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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai wang Qixin Chen Chengzhen Liang department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang university Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species

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Integrative Zoology 2021年第2期16卷 149-159页

作者： Shuli HUANG Guoliang LI yongliang PAN Mingjing SONG Jidong ZHAO Xinrong WAN Charles JKREBS Zuoxin wang Wenxuan HAN Zhibin ZHANG State Key Laboratory of Integrated Pest Management Institute of ZoologyChinese Academy of SciencesBeijingChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina School of Medicine Huzhou UniversityHuzhouChina Key Laboratory of Human Disease Comparative Medicine National Health Commission of China(NHC)Beijing Engineering Research Center for Experimental Animal Models of Human DiseasesInstitute of Laboratory Animal SciencePeking Union Medicine CollegeChinese Academy of Medical ScienceBeijingChina department of Zoology University of British ColumbiaVancouverBritish ColumbiaCanada department of Psychology and Program in Neuroscience Florida State UniversityTallahasseeFloridaUSA College of Resources and Environmental Sciences China Agricultural UniversityBeijingChina

It is known that social stress could alter oxytocin(OT)and arginine-vasopressin(AVP)expression in specific regions of brains which regulate the aggressive behavior of small rodents,but the effects of density-induced social stress are still ***’s voles(Lasiopodomys brandtii)are small herbivores in the grassland of china,but the underlying neurological mechanism of population regulation is still *** tested the effects of housing density of Brandt’s voles on OT/AVP system with physical contact(allowing aggression)and without physical contact(not allowing aggression)under laboratory ***,we tested the effects of paired-aggression(no density effect)of Brandt’s voles on OT/AVP system under laboratory *** hypothesized that high density would increase aggression among animals which would then increase AVP but reduce OT in brains of *** results showed that high housing density induced more aggressive *** found high-densityinduced social stress(with or without physical contact)and direct aggression significantly increased expression of mRNA and protein of AVP and its receptor,but decreased expression of mRNA and protein of OT and its receptor in specific brain regions of *** results suggest that density-dependent change of OT/AVP systems may play a significant role in the population regulation of small rodents by altering density-dependent aggressive behavior.

关键词： aggression behavior density-dependent stress oxytocin(OT) social stress vasopressin(AVP)

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准二维各向同性激光冷却的光场仿真

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光学学报 2024年第3期44卷 155-165页

作者：张孝王鑫王文丽孙远刘亮中国科学院上海光学精密机械研究所航天激光工程部上海201800 中国科学院上海光学精密机械研究所量子光学重点实验室上海201800 中国科学院大学北京100049

在各向同性激光冷却原子实验中,光场分布是影响冷原子分布的重要因素,可以利用真空腔的结构和激光的注入方式的不同来调控腔内的冷原子分布。本文提出了一种扁平形漫反射腔体结构,并对冷却光的不同注入方式和不同尺寸的腔体结构形成的... 详细信息

在各向同性激光冷却原子实验中,光场分布是影响冷原子分布的重要因素,可以利用真空腔的结构和激光的注入方式的不同来调控腔内的冷原子分布。本文提出了一种扁平形漫反射腔体结构,并对冷却光的不同注入方式和不同尺寸的腔体结构形成的光场分布进行了仿真。仿真结果表明,与自由空间光入射相比,激光由光纤入射能够获得更均匀的准二维分布的光场,因此可以通过调节光纤的入射角度及光纤参数,实现对光场均匀度的优化。此外,随着腔体边长的等比放大,腔内光功率密度呈负指数幂衰减。扁平形漫反射腔形状接近二维,在准二维分布的光场和特殊的扁平形腔体结构的作用下,能够获得呈准二维分布的冷原子,在量子传感及量子精密测量领域具有重要的应用前景。

关键词：光场仿真漫反射准二维光场各向同性激光冷却

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光纤时间频率同步技术及应用

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仪器仪表学报 2024年第2期45卷 47-62页

作者：陈雨锋王波清华大学精密仪器系北京100084 时空信息精密感知技术全国重点实验室北京100084 光子测控技术教育部重点实验室北京100084 中国兵器工业导航与控制技术研究所北京100089

时间是人类目前测量和复现不确定度指标最高的物理量,代表了人类科技发展的最高水平。光纤时频同步技术经过几十年的发展,目前已广泛应用于量子计量、射电干涉测量、定位导航、现代通信、电力电网、高能物理、大地测量等诸多领域,成为... 详细信息

