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Understanding celiac disease monitoring patterns and outcomes after diagnosis:A multinational,retrospective chart review study

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World Journal of Gastroenterology 2021年第20期27卷 2603-2614页

作者： Knut ea Lundin Ciaran P Kelly David S Sanders Kristina Chen Sheena Kayaniyil Sisi wang Rajvi J Wani Caitlin Barrett Shakira Yoosuf Ellen S Pettersen Robert Sambrook Daniel A Leffler K.G.Jebsen Coeliac Disease Research Centre University of OsloOslo 0450Norway Department of Gastroenterology Oslo University Hospital RikshospitaletOslo 0372Norway Celiac Center Beth Israel Deaconess Medical Center Celiac Research Program Harvard Medical SchoolBostonMA 02115United States Royal Hallamshire Hospital University of SheffieldSheffield S102TNUnited Kingdom Takeda Pharmaceuticals International Co. CambridgeMA 02139United States Real World Evidence Strategy and Analytics ICON plc.TorontoON L7N 3G2Canada Real World Evidence Strategy and Analytics ICON plc.VancouverBC V6B 1P1Canada

BACKGROUND Long-term outcomes and monitoring patterns in real-world practice are largely unknown among patients with celiac *** To understand patterns of follow-up and management of patients with celiac disease,and to characterize symptoms and villous atrophy after *** A retrospective chart review study was performed using medical chart data of patients diagnosed with celiac *** gastroenterology referral centers,with substantial expertise in celiac disease,participated in the United Kingdom,United States,and *** and clinical data were collected from medical *** analyses were conducted on patients with biopsyconfirmed celiac disease,diagnosed between 2008 and 2012,with at least one follow-up visit before December 31,*** demographic and clinical characteristics,biopsy/serology tests and results,symptoms,and comorbidities were captured at diagnosis and for each clinic visit occurring within the study period(i.e.,before the study end date of December 31,2017).RESULTS A total of 300 patients were included in this study[72%female;mean age at diagnosis:38.9 years,standard deviation(SD)17.2].Patients were followed-up for a mean of 29.9 mo(SD 22.1)and there were,on average,three follow-up visits per patient during the study *** two-thirds(68.4%)of patients were recorded as having ongoing gastrointestinal symptoms and 11.0%had ongoing symptoms and enteropathy during *** 80%of patients were referred to a dietician at least once during the follow-up ***(50.0%)of the patients underwent at least one follow-up duodenal biopsy and 36.6%had continued villous *** of monitoring varied between *** were conducted more frequently in Norway and patients in the United States had a longer follow-up *** This real-world study demonstrates variable follow-up of patients with celiac disease despite most patients continuing to have abnormal histology

关键词： Celiac disease Outcomes research Endoscopy Real-world General practice Villous atrophy

Electroacupuncture Alleviates Motor Symptoms and Up-Regulates Vesicular Glutamatergic Transporter 1 Expression in the Subthalamic Nucleus in a Unilateral 6-Hydroxydopamine-Lesioned Hemi-Parkinsonian Rat Model

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Neuroscience Bulletin 2018年第3期34卷 476-484页

作者： Yanyan wang Yong wang Junhua Liu Xiaomin wang Department of Neurobiology Capital Medical UniversityBeijing 100069 China Department of Physiology Capital Medical UniversityBeijing 100069 China Key Laboratory for Neurodegenerative Disorders The Ministry of Education of China Beijing 100069 China Beijing Institute for Brain Disorders Beijing 100069 China

Previous studies have shown that electroacupuncture（ea） promotes recovery of motor function in Parkinson＇s disease（PD）. However the mechanisms are not completely understood. Clinically, the subthalamic nucleus（STN） is a critical target for deep brain stimulation treatment of PD, and vesicular glutamate transporter 1（VGlu T1） plays an important role in the modulation of glutamate in the STN derived from the cortex. In this study,a 6-hydroxydopamine（6-OHDA）-lesioned rat model of PD was treated with 100 Hz ea for 4 weeks. Immunohistochemical analysis of tyrosine hydroxylase（TH） showed that ea treatment had no effect on TH expression in the ipsilateral striatum or substantia nigra pars compacta,though it alleviated several of the parkinsonian motor symptoms. Compared with the hemi-parkinsonian rats without ea treatment, the 100 Hz ea treatment significantly decreased apomorphine-induced rotation and increased the latency in the Rotarod test. Notably, the ea treatment reversed the 6-OHDA-induced down-regulation of VGlu T1 in the STN. The results demonstrated that ea alleviated motor symptoms and up-regulated VGlu T1 in the ipsilateral STN of hemi-parkinsonian rats, suggesting that up-regulation of VGlu T1 in the STN may be related to the effects of ea on parkinsonian motor symptoms via restoration of function in the cortico-STN pathway.

