检索结果-南通市图书馆

Chinese Medical Journal 2017年第12期130卷 1505-1506页

作者： Chun-Nianwang Su-Ying wang Min-Jiang Lin Hong-wei wang Department of Pathology Ningbo Clinical and Pathological Diagnosis Center Ningbo Zhejiang 315000 China Department of Radiology Ningbo City Medical Treatment Center Lihuili Hospital Ningbo Zhejiang 315000 China

The kidney is affected in about 80-85% of tuberous sclerosis complex （TSC） patients. Renal manifestations in TSC patients include an increased incidence of epithelial cysts and tumors, such as multiple renal angiomyolipomas （AMLs）, renal cell carcinoma （RCC）, and oncocytoma. The coexistence of RCC and renal AML within same tumor masses, namely collision tumor, is very rare, and about six cases have been reported. Here, we present a case of a young male with TSC and multiple AMLs, containing RCC with eosinophilic morphology.

关键词： Angiomyolipoma Collision Tumor Renal Cell Carcinoma Tuberous Sclerosis Complex

Spatial-Temporal Analysis of Drinking Water Type of Endemic Fluorosis—China,2009–2022

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2024年第2期6卷 25-29页

作者： Lijun Zhao Zhe Li Mang Li Hongna Sun wei wei Lin Gao Qiaoshi Zhao Yang Liu Xiaohong Ji Cheng Li Jian wang Yanhui Gao Junrui Pei Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina Key Lab of Etiology and Epidemiology Education Bureau of Heilongjiang Province(23618504)Ministry of Health of PRHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Endemic fluorosis,caused by high fluoride levels in drinking water,has been a significant health issue in rural areas of China for many *** is added by this report?There has been a notable decline in the detection rate of dental fluorosis in children aged 8–12 years in drinking water fluorosis areas across the country from 2009 to *** 14 provincial-level administrative divisions are classified as low-probability clusters,Tianjin remains classified as a high-probability *** are the implications for public health practice?The current policy for preventing and controlling endemic fluorosis in China needs *** than focusing solely on regions with high incidence,there should be a shift towards monitoring and early warning of fluoride ***,local containment measures should be intensified.

关键词： intensified Spatial fluoride

一种改性HTPB固体推进剂的流变特性及其3D打印成型

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

含能材料 2022年第8期30卷 826-832页

作者：史钰任全彬黄谱王凯王伟曹成硕石柯付晓梦王芳李伟王艳薇航天化学动力技术重点实验室湖北襄阳441003 湖北航天化学技术研究所湖北襄阳441003 航天动力技术研究院陕西西安710025

快速发展的增材制造技术为固体推进剂传统浇注成型的柔性化、适应性差等问的解决题提供了有效途径。传统热固性固体推进剂的流平性好,无法逐层沉积成型。因而,为实现热固性固体推进剂的3D打印成型,本研究对其液相组分进行了改性,通过添... 详细信息

快速发展的增材制造技术为固体推进剂传统浇注成型的柔性化、适应性差等问的解决题提供了有效途径。传统热固性固体推进剂的流平性好,无法逐层沉积成型。因而,为实现热固性固体推进剂的3D打印成型,本研究对其液相组分进行了改性,通过添加少量定型助剂共混改性端羟基聚丁二烯(HTPB),制备得到改性HTPB固体推进剂,并对其的流变特性进行了研究。结果表明,共混改性使黏合剂黏度、表观黏流活化能升高;改性HTPB固体推进剂流变特性符合Herschel‑Bulkley方程,且流动性随温度升高而提高;同时,改性HTPB固体推进剂在室温下具有较高储能模量(>104 Pa)以及较小的损耗角正切(ω<10 rad·s^(-1),G″/G'<0.5),整体不呈现流动性,且少量定型助剂对推进剂的热分解行为没有产生显著影响,实现了改性HTPB固体推进剂的3D打印成型。

关键词：固体推进剂 3D打印流变特性 Herschel-Bulkley方程黏流活化能

Pharmacological Study on Antitumor Activity of 5-Fluorouracil-1-Acetic Acid and Its Rare Earth Complexes

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2000年第2期18卷 140-143页

作者： Yang, Zheng-Yin wang, Liu-Fang Yang, Xin-Ping wang, Da-wei Li, Yu-Ming Dept. of Chem. Lanzhou Univ. Lanzhou 730000 China

The antitumor activity of 5 fluorouracil 1 acetic acid(HFAA) and its lanthanide complexes(La(FAA) 3, Eu(FAA) 3) were studied. The results show that HFAA, La(FAA) 3 and Eu(FAA) 3 with the concentrations of 1 0×10 -5 ～1 0×10 -2 μg·ml -1 inhibit the colony formation of leukemia cells(L 1210 ) and the growth of transplanted tumor sarcoma 180(S 180 ), hepatic carcinoma(HEPA) and ehrlich ascites tumor(EC) as well. The maximum inhibitory rate of Eu(FAA) 3 for S 180 is 38 4%, that HFAA and La(FAA) 3 for EC are 22 4% and 43 4%, respectively. The life prolongation rate of Eu(FAA) 3 for HEPA bearing mice is as long as 284%.

