者：曹璐璐王照钦龙俊燚刘慧荣吴焕淦上海中医药大学附属岳阳中西医结合医院上海200437 上海市针灸经络研究所上海200030

《黄帝内经》的形神观念对心身医学的研究具有重要的引领作用,其中“神”在心身病的发生发展中占有核心主导地位。通过探讨心身医学中“神”的重要性,阐释神与经络脏腑的关系和针灸调神在心身病中的关键角色。详述针灸治疗心身病的全过... 详细信息

《黄帝内经》的形神观念对心身医学的研究具有重要的引领作用,其中“神”在心身病的发生发展中占有核心主导地位。通过探讨心身医学中“神”的重要性,阐释神与经络脏腑的关系和针灸调神在心身病中的关键角色。详述针灸治疗心身病的全过程,强调医患之间的神气互动和腧穴选择的重要性,达到针灸调神养形的治疗效果。以期为现代心身病的治疗提供新的视角和方法。

关键词：针灸心身病形神理论神黄帝内经理论研究

Herb-partitioned moxibustion regulated the miRNA expression profile in the thyroid tissues of rats with experimental autoimmune thyroiditis

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Journal of Traditional Chinese Medicine 2021年第5期41卷 789-798页

作者： wang zhaoqin CUI Yunhua HUANG Yan WU Huangan ZHAO Jimeng HE Jinsen LIU Huirong ZHENG Handan WU Luyi HU Zhihai LIU Yanan Department of Aeronautics and Astronautics Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint FunctionFudan UniversityShanghai 200433China Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 200030China Yueyang Hospital of Integrative Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai TCM-integrated Hospital Shanghai University of Traditional Chinese MedicineShanghai 200082China

OBJECTIVE:To observe the effect of herb-partitioned moxibustion(HPM)on the miRNA expression profile of thyroid tissue in experimental autoimmune thyroiditis(EAT)***:Rats were randomly divided into normal control(NC)group,EAT model(EAT)group,HPM group and western medicine(Med)*** model rats were prepared by a combined immunization with complete and incomplete Freund’s adjuvant emulsified with porcine thyroglobulin and *** in the HPM group were treated with HPM,while rats in the Med group were treated with levothyrocine(1μg/2 m L)by *** staining was used to observe the pathological morphological changes of thyroid tissue,ELISAs was uaed to detect the serum concentrations of TGAb,TPOAb,FT3,FT4,*** then performed high-throughput mi RNA sequencing to analyse the mi RNA expression profiles in the thyroid tissues,followed by a bioinformatics ***-q PCR was used to verify the identified differentially expressed mi ***:HPM improved the thyroid tissue morphology and reduced serum TPOAb,TGAb,TSH concentration in EAT rats(P<0.05),but with no obvious effect on FT3 and FT4 *** the TSH,FT3 and FT4 concentration was significantly changed in the Med group(P<0.01 or P<0.05)compared with that of EAT *** results showed that a total of 17 mi RNAs were upregulated,and 4 were downregulated in the EAT rats,in which the expression levels of mi R-346 and mi R-331-5 p were reversed by *** target genes of the mi RNAs that regulated by HPM wereassociated with a variety of immune factors and immune ***-q PCR verification showed that the expression of mi RNA-346 and mi RNA-331-5 p was consistent with the sequencing ***:HPM could regulate the the expression of mi RNA-346 and mi RNA-331-5 p,then act on their target genes to immune and inflammation-related pathways,which may be one of the mechanisms of HPM on EAT rats.

关键词： Experimental autoimmune thyroiditis Herb-partitioned moxibustion miRNA expression profile Immuneregulation

基于中性粒细胞胞外诱捕网研究隔药灸减轻克罗恩病大鼠结肠炎症的效应机制

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Journal of Acupuncture and Tuina Science 2024年第3期22卷 173-183页

作者：路驰徐静陆嫄吴璐一包春辉马喆钟蕊王照钦孙可鑫郑寒丹翁志军黄艳吴焕淦杨燕萍(译) Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Research Institute of Acupuncture and Meridian Shanghai 200030China 不详