关键词： Parkinson's disease Electroacupuncture Motor behavior Vesicular glutamate transporter 1

Removal of Vand Fe from spent denitrification catalyst by using oxalic acid:Study of dissolution kinetics and toxicity

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Green Energy & Environment 2021年第5期6卷 660-669页

作者： Wenfen Wu Chenye wang Xingrui wang Huiquan Li CAS Key Laboratory of Green Process and Engineering National Engineering Laboratory for Hydrometallurgical Cleaner Production TechnologyInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China College of Chemical and Engineering University of Chinese Academy of SciencesBeijing100049China

The selective dissolution of V and Fe from spent denitrification catalyst(SDC)with oxalic acid was investigated to minimise their environmental *** dissolution kinetics of different elements from SDC by using 0.1–1.5 mol L^(-1) oxalic acid concentration was studied at 60℃–90℃.V and Fe were preferentially released(65%and 81%)compared with Al,Ti and W within 5 min due to the redox reactions of oxalic *** dissolved fractions of Fe,V,Al,Wand Ti increased with the increase of oxalic acid concentration and reaction *** dissolution kinetic experiments were analysed and controlled diffusion with neaction model(R^(2)>0.92).The Arrhenius parameters of the ea values of Ti,W,V,Fe and Al from SDC with oxalic acid were 30,26,20,19 and 11 kJ mol^(-1),*** obtained Avrami equation of V and Fe was successfully used to predict their leaching behaviour in oxalic *** characteristic leaching procedure revealed that the toxicity risk of Vand Fe metals from SDC after leaching with oxalic acid decreased to below 5 mg kg^(-1) ***,the leaching residua by oxalic acid indicated its safety for the environment.

关键词： Spent denitrification catalyst Oxalic acid Dissolution kinetic Avrami model

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日光温室热环境模拟模型的构建

农业工程学报 2009年第1期25卷 164-170页

作者：孟力力杨其长 Gerard.ea.Bot 王柟中国农业科学院农业环境与可持续发展研究所北京100081 农业部农业环境与气候变化重点实验室北京100081 荷兰瓦赫宁根大学荷兰6700AA

该文建立了日光温室热环境模拟模型,定量描述了日光温室内的太阳辐射、对流换热、辐射换热、热传导、自然通风和水分相变带来的潜热对日光温室热环境的影响,根据质能平衡和传热学理论,得到一组关于覆盖物、室内空气、温室分层后墙、分... 详细信息

该文建立了日光温室热环境模拟模型,定量描述了日光温室内的太阳辐射、对流换热、辐射换热、热传导、自然通风和水分相变带来的潜热对日光温室热环境的影响,根据质能平衡和传热学理论,得到一组关于覆盖物、室内空气、温室分层后墙、分层地面土壤、分层后坡和作物热平衡的微分方程组。利用MATLAB的强大计算能力与VB的良好用户界面建立模拟计算软件,可求得温室各组成部分的温度。通过试验验证,该模型能够比较准确预测日光温室环境温度。

关键词：日光温室模拟模型热环境

Mobility-Aware Caching Strategy in an SDN-Based Cooperative Caching Network

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China Communications 2023年第9期20卷 196-214页

作者： Qi Li Xiaoxiang wang Dongyu wang Information and Communication Engineering Beijing University of TechnologyBeijing 100124China Beijing University of Posts and Telecommunications Beijing 100876China

The upsurge of mobile multimedia traf-fic puts a heavy burden on the cellular network,and wireless caching has emerged as a powerful tech-nique to overcome the backhaul bottleneck and al-leviate the network ***,most previ-ous works ignored user mobility,thus not reaping the caching gain from user mobility and having lim-ited practical *** this paper,a mobility-aware caching strategy for the software-defined net-work(SDN)-based network is ***,since typical mobile user(MU)has multiple opportunities to connect with the nearby MUs and Small-base stations(SBSs),the contact times between MUs as well as be-tween MU and SBSs are derived as the Poisson distri-bution and Gamma ***,we propose a two-tier cooperative caching strategy,where SBSs cache the rateless Fountain code encoded video blocks probabilistically and nonrepeatedly while MUs just store the whole encoded video received last *** corresponding four-stage transmission process is ana-lyzed,where the key intermediate step is the deriva-tion of the service and the failing probabilities of each transmission ***,we derive the success-ful offloading rate and average data offloading ra-tio(ADOR)as performance metrics.A system op-timization problem based on ADOR is formulated,and two solutions are proposed,namely,derivativebased solution(DB-Solution)and long-tail distribution approximation(LTD-Approximation).Simulation results demonstrate that the effectiveness of LTDApproximation is similar to the DB-Solution,and the proposed caching strategy can achieve quasi-optimal performance compared with other contrast schemes.

关键词： wireless caching mobility SDN

Hot deformation behavior of ea4T steel

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Acta Metallurgica Sinica(English Letters) 2012年第5期25卷 374-382页

作者： Gang XU Lina wang Shiqi LI Le wang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083 China School of Materials Science and Engineering University of Science and Technology Beijing Beijing100083 China

The compressive deformation behavior of ea4T steel was investigated at tempera- tures ranging from 950 to 1150℃ and strain rates from 0.1 to 20 s-1 on Gleeble-1500 thermo-simulation machine. The work hardening rate versus stress curves were used to determine the characteristic points of flow curves. The application of constitutive equations to determine the hot working constants of this material was discussed. Fur- thermore, the effect of Zener-Hollomon parameter （Z） on the characteristic points of flow curves was studied using the power law relation. The deformation activation energy of this steel was determined as 309.5 kJ/mol. Some behaviors were compared to other steels.

