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Controllable fabrication of Au micro/nanostructures on self-doped polyaniline nanofibers via electrochemical deposition and its application for DNA immobilization

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Chinese Science Bulletin 2010年第36期55卷 4125-4131页

作者： wang xinxing YANG Tao JIAO Kui Shandong Provincial Key Laboratory of Biochemical Analysis College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China

Four electrochemical methods, cyclic voltammetric deposition, potentiostatic electrodeposition, multi-potential step electrodeposition and three-step electrodeposition, were used to fabricate Au micro/nanostructures on self-doped polyaniline nanofibers-coated glassy carbon electrodes (Au/nanoSPAN/GCEs). The Au micro/nanostructures deposited on the nanoSPAN-modified electrodes were shown by scanning electron microscopy to exhibit different morphologies, such as Au nanoparticle clusters, monodisperse nanoparticles and homogeneously dispersed flower-like microparticles, depending on the deposition method. This phenomenon demonstrates that control over the morphology of Au metal can be easily achieved by adjusting the electrodeposition method. The electrochemical behaviors of the Au/nanoSPAN/GCEs also varied with above four methods, which were characterized by cyclic voltammetry and electrochemical impedance spectroscopy. In comparison with Au nanoparticle clusters and monodisperse Au nanoparticles, homogeneously dispersed flower-like Au microparticles had the largest surface area and obviously enhanced electrochemical response towards the redox reactions of [Fe(CN)6]3–/4– on the modified electrode. DNA immobilization on the Au/nanoSPAN/GCEs was investigated by differential pulse voltammetry using [Fe(CN)6]3–/4– as an indicator. The efficiency of DNA immobilization was inherently related to their different Au micro/nanostructure morphologies. The Au/nano-SPAN/GCE fabricated by three-step electrodeposition showed the largest capacity for immobilization of single stranded DNA, which makes it a promising DNA biosensor.

关键词：单链DNA 电化学沉积纳米纤维纳米结构可控制备固定化聚苯胺自掺杂

The effect of evaporator operating parameters on the flow patterns inside horizontal pipes

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Journal of Thermal Science 2011年第4期20卷 324-331页

作者： Lige Tong Haiyan Li Li wang xinxing Sun Yunfei Xie Department of Thermal Science and Energy Engineering University of Science and Technology Beijing Beijing 100083 China

A general and simple model for simulating the steady state behaviors of Mr-m-refrigerant fin-and-tube evaporator is introduced with the focus on the detailed flow patterns inside the tubes. In order to simulate the heat transfer between air and the working fluid, the evaporator is divided into a number of control volumes. Empirical correlations from literature were also adopted to estimate the void fraction, the internal and external heat transfer coefficients, and the pressure drops. Simulations were performed to study the effects of varying inlet air temperature, refrigerant mass flow rate and evaporation pressure on the flow patterns inside the horizontal pipe of the evaporator. The simulation results indicate that the proposed model can be used to predict flow patterns well. The predicted results of the model agree well with experimental results, the difference is within ±3% for the cooling capacity, and is within ±0.2% for refrigerant evaporation temperature.

关键词： evaporator distributed model two-phase zone flow pattern

Distributed cache replacement method for geospatial data using spatiotemporal localitybased sequence

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Geo-Spatial Information Science 2015年第4期18卷 171-182页

作者： Rui LI Jiapei FAN xinxing wang Zhen ZHOU Huayi WU State key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing(LIESMARS)Wuhan University129 Luoyu RoadWuhan 430079China Collaborative Innovation Center of Geospatial Technology Wuhan University129 Luoyu RoadWuhan 430079China

Specific features of tile access patterns can be applied in a cache replacement strategy to a limited distributed high-speed cache for the cloud-based networked geographic information services(NGISs),aiming to adapt to changes in the access distribution of *** taking advantage of the spatiotemporal locality,the sequential features in tile access patterns,and the cache reading performance in the burst mode,this article proposes a tile sequence replacement method,which involves structuring a Least Recently Used(LRU)stack into three portions for the different functions in cache replacement and deriving an expression for the temporal locality and popularity of the relevant tile to facilitate the replacement *** on the spatial characteristics of both the tiles and the cache burst mode with regard to reading data,the proposed method generates multiple tile sequences to reflect spatiotemporal locality in tile access ***,we measure the caching value by a technique based on a weighted-based *** technique draws on the recent access popularity and low caching costs of tile sequences,with the aim of balancing the temporal and spatial localities in tile *** ranks tile sequences in a replacement queue to adapt to the changes in accessed hotspots while reducing the replacement *** results show that the proposed method effectively improves the hit rate and utilization rate for a limited distributed cache while achieving satisfactory response performance and high throughput for users in an ***,it can be adapted to handle numerous data access requests in NGISs in a cloud-based environment.

