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不同聚能射流水下毁伤性能对比分析

哈尔滨工程大学学报 2024年第8期45卷 1434-1441页

作者：刘晓波梁德利刘启庆王诗平哈尔滨工程大学船舶工程学院黑龙江哈尔滨150001 北京宇航系统工程研究所北京100076 上海交通大学航空航天学院上海200240

为进一步探究药型罩形状在不同壳体结构下的适用性问题及水层厚度影响,本文讨论了球缺形、60°锥角形及圆顶锥形3种药型罩结构及炸高中水层厚度因素对聚能射流毁伤性能的影响。通过对聚能射流形状、速度、头部宽度变化及靶板破口尺寸进... 详细信息

为进一步探究药型罩形状在不同壳体结构下的适用性问题及水层厚度影响,本文讨论了球缺形、60°锥角形及圆顶锥形3种药型罩结构及炸高中水层厚度因素对聚能射流毁伤性能的影响。通过对聚能射流形状、速度、头部宽度变化及靶板破口尺寸进行数值分析,发现球缺形药型罩对近距离单层壳结构破坏最大,而对于双层壳结构,圆顶锥形药型罩形成的聚能射流连续性和侵彻效果更优,60°锥角形药型罩次之。随着炸高中水层厚度的增加,靶板破口尺寸增大,并在水层厚度为300 mm附近其增量发生正向突跃。研究表明:控制水层厚度可以进一步增强聚能射流水下毁伤效果,本文研究可为聚能战斗部毁伤性能研究提供参考。

关键词：聚能射流药型罩水层厚度毁伤性能水下爆炸数值模拟射流侵彻炸高

TWO-DIMENSIONAL NUMERICAL HAILCLOUD MODEL

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Acta meteorologica Sinica 1989年第2期3卷 200-211页

作者：许焕斌王思微 Academy of meteorological Science State Meteorological AdministrationBeijing

This paper describes a two-dimensional slab-symmetric hailcloud model,of which dynamics almost con- tains all the dynamic *** model with the improved precipitation process included can show the bipara- meter change of particle size-distribution.A new suspending lateral boundary condition is proposed which may improve the influence of boundary on the airflow within computing *** subroutines designed for studying the change in outline of precipitating particle region can describe the interaction between airflow and precipitation *** this model the structure of weak ccho region in hailcloud is simulated and the airflow patterns under different thermal disturbances and wind shear are studied.

关键词： WER TWO-DIMENSIONAL NUMERICAL HAILCLOUD MODEL

PEGylated graphene oxide-mediated stimulation of vascular endothelial cells and responsive release of PD-1/PD-L1 inhibitor for efficient chemo-immunotherapy against cancer Author links open overlay panel

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Particuology 2024年第8期91卷 280-290页

作者： Yan wang Feng Li Shuang wang Jiaqi Meng Xiao Zhang Wei Wei state Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Immune checkpoint blockade(ICB)has emerged as a promising immunotherapeutic modality against cancer in the ***,only 10-30%of patients respond to ICB,primarily due to poor immunogenicity and insufficient T cell infiltration in solid ***,we presented an approach for high-performance cancer treatment using the programmed cell death protein-1 and programmed cell death ligand-1(PD-1/PD-L1)inhibitor(BMS-202)-loaded PEGylated graphene oxide(GPi).On the one hand,GPi dissociated tight junctions of vascular endothelial cells(VECs)in tumor,thus promoting the extravasation and intratumoral accumulation of liposomal doxorubicin(LipDox),which then effectively induced immunogenic cell death of tumor *** the other hand,GPi also stimulated VECs to upregulate the expression of cell-cell interaction molecules,such as intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1,which facilitated the infiltration of T cells in *** acting as a stimulator of VECs,GPi could exert responsive release of BMS-202 under the acidic tumor microenvironment and blockade PD-1/PD-L1 axis in ***,the alternating administration of GPi and LipDox effectively inhibited tumor growth in a 4T1 tumor model,providing a novel treatment mode for chemo-immunotherapy.

关键词： PEGylated graphene oxide Vascular endothelial cells Immune checkpoint blockade Immunogenic cell death Chemo-immunotherapy

Rapid and sensitive detection of Epstein-Barr virus antibodies in nasopharyngeal carcinoma by chemiluminescence strips based on iron-porphyrin single atom nanozyme

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Nano Research 2024年第3期17卷 1827-1836页

作者： Daji wang Jie wang Dan Liu Jiuyang He Meiying wang Haibing Huang Guohui Nie Hui Ding Xiyun Yan Nanozyme Synthesis Center Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China Shenzhen Key Laboratory of nanozymes and Translational Cancer Research Department of Otolaryngologyand Shenzhen Institute of Translational MedicineShenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen 518035China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Department of Rheumatology and Immunology Shenzhen Second People’s HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhen 518055China

