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Three-dimensional choroidal vascularity index and choroidal thickness in fellow eyes of acute and chronic primary angle-closure using swept-source optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 42-52页

作者： Hai-Li Huang Guan-Hong wang liang-liang Niu Xing-huai Sun Department of Ophthalmology&Visual Science Eye&ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200032China NHC Key Laboratory of Myopia Chinese Academy of Medical Sciencesand Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)Shanghai 200031China

AIM:To compare the three-dimensional choroidal vascularity index(CVI)and choroidal thickness between fellow eyes of acute primary angle-closure(F-APAC)and chronic primary angle-closure glaucoma(F-CPACG)and the eyes of normal ***:This study included 37 patients with unilateral APAC,37 with asymmetric CPACG without prior treatment,and 36 healthy *** swept-source optical coherence tomography(SS-OCT),the macular and peripapillary choroidal thickness and three-dimensional CVI were measured and compared globally and ***’s correlation analysis and multivariate regression models were used to evaluate choroidal thickness or CVI with related ***:The mean subfoveal CVIs were 0.35±0.10,0.33±0.09,and 0.29±0.04,and the mean subfoveal choroidal thickness were 315.62±52.92,306.22±59.29,and 262.69±45.55μm in the F-APAC,F-CPACG,and normal groups,*** macular sectors showed significantly higher CVIs and choroidal thickness in the F-APAC and F-CPACG eyes than in the normal eyes(P<0.05),while there were no significant differences between the F-APAC and F-CPACG *** the peripapillary region,the mean overall CVIs were 0.21±0.08,0.20±0.08,and 0.19±0.05,and the mean overall choroidal thickness were 180.45±54.18,174.82±50.67,and 176.18±37.94μm in the F-APAC,F-CPACG,and normal groups,*** were no significant differences between any of the two groups in all peripapillary *** age,shorter axial length,and the F-APAC or F-CPACG diagnosis were significantly associated with higher subfoveal CVI and thicker subfoveal choroidal thickness(P<0.05).CONCLUSION:The fellow eyes of unilateral APAC or asymmetric CPACG have higher macular CVI and choroidal thickness than those of the normal *** CVI nor choroidal thickness can distinguish between eyes predisposed to APAC or CPACG.A thicker choroid with a higher vascular volume may play a role in the pathogenesis of primary angle-closure glaucoma.

关键词： choroidal thickness choroidal vascularity index swept-source optical coherence tomography acute primary angle-closure chronic primary angle-closure glaucoma

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钢纤维高性能轻骨料混凝土多轴强度和变形特性研究

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工程力学 2019年第8期36卷 122-132页

作者：王怀亮广西大学土木建筑工程学院工程防灾与结构安全教育部重点实验室大连理工大学海岸与近海工程国家重点实验室

为了研究钢纤维掺量和三轴应力比对高性能轻骨料混凝土破坏准则和本构关系的影响规律,进行了钢纤维全轻混凝土和钢纤维次轻混凝土多轴强度和变形特性的试验研究,考虑到试验机加载能力和新拌高性能轻骨料混凝土的工作性能,选取的钢纤维... 详细信息

为了研究钢纤维掺量和三轴应力比对高性能轻骨料混凝土破坏准则和本构关系的影响规律,进行了钢纤维全轻混凝土和钢纤维次轻混凝土多轴强度和变形特性的试验研究,考虑到试验机加载能力和新拌高性能轻骨料混凝土的工作性能,选取的钢纤维体积掺量为0、0.5%、1.0%和1.5%,试验加载路径有单轴拉、压,双轴等压和真三轴压。结果发现在单轴应力和低应力比条件下,钢纤维能够明显地发挥增强阻裂作用,随着钢纤维掺量的增加,中间主应力对极限抗压强度和峰值应变的影响越来越大,且钢纤维体积掺量对两种轻骨料混凝土应力-应变曲线下降段有一定的影响;在高应力比条件下,钢纤维体积掺量对峰值强度、峰值应变和应力-应变曲线下降段无明显影响,但对高应力比下轻骨料混凝土应力-应变曲线上特有的应力平台区域有较大的影响。考虑钢纤维含量特征参数的影响,对普通骨料混凝土的Kotsovos破坏准则进行了相应的修正,得出了适合钢纤维增强轻骨料混凝土的破坏准则表达式。

