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Bystander Effects on mammalian Cells Induced by Carbon-ion-radiation

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IMP & HIRFL Annual Report 2004年 111-111页

作者： wang jufang, li wenjian, dang bingrong and ma qiufeng

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Growth Delay of Mouse Lewis Tumors by Carbon Ion Radiation

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IMP & HIRFL Annual Report 2002年 66-67页

作者： li wenjian, Guo Hongyun, li Dexing, dang bingrong, ma qiufeng, Yuan Shibin wang Xiaci, Hao Jifang, Zhou libin, mao Shuhong and Wei Zengquan Gansu Academy of Medical Sciences.

Growth delay of transplantable Lewis tumors growing in right hind legs in C57 BI/6J mice were investigated after 12C6+ ion radiation at HIRFL. Half and half of C57 BL/6J female and male mice, weight of 18-20 g, were provided by Military Academy of Medical Sciences. Before radiation the Lewis tumor cell fluid of 0.2 ml with

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mass Deposition Induced by Implantation of Low Energy Fe^+ Ions into Amino Acids

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IMP & HIRFL Annual Report 2001年第1期 76-77页

作者： Yuan Shibin, Wei Zengquan, li wenjian, dang bingrong, li Qiang, Zhou Guangmingwang jufang, Xie Hongmei, Hao Jifang, ma qiufeng, Zhao limin, wang JingyanFu Baojun, li Hengyuan, Gao Qingxiang1 and li Haiyan1 School of life Sciences, Lanzhou University.

Fe^+ion beams with the energy of 110keV were implanted into films ofL(+)-cysteine[HSCH^2CH(NH^2)COOH].One of the single crystals grown in hydrochloric acid solution with the implanted samples through slow evapo-ration... 详细信息

关键词： structurally monoclinic implanted hydrochloric cysteine bonded coordinates proof irradiation isotropic

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Distribution of Heavy Ions in Space on Experiment and Monte Carlo Simulation for Radiation Breeding

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2002年第1期 67-67页

作者： ma qiufeng, li wenjian, dang bingrong, Xie Hongmei and Jin Genming

Our rice seeds which were let between in the CR-39 solid state nuclear track detectors were carried on Shenzhou III Airship fight in space and the track of heavy ions hit on seeds were memorized by the CR-39 *** heave... 详细信息

关键词：空间辐射育种重离子分布蒙特卡罗模拟水稻种子神舟三号飞船离子轰击

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Investigation of Cell Cycle and Survival of 60Co γ-ray Irradiation on SMMC-7721

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IMP & HIRFL Annual Report 2004年 112-112页

作者： dang bingrong, li wenjian, Gao Qinxiang, ma qiufeng, Hao Jifang wang jufang, Jin Xaiodong, Xie Yi and Guo Chuanling

many studies have shown that tumor is a kind of cell cycle disease. The cell cycle research results play an important role in research tumor occurrence, development and treatment. Most research results have shown that malignant grade and pharmic sensitivity of tumor have relation with cell cycle. The sensitivity of medications is different to different phases of cell cycle of tumor. In general, the cell of M is more sensitivity. On the side,

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Investigation of Cell Cycle and Survival of ^(60)Co γ-ray Irradiation on SMMC-7721

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2004年第1期 91-91页

作者： dang bingrong, li wenjian, Gao Qinxiang, ma qiufeng, Hao Jifang wang jufang, Jin Xaiodong, Xie Yi and Guo Chuanling

关键词：细胞周期射线辐照肿瘤发生敏感性研究成果 M细胞药物

Ab Initio Molecular Dynamics Simulation Diffusion Mechanism of .OH Radical in liquid Water

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2004年第1期 30-30页

作者： Yang Wei, ma qiufeng, li wenjian, Jin Genming, wang Xiao, dang bingrong and Xiao Guoqing

Water occupies over 70% in a cell and clouds cover approximately 60% of the earth's surface. The radiation of high-energy particles (γray, heavy ions, election) on liquid water generate copious quantities hydroxyl radial (OH). The OH which is open shell radial species initiates many of the cycle of the chemistry of atmosphere and governs many chemical and biological processes in nature. Due to difficulties in direct measurements

关键词：分子动力学模拟液态水氢氧自由基扩散机制从头计算大气化学地球表面粒子辐射

Ab Initio Molecular Dynamics Simulation Diffusion Mechanism of .OH Radical in liquid Water

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IMP & HIRFL Annual Report 2004年 51-51页

作者： Yang Wei, ma qiufeng, li wenjian, Jin Genming, wang Xiao, dang bingrong and Xiao Guoqing

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羧甲基-β-1,3-葡聚糖对人肝癌HepG2细胞的放射增敏作用

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原子核物理评论 2017年第4期34卷 797-802页

作者：马斌博王转子魏巍党秉荣李文建中国科学院近代物理研究所兰州730000 兰州大学兰州730000

本研究旨在探讨羧甲基-β-1,3葡聚糖(CMG)对人肝癌HepG2细胞X射线或^(12)C^(6+)离子束辐射敏感性的影响。首先用CCK-8法检测CMG对HepG2细胞的生长抑制情况,得到半数抑制浓度(IC50)为120.6μg/m L。用浓度为0.1×IC50的CMG预处理HepG2细... 详细信息

本研究旨在探讨羧甲基-β-1,3葡聚糖(CMG)对人肝癌HepG2细胞X射线或^(12)C^(6+)离子束辐射敏感性的影响。首先用CCK-8法检测CMG对HepG2细胞的生长抑制情况,得到半数抑制浓度(IC50)为120.6μg/m L。用浓度为0.1×IC50的CMG预处理HepG2细胞24 h,再给予2 Gy X射线或^(12)C^(6+)离子束辐照(CMG+辐照组);CMG未处理组直接接受2 Gy X射线或^(12)C^(6+)离子束辐照(辐照组)。对比分析辐照组和CMG+辐照组细胞的克隆存活、DNA损伤、凋亡与周期分布、细胞内活性氧(ROS)水平。发现:与X射线辐照组相比,相同剂量的^(12)C^(6+)离子辐照组克隆存活率更小,DNA损伤和周期阻滞更加严重,细胞凋亡率和细胞内ROS水平也更高。与单独X射线或^(12)C^(6+)离子束辐照组相比,CMG+辐照组克隆存活率明显降低,细胞凋亡率随辐照后CMG作用时间的延长而明显增加,CMG使辐照后细胞内ROS维持在一个较高的水平,同时CMG明显加重了单独辐照诱导的DNA损伤和周期阻滞。结果表明,与X射线相比,HepG2细胞对相同剂量的^(12)C^(6+)离子辐射更敏感;CMG可增加HepG2细胞对X射线或^(12)C^(6+)离子辐射的敏感性;CMG可能通过增加受照HepG2细胞内的ROS水平,加剧辐照诱导的DNA损伤,促进辐射诱导细胞凋亡而起到辐射增敏作用。

关键词：羧甲基-β-1 3-葡聚糖 Hep G2细胞 X射线辐照 12C6+离子辐照辐射敏感性

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