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习近平文化思想的生成逻辑、核心要义与时代价值

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南昌航空大学学报（社会科学版） 2024年第2期26卷 11-18,84页

作者：王一喆李涵北京化工大学马克思主义学院北京100029

习近平文化思想是中国共产党领导社会主义文化建设的最新理论成果。探寻习近平文化思想的生成脉络,百年来中国共产党人领导社会主义文化建设的现实经验为其提供了深厚的历史沉淀,马克思主义文化观、中国共产党人文化理论、中华优秀传统... 详细信息

习近平文化思想是中国共产党领导社会主义文化建设的最新理论成果。探寻习近平文化思想的生成脉络,百年来中国共产党人领导社会主义文化建设的现实经验为其提供了深厚的历史沉淀,马克思主义文化观、中国共产党人文化理论、中华优秀传统文化为其提供了丰富的理论渊源,新时代中国特色社会主义文化发展的现实需要为其提供了实践基础。习近平文化思想具有十分丰富的核心要义,是坚持党的全面领导、秉持人民中心理念、突出问题导向、强调文化建设自信自立、坚持文化发展守正创新的科学理论。习近平文化思想丰富发展了马克思主义文化理论,提供了中华民族现代文明繁荣发展的理论指导,开拓了世界文化繁荣发展的现实路径,是富有中国智慧的理论创造。

关键词：习近平文化思想生成逻辑核心要义时代价值

考虑时空协同优先的城市应急车辆路径优化方法

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公路交通科技 2024年第3期41卷 169-178,198页

作者：郝正博杨晓光王一喆高乃航苏岳龙同济大学道路与交通工程教育部重点实验室上海201804 上海市消防救援总队上海200051 高德软件有限公司北京102299

目前城市应急救援车辆救援效能提升面临交通拥堵、交叉口延误、突发事故等诸多挑战。传统路径算法忽略了实际救援工作需求和路径选择偏好特征,无法很好满足快速高效、安全可靠的救援需求。针对这一问题,立足应急车辆与社会车辆在优先通... 详细信息

目前城市应急救援车辆救援效能提升面临交通拥堵、交叉口延误、突发事故等诸多挑战。传统路径算法忽略了实际救援工作需求和路径选择偏好特征,无法很好满足快速高效、安全可靠的救援需求。针对这一问题,立足应急车辆与社会车辆在优先通行政策、车辆特性、优化目标、路径选择偏好等多特征差异,提出一种考虑时空协同优先的两阶段应急车辆救援路径动态优化方法。第1阶段,将用于求解静态K最短路径的Yen算法与城市路网时空动态性、高度随机性及不确定性等特征结合,增加基于层次聚类算法的路径安全风险约束与基于偏斜度指数等综合评价指标的可靠性约束,构建带有安全可靠性约束的动态K最短路径精确算法。第2阶段,结合车道数量、路段限速、路段长度等静态属性特征与拥堵延迟指数、路段平均车速等动态属性特征,求解在时空协同优先条件下的最佳救援路径。结果表明:与历史救援轨迹相比,考虑时空协同优先的两阶段城市应急车辆路径优化方法能够有效缩短城市应急车辆的救援响应时间,并提高应急车辆救援安全性与可靠性。因此,本方法面向实际救援工作,具有较好的应用前景。

关键词：城市交通路径动态优化时空协同优先应急车辆安全风险可靠性

The importance of data assimilation components for initial conditions and subsequent error growth

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Science China Earth Sciences 2024年第1期67卷 105-116页

作者： Zhongrui wang Haohao SUN Lili LEI zhe-Min TAN yi ZHANG Key Laboratory of Mesoscale Severe Weather Ministry of Educationand School of Atmospheric SciencesNanjing UniversityNanjing 210023China Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China