The correlation between Epstein-Barr virus(EBV)infection and nasopharyngeal carcinoma(NPC)risk has been extensively *** continual monitoring of EBV-IgAs provides a promising approach of NPC screening in its early *** this study,we successfully synthesized a single-atom nanozyme(SANzyme)through the application of iron-porphyrin based metal organic framework(MOF-FeP).The MOF-FeP possesses precisely-defined electronic and geometric structures that accurately mimic highly-evolved catalytic site of natural *** peroxidase-like activity of MOF-FeP enables it to catalyze the chemiluminescence of luminol *** integrating MOF-FeP into a traditional strip,we created a rapid and highly-sensitive evaluation tool for detecting ***,the MOF-FeP strip enables the simultaneous detection of three EBV-IgAs,greatly improving the accuracy of EBV-associated NPC *** sensitivities of the MOF-FeP strip(75.56%–93.30%)surpass those of current enzyme-linked immunosorbent assay(ELISA)methods(64.44%–82.22%).This test takes only 16 min to perform as opposed to the customary 1–2 h required for standard ***,the MOF-FeP strip is suitable for whole blood samples,thereby significantly simplifying the sample preparation and detection *** conclusion,the MOF-FeP strip combines the simplicity of traditional strip with the high catalytic activity of *** innovative MOF-FeP strip offers a new point-of-care strategy for EBV-IgAs detection,which is expected to markedly facilitate early screening for EBV-associated diseases.

关键词： iron-porphyrin single-atom nanozyme(SANzyme) chemiluminescence strips Epstein-Barr virus(EBV) nasopharyngeal carcinoma(NPC) antibody detection

Differential metabolite analysis of the pharmacodynamic differences between different ratios of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae) herb pair

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Journal of Traditional Chinese Medicine 2024年第3期44卷 515-523页

作者： wang Xiang HUANG Jianping wang Yupeng wang Qilong JING Yajiang ZHANG Gang PENG Liang GAO Jing wang Hongyan YAN Yonggang Department of Key Laboratory of"Qin Pharmaceutical"Research and Development Shaanxi University of Traditional Chinese MedicineXianyang 712046China Department of Yupeng Shaanxi Haitian Pharmaceutical Co. Ltd.Xianyang 712046China Department of Acupuncture and Tuina Shaanxi University of Traditional Chinese MedicineXianyang 712000China

OBJECTIVE: To explore the material basis of the difference of efficacy of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae)(DT) drugs with different proportions. METHODS: Samples of different ratios of Dahuang(Radix et Rhizoma Rhei Palnati, DH) to Taoren(Semen Persicae, TR)(Group A 1∶1, B 2∶3, C 3∶2) were analyzed based on gas chromatography time-of-flight mass spectrometry untargeted metabolomics technique. RESULTS: A total of 240 primary metabolites were detected. Forty-one differential metabolites involved nine differential metabolic pathways, of which four were closely related to the efficacy of DT in the treatment of heat and blood stasis syndrome. These pathways included the biosynthesis of amino acid(phenylalanine tyrosine and tryptophan), flavonoids, unsaturated fatty acids, and the glycolysis/glycogenesis pathway. CONCLUSION: There are significant differences in the efficacy of different ratios of DT drugs, and their optimal ratio for the treatment of heat and blood stasis syndrome should be 1∶1.

关键词： metabolomics metabolic networks and pathways differential metabolites Dahuang(Radix Et Rhizoma Rhei Palmati) Taoren(Semen Persicae) kernel drug pairs

葡萄果实内油菜素内酯生物合成调控及生理效应

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分子植物育种 2024年第6期22卷 2060-2068页

作者：李嘉佳李相怡王磊王世平上海交通大学农业与生物学院上海200240

油菜素内酯是调控植物生长发育的重要植物激素,具有促进植物细胞分裂和生长、光合作用和呼吸作用、植株光形态的建成、提高抗逆性以及降低蒸腾等作用,对葡萄果实产量和品质的提高均有着极其重要的贡献。本研究综述了油菜素内酯的生物合... 详细信息

油菜素内酯是调控植物生长发育的重要植物激素,具有促进植物细胞分裂和生长、光合作用和呼吸作用、植株光形态的建成、提高抗逆性以及降低蒸腾等作用,对葡萄果实产量和品质的提高均有着极其重要的贡献。本研究综述了油菜素内酯的生物合成途径及其关键酶、生物合成途径的影响因素,以及其对葡萄果实产量和品质的影响,总结了油菜素内酯对植物光合作用、呼吸作用、蒸腾作用及植物光形态的建成的生理效应。同时,对油菜素内酯与其他植物内源激素的互作网络进行了梳理,并提出未来的研究方向应以油菜素内酯合成相关转录因子、与其他植物激素互作机理和开发新型高效的油菜素内酯类植物调节剂为主。

