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PFC^(2D)-based investigation on the mechanical behavior of anisotropic shale under Brazilian splitting containing two parallel cracks

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Frontiers of Earth Science 2021年第4期15卷 803-816页

作者： Bo HE Jun LIU Peng ZHAO jingfeng wang Key Laboratory of Deep Underground Science and Engineering Sichuan UniversityChengdu 610065China College of Architecture and Environment Sichuan UniversityChengdu 610065China Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengdu 610207China

A validated particle flow code(PFC^(2D))-based model was developed to investigate the indirect tensile mechanical behavior of shale containing two central parallel cracks under Brazilian splitting test *** results show that preexisting cracks have a significant and insignificant influence on the tensile strength of shale under LPL and LVL conditions,*** L≥10 mm,changing the L and H values has little effect on the tensile strength of ***,the inclusion of preexisting cracks have a positive effect on reducing the anisotropy of the shale specimens,and in the case of an L/D ratio of 0.3,the shale anisotropy is the *** failure modes were formed at differentβandθvalues under LPL *** the case ofβ≥60°,the failure mode is mainly affected byβ,and whenβ≤45°,the failure mode is more complicated than in the case ofβ≥60°.Only three major failure modes were observed under LVL conditions;in the case of 45°≤β≤75°andθ≤30°,the most complex failure mode occurred.

关键词： anisotropy preexisting cracks tensile strength mechanical behavior PFC^(2D)

Fucoidans from Thelenota ananas with 182.4 kDa Exhibited Optimal Anti-Adipogenic Activities by Modulating the Wnt/β-Catenin Pathway

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Journal of Ocean University of China 2021年第4期20卷 921-930页

作者： LIU Yuanyuan wang Na TIAN Yingying CHANG Yaoguang wang jingfeng College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Marine Biomedical Research Institute of Qingdao Qingdao 266061China

In this study,fucoidans were extracted from the sea cucumber Thelenota ananas(Ta-FUCs)by enzymatic *** products with molecular weights of 1380.3,524.0,182.4,and 110.3 kDa were obtained,and the Ta-FUC showing optimal anti-adipogenic activities was *** of MTT and Oil red O staining analyses showed that the Ta-FUCs inhibited the proliferation and differentiation of 3T3-L1 ***,Ta-FUCs significantly downregulated the key transcriptional factors,such as SREBP-1c,PPARγ,and C/EBPαof *** Ta-FUCs also activated Wnt/β-catenin pathway-related genes,such asβ-catenin,LRP5,and *** Ta-FUCs suppressed lipid accumulation in 3T3-L1 adipocytes possibly by decreasing the expression of genes ACC,FAS,ME,GPAT,DGAT,and PILN,which are important in the synthesis of fatty acids and triglycerides;and by increasing the expression of genes PPARα,CPT-1α,and ACOX,which are crucial in fatty acidβ-*** anti-adipogenic activities initially increased and then declined with decreasing molecular *** the Ta-FUCs,the 182.4 kDa Ta-FUC exhibited optimal *** study reports for the first time that Ta-FUCs can prevent obesity by regulating the differentiation and lipid accumulation of adipocytes.

关键词： fucoidan from Thelenota ananas molecular weight anti-adipogenic activities adipocyte differentiation lipid accumulation Wnt/β-catenin pathway

SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1

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Cellular & Molecular Immunology 2022年第8期19卷 872-882页

作者： Shilei Zhang jingfeng wang Lulan wang Saba Aliyari Genhong Cheng Department of Microbiology Immunologyand Molecular GeneticsUniversity of CaliforniaLos AngelesLos Angeles90095CAUSA

Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome(ARDS)-related respiratory *** storms and oxidative stress are the major players in ARDS development during respiratory virus ***,it is still unknown how oxidative stress is regulated by viral and host factors in response to SARS-CoV-2 ***,we found that activation of NRF2/HMOX1 significantly suppressed SARS-CoV-2 replication in multiple cell types by producing the metabolite biliverdin,whereas SARS-CoV-2 impaired the NRF2/HMOX1 axis through the action of the nonstructural viral protein ***,NSP14 interacts with the catalytic domain of the NAD-dependent deacetylase Sirtuin 1(SIRT1)and inhibits its ability to activate the NRF2/HMOX1 ***,both genetic and pharmaceutical evidence corroborated the novel antiviral activity of SIRT1 against ***,our findings reveal a novel mechanism by which SARS-CoV-2 dysregulates the host antioxidant defense system and emphasize the vital role played by the SIRT1/NRF2 axis in host defense against SARS-CoV-2.