Despite a specific data assimilation method,data assimilation(DA)in general can be decomposed into components of the prior information,observation forward operator that is given by the observation type,observation error covariances,and background error *** a classic Lorenz model,the influences of the DA components on the initial conditions(ICs)and subsequent forecasts are systematically investigated,which could provide a theoretical basis for the design of DA for different scales of *** forecast errors undergo three typical stages:a slow growth stage from 0 h to 5 d,a fast growth stage from 5 d to around 15 d with significantly different error growth rates for ensemble and deterministic forecasts,and a saturation stage after 15 *** strategies that provide more accurate ICs can improve the *** assimilation is superior to offline assimilation,and a flow-dependent background error covariance matrix(Pf)provides better analyses than a static background error covariance matrix(B)for instantaneous observations and frequent time-averaged observations;but the opposite is true for infrequent time-averaged observations,since cycling simulation cannot construct informative priors when the model lacks predictive skills and the flow-dependent Pf cannot effectively extract information from low-informative observations as the static *** observations contain more information than time-averaged observations,thus the former is preferred,especially for infrequent observing ***,ensemble forecasts have advantages over deterministic forecasts,and the advantages are enlarged with less informative observations and lower predictive-skill model priors.

关键词： Data assimilation Atmospheric predictability Background error covariances Ensemble forecasts

Amino-functionalized UiO-66-doped mixed matrix membranes with high permeation performance and fouling resistance

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Chinese Journal of Chemical Engineering 2024年第3期67卷 68-77页

作者： yi Zhang Di Liu Zhaoli wang Junjian Yu Yanyin Cheng Wenjing Li zhe wang Hongzhe Ni Yuchao wang School of Chemical Engineering Changchun University of TechnologyChangchun 130012China Advanced Institute of Materials Science Changchun University of TechnologyChangchun 130012China Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province Changchun 130012China School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China

For the reduction of bovine serum proteins from wastewater,a novel mixed matrix membrane was prepared by functionalizing the substrate material polyaryletherketone(PAEK),followed by carboxyl groups(C-SPAEKS),and then adding amino-functionalized UiO-66-NH_(2)(Am-UiO-66-NH_(2)).Aminofunctionalization of UiO-66 was accomplished by melamine,followed by an amidation reaction to immobilize Am-UiO-66-NH_(2),which was immobilized on the surface of the membrane as well as in the pore channels,which enhanced the hydrophilicity of the membrane surface while increasing the negative potential of the membrane *** nanoparticle-loaded ultrafiltration membrane has good permeation performance,with a pure water flux of up to 482.3 L·m^(-2)·h^(-1) for C-SPAEKS/AmUiO-66-NH_(2) and a retention rate of up to 98.7%for bovine serum albumin(BSA)-contaminated ***,after several hydrophilic modifications,the flux recovery of BSA contaminants by this series of membranes increased from 56.2%to 80.55%of pure *** results of ultra-filtration flux time tests performed at room temperature showed that the series of ultrafiltration membranes remained relatively stable over a test time of 300 ***,the newly developed mixed matrix membrane showed potential for high efficiency and stability in wastewater treatment containing bovine serum proteins.

关键词： Ultrafiltration Mixed matrix membranes Amino functionalization Hydrophilic modification Negatively charged

Amine-functionalized metal organic framework@graphene oxide as filler in PAEK-containing carboxyl group membrane for ultrafiltration with ultra-high permeability and strong fouling resistance

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Chinese Journal of Chemical Engineering 2024年第6期70卷 93-103页

作者： Zhaoli wang Wenjing Li yi Zhang Yanyin Cheng Junjian Yu Tianming Dong Xiaoyu Chi Di Liu zhe wang School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China Advanced Institute of Materials Science Changchun University of TechnologyChangchun 130012China Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province Changchun 130012China

Achieving high fouling resistance and permeability using membrane separation technology in water treatment processes remains a *** this work,a novel mixed-matrix membrane(MMM)(poly(arylene ether ketone)[PAEK]-containing carboxyl groups[PAEK-COOH]/UiO-66-NH_(2)@graphene oxide[GO])with superb fouling resistance and high permeability was prepared by the nonsolvent-induced phase separation method,by in-situ growth of UiO-66-NH_(2) on the GO layer,and by preparing hydrophilic *** the basis of the structure and performance analysis of the MMM,the maximum water flux reached 591.25 L·m^(-2)·h^(-1) for PAEK-COOH/UiO-66-NH_(2)@GO,whereas the retention rate for bovine serum albumin increased from 85.40%to 94.87%.As the loading gradually increased,the hydrophilicity of the MMMs increased,significantly enhancing their fouling *** strongest anti-fouling ability observed was 94.74%,which was 2.02 times greater than that of the pure *** the same time,the MMMs contained internal amide and hydrogen bonds during the preparation process,forming a cross-linked structure,which further enhanced the mechanical strength and chemical *** summary,the MMMs with high retention rate,strong permeability,and anti-fouling ability were successfully prepared.