关键词：葡萄油菜素内酯合成生理效应互作机理

Rebuilding the theory of isotope fractionation for evaporation of silicate melts under vacuum condition

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Acta Geochimica 2024年第4期43卷 661-676页

作者： Jie wang Yun Liu Research Center for Planetary Science College of Earth and Planetary SciencesChengdu University of TechnologyChengdu 610059China state Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China CAS Center for Excellence in Comparative Planetology Hefei 230026China

Isotope eff ects are pivotal in understanding silicate melt evaporation and planetary accretion *** on the Hertz-Knudsen equation,the current theory often fails to predict observed isotope fractionations of laboratory experiments due to its oversimplified ***,we point out that the Hertz-Knudsen-equation-based theory is incomplete for silicate melt evaporation cases and can only be used for situations where the vaporized species is identical to the one in the *** propose a new model designed for silicate melt evaporation under *** model considers multiple steps including mass transfer,chemical reaction,and *** derivations reveal a kinetic isotopic fractionation factor(KIFF orα)αour model=[m(^(1)species)/m(^(2)species)]^(0.5),where m(species)is the mass of the reactant of reaction/nucleation-limiting step or species of diffusion-limiting step and superscript 1 and 2 represent light and heavy isotopes,*** model can eff ectively reproduce most reported KIFFs of laboratory experiments for various elements,i.e.,Mg,Si,K,Rb,Fe,Ca,and ***,the KIFF-mixing model referring that an overall rate of evaporation can be determined by two steps jointly can account for the eff ects of low P_(H2)pressure,composition,and *** addition,we find that chemical reactions,diffusion,and nucleation can control the overall rate of evaporation of silicate melts by using the fitting slope in ln(−ln f)versus ln(t).Notably,our model allows for the theoretical calculations of parameters like activation energy(E_(a)),providing a novel approach to studying compositional and environmental eff ects on evaporation processes,and shedding light on the formation and evolution of the proto-solar and Earth-Moon systems.

关键词： Evaporation Kinetic isotopic fractionation Chemical kinetics Hertz-Knudsen equation CAIS

Study of fouling organisms at Tuoji Island in the Bohai Channel

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Acta Oceanologica Sinica 1989年第2期8卷 285-292页

作者： wang Jianjun, Huang Zongguo, Li Chuanyan, Zheng Chengxing Lin Sheng Third Institute of Oceanography, state Oceanic administration, Xiamen, china Third Inst. of Oceanography State Oceanic Admin. Xiamen China China

From June 1984 to May 1985, monthly and seasonal panel tests of fouling organisms were carried out on rafts at Tuoji Island. Seventy - three species were obtained. The occurring frequencies of the following species are all at least 30%: Ectocarpus confervoides, Polysiphonia urceolata, Tubularia mesembryanthmum, Cfytia edwardsi, Tubulipora pulchra, Celleporella hyalina, Mytilus edulis, Hiatella arctica, Caprella acanthogaster, Corophium crassicome, Jassa *** and Podocerus cf . inconspicuus. Large or calcareous species are not dominant ones. The wet weight is comparatively light, the yearly wet weight being 9.12 kg m-2. Attaching seasons of major species are from June to October and no bio - attachment occurs between January and April. Fouling organisms at Tuoji Island differ rather greatly from those in the harbours along the continental coast, showing the charcteristics of fouling organisms in the northern island harbours of china.

关键词： Study of fouling organisms at Tuoji Island in the Bohai Channel

Reconstructing mean maximum temperature of growing season from the maximum density of the Schrenk Spruce in Yili,Xinjiang,china

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Chinese Science Bulletin 2009年第13期54卷 2300-2308页

To study the historical temperature variation in Yili of Xinjiang,the tree-ring chronologies of maximum density(MXD) and tree-ring width(TRW) were established with the Schrenk Spruce(Picea schrenkiana *** Mey) collected from six sites to analyze the characteristics and ability of response to climate *** results suggest that the MXD chronology of the Schrenk Spruce from different sampling sites responded to climate change well and were positively correlated with the mean maximum temperature and the mean temperature from April to August in the study *** mean maximum temperature anomaly from April to August,spanning the years from 1848 to 2000,was reconstructed by three MXD chronologies which were selected by stepwise *** reconstructed function was stable and explained 56.2% of the *** reconstructed results indicated a cold span of 153 years in spring and summer from the beginning of the 1950s to the beginning of the 1970s in the Yili *** strongly increasing tendency was detected in the mean maximum temperature anomaly from April to August during this reconstructed period.

关键词：平均最高气温伊犁谷地最大密度云杉胡杨生长季节新疆树木年轮宽度