关键词： ea4T steel Constitutive equations Activation energy Workhardening rate

Variation in glomalin in soil profiles and its association with climatic conditions,shelterbelt characteristics,and soil properties in poplar shelterbelts of Northeast China

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Journal of Forestry Research 2020年第1期31卷 279-290页

作者： Qiong wang Wenjie wang Zhaoliang Zhong Huimei wang Yujie Fu Northeast Forestry University Harbin 150040People’s Republic of China Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Glomalin-related soil protein(GRSP)sequesters large amounts of carbon and plays important roles in maintaining terrestrial soil ecosystem functions and ecological restoration;however,little is known about GRSP variation in 1-m soil profiles and its association with stand characteristics,soil properties,and climatic conditions,hindering GRSP-related degraded soil improvement and GRSP *** this study,we sampled soils from 1-m profiles from poplar(Populus spp.)shelterbelts in Northeast *** contents were 1.8–2.0 times higher in the upper 40 cm soil layers than at 40–100 ***-related soil organic carbon(SOC)sequestration in deeper soil layers was*1.2 times higher than in surface *** amounts of GRSP-related nutrients were similar throughout the soil profile.A redundancy analysis showed that in both surface and deeper layers,soil properties(pH,electrical conductivity,water,SOC,and soil nutrients)explained the majority of the GRSP variation(59.5–84.2%);the second-most-important factor in GRSP regulation was climatic conditions(temperature,precipitation,and altitude),while specific shelterbelt characteristics had negligible effects(eatures via soil properties,as manifested by structural equation model *** findings demonstrate that GRSP is important for carbon storage in deep soils,regardless of shelterbelt *** glomalin assessments should consider these vertical patterns and possible regulating mechanisms that are related to soil properties and climatic changes.

关键词： Soil depth Glomalin-related soil protein(GRSP) Soil organic carbon storage Climate change Soil improvement

A systematic study of light dependency of persistentphotoconductivity in a-InGaZnO thin-film transistors

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Chinese Physics B 2020年第11期29卷 508-515页

作者： Yalan wang Mingxiang wang Dongli Zhang Huaisheng wang School of Electronic and Information Engineering Soochow UniversitySuzhou 215006China

Persistent photoconductivity(PPC)effect and its light-intensity dependence of both enhancement and depletion(E-/D-)mode amorphous InGaZnO(a-IGZO)thin-film transistors(TFTs)are systematically *** of oxygen vacancy(V O)defects of E-mode TFTs is relatively small,in which formation of the photo-induced metastable defects is thermally activated,and the activation energy(E a)decreases continuously with increasing *** of V O defects of D-mode TFTs is much larger,in which the formation of photo-induced metastable defects is found to be spontaneous instead of thermally ***,for the first time it is found that a threshold dose of light-exposure is required to form fully developed photo-induced metastable *** low light-exposure below the threshold,only a low PPC barrier is formed and the PPC recovery is *** increasing the light-exposure to the threshold,the lattice relaxation of metal cations adjacent to the doubly ionized oxygen vacancies(V O^2+)is fully developed,and the PPC barrier increases to∼0.25 eV,which remains basically unchanged under higher *** on the density of V O defects in the channel and the condition of light illumination,a unified model of formation of photo-induced metastable defects in a-IGZO TFTs is proposed to explain the experimental observations.

关键词： amorphous indium-gallium-zinc oxide thin-film transistors persistent photoconductivity lightintensity

Spatial Coded Modulation:Coding over Antennas

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China Communications 2024年第11期21卷 104-122页

作者： Luo Junshan wang Fanggang wang Shilian School of Electronic Science National University of Defense TechnologyChangsha 410073China State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong UniversityBeijing 100044China

In spatial modulation systems,the reliability of the active antenna detection is of vital importance since the modulated symbols tend to be correctly demodulated when the active antennas are accurately *** this paper,we propose a spatial coded modulation(SCM)scheme,which improves the accuracy of the active antenna detection by coding over the transmit ***,the antenna activation pattern in the SCM corresponds to a codeword in a properly designed codebook with a larger minimum Hamming distance than the conventional spatial *** the minimum Hamming distance increases,the reliability of the active antenna detection is directly enhanced,which yields a better system *** addition to the reliability,the proposed SCM scheme also achieves a higher capacity with the identical antenna configuration compared to the conventional *** optimal maximum likelihood detector is first ***,a low-complexity suboptimal detector is proposed to reduce the computational *** derivations of the channel capacity and the bit error rate are presented in various channel *** derivation on performance bounding is also provided to reveal the insight of the benefit of increasing the minimum Hamming *** results validate the analysis and demonstrate that the proposed SCM outperforms the conventional spatial modulation techniques in both channel capacity and system reliability.

关键词： antenna correlation channel capacity Hamming distance reliability spatial modulation