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Dynamic Event-Triggered Quadratic Nonfragile Filtering for Non-Gaussian Systems:Tackling Multiplicative Noises and Missing Measurements

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1127-1138页

作者： shaoying wang Zidong wang Hongli Dong Yun Chen Guoping Lu College of Science Shandong University of AeronauticsBinzhou 256603China College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590 department of Computer Science Brunel University LondonUxbridge UB83PHUK Artificial Intelligence Energy Research Institute Northeast Petroleum UniversityDaqing 163318 Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Northeast Petroleum UniversityDaqing 163318China School of Automation Hangzhou Dianzi UniversityHangzhou 310018China School of Electrical Engineering Nantong UniversityNantong 226019China

This paper focuses on the quadratic nonfragile filtering problem for linear non-Gaussian systems under multiplicative noises,multiple missing measurements as well as the dynamic event-triggered transmission *** multiple missing measurements are characterized through random variables that obey some given probability distributions,and thresholds of the dynamic event-triggered scheme can be adjusted dynamically via an auxiliary *** attention is concentrated on designing a dynamic event-triggered quadratic nonfragile filter in the well-known minimum-variance *** this end,the original system is first augmented by stacking its state/measurement vectors together with second-order Kronecker powers,thus the original design issue is reformulated as that of the augmented ***,we analyze statistical properties of augmented noises as well as high-order moments of certain random *** the aid of two well-defined matrix difference equations,we not only obtain upper bounds on filtering error covariances,but also minimize those bounds via carefully designing gain ***,an example is presented to explain the effectiveness of this newly established quadratic filtering algorithm.

关键词： filtering quadratic bounds

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Acinic cell carcinoma of the parotid gland:MR features

Acinic cell carcinoma of the parotid gland:MR features

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The 9th Asian Congress of Oral and Maxillofacial radiology

作者： Shi Huimin wang shaoying department of radiology Ninth People’s Hospital School of Medicine Shanghai Jiao Tong University

＜正＞Aims:To evaluate the diagnostic value of MR imaging feature and conventional contrast -enhanced MR imaging appearance in acinic cell carcinoma of the parotid gland. Methods:We retrospectively reviewed pre- and p...

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Acinic cell carcinoma of the parotid gland:MR features

Acinic cell carcinoma of the parotid gland:MR features

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第10次全国口腔颌面医学影像学专题研讨会暨国家级口腔颌面医学影像诊断学新进展学习班

作者： Shi Huimin,wang shaoying department of radiology,Ninth People’s Hospital,School of Medicine,Shanghai Jiao Tong University,639 Zhi Zao Ju Road,Shanghai 200011,China

Purpose:To evaluate the diagnostic value of MR imaging feature and conventional contrast -enhanced MR imaging appearance in acinic cell carcinoma of the parotid gland. Methods:We retrospectively reviewed pre- and post... 详细信息

关键词： Acinic cell adenocarcinomas MR imaging parotid gland

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Pigmented villonodular synovitis of the temporomandibular joint:CT imaging findings

Pigmented villonodular synovitis of the temporomandibular jo...

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第10次全国口腔颌面医学影像学专题研讨会暨国家级口腔颌面医学影像诊断学新进展学习班

作者： wang shaoying,Shi Huimin department of radiology,Ninth People’s Hospital,School of Medicine,Shanghai Jiao Tong University,639 Zhi Zao Ju Road,Shanghai 200011,China

Objective:The purpose of this study was to determine the computed tomography(CT) findings of pigmented viilonoduiar synovitis(PVNS) of the temporomandibular joint(TMJ). Study design:Eight subjects with PVNS were exami...

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体力劳动者和脑力劳动者的行为和生活方式对其抑郁症状的影响

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中华劳动卫生职业病杂志 2024年第9期42卷 673-678页

作者：张建江王少颖雷乐莺沈成万宁德师范学院医学院宁德352100 宁德人民医院感染科宁德352100

目的分析体力劳动者和脑力劳动者的抑郁症状及行为和生活方式对其抑郁症状的影响。方法于2022年8月,采用横断面研究设计,应用整群抽样法选择553名职业人群为研究对象,收集其一般人口学资料、健康相关行为和生活方式,应用中文版抑郁症筛... 详细信息