目的:从中性粒细胞胞外诱捕网(NETs)参与克罗恩病(CD)进展的角度,阐释隔药灸减轻CD大鼠肠道炎症的效应机制。方法:将大鼠随机分为正常组、模型组、隔药灸组和美沙拉嗪组。除正常组外,其余大鼠采用2,4,6-三硝基苯磺酸制备CD模型。正常组... 详细信息

目的:从中性粒细胞胞外诱捕网(NETs)参与克罗恩病(CD)进展的角度,阐释隔药灸减轻CD大鼠肠道炎症的效应机制。方法:将大鼠随机分为正常组、模型组、隔药灸组和美沙拉嗪组。除正常组外,其余大鼠采用2,4,6-三硝基苯磺酸制备CD模型。正常组和模型组不治疗仅做与其他组相同的固定。隔药灸组予以隔药灸气海和双侧天枢穴。美沙拉嗪组接受美沙拉嗪肠溶片灌胃治疗。比较各组大鼠一般情况,苏木精-伊红染色观察结肠组织病理学变化并评分。采用ABC酶联免疫吸附测定法检测各组大鼠血清中性粒细胞胞外诱捕网DNA(NETs-DNA)、中性粒细胞弹性蛋白酶DNA(NE-DNA)、过氧化物酶DNA(MPO-DNA)浓度,采用免疫荧光和实时定量聚合酶链反应技术观察各组大鼠结肠组织瓜氨酸化组蛋白3(citH3)、MPO和NE蛋白和mRNA的表达。结果:与正常组比较,模型组结肠黏膜溃疡深达肌层,上皮不完整,杯状细胞明显减少,可见大量炎性细胞浸润,结肠黏膜损伤指数(CMDI)评分显著增加(P<0.01),模型组血清NETs-DNA、NE-DNA、MPO-DNA浓度均增加(P<0.05),模型组结肠组织NE、citH3和MPO蛋白和mRNA表达均上调(P<0.01或P<0.05);与模型组相比,隔药灸组和美沙拉嗪组结肠黏膜上皮修复,杯状细胞明显增多,可见少量炎性细胞浸润,CMDI评分明显降低(P<0.01),隔药灸组和美沙拉嗪组血清NETs-DNA、NE-DNA、MPO-DNA浓度均下降(P<0.05),隔药灸组和美沙拉嗪组NE、citH3和MPO蛋白和mRNA表达下调(P<0.01或P<0.05)。结论:隔药灸能降低血清中性粒细胞NETs复合物的浓度,抑制结肠组织中的NETs复合物的蛋白和mRNA表达,可能是隔药灸缓解CD结肠黏膜炎症的机制之一。

关键词：隔药灸疗法药饼灸疗法炎症性肠病克罗恩病中性粒细胞胞外诱捕网

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

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Science China(Life Sciences) 2020年第3期63卷 364-374页

作者： Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang wang Jing Yuan zhaoqin wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical CollegeBeijing 100005China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China Emergence Department Peking Union Medical College Hospital Beijing 100731China

The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other *** we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,*** 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 *** viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease ***,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung ***,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease ***,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung *** results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.

关键词： 2019-nCoV AngiotensinⅡ ARDS

Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury

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National Science Review 2020年第6期7卷 1003-1011页

作者： Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li DANDan Zhao Shunwang Li Shuguang Tan zhaoqin wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious Disease State Key Discipline of Infectious Disease Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of China The State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Department of Biochemistry Peking Union Medical College The NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChina CDC The NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC

A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19). We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen, China. To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V, we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients. Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy *** cytokines were linked to 2019-nCoV loads. Fifteen cytokines, namely M-CSF, IL-10, IFN-α2,IL-17, IL-4, IP-10, IL-7, IL-1 ra, G-CSF, IL-12, IFN-γ, IL-1α, IL-2, HGF and PDGF-BB, were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics. Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of which could be potential biomarkers of disease severity of 2019-n Co V infections. These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease. Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized.