关键词： Poly(arylene ether ketone)-containing Carboxyl groups(PAEK-COOH) UiO-66-NH_(2)@graphene oxide Hydrophilic modification Ultra-high selectivity Strong anti-fouling

多元化教学模式在中医院普外科临床带教中的应用

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中国城乡企业卫生 2024年第3期39卷 1-5页

作者：邵荣江宋晓冬卢宏亮杜海伟葛善义王意喆天津中医药大学第一附属医院普外科国家中医针灸临床医学研究中心天津300072

目的研究多元化教学模式在中医院普外科临床带教中的应用价值,为中医院校医学生的西医学科教学提供参考方案。方法选取2020年10月-2022年10月在天津中医药大学第一附属医院普外科临床实习的77名中医学专业医学生为研究对象,根据入科时... 详细信息

目的研究多元化教学模式在中医院普外科临床带教中的应用价值,为中医院校医学生的西医学科教学提供参考方案。方法选取2020年10月-2022年10月在天津中医药大学第一附属医院普外科临床实习的77名中医学专业医学生为研究对象,根据入科时间分为对照组43名和观察组34名。对照组采用传统的西医外科教学授课模式,观察组采用多种教学模式融合的多元化教学模式,并且充分引入中医元素。记录并比较两组医学生理论考核、临床操作和临床思维能力、对教学模式及教师授课的满意率。结果观察组病例分析、病史采集、影像学检查阅片、化验分析及病历书写等理论考核成绩高于对照组,差异均有统计学意义(P<0.05)。观察组临床操作及临床思维能力考核成绩高于对照组,差异均有统计学意义(P<0.05)。观察组医学生对教学模式及教师总满意度率为100.00%,高于对照组的76.74%,差异有统计学意义(χ^(2)=9.087,P<0.05)。结论在中医院普外科临床带教中应用多种教学模式融合的多元化教学模式,能够提升教学质量,促进学生中西医结合临床思维的建立,提高学生满意率,值得在中医院普外科的临床教学中推广应用。

关键词：多元化教学模式普外科临床带教临床思维

Human bone marrow mesenchymal stem cell-derived exosomes loaded with gemcitabine inhibit pancreatic cancer cell proliferation by enhancing apoptosis

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4006-4013页

作者： Zu-Gui Tang Tie-Mei Chen yi Lu zhe wang Xi-Cheng wang yi Kong Department of Oncology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina Faculty of Pharmaceutical Sciences Shenzhen University of Advanced TechnologyShenzhen 518000Guangdong ProvinceChina Guangdong Pharmaceutical University Guangzhou 510006Guangdong ProvinceChina

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies,and has limited effective ***(GEM),a chemotherapeutic agent,is commonly used for clinical treatment of pancreatic cancer,but it has characteristics of low drug delivery efficiency and significant side *** study tested the hypothesis that human bone marrow mesenchymal stem cell(MSC)-derived exosomes loaded with GEM(Exo-GEM)would have a higher cytotoxicity against human pancreatic cancer cells by enhancing their *** To investigate the cytotoxicity of MSC-derived Exo-GEM against pancreatic cancer cells in *** Exosomes were isolated from MSCs and characterized by transmission electron microscopy and nanoparticle tracking ***-GEM through electroporation,sonication,or incubation,and the loading efficiency was *** cytotoxicity of Exo-GEM or GEM alone against human pancreatic cancer Panc-1 and MiaPaca-2 cells was assessed by MTT and flow cytometry *** The isolated exosomes had an average size of 76.7 *** encapsulation efficacy and loading efficiency of GEM by electroporation and sonication were similar and significantly better than *** cytotoxicity of Exo-GEM against pancreatic cancer cells was stronger than free GEM and treatment with 0.02μM Exo-GEM significantly reduced the viability of both Panc-1 and MiaPaca-2 ***,Exo-GEM enhanced the frequency of GEMinduced apoptosis in both cell *** Human bone marrow MSC-derived Exo-GEM have a potent cytotoxicity against human pancreatic cancer cells by enhancing their apoptosis,offering a promising drug delivery system for improving therapeutic outcomes.