目的分析体力劳动者和脑力劳动者的抑郁症状及行为和生活方式对其抑郁症状的影响。方法于2022年8月,采用横断面研究设计,应用整群抽样法选择553名职业人群为研究对象,收集其一般人口学资料、健康相关行为和生活方式,应用中文版抑郁症筛查量表(PHQ-9)对其抑郁症状进行评价,分析体力劳动者和脑力劳动者基本特征及行为和生活方式的差异,并采用logistic回归分析职业人群抑郁症状的影响因素。结果553名研究对象中,体力劳动者317人(57.32%),脑力劳动者236人(42.68%),两组研究对象在文化程度、月收入、吸烟率、经常参加体育锻炼率、睡眠时间适宜率等方面比较,差异有统计学差异(P<0.05)。体力劳动者抑郁症状得分和抑郁症状检出率分别为(9.67±2.75)分和20.82%(66/317),高于脑力劳动者的抑郁症状得分和抑郁症状检出率[(8.34±2.18)分,12.71%(30/236)](t=6.13、χ^(2)=6.20,P<0.05)。logistic回归分析的结果显示,吸烟、经常参加体育锻炼、睡眠时间适宜和脑力劳动是职业人群抑郁症状的影响因素(OR=1.592,95%CI:1.316~1.825;OR=0.659,95%CI:0.416~0.830;OR=0.502,95%CI:0.257~0.717;OR=0.839,95%CI:0.522~0.967;P<0.05)。结论体力劳动者的抑郁症状比脑力劳动者严重,文化程度低、不经常参加体育锻炼、吸烟、睡眠时间不适宜是影响职业人群抑郁症状的潜在危险因素。

关键词：抑郁抑郁症状生活方式体力劳动者脑力劳动者

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Solid-state atomic hydrogen as a broad-spectrum RONS scavenger for accelerated diabetic wound healing

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National Science Review 2024年第2期11卷 196-206页

作者： Man Luo Qin wang Gang Zhao Wei Jiang Cici Zeng Qingao Zhang Ruyu Yang wang Dong Yunxi Zhao Guozhen Zhang Jun Jiang Yucai wang Qing Zhu Key Laboratory of Precision and Intelligent Chemistry School of Chemistry and Materials Science University of Science and Technology of China department of radiology The First Affiliated Hospital of University of Science and Technology of China Division of Life Sciences and Medicine University of Science and Technology of China Shenzhen Senior High School Institute of Intelligent Innovation Henan Academy of Sciences

Hydrogen therapy shows great promise as a versatile treatment method for diseases associated with the overexpression of reactive oxygen and nitrogen species（RONS）. However, developing an advanced hydrogen therapy platform that integrates controllable hydrogen release, efficient RONS elimination, and biodegradability remains a giant technical challenge. In this study, we demonstrate for the first time that the tungsten bronze phase H0.53WO3（HWO） is an exceptionally ideal hydrogen carrier, with salient features including temperature-dependent highly-reductive atomic hydrogen release and broad-spectrum RONS scavenging capability distinct from that of molecular hydrogen. Moreover, its unique p H-responsive biodegradability ensures post-therapeutic clearance at pathological sites. Treatment with HWO of diabetic wounds in an animal model indicates that the solid-state atomic H promotes vascular formation by activating M2-type macrophage polarization and anti-inflammatory cytokine production, resulting in acceleration of chronic wound healing. Our findings significantly expand the basic categories of hydrogen therapeutic materials and pave the way for investigating more physical forms of hydrogen species as efficient RONS scavengers for clinical disease treatment.

关键词： atomic hydrogen RONS scavenger inflammatory regulation diabetic wound healing hydrogen therapy

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Aggregation-induced T_(1)/T_(2) contrast enhancement for magnetic resonance imaging-guided intraoperative surgery

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Science China Chemistry 2024年第6期67卷 2046-2055页

作者： Wenbo Sun Bin Yu Dianshuai Huang Chunhuan Jiang Wei wang Jianhua Liu Zonghua wang Lehui Lu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China College of Chemistry and Chemical Engineering Shandong Sino-Japanese Center for Collaborative Research of Carbon NanomaterialsQingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and TreatmentQingdao UniversityQingdao266071China department of radiology Second Hospital of Jilin UniversityChangchun130041China

Magnetic resonance imaging(MRI)plays an important role in precision medicine that is hampered by the lack of contrast agents with high efficiency and the ability to translate diagnostic accuracy into therapeutic ***,we demonstrate a DNA-based MRI probe that overcomes previous single-mode enhancement and provides a mechanism of action for aggregationinduced dual-modal MRI signal enhancement.A facile method is developed to produce aggregated T_(1)/T_(2)dual-modal NaGdF_(4):Dy@PDA-DNA(PDA=polydopamine)MRI *** aggregated,this probe can further amplify MRI signal intensity and exhibit improved geometrical and positional stability in *** performance of the NaGdF_(4):Dy@PDA-DNA MRI probe toward MRI-guided preoperative planning and visualization-guided surgery is verified using an orthotopic tumor-bearing mouse *** result shows that the rapid metabolism of the degraded probe leads to the mitigation of long-term toxic ***,the developed high-performance MRI probe is of great significance for enhancing MRI diagnostic accuracy into precision medical therapeutic interventions.