关键词： rare earths antitumor activity 5 fluorouracil 1 acetic acid

Mutations of voltage-gated sodium channel contribute to pyrethroid resistance in Panonychus citri

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第3期31卷 803-816页

作者： Deng Pan Qiu-Juan Luo Andrias O.O'Reilly Guo-Rui Yuan Jin-Jun wang wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwest UniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina School of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpoolUK

Insecticide resistance in Panonychus citri is a major obstacle to mite control in citrus *** insecticides are continually used to control mites in China,although resistance to pyrethroids has evolved in some ***,the resistance to the pyrethroid fenpropathrin was investigated and 7 out of 8 field-collected populations of P citri exhibited a high level of resistance,ranging from 171-fold to 15391-fold higher than the susceptible(SS)comparison *** voltage-gated sodium channel(VGSC)mutations were identified in the tested populations:L1031V,F1747L,and *** sequencing was used to evaluate the frequency of these mutations in the 19 field populations.L1031V and F1751I were present in all populations at frequencies of 11.6%-82.1%and 0.5%-31.8%,respectively,whereas the F1747L mutation was only present in 12 populations from Chongqing,Sichuan,Guangxi,and Yunnan *** of these mutations singly or in combination into transgenic flies significantly increased their resistance to fenpropathrin and these flies also exhibited reduced mortality after exposure to the pyrethroids permethrin andβ-*** citri VGSC homology modeling and ligand docking indicate that F1747 and F1751 form direct binding contacts with pyrethroids,which are lost with mutation,whereas L1031 mutation may diminish pyrethroid effects through an allosteric ***,the results provide molecular markers for monitoring pest resistance to pyrethroids and offer new insights into the basis of pyrethroid actions on sodium channels.

关键词： amplicon sequencing kdr mutation molecular docking Panonychus citri pyrethroid resistance transgenic flies

Effect of Microstructure on Hydrogen Induced Cracking Behavior of a High Deformability Pipeline Steel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research(International) 2015年第10期22卷 937-942页

作者： Xian-bo SHI wei YAN wei wang Lian-yu ZHAO Yi-yin SHAN Ke YANG Institute of Metal Research Chinese Academy of Sciences University of Chinese Academy of Sciences Petro China Pipeline Company

The hydrogen induced cracking （HIC） behavior of a high deformability pipeline steel was investigated with three different dual-phase microstructures, ferrite and bainite （F＋B）, ferrite and martensite/austenite islands （F＋M/A） and ferrite and martensite （F＋M）, respectively. The HIC test was conducted in hydrogen sulfide （H2S）-saturated solution. The results showed that the steels with F＋B and F＋M/A dual-phase microstructures had both higher deformability and better HIC resistance, whereas the harder martensite phase in F＋M microstructure was responsible for the worst HIC resistance. The band-like hard phase in dual-phase mi- crostructure was believed to lead to increasing susceptibility to HIC.

关键词： pipeline steel high deformability dual-phase microstructure mechanical property hydrogen induced cracking

Opportunities for production and property research of neutron-rich nuclei around N=126 at HIAF

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： Shao-Bo Ma Li-Na Sheng Xue-Heng Zhang Shi-Tao wang Kai-Long wang Chun-wang Ma Hool-Jin Ong Zhi-Yu Sun Shu-Wen Tang Yu-Hong Yu Xin-Tong Du Xiao-Bao wei Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for Nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEN Nishina Center Saitama 351-0198Japan Northwest Normal University Lanzhou 730070China

The study of nuclide production and its properties in the N=126 neutron-rich region is prevalent in nuclear physics and astrophysics *** upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution *** provides an opportunity to study the production and properties of neutron-rich nuclei around N=*** this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through *** results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high *** the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously ***,the masses of some neutron-rich nuclei near N=126 can be measured with high precision using the time-of-flight magnetic rigidity *** indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation Neutron-rich nuclei around N=126 Mass measurement Lifetime

Biocompatibility and Immunotoxicology of the Preclinical Implantation of a Collagen-based Artificial Dermal Regeneration Matrix

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2018年第11期31卷 829-842页

作者： wang wei ZHANG Lin SUN Lei SHE Zhen Ding TAN Rong wei NIU Xu Feng Department of Immunology School of Basic Medical SciencesNHC Key Laboratory of Medical ImmunologyPeking UniversityBeijing 100191China Beijing Advanced Innovation Center for Biomedical Engineering Key Laboratory for Biomeehanics and Meehanobiology of Ministry of EducationSchool of Biological Science and Medical Engineering Beihang UniversityBeijing 100083China Shenzhen Lando Biomaterials Company Limtd Shenzhen 518107China Research Institute of Beihang University in Shenzhen Shenzhen 518057China