关键词：钢纤维高性能轻骨料混凝土应力比极限强度变形特性

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Effects of tetrandrine on smooth muscle contraction induced by mediators in pulmonary hypertension

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Acta Pharmacologica Sinica 2002年第12期 61-67页

作者： wang huai-liang, ZHANG Xin-Hua, CHANG Tian-HuiDepartment of Clinical Pharmacology, China Medical University, Shenyang 110001, China

AIM: In attempt to characterize tetrandrine on pulmonary hypertension, biological activities induced by a range of mediators implicated in the pathogenesis of pulmonary hypertension were investigated. METHODS: Pulmonary artery rings and tracheal segments were contracted with couples of bioactive substances in which a series experi-ments including effects of tetrandrine on calcium agonist, endothelin, thromboxane A2, angiotensin II, neuropeptide Y, histamine, 5-methyl furmethide were performed, the influences of tetrandrine in the concentration of 1 to 30 μmol/L were investigated. RESULTS: Tetrandrine inhibited calcium agonist BayK8644, endothelin-1 and throm-boxane A2 mimetic U46619, angiotensin II- and neuropeptide Y-induced contractile responses with depression of the maximal contraction of pulmonary artery rings in a varying extent. Tetrandrine inhibited leukotriene E4-induced concentration-response curve in a competitive antagonist manner with a pKB of (5.29 ±0.11) without any influence leukotrien

关键词： tetrandrine endothelin-1 thromboxane A2 leukotriene C4 leukotriene D4 leukotriene E4 histamine neuropeptide Y angiotensin II pulmonary artery

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Seismicity changes and numerical simulation of coseismic deformation following the 2022 M_(s)6.8 Luding earthquake in Sichuan,China

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Science China Earth Sciences 2024年第8期67卷 2507-2521页

作者： Qiu MENG Zitao wang huai ZHANG Key Laboratory of Computational Geodynamics of Chinese Academy of Sciences College of Earth and Planetary SciencesUniversity of Chinese Academy of SciencesBeijing 100049China Institute of Earthquake Forecasting China Earthquake AdministrationBeijing 100036China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China Beijing Yanshan Earth Critical Zone National Research Station Beijing 101408China

The Xianshuihe fault is a major tectonic boundary between the Sichuan-Yunnan rhombic and Bayanhar blocks in Southwest *** an average left-lateral strike-slip movement of 10–15 mm/yr,it is a fast-moving strike-slip continental *** September 5,2022,the Ms6.8 Luding earthquake occurred along the Moxi segment of the Xianshuihe fault,reaching a maximum intensity of IX and resulting in a significant number of casualties and severe property *** earthquake broke the long-standing seismic quiescence of the Xianshuihe fault,which lasted for more than 40 years,and was followed by a significant number of *** outstanding question is how the behavior of the Xianshuihe fault and major earthquakes changed following this *** this study,we examined the changes in regional seismicity following the Luding earthquake and identified the potential for future strong earthquakes along the Xianshuihe *** used a finite element numerical method to simulate the environment of the seismogenic fault and its adjacent *** addition,we used the coseismic slip model of the Luding earthquake with the split-node method to calculate how the stress and strain fields in the surrounding area were affected by the2022 *** stress changes were resolved in the main faults,and the seismicity of adjacent faults was analyzed in conjunction with the observed seismic *** results indicate that regional tectonic movement primarily occurred to the southeast along the Moxi *** stress field is approximately north-south in tension and east-west in *** in the stress field in the epicentral region of the Luding earthquake exceeded 1 *** maximum displacement of the coseismic deformation field was concentrated between Moxi town and Tuanjie village,and the Coulomb stress of the fault zone in this region experienced the largest ***,the b-value of the Gutenberg-Richter magnitude-frequency relationship at the epicenter a

关键词： Luding earthquake Seismicity Coulomb failure stress change Finite element numerical simulation

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A nonlocal dispersal and time delayed HIV infection model with general incidences

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 448-457页

作者： WU Peng ZHANG Yu-huai wang Ling School of Sciences Hangzhou Dianzi UniversityHangzhou 310018China School of Humanities and Management Zhejiang Chinese Medical UniversityHangzhou 311402China Public Foundational Courses Department Nanjing Vocational University of Industry TechnologyNanjing 210023China

Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be *** this paper,we establish an HIV infection model with nonlocal dispersal and infection ***,applying the theory of Fourier transformation and von Foerster rule,we transform the model to an integrodifferential equation with nonlocal time delay and *** well-posedness,positivity,and boundedness of the solution for the model are studied.