关键词： spatiotemporal replacement access pattern Least Recently Used(LRU)stack networked GIS

Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy

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Nano Research 2020年第8期13卷 2246-2258页

作者： Lifang Yang Chuchu Ren Min Xu Yilin Song Qianglan Lu Yule wang Yan Zhu xinxing wang Nan Li Tianjin Key Laboratory of Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin300072China Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineBeihua South RoadJingHai DistrictTianjin301617China Research and Development Center of TCM Tianjin International Joint Academy of Biotechnology and Medicine220 Dongting RoadTEDATianjin300457China Tianjin Institute of Environmental and Operational Medicine 1 Dali RoadHeping DistrictTianjin300050China

Biomimetic nanozymes possessing natural enzyme-mimetic activities have been extensively applied in nanocatalytic tumor ***,engineering hybrid biomimetic nanozymes to achieve superior nanozyme activity remained to be an intractable challenge in hypoxic ***,a rod-like biomimetic hybrid inorganic MnO2-Au nanozymes are developed,where MnO2 and ultrasmall Au nanoparticles(NPs)are successively deposited on the mesoporous silica nanorod to cooperatively improve the O2 content and thermal sensitivity of hypoxic solid tumors guided by multi-modal *** the catalyzing of MnO2,the intratumoral H2O2 is decomposed to greatly accelerate O2 generation,which could boost the curative effect of radiation therapy(RT)and further enhance the Au-catalyzed glucose ***,the Au NPs can steadily and efficiently catalyze the oxidation of glucose in harsh tumor microenvironment,thus sensitizing tumor cells to thermal ablation for mild photothermal therapy and further promoting the catalytic efficiency of MnO2 with the self-supplied H2O2/H+.As a result,this mutual-reinforcing cycle can endow the nanoplatform with accelerated O2 generation,thus alleviating hypoxic environment and further boosting RT ***,acute glucose consuming can induce downregulation expression of heat shock protein(HSP),achieving starvation-promoted mild photothermal *** synthesized hybrid nanozymes proves to be a versatile theranostic agent for nanocatalytic cancer therapy.

关键词： nanozyme self-supplied mutual-reinforcing hypoxia catalysis-enhanced therapy

Effect of Dietary Vitamin E on the Sperm Quality of Turbot(Scophthalmus maximus)

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Journal of Ocean University of China 2015年第4期14卷 695-702页

作者： XU Houguo HUANG Lina LIANG Mengqing ZHENG Keke wang xinxing Key Laboratory for Sustainable Utilization of Marine Fisheries Resources of Ministry of Agriculture Yellow Sea Fisheries Research Institute

A 3-month feeding experiment was conducted in an in-door seawater system to investigate the effect of dietary vitamin E （Ve） on the sperm quality of turbot （Scophthalmus maximus）. D-α-tocopherol acetate was supplemented to the basal （control） diet （65.14 mg kg-l Ve） to obtain low and high levels of dietary Ve （244.60 mgkg-1, LVe; 721.60 mg kg-1, HVe）. Compared with the con- trol, sperm concentration was significantly increased in Ve-supplemented groups （LVe and HVe）; while relative sperm volume and testis-somatic index were significantly increased in group HVe only. Sperm motility duration was significantly longer in group HVe than in the control, but no significant difference was observed in percent motility among groups. Sperm size, the uniformity of mito- chondrial size, and the integrity of mitochondria cristae and plasma membrane were improved by dietary Ve, especially in HVe. The content of Ve in testis and liver as well as polyunsaturated fatty acids in sperm increased with dietary Ve. These results suggested that dietary Ve, especially at the high level （721.60 mg kgl）, significantly improved sperm concentration and motility duration and main- tained normal sperm morphology of *** A 3-month feeding experiment was conducted in an in-door seawater system to investigate the effect of dietary vitamin E （Ve） on the sperm quality of turbot （Scophthalmus maximus）. D-α-tocopherol acetate was supplemented to the basal （control） diet （65.14 mg kg-l Ve） to obtain low and high levels of dietary Ve （244.60 mgkg-1, LVe; 721.60 mg kg-1, HVe）. Compared with the con- trol, sperm concentration was significantly increased in Ve-supplemented groups （LVe and HVe）; while relative sperm volume and testis-somatic index were significantly increased in group HVe only. Sperm motility duration was significantly longer in group HVe than in the control, but no significant difference was observed in percent motility among groups. Sperm size, the uniformity of mito- chondrial s