关键词： SARS-CoV-2 NRF2 HMOX1 NSP14 SIRT1 Oxidative stress

Portland cementitious coating with autogenerated oxide film and its anticorrosion behavior on magnesium alloy

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Journal of Materials Science & Technology 2024年第9期176卷 99-111页

作者： Danqian wang Ye wang Kai Ma Chaoneng Dai Jinxing wang jingfeng wang Fusheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing 400045China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

A simple one-step anticorrosion Portland cement(PC)-based coating with an autogenerated oxide film on the surface of Mg alloy was successfully prepared in this *** anticorrosion of coated Mg alloys was assessed by several electrochemical methods including open circuit potential,electrochemical impedance spectroscopy,and cyclic potentiodynamic *** morphology and composition of PC-based coatings were characterized via scanning electron microscopy and X-ray *** composition of the autogenerated oxide film was analyzed via X-ray photoelectron *** show that the PC-based coatings can significantly enhance the corrosion resistance of AZ41 Mg alloy due to the synergetic effect of PC-based coating and autogenerated oxide ***,the quality of oxide film plays a dominant role in determining anticorrosion of Mg ***,the addition of metakaolin and dolomite enhances the resistance of PC-based coating and meanwhile,MoO_(4)^(2–)ions from PC-based coating can adsorb in the oxide film,improving the quality of the oxide film.

关键词： Mg alloy Oxide film Portland cement Coating Corrosion resistance

Impact of photogenerated charge behaviors on luminescence of Eu^(3+) -incorporated microporous titanosilicate ETS-10

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Science China Chemistry 2013年第4期56卷 428-434页

作者： GUO XingXing WEI Xiao wang KaiXue wang jingfeng CHEN JieSheng School of Chemistry and Chemical Engineering Shanghai Jiao Tong University

A series of Eu3+ -incorporated ETS-10 samples were successfully prepared based on the traditional ion exchange method. The relationship between photogenerated charge behaviors and luminescent properties has been investigated in detail. It has been demonstrated that as a result of the charge transfer from the titanate quantum wires to Eu3+ crystal field states, the host matrix ETS-10 functions as the sensitizer of Eu3+ to enhance the red luminescence, while Eu3+ cations contribute to the recombination of photogenerated charges. The behavior of photogenerated charges has significant impact on the luminescent properties of Eu3+ -incorporated ETS-10 materials.

关键词： ETS-IO ion exchange photoluminescence photogenerated charges photovoltage sensitization

Presenilin and Alzheimer’s disease interactions with aging,exercise and high-fat diet:A systematic review

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BIOCELL 2023年第1期47卷 41-49页

作者： YINGHUI GAO DENGTAI WEN SHIJIE wang jingfeng wang Ludong University Yantai264025China

Presenilin(Psn)protein is associated with organismal *** in the Psn gene may lead to Alzheimer’s disease(AD),dilated cardiomyopathy(DCM),and many age-dependent degenerative *** diseases seriously affect the quality of life and longevity of the population and place a huge burden on health care and economic systems around the *** have two types of Psn,presenilin-1(PSEN1)and presenilin-2(PSEN2).Mutations in the genes encoding PSEN1,PSEN2,and amyloid precursor protein(APP)have been identified as the major genetic causes of *** is a complex gene strongly influenced by genetic and environmental *** effects of exercise,training,and a high-fat diet on the Psn gene expressed in the heart and its related pathways are not fully ***,relevant aspects of the mutational effects on Psn can be studied experimentally in easily handled animal models,including Drosophila,mice,and other animals,all of which share orthologous genes of Psn with *** previous studies have linked aging,exercise training,and a high-fat diet to the Psn *** review discusses the interrelationship between aging,exercise training,and a high-fat diet on the Psn gene and its associated disease,*** aim is to understand the adverse effects of Psn gene mutations on the body and the diseases caused by AD,find ways to alleviate the adverse effects and provide new directions for the improvement of treatment strategies for diseases caused by Psn gene mutations.