时间是人类目前测量和复现不确定度指标最高的物理量,代表了人类科技发展的最高水平。光纤时频同步技术经过几十年的发展,目前已广泛应用于量子计量、射电干涉测量、定位导航、现代通信、电力电网、高能物理、大地测量等诸多领域,成为人类社会高效运行的重要支撑。得益于光纤时频同步技术的高可靠性和高稳定度,综合原子时“分布式”和“实时性”这一长期存在的矛盾得到了解决。文章介绍了光纤时频同步技术的发展历史、各技术路径的研究现状,以及基于北京地区光纤时频同步网生成的分布式实时综合原子时。在此基础上,指出光纤时频同步的发展重点正从技术研究转为大规模网络化应用,开展基于光网络的多功能、多应用融合研究,实现一体化通信、感知、计算、测量、控制,将是未来的重要发展趋势。

关键词：光纤网络时间同步频率同步光载射频综合原子时

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基于离散泰勒级数的新型联想记忆系统

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天津工业大学学报 2003年第4期22卷 56-58页

作者：王俊松徐宁寿崔世钢邴志刚天津职业技术师范学院自动化系天津300022 北京工业大学自动化系北京100080

基于离散泰勒级数提出一种对任意阶多维函数可实现无差逼近的新型联想记忆系统,详细讨论了该系统的插值算法、训练规则及寻址机制.新型联想记忆系统相对于CMAC具有逼近精度更高、占用存储单元较少、学习速度较快等优点.该系统在信号处... 详细信息

基于离散泰勒级数提出一种对任意阶多维函数可实现无差逼近的新型联想记忆系统,详细讨论了该系统的插值算法、训练规则及寻址机制.新型联想记忆系统相对于CMAC具有逼近精度更高、占用存储单元较少、学习速度较快等优点.该系统在信号处理、模式识别、过程建模及高精度实时智能控制等领域具有广泛的应用价值.仿真实例表明了系统的可行性与有效性.

关键词：离散泰勒级数联想记忆系统插值算法训练规则

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Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury

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Zoological Research 2024年第3期45卷 648-662页

作者： Dan Yang Bin-Bin Nie Jin-Gang He Zong-Qiang Lv Feng-Feng Mo Si-Yi Ouyang Jie wang Ju-Xiang Chen Tao Tao department of Anesthesiology Central People’s Hospital of ZhanjiangZhanjiangGuangdong 524045China Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhanHubei 430071China department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghai 200082China department of Nutrition and Food Hygiene Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Institute of Neuroscience and Brain Diseases/Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei 441021China Songjiang Hospital and Songjiang Research Institute Shanghai Jiao Tong University School of MedicineShanghai 201600China department of Anesthesiology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability *** PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely *** potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced *** this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term *** indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury *** kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of ***,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying ***,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for *** studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment.

关键词： Post-traumatic headache(PTH) Mild traumatic brain injury(mTBI) Metabolic kinetics fMRI Cerebellum

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CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression

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International Journal of Oral Science 2024年第1期16卷 134-144页

作者： Xuan Zhou Xinjia Cai Fengyang Jing Xuefen Li Jianyun Zhang Heyu Zhang Tiejun Li department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Research Unit of precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)BeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina

Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanoreceptors on the surface of monocytes/macrophages, especially adhesion G protein-coupled receptors (aGPCRs), play important roles in force ***, its role in the regulation of osteoclast differentiation remains unclear. Herein, through single-cell analysis, we revealed that CD97, a novel mechanosensitive aGPCR, was expressed in macrophages. Compression upregulated CD97 expression and inhibited osteoclast differentiation;while knockdown of CD97 partially rescued osteoclast differentiation. It suggests that CD97 may be an important mechanosensitive receptor during osteoclast differentiation. RNA sequencing analysis showed that the Rap1a/ERK signalling pathway mediates the effects of CD97 on osteoclast differentiation under compression. Consistently, we clarified that administration of the Rap1a inhibitor GGTI2.8 increased osteoclast activity, thereby accelerating tooth movement. In conclusion,our results indicate that CD97 suppresses osteoclast differentiation through the Rap1a/ERK signalling pathway under orthodontic compressive force.