关键词： HIV model nonlocal dispersal time delay general incidences

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A three-dimensional co-continuous network structure polymer electrolyte with efficient ion transport channels enabling ultralong-life all solid-state lithium metal batteries

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Journal of Energy Chemistry 2024年第7期94卷 635-645页

作者： Meng wang Hu Zhang Yewen Li Ruiping Liu huai Yang School of Chemical&Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering&School of Materials Science and Engineering Peking UniversityBeijing 100871China

Solid polymer electrolytes(SPEs)have emerged as one of the most promising candidates for the construction of solid-state lithium batteries due to their excellent flexibility,scalability,and interface compatibility with ***,a novel all-solid polymer electrolyte(PPLCE)was fabricated by the copolymer network of liquid crystalline monomers and poly(ethylene glycol)dimethacrylate(PEGDMA)acts as a structural frame,combined with poly(ethylene glycol)diglycidyl ether short chain interspersed serving as mobile ion transport *** preparaed PPLCEs exhibit excellent mechanical property and out-standing electrochemical performances,which is attributed to their unique three-dimensional cocontinuous structure,characterized by a cross-linked semi-interpenetrating network and an ionic liquid phase,resulting in a distinctive nanostructure with short-range order and long-range ***,the addition of PEGDMA is proved to be critical to the comprehensive performance of the PPLCEs,which effectively modulates the microscopic morphology of polymer networks and improves the mechanical properties as well as cycling stability of the solid *** used in a lithiumion symmetrical battery configuration,the 6 wt%-PPLCE exhibites super stability,sustaining operation for over 2000 h at 30 C,with minimal and consistent overpotential of 50 *** resulting Li|PPLCE|LFP solid-state battery demonstrates high discharge specific capacities of 160.9 and 120.1 mA h g^(-1)at current densities of 0.2 and 1 C,*** after more than 300 cycles at a current density of 0.2 C,it retaines an impressive 73.5%***,it displayes stable cycling for over 180 cycles at a high current density of *** super cycle stability may promote the application for ultralong-life all solid-state lithium metal batteries.

关键词： Solid-state electrolyte Lithium-metal batteries Liquid crystalline polymer Copolymer 3D co-continuous structure Long cycle stability

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Mechanical properties and thermal deformation behavior of low-cost titanium matrix composites prepared by a structure-optimized Y_(2)O_(3) crucible

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Journal of Iron and Steel Research International 2024年第3期31卷 738-751页

作者： Qian Dang Gang Huang Ye wang Chi Zhang Guo-huai Liu Zhao-dong wang The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150004HeilongjiangChina School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870LiaoningChina

A porous yttrium oxide crucible with both thermal shock resistance and erosion resistance was developed by structural *** structure-optimized yttrium oxide crucible was proved to be suitable for melting highly reactive titanium ***-cost(TiB+Y2O_(3))-reinforced titanium matrix composites were prepared by vacuum induction melting using the prepared *** thermal deformation behavior and microstructure evolution of(TiB+Y2O_(3))-reinforced tita-nium matrix composites were investigated at deformation temperatures of 900-1100℃with strain rates of 0.001-1 *** results showed that the prepared yttrium oxide crucible had both thermal shock and erosion resistance,the low-cost titanium matrix composites could be prepared by the developed yttrium oxide crucibles which were homogeneous in composition and highly sensitive to strain rate and deformation temperature,and the peak and theological stresses decreased with increasing deformation temperature or decreasing strain *** addition,the average thermal deformation activation energy of the composites was calculated to be 574.6 kJ/mol by establishing the Arrhenius constitutive equation in consideration of the strain variables,and the fitting goodness between the predicted stress value and the measured value was 97.624%.The calculated analysis of the hot processing map showed that the best stable thermal deformation zone was located in the deformation temperature range of 1000-1100℃and strain rate range of 0.001-0.01 s^(-1),where the peak dissipation coefficient wasη=71%.In this zone,the deformation of the reinforcement and matrix was harmonious,the reinforcement was less likely to fracture,dynamic recrystallization occurred more fully and the alloy exhibited near steady rheological characteristics.