关键词： MRI probe DNA aggregation-induced T_(1)/T_(2)contrast enhancement precision medicine degradable probe

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Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1690-1705页

作者： Yan Fu Keyu Shen Hao wang Shun wang Xufeng wang Le Zhu Yan Zheng Tiantian Zou Hongfei Ci Qiongzhu Dong Lun-Xiu Qin Hepatobiliary Surgery Department of General SurgeryHuashan Hospital&Cancer Metastasis InstituteFudan University200040 ShanghaiChina Center of Interventional radiology and Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast University87 Dingjiaqiao Road210009 NanjingChina institutes of Biomedical Sciences Fudan University200032 ShanghaiChina Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer Shanghai Municipal Health CommissionMinhang HospitalFudan UniversityShanghaiChina

Neurotransmitter-initiated signaling pathway were reported to play an important role in regulating the malignant phenotype of tumor *** cells could exhibit a"neural addiction"property and build up local nerve networks to achieve an enhanced neurotransmitter-initiated signaling through nerve growth factor-mediated *** the dysregulated nervous systems might represent a novel strategy for cancer ***,whether intrahepatic cholangiocarcinoma(ICC)could build its own nerve networks and the role of neurotransmitters in the progression ICC remains largely *** staining and Enzyme-linked immunosorbent assay suggested that IcC cells and the infiltrated nerves could generate a tumor microenvironment rich in acetylcholine that promotes IcC metastasis by inducing epithelial-mesenchymal transition(EMT).Acetylcholine promoted iCC metastasis through interacting with its receptor,alpha 5 nicotine acetylcholine receptor subunits(CHRNA5).Furthermore,acetylcholine/CHRNA5 axis activated GSK3β/β-catenin signaling pathway partially through the influx of Ca^(2+)-mediated activation of Ca/calmodulin-dependent protein kinases(CAMKll).In addition,acetylcholine signaling activation also expanded nerve infiltration through increasing the expression of Brain-Derived Neurotrophic Factor(BDNF),which formed a feedforward acetylcholine-BDNF axis to promote ICC ***93,a small-molecule inhibitor of CAMKIll,significantly inhibited the migration and enhanced the sensitivity to gemcitabine of ICC *** all,Acetylcholine/CHRNA5 axis increased the expression ofβ-catenin to promote the metastasis and resistance to gemcitabine of ICC via CAMKIl/GSK3βsignaling,and the CAMKIl inhibitor KN93 may be an effective therapeutic strategy for combating ICC metastasis.

关键词： GSK3β metastasis Alpha

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In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug

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Nano-Micro Letters 2024年第1期16卷 341-359页

作者： Jiawei Kang Yaping Li Yating Qin Zhongming Huang Yifan Wu Long Sun Cong wang Wei wang Gang Feng Yiying Qi department of Orthopaedic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou City 310009Zhejiang ProvincePeople’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215ZhejiangPeople’s Republic of China The Affiliated Nanhua Hospital Orthopedic Research CentreHengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanPeople’s Republic of China department of radiology Jining No.1 People’s HospitalJining Medical UniversityJining 272000ShandongPeople’s Republic of China

The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage *** multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense ***,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their *** hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural *** resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and *** vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,*** vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral *** biomaterial delivery approach represents a significant toward improved osteochondral repair.

关键词： Osteochondral regeneration Oriented hydrogel Kartogenin miRNA-26a

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An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke

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Journal of Pharmaceutical Analysis 2024年第4期14卷 578-584页

作者： Junfeng wang Qibing Liu Yingbo Li Yi Pang department of Chemistry The University of AkronAkronOH 44325USA Gordon Center for Medical Imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA department of Pharmacy The First Affiliated Hospital of Hainan Medical UniversityHaikou570100China Engineering Research Center of Tropical Medicine Ministry of EducationHainan Medical UniversityHaikou571199China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing100191China Maurice Morton Institute of Polymer Science The University of AkronAkronOH 44325USA

A two-photon near infrared(NIR)fluorescence turn-on sensor with high selectivity and sensitivity for Zn^(2+)detection has been *** sensor exhibits a large Stokes'shift(-300 nm)and can be excited from 900 to 1000 nm,with an emission wavelength of-785 nm,making it ideal for imaging in biological *** sensor's high selectivity for Zn^(2+)over other structurally similar cations,such as Cd^(2+),makes it a promising tool for monitoring zinc ion levels in biological *** the high concentration of zinc in thrombi,this sensor could provide a useful tool for in vivo thrombus imaging.

关键词： Near-infrared Molecular imaging Thrombus Stroke

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