关键词： male turbot vitamin E dietary supplementation sperm quality

Efficacy and safety of Yiqi Huoxue Jiedu decoction for the treatment of advanced epithelial ovarian cancer patients: a double-blind randomized controlled clinical trial

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Journal of Traditional Chinese Medicine 2020年第1期40卷 103-111页

作者： Li Yifan Li Juan Fan Bifa wang Yitong Jiang Juling Zhang Zhenhua wang xinxing Lu Wenping Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Graduate School Beijing University of Chinese MedicineBeijing 100029China Department of Graduate School China Academy of Chinese Medical SciencesBeijing 100700China Department of Pain China-Japan Friendship HospitalBeijing 100029China

OBJECTIVE:To further evaluate the complementary effect of Yiqi Huoxue Jiedu decoction(YHJD)on patients with advanced epithelial ovarian cancer(EOC).METHODS:All 330 enrolled participants diagnosed with stageⅢc EOC were randomly divided into two groups that received YHJD or a *** primary end point was health-related quality of life(HRQL)measured by the functional assessment of cancer therapy-ovary cancer(FACT-O)*** secondary end point was progression-free survival(PFS).RESULTS:A total of 299 participants completed the trial with 153 and 146 in YHJD and control groups,*** 6 months of treatment,YHJD increased physical wellbeing(PWB),functional wellbeing(FWB),additional concerns(AC),and the trial outcome index(TOI)(P<0.05)by various degrees compared with the *** also had notable advantages over the placebo at 3 and 6 months in terms of PWB,FWB,AC(P<0.05),and TOI(P<0.01).In addition,YHJD had a significant advantage in terms of PFS compared with the placebo(21 vs18 months,P<0.05).No adverse events were ***:YHJD is an effective and safe choice as a complementary therapy to improve HRQL and prolong PFS of stageⅢc EOC patients.

关键词： Ovarian neoplasms Quality of life Disease-free survival Yiqi Huoxue Jiedu decoction Randomized controlled trial

港珠澳大桥北侧沿线中华白海豚栖息地利用及保护建议

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南方水产科学 2025年第1期21卷 28-34页

作者：黄志雄温华陈涛王新星陈宇健陈希肖尤盛张朝明方亮港珠澳大桥管理局广东珠海519015 中国水产科学研究院南海水产研究所/广东省渔业生态环境重点实验室广东广州510300 三亚热带水产研究院海南三亚572000 珠江口中华白海豚国家级自然保护区管理局广东珠海519015

为了解在港珠澳大桥建成后,中华白海豚(Sousa chinensis)对大桥水域北侧栖息地的利用情况,及其可能穿越大桥的潜在通道。在大桥北侧沿线水域布置了A、B、C、D 4个固定被动声学监测位点,总共进行了2 947 h的声学录音。在4个监测位点发现... 详细信息

为了解在港珠澳大桥建成后,中华白海豚(Sousa chinensis)对大桥水域北侧栖息地的利用情况,及其可能穿越大桥的潜在通道。在大桥北侧沿线水域布置了A、B、C、D 4个固定被动声学监测位点,总共进行了2 947 h的声学录音。在4个监测位点发现中华白海豚声学事件的概率分别为15.31%(A)、17.30%(B)、8.97%(C)、5.85%(D),表明大桥北侧沿线水域依然是中华白海豚的重要栖息地,且其活动存在时空差异。在不同监测位点发现的中华白海豚声学事件并无明显的昼夜差异。在桥梁结构的A、B和C 3个监测位点,低潮位阶段发现中华白海豚的概率分别为1.56%、1.82%和0.78%,均高于高潮位阶段(0.94%、1.56%和0.26%);A和B点在涨潮和落潮阶段发现中华白海豚的概率相近,但C和D点在涨潮阶段的发现概率分别为4.55%和3.64%,均高于落潮阶段(3.12%和1.30%),表明潮汐变化对中华白海豚在桥梁结构水域的栖息地选择上有一定影响且存在空间差异。根据声学监测结果推测,A和B点之间的水域可能是中华白海豚穿越大桥的重要区域,建议加强对该区域的巡查和管理。

