Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy
作者机构：Tianjin Key Laboratory of Drug Delivery&High-EfficiencySchool of Pharmaceutical Science and TechnologyTianjin UniversityTianjin300072China Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineBeihua South RoadJingHai DistrictTianjin301617China Research and Development Center of TCMTianjin International Joint Academy of Biotechnology and Medicine220 Dongting RoadTEDATianjin300457China Tianjin Institute of Environmental and Operational Medicine1 Dali RoadHeping DistrictTianjin300050China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2020年第13卷第8期
页 面：2246-2258页
核心收录：
学科分类：0808[工学-电气工程] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学]
基 金：This work was supported by Young Elite Scientists Sponsorship Program by Tianjin(No.0701320001) this work was partially supported by the grants of the National Natural Science Foundation of China(Nos.31971106 and 81372124)
主 题：nanozyme self-supplied mutual-reinforcing hypoxia catalysis-enhanced therapy
摘 要：Biomimetic nanozymes possessing natural enzyme-mimetic activities have been extensively applied in nanocatalytic tumor ***,engineering hybrid biomimetic nanozymes to achieve superior nanozyme activity remained to be an intractable challenge in hypoxic ***,a rod-like biomimetic hybrid inorganic MnO2-Au nanozymes are developed,where MnO2 and ultrasmall Au nanoparticles(NPs)are successively deposited on the mesoporous silica nanorod to cooperatively improve the O2 content and thermal sensitivity of hypoxic solid tumors guided by multi-modal *** the catalyzing of MnO2,the intratumoral H2O2 is decomposed to greatly accelerate O2 generation,which could boost the curative effect of radiation therapy(RT)and further enhance the Au-catalyzed glucose ***,the Au NPs can steadily and efficiently catalyze the oxidation of glucose in harsh tumor microenvironment,thus sensitizing tumor cells to thermal ablation for mild photothermal therapy and further promoting the catalytic efficiency of MnO2 with the self-supplied H2O2/H+.As a result,this mutual-reinforcing cycle can endow the nanoplatform with accelerated O2 generation,thus alleviating hypoxic environment and further boosting RT ***,acute glucose consuming can induce downregulation expression of heat shock protein(HSP),achieving starvation-promoted mild photothermal *** synthesized hybrid nanozymes proves to be a versatile theranostic agent for nanocatalytic cancer therapy.
维普期刊数据库