关键词： 2019-nCoV COVID-19 cytokine storm IP-10 IL-17

Quantifying the Temperature Effects on the Morbidity of Digestive Diseases In an Inland Plateau-Valley City

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Biomedical and Environmental Sciences 2024年第9期37卷 1101-1105页

作者： Pan Ma Yang Yang Ning Zhou Xinzi wang Yulu wang Wenjuan Feng zhaoqin Bai Shigong wang Plateau Atmosphere and Environment Key Laboratory of Sichuan Province College of Atmospheric ScienceChengdu University of Information TechnologyChengdu 610225SichuanChina Chengdu Plain Urban Meteorology and Environment Observation and Research Station of Sichuan Province Chengdu 610225SichuanChina The Infectious Disease Department The First People’s Hospital of LanzhouLanzhou 730050GansuChina Meteorological Bureau of Jinnan District Tianjin 300350China Gansu University of Chinese Medicine Lanzhou 730000GansuChina

Extreme air temperature and increased weather oscillations caused by climate change have been threatening global *** conditions are external inducers that may trigger the onset of gastrointestinal diseases,in addition... 详细信息

关键词： Plateau weather consumption

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醇酸树脂的油度和其溶度参数的关系

涂料工业 2007年第8期37卷 1-3,15页

作者：王兆勤广东揭阳深展实业有限公司广东揭阳522061

醇酸树脂的溶度参数随油度变化而改变。本文采用重复单元基团加和法计算了醇酸树脂不同油度的溶度参数。进而整理出一组随油度改变的醇酸树脂的三维溶度参数的方程式,推算结果与实际相符。这组方程式可用于估算各种多元醇和不同植物油... 详细信息

醇酸树脂的溶度参数随油度变化而改变。本文采用重复单元基团加和法计算了醇酸树脂不同油度的溶度参数。进而整理出一组随油度改变的醇酸树脂的三维溶度参数的方程式,推算结果与实际相符。这组方程式可用于估算各种多元醇和不同植物油作原料制备的醇酸树脂的油度和其溶解度的关系。

关键词：溶度参数醇酸树脂油度基团加和法

Study on Colloidal Gold Immunochromatography Assay for Rapid Detection of Spectinomycin

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Agricultural Biotechnology 2019年第1期8卷 188-189,193页

作者： zhaoqin wang Yuping WAN Xiaosheng WU Yu ZHANG Fangfang JIA Guangyao HAN Zhengxue PENG Fangyang HE Beijing Kwinbon Biotechnology Company Beijing Engineering Research Centre of Food Safety Immunodetection Beijing wanger Biotechnology Company

[Objectives] This study was conducted to establish a rapid detection method for spectinomycin in pork,chicken,fish,shrimp flesh and water.[Methods]A test strip for rapid detection of spectinomycin in milk was developed by colloidal gold immunochromatography assay. [Results]The test strip had a detection limit of 50 μg/kg to milk with a detection time of 15 min,and the false positive rate and false negative rate were both 0. [Conclusions]The method is accurate,simple,reliable and convenient,and is suitable for rapid on-site spectinomycin detection.

关键词： Spectinomycin Gold immunochromatography assay rapid test strip Rapid detection

Preparation of Immunomagnetic Beads Enrichment Kit for Detection of Aflatoxin B1

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Plant Diseases and Pests 2018年第3期9卷 1-3页

作者： Wu Xiaosheng wang zhaoqin Jia Fangfang Du Meihong Cui Tingting Cui Haifeng Cao Dongshan Wan Yuping Beijing Kwinbon Biotechnology Co. Ltd. Beijing 102206 China Beijing Rapid Detection Engineering Technical Center for Food Safety and Immunization Beijing 102206 China Beijing Physical and Chemical Analysis Testing Center Beijing 100089 China

Immunomagnetic beads enrichment kit for detection of aflatoxin B1(AFB1) was prepared through reaction of AFB1 and p-phenylenediamine. The catches of AFB1 by the kit were 25 ng/mg. Furthermore, AFB1 was conducted specific reaction with competitive drugs with similar structure or function to AFB1, including aflatoxin M1, T-2 toxin, ochratoxin A, zearalenone and patulin, and no cross reaction was observed.

关键词： Aflatoxin B1(AFB1) Monoclonal antibody Immunomagnetic beads enrichment kit