关键词：中华白海豚港珠澳大桥被动声学监测栖息地利用珠江口

LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral

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Oncology Research 2023年第4期31卷 481-493页

作者： FAYU SHAN LANLAN LIANG CHONG FENG HONGBAO XU ZIROU wang WEILI LIU LINGLING PU ZHAOLI CHEN GANG CHEN xinxing wang Department of Environmental Medicine Tianjin Institute of Environmental and Operational MedicineTianjin300070China School and Hospital of Stomatology Tianjin Medical UniversityTianjin300050China

Background:Oral squamous cell carcinoma(OSCC)is a common malignant ***,Laminin Gamma 2(LAMC2)has been shown to be abnormally expressed in OSCC;however,how LAMC2 signaling contributes to the occurrence and development of OSCC and the role of autophagy in OSCC has not been fully *** study aimed to analyze the role and mechanism of LAMC2 signaling in OSCC and the involvement of autophagy in ***:To explore the mechanism by which LAMC2 is highly expressed in OSCC,we used small interfering RNA(siRNA)to knock down LAMC2 to further observe the changes in the signaling ***,we used cell proliferation assays,Transwell invasion assays,and wound-healing assays to observe the changes in OSCC proliferation,invasion,and ***-LC3 was used to detect the level of autophagy intensity.A cell line-derived xenograft(CDX)model was used to detect the effect of LAMC2 on tumor growth in ***:This study found that the level of autophagy was correlated with the biological behavior of *** downregulation of LAMC2 activated autophagy and inhibited OSCC proliferation,invasion,and metastasis via inhibiting the PI3K/AKT/mTOR ***,autophagy has a dual effect on OSCC,and the synergistic downregulation of LAMC2 and autophagy can inhibit OSCC metastasis,invasion,and proliferation via the PI3K/AKT/mTOR ***:LAMC2 interacts with autophagy to regulate OSCC metastasis,invasion,and proliferation via the PI3K/AKT/mTOR ***2 down-regulation can synergistically modulate autophagy to inhibit OSCC migration,invasion,and proliferation.

关键词： LAMC2 OSCC Autophagy PI3K/AKT/mTOR pathway 3-Methyladenine Rapamycin

4T1 cell membrane-derived biodegradable nanosystem for comprehensive interruption of cancer cell metabolism

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Chinese Chemical Letters 2023年第9期34卷 210-218页

作者： Yingzi Ren Huaqing Jing Yue Zhou Chuchu Ren Guangxu Xiao Siyu wang Xiaoyang Liang Yunsheng Dou Ziqiao Ding Yan Zhu xinxing wang Nan Li Tianjin Key Laboratory of Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China Tianjin Institute of Environmental and Operational Medicine Tianjin 300050China State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Glycolysis inhibition can effectively block the energy supply and interrupt tumorigenesis in many types of ***,when glycolysis is inhibited,tumor cells will break down glutamine as the raw material for the replenishment pathway to maintain the tricarboxylic acid cycle ensuring energy supply,therefore inducing ineffective interruption of ***,we designed glutamine transporter antagonist L-γ-glutamyl-p-nitroanilide(GPNA)loaded and 4T1 cancer cell membrane coated iridium oxide nanoparticles(IrO_(2)-GPNA@CCM)to realize a comprehensive inhibition of tumor energy supply which synergistically mediated by glycolysis and glutamine ***_(2)NPs were used to catalyze the O_(2)generation by facilitating the decomposition of endogenous H_(2)O_(2)in tumor cells,which further downregulated the expression of HIF-1αand PI3K/pAKT to interrupt the generation of ***,the loaded GPNA was released under NIR irradiation to bind to alanine-serine-cysteine transporter(ASCT2)for glutamine uptake suppression,therefore realizing the comprehensive dysfunction of cell ***,both in vitro and in vivo results convinced the thorough energy inhibition effect based on Ir O_(2)-GPNA@CCM NPs,which provided an inspiring strategy for future construction of tumor therapeutic regimen.

关键词： Iridium oxide Glycolysis inhibition Glutamine suppression GPNA Tumor cell membrane