关键词： Yttrium oxide crucible Titanium matrix composite Thermal deformation behavior Constitutive equation Hot processing map Microstructure evolution

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The hard X-ray nanoprobe beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 79-88页

作者： Yan He Hui Jiang Dong-Xu liang Zhi-Sen Jiang huai-Na Yu Hua wang Cheng-Wen Mao Jia-Nan Xie Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The hard X-ray nanoprobe beamline BL13U is a phase-Ⅱ beamline project at the Shanghai Synchrotron Radiation *** beamline aims to enable comprehensive experiments at high spatial resolutions ranging from 50 to 10 nm. The X-ray energy range of the beamline, 5–25 keV, can detect most elements in the periodic table. Two operating modes were designed to accommodate the experimental requirements of high-energy resolution or high photon flux, respectively. X-ray nanofluorescence, nanodiffraction, and coherent diffraction imaging are developed as the main experimental techniques for BL13U. This paper describes the beamline optics, end station configurations, experimental methods under development, and preliminary test results. This comprehensive overview aims to provide a clear understanding of the beamline capabilities and potential applications.

关键词： Shanghai synchrotron radiation facility Hard X-ray nanoprobe X-ray nanofocusing

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Cavitation research with computational fluid dynamics:From Euler-Euler to Euler-Lagrange approach

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Journal of Hydrodynamics 2024年第1期36卷 1-23页

作者： Bin Ji Zi-yang wang huai-yu Cheng Rickard E.Bensow State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan430072China Department of Mechanics and Maritime Sciences Chalmers University of TechnologyGothenburgSweden

Unsteady cavitating flow often contains vapor structures with a wide range of different length scales,from micro-bubbles to large cavities,which issues a big challenge to precisely investigate its evolution mechanism by computational fluid dynamics(CFD)*** present work reviews the development of simulation methods for cavitation,especially the emerging Euler-Lagrange ***,the progress of the numerical investigation of hot and vital issues is discussed,including cavitation inception,cloud cavitation inner structure and its formation mechanism,cavitation erosion,and cavitation *** is indicated that the Euler-Lagrange method can determine cavitation inception point *** cloud cavitation,the Euler-Lagrange method can reveal the source of microbubbles and their distribution law inside the shedding *** method also has advantages and great potential in assessing cloud cavitation-induced erosion and *** the ever-growing demands of cavitation simulation accuracy in basic research and engineering applications,how to improve the Euler-Lagrange method’s stability and applicability is still an open *** further promote the application of this advanced CFD simulation technology in cavitation research,some key issues are to be solved and feasible suggestions are put forward for further work.

关键词： numerical simulation Euler-Euler method Euler-Lagrange method bubble dynamicsgy,Gothenburg,Sweden

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Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

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Chinese Journal of Integrative Medicine 2024年第9期30卷 842-851页

作者： GAO Kai-xin YANG Yi-hong liang Qi MEI Li-yan liang You-bang wang Mao-jie CHEN Xiu-min HUANG Qing-chun WEN Ze-huai HUANG Run-yue Section of Rheumatology and Immunology Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou510405China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou510405China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou510120China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510120China The Key Unit of Methodology of Clinical Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

Rheumatoid arthritis(RA)is a worldwide public health *** to delay or prevent the onset of RA have attracted much attention in recent years,and researchers are now exploring various prevention *** present,there is still no unified consensus for RA prevention,but targeting therapeutic windows and implementing interventions for at-risk individuals are extremely *** to the limited number of clinical trials on pharmacologic interventions,further studies are needed to explore and establish optimal intervention regimens and effective measures to prevent progression to *** this review,we introduce the RA disease process and risk factors,and present research on the use of both Western and Chinese medicine from clinical perspectives regarding RA ***,we describe several complete and ongoing clinical studies on the use of Chinese herbal formulae for the prevention of RA.

关键词： rheumatoid arthritis prevention Chinese medicine review

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