关键词： Genetic mutations Drosophila Cardiac aging Muscle aging Neurodegenerative disease

Sialoglycoproteins Isolated from the Eggs of Gadus morhua Inhibit Bone Resorption in Ovariectomized Rats by Suppressing the MAPK and NF-κB Pathways

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Journal of Ocean University of China 2019年第5期18卷 1174-1184页

作者： MAO Lei wang Yiming wang Meiling DAI Yufeng wang jingfeng XUE Changhu College of Food Science and Engineering Ocean University of China

The present study investigated the anti-osteoporosis function and the mechanism of sialoglycoproteins isolated from the eggs of Gadus morhua(Gm-SGP)on ovariectomized(OVX)*** 3 months of Gm-SGP treatment,OVX-induced bone loss was suppressed and uncoupling bone turnover was balanced,as indicated by systemic biomarkers of bone metabolism;no uterine estrogenicity was ***,rats administered with Gm-SGP exhibited increased bone mineral density and biomechanical strength and significant restoration of the trabecular microarchitecture compared with rats in the control ***-SGP significantly decreased bone resorption-related indicators in *** of the associated mechanisms revealed that Gm-SGP significantly increases the OPG/RANKL ratio at the mRNA and protein *** research suggested that Gm-SGP inhibits the mRNA and protein expressions of important transcription factors of the MAPK and NF-κB signaling *** also attenuates the activation of related transduction signaling pathways by inhibiting phosphorylation of JNK,ERK,p38,and NF-κB,and ultimately suppresses the induction of c-Fos and ***,these results demonstrate that Gm-SGP inhibits bone resorption by suppressing osteoclastogenesis-related MAPK and NF-κB pathways,thereby improving osteoporosis.

关键词： Sialoglycoprotein osteoporosis MAPKs NF-κB bone resorption

Expression of hippocampal adrenergic receptor mRNA in a rat model of depression

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Neural Regeneration Research 2011年第16期6卷 1248-1253页

作者： Jianbin Zhang Lingling wang Xinjun wang jingfeng Jiang Xiaoren Xiang Tianjun wang Laboratory of Acupuncture and Medicine Nanjing University of Chinese Medicine Nanjing 210029 Jiangsu Province China

Adrenergic receptor dysfunction is suggested as a potential cause of hippocampal vulnerability to stress-related pathology. We examined mRNA expression of adrenergic receptor （AR） subtypes α1-AR, α1-AR, and β1-AR in hippocampal subregions （CA1, CA3, dentate gyrus） using in situ hybridization in a depression model induced by chronic unpredictable mild stress and social isolation, α1-AR mRNA expression was significantly increased in the CA3 and dentate gyrus, β1-AR mRNA was significantly increased in the CA1, and α1-AR mRNA remained unchanged in all regions of depression rats compared with controls. Thus, different AR subtypes exhibit a differing pattern of mRNA expression in various hippocampal subregions following depression.

关键词： noradrenaline adrenergic receptor depression hippocampus CA1 CA3 dentate gyrus

Enhanced Damping Capacities of Mg–Ce Alloy by the Special Microstructure with Parallel Second Phase

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Journal of Materials Science & Technology 2017年第9期33卷 941-946页

作者： Zhongshan Wu jingfeng wang Haibo wang She Ma Song Huang Shun Li Fusheng Pan National Engineering Research Center for Magnesium Alloys College of Materials Science and EngineeringChongqing University The State Key Laboratory of Mechanical Transmission Chongqing University Institute of Applied Electronics China Academy of Engineering Physics

Microstructure evolution and damping capacities of Mg–Ce binary alloys with three different Ce contents（0.5, 1, or 2 wt%） have been systematically investigated in this work. Numerous fine parallel second phases in Mg–2Ce alloy are obtained, as well as a large number of dislocations around them, but few dislocations appear around the reticular second phase in the Mg–1Ce alloy. Among the three alloys, two internal friction peaks（P;and P;） are detected at about 78 and 167?C in both the Mg–0.5Ce and Mg–1Ce *** addition, the alloy with special parallel second phase structure exhibits excellent damping capacity in both strain amplitude and temperature-dependent regions. These results may be ascribed to the stress concentration and the formation of abundant parallel and uniform dislocation configurations in the ?-Mg matrix without the influence of crystal orientation. The obtained results may provide a novel idea to prepare high-damping magnesium alloys by tailoring their microstructure.

关键词： Mg–Ce alloy Parallel second phase Dislocation configuration Damping capacity