Objective Graft rejection, with the possibility of a violent immune response, may be severe and life threatening. Our aim was to thoroughly investigate the biocompatibility and immunotoxicology of collagen-based dermal matrix(DM) before assessment in clinical trials. Methods DM was subcutaneously implanted in BALB/c mice in two doses to induce a potential immune response. The spleen and lymph nodes were assessed for shape, cell number, cell phenotype via flow cytometry, cell activation via CCK8 kit, Annexin V kit, and Ki67 immunostaining. Serum samples were used to measure antibody concentration by enzyme-linked immunosorbent assay. Local inflammation was analyzed by histology and immunohistochemistry staining. Data analysis was performed by one-way ANOVA and non-parametric tests. Results Our data illustrate that the spleen and lymph node sizes were similar between the negative control mice and mice implanted with DM. However, in the high-dose DM(DM-H) group, the total cell populations in the spleen and lymph nodes, T cells and B cells in the spleen had slight increases in prophase, and the low-dose DM(DM-L) group did not display gross abnormities. Moreover, DM-H initiated moderate cell activation and proliferation in the early phase post-immunization, whereas DM-L did not. Neither DM-H nor DM-L implantation noticeably increased IgM and IgG serum concentrations. Examination of the local cellular response revealed only benign cell infiltration and TNF-α expression in slides of DM in the early phase. Conclusion Overall, DM-H may have induced a benign temporary acute immune response post-implantation, whereas DM-L had quite low immunogenicity. Thus, this DM can be regarded as a safe product.

关键词： Collagen Lymphocytes Immunogenicity Flow cytometry

Symmetry breaking of highly symmetrical nanoclusters for triggering highly optical activity

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2024年第1期4卷 63-68页

作者： Xiao wei Hao Li Honglei Shen Chuanjun Zhou Shuxin wang Xi Kang Manzhou Zhu Department of Chemistry and Centre for Atomic Engineering of Advanced Materials Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationInstitutes of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials.Anhui UniversityHefei 230601China

Developing new approaches to fulfill the enantioseparation of nanocluster racemates and construct cluster-based nanomaterials with optical activity remains highly desired in cluster science,because it is an essential prerequisite for fundamental research and extensive applications of these *** herein propose a strategy termed“active-site exposing and partly re-protecting”to trigger the symmetry breaking of highly symmetrical nanoclusters and to render cluster crystals optically *** vertex PPh_(3)of the symmetrical Ag_(29)(SSR)_(12)(PPh_(3))_(4)(SSR=1,3-benzenedithiol)nanocluster was firstly dissociated in the presence of counterions with large steric hindrance,and then the exposed Ag active sites of the obtained Ag_(29)(SSR)_(12)nanocluster were partly re-protected by Ag^(+),yielding an Ag_(29)(SSR)_(12)-Ag_(2)nanocluster with a symmetry-breaking ***_(29)(SSR)_(12)-Ag_(2)followed a chiral crystallization mode,and its crystal displayed strong optical activity,derived from CD and CPL ***,this work presents a new approach(i.e.,active-site exposing and partly re-protecting)for the symmetry breaking of highly symmetrical nanoclusters,the enantioseparation of nanocluster racemates,and the achievement of highly optical activity.

关键词： Atomically precise nanocluster Symmetry breaking Enantioseparation Circularly polarized luminescent Photoluminescence

Immune checkpoint molecules:“new”kids on the block of skin photoimmunology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2021年第1期8卷 1-5页

作者： wei wang Zhao-Hui Wu Department of Pathology and Laboratory Medicine University of Tennessee Health Science CenterMemphisTNUSA Center for Cancer Research University of Tennessee Health Science CenterMemphisTNUSA Center for Cancer Research University of Tennessee Health Science CenterMemphisTNUSA Department of Radiation OncologyUSA

Ultraviolet radiation(UVR)is a prominent etiological factor of the pathogenesis of skin diseases such as squamous cell carcinoma and *** exposure to the natural sources of UVR such as sunlight or artificially from tanning lamps has been linked to the increasing incidence of skin cancers in the United *** the skin inflammation,DNA damage and oncogenic mutation caused by UVR,UV exposure also plays a critical role in suppressing local and systemic immune responses which enable premalignant and cancer cells to escape immune surveillance.A variety of mechanisms have been reported to regulate the immune-suppressive effects of *** we discuss the current understanding of how UV modulates the local and systemic immunity,the recent progress in roles of immune checkpoint molecules in UVR-induced immune suppression,and how the crosstalk between the immune cells may shape the immune landscape of the skin upon UVR.

关键词： immunity inflammation Immune