关键词： Mesenchymal stem cells Exosomes Extracellular vesicles Gemcitabine Pancreatic cancer Drug delivery

A direct polymeric carbon nitride/tungsten oxide Z-scheme heterostructure for efficient photocatalytic hydrogen generation via reforming of plastics into value-added chemicals

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Rare Metals 2024年第8期43卷 3771-3783页

作者： Rui-zhe wang Zhi Lin yi-Qing wang Kai-Ni Zhang Ge-Hong Zhang Jie Zhang Samuel S.Mao Shao-Hua Shen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi'an Jiaotong UniversityXi'an 710049China School of Civil and Architecture Engineering Xi'an Technological UniversityXi'an 710021China Department of Mechanical Engineering University of California at BerkeleyBerkeleyCA94720USA

To promote charge transfer and separation for efficient photocatalysis,a direct Z-scheme heterostructure was constructed by coupling polymeric carbon nitride(PCN) and WO_(3).Interestingly,the obtained PCN/WO_(3)Z-scheme heterostructure could photocataly tic ally produce hydrogen and value-added chemicals(e.g.,formate and acetate) by reforming of plastic polylactic acid(PLA) in alkaline aqueous *** optimizing WO_(3) contents and reaction conditions,the obtained PCN/WO_(3)heterostructure exhibits much increased photocatalytic activity for PLA photoreforming under visible light,with hydrogen evolution rate reaching 402.90 μmol·g~(-1)·h~(-1),which is 3.5 times that of *** is revealed that the Z-scheme charge transfer between PCN and WO_(3) mainly contributes to the promoted charge separation and thus the improved photocatalytic ***,with h+and·OH experimentally evidenced as the predominant active species,a possible reaction pathway for the reforming of PLA into value-added chemicals(e.g.,formate and acetate)over PCN/WO_(3) Z-scheme heterostructure is cleared by monitoring the reaction intermediates and *** work paves a carbon neutrality and scalable route toward the synergistical production of hydrogen and value-added chemicals by utilizing and recycling plastic waste.

关键词： Carbon nitride Z-scheme heterojunction Plastic waste conversion Photocatalytic H_(2)production Value-added chemicals

Clinical features and possible pathogenesis of multiple evanescent white dot syndrome with different retinal diseases and events:a narrative review

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 583-595页

作者： Chun-Li Chen yi-zhe Cheng Zhi-Han Zhang Ge wang Xiao-Yan Peng Department of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Ophthalmology and Visual Science Key Laboratory Beijing 100730China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510600Guangdong ProvinceChina

●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field *** previous studies have explained the possible pathogenesis and clinical features of primary ***,as the number of reported cases increases,secondary MEWDS occurs in other related retinal diseases and injuries,exhibiting some special *** associated retinal diseases include multifocal choroiditis/punctate inner choroidopathy(MFC/PIC),acute zonal occult outer retinopathy,best vitelliform macular dystrophy,pseudoxanthoma elasticum,and ocular *** related retinal injury is laser photocoagulation,surgery,and *** primary MEWDS often have a self-limiting course,secondary MEWDS may require treatment in some cases,according to the severity of concomitant diseases and ***,MEWDS secondary to MFC/PIC that is prone to forming choroidal neovascularization and focal choroidal excavation,needs positive treatment with *** possible underlying pathogenesis of secondary MEWDS is the exposure of choroidal antigen after the disruption of Bruch’s *** MEWDS-related features in secondary MEWDS are still evanescent under most *** prognosis and treatment depend on the severity of *** studies propose that the etiology is associated with immune factors,including viral infection,inflammation in choroid and Bruch’s membrane,and antigen exposure caused by retinal and/or choroidal *** pathogenic studies should be conducted in the *** diagnosis for secondary MEWDS could benefit patients in aspects of management and prognosis.

关键词： multiple evanescent white dot syndrome punctate inner choroidopathy multifocal choroiditis secondary multiple evanescent white dot syndrome