关键词： CD97 osteoclast inhibited

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认知研究的新技术——一套图形标准化资料和计算机实验软件

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心理学报 1992年第4期24卷 386-392页

作者：舒华张厚粲李文玲王爱平储齐人北京师范大学心理系北京师范大学天文系

本工作是建立一套适合我国特点并有利于开展跨文化研究的图形加工实验的技术资料。工作包括两部分:1.建立一套图形标准化常模。2.建立相应的图库及图一词实验计算机软件,其中包括识别、启动、同时匹配和Stroop四个实验程序。为保证实验... 详细信息

本工作是建立一套适合我国特点并有利于开展跨文化研究的图形加工实验的技术资料。工作包括两部分:1.建立一套图形标准化常模。2.建立相应的图库及图一词实验计算机软件,其中包括识别、启动、同时匹配和Stroop四个实验程序。为保证实验的精度,程序编制中解决了图形的即时呈现、即时消失、刺激的随机呈现、反应时精度1毫秒等问题。

关键词：图形实验软件呈现认知

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Microplastome visualizations:From spatiotemporal distribution to risk assessment

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The Innovation 2024年第5期5卷 23-24页

作者： Chao Zhao Bailin Zhao Fengbang wang Guangbo Qu Qian Luo Ling Guo Xiaotian Tan Xiaona Li Peng Zhou Zongwei Cai Institute of Scientific Instrumentation Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongSAR 999077China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100083China Institute of Molecular and Translational Medicine(IMTM) and Department of Biochemistry and Molecular BiologyXi’an Jiaotong University Health Science CenterXi’an 710049China The Second Affiliated Hospital of Xi’an Jiaotong university Xi’anShaanxi 710049China Shenzhen Key Laboratory of Epigenetics and precision Medicine for Cancers National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academic of Medical Sciences&Peking Union Medical CollegeShenzhen 518100China department of Pharmacy Peking University Third HospitalBeijing 100096China department of Ultrasound First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen Second People’s HospitalShenzhen 518037China Shenzhen Key Laboratory of precision Diagnosis and Treatment of Depression Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

VECTOR EFFECT OF MICROPLASTIC *** microplastic pollution issue is infamous for its enormous multidimensionality and the intricate combination arising from plastics themselves and“plasticassociated chemicals.”Interactions between microplastic particles with multiple chemicals can affect biological health and alter the toxicity of the primary environmental *** complex combinations raise great challenges to experimental design for toxicity evaluation,going beyond the investigation of individual or dual *** research and an integrated visualization strategy are needed to decipher these biochemical processes and molecular mechanisms.1,2.

关键词： distribution visualization chemicals

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Remote sensing and its applications using GNSS reflected signals:advances and prospects

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Satellite Navigation 2024年第1期5卷 10-51页

作者： Shuanggen Jin Adriano Camps Yan Jia Feng wang Manuel Martin-Neira Feixiong Huang Qingyun Yan Shuangcheng Zhang Zhongyu Li Komi Edokossi Dongkai Yang Zhiyu Xiao Zhongmin Ma Weihua Bai Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai200030China School of Surveying and Land Information Engineering Henan Polytechnic UniversityJiaozuo454003China department of Signal Theory and Communications Technical University of CataloniaBarcelona08034Spain department of Surveying and Geoinformatics Nanjing University of Posts and TelecommunicationsNanjing210023China School of Electronics and Information Engineering Beihang UniversityBeijing100191China European Space Research and Technology Centre(ESTEC) European Space Agency2200-AGNoordwijkThe Netherlands National Space Science Center Chinese Academy of SciencesBeijing100190China School of Remote Sensing and Geomatics Engineering Nanjing University of Information Science and TechnologyNanjing210044China College of Geological Engineering and Geomatics Chang’an UniversityXi’an710054China university of Electronic Science and Technology of china Chengdu611731China

The Global Navigation Satellite Systems(GNSS),including the US’s GPS,china’s BDS,the European Union’s Galileo,and Russia’s GLONASS,offer real-time,all-weather,any-time,anywhere and high precision observations by transmitting L band signals continuously,which have been widely used for positioning,navigation and *** the development of GNSS technology,it has been found that GNSS-reflected signals can be used to detect Earth’s surface characteristics together with other signals of *** this paper,the current status and latest advances are presented on Global Navigation Satellite System-Reflectometry(GNSS-R)in theory,methods,techniques and *** developments and progresses in GNSS-R instruments,theoretical modeling,and signal processing,ground and space-/air-borne experiments,parameters retrieval(*** speed,sea surface height,soil moisture,ice thickness),sea surface altimetry and applications in the atmosphere,oceans,land,vegetation,and cryosphere are given and reviewed in ***,the challenges in the GNSS-R development of each field are also ***,the future applications and prospects of GNSS-R are discussed,including multi-GNSS reflectometry,new GNSS-R receivers,GNSS-R missions,and emerging applications,such as mesoscale ocean eddies,ocean phytoplankton blooms,microplastics detection,target recognition,river flow,desert studies,natural hazards and landslides monitoring.

关键词： GNSS Reflectometry Remote sensing Environmental change

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