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Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism

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Neural Regeneration Research 2024年第3期19卷 650-656页

作者： Jie Li Wen Jiang Yuefang Cai Zhenqiu Ning Yingying Zhou chengyi wang Sookja Ki Chung Yan Huang Jingbo Sun Minzhen Deng Lihua Zhou Xiao Cheng Guangzhou University of Traditional Chinese Medicine GuangzhouGuangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Research on Emergency in TCM GuangzhouGuangdong ProvinceChina Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anatomy Sun Yat-Sen School of MedicineSun Yat-Sen UniversityShenzhenGuangdong ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao Special Administration RegionChina

Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.

关键词： astrocytic endothelin-1 dentate gyrus differentially expressed proteins hippocampus ischemic stroke learning and memory deficits lipid metabolism neural stem cells neurogenesis proliferation

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THE APPROACH TO THE PRACTICAL TEACHING MODE ON THE BASIS OF THE FTULLY-OPEN NEWORK ENGINEERING LABORATORY

THE APPROACH TO THE PRACTICAL TEACHING MODE ON THE BASIS OF ...

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2007中国宁波国际计算机科学与技术学术大会

作者： wang chengyi Dept.of Computer and Electronics Science Hubei University of Economics

ISBN: (纸本)9780972147903

The paper has analyzed the main factors for the students’ comprehensive ability acquisition concerning the cultivation mode of students majoring in network engineering in the newly established university for the undergraduates.It has also introduced a structure of a fully-open network engineering laboratory.Based on its features and main factors of students’ ability acquisition,typical cases study has indicated the way to improve the classroom teaching method and has analyzed the basic practical teaching system of a fully-open network engineering laboratory in terms of how to make the good use of and intensify the new features of the practical teaching system.

关键词： The fully-open network engineering laboratory（FONEL） Classroom teaching method Practical teaching mode

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一类含芴结构改性聚芳酰胺的合成与性能研究

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石油炼制与化工 2024年第2期55卷 207-212页

作者：向艳丽曹世杰任强李坚汪称意常州大学材料科学与工程学院江苏常州213164

采用三步反应制备出含芴结构的二胺单体9,9-双[3,5-二甲氧基-4-(4-氨基-2-甲基苯氧基)苯基]芴,再通过低温溶液缩聚与4种商业化的芳香二酸[对苯二酸、2,2-双(4-羧基苯基)六氟丙烷、4,4-二苯醚二甲酸、4-叔丁基间苯二酸]反应得到系列含芴... 详细信息

采用三步反应制备出含芴结构的二胺单体9,9-双[3,5-二甲氧基-4-(4-氨基-2-甲基苯氧基)苯基]芴,再通过低温溶液缩聚与4种商业化的芳香二酸[对苯二酸、2,2-双(4-羧基苯基)六氟丙烷、4,4-二苯醚二甲酸、4-叔丁基间苯二酸]反应得到系列含芴结构改性聚芳酰胺(PA 3a~3d)。利用核磁共振氢谱、傅里叶变换红外光谱、凝胶渗透色谱等方法对该聚芳酰胺的结构、溶解性、耐热性和力学性能进行表征。结果表明:含芴结构聚芳酰胺在高沸点极性溶剂(N,N-二甲基乙酰胺、N,N-甲基吡咯烷酮、二甲基甲酰胺、吡啶)和低沸点溶剂四氢呋喃中均能较好地溶解;玻璃化转变温度(T_(g))在217~234℃之间,空气和N 2中的10%热失重温度均高于450℃,耐热性优异;其薄膜的拉伸强度在76.6 MPa以上,断裂伸长率在8.7%以上,表现出较好的力学性能;含芴结构聚芳酰胺表现出优异的综合性能。

关键词：聚芳酰胺芴基热稳定性溶解性力学性能

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基于熵权法的电子工业行业绩效指标构建与评价研究

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工信财经科技 2024年第2期 78-89页

作者：王承祎周艺南京审计大学

本文基于熵权法和K-Means聚类算法,构建并评价了2012—2021年沪深两市A股电子工业上市公司的绩效指标体系。研究选取半导体、元件、光学光电子、消费电子四大细分行业,从盈利能力、资产质量、债务风险、经营状况四大维度出发,揭示了不... 详细信息

本文基于熵权法和K-Means聚类算法,构建并评价了2012—2021年沪深两市A股电子工业上市公司的绩效指标体系。研究选取半导体、元件、光学光电子、消费电子四大细分行业,从盈利能力、资产质量、债务风险、经营状况四大维度出发,揭示了不同细分行业内企业绩效的差异,并探讨了企业发展的不足及其可能的影响因素。研究发现,半导体行业盈利能力最强,元件行业资产质量最优,消费电子行业经营增长速度最快。最后,文章提出了针对电子工业行业发展的政策建议,强调创新驱动、金融支持与产业升级的重要性。

关键词：电子工业行业绩效评价指标体系熵权法聚类分析

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Defective/Doped Graphene-Based Materials as Cathodes for Metal-Air Batteries

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Energy & Environmental Materials 2022年第4期5卷 1103-1116页

作者： Qinming Zhang chengyi wang Zhaojun Xie Zhen Zhou School of Materials Science and Engineering Institute of New Energy Material ChemistryNankai UniversityTianjin 300350China Engineering Research Center of Advanced Functional Material Manufacturing of Ministry of Education School of Chemical EngineeringZhengzhou UniversityZhengzhou 450001China

Graphene,as a proof-of-concept two-dimensional material,has proven to have excellent physical and chemical properties.Its derivatives,such as defective or doped graphene,are also applied as catalytic materials for metal-air batteries(MABs).MABs have been recognized as possible candidates for new-generation energy storage systems due to their ultra-high theoretical energy density.So far,graphene and its derivatives with optimized structures have been widely explored to improve the electrochemical performance in MABs.Generally speaking,perfect graphene crystalline is inert for many catalytic processes,while defects and heteroatoms can endow graphene with high activity for many electrocatalytic reactions.Under this circumstance,recent progress is summarized for defective/doped graphene as air cathodes in aqueous or organic MABs,which are actually different electrochemical systems with distinct requirements for air cathodes.Also,the relationship is clarified between graphene defects/doping and electrocatalytic mechanisms that can be the guidance for catalyst design.Future directions are also prospected for the development of graphene-based MAB cathodes.

关键词： defective/doped graphene electrocatalysts metal-air batteries OER ORR

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20CrMnTiH齿轮钢在BOF-LF-RH-CC流程中的夹杂物演变

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中国冶金 2024年第1期34卷 36-43,60页

作者：苑一波杨利彬赵进宣汪成义钢铁研究总院有限公司冶金工艺所北京100081

某厂生产的20CrMnTiH齿轮钢在冶炼过程中产生大量的CaS类夹杂物,影响了铸坯质量。为研究20CrMnTiH齿轮钢氧化物夹杂的演变规律,提出合理的钙处理工艺,以减少CaS类夹杂物的析出,对某厂BOF-LF-RH-CC流程生产的20CrMnTiH齿轮钢进行精炼全... 详细信息

某厂生产的20CrMnTiH齿轮钢在冶炼过程中产生大量的CaS类夹杂物,影响了铸坯质量。为研究20CrMnTiH齿轮钢氧化物夹杂的演变规律,提出合理的钙处理工艺,以减少CaS类夹杂物的析出,对某厂BOF-LF-RH-CC流程生产的20CrMnTiH齿轮钢进行精炼全过程的取样,并通过电镜、夹杂物自动扫描分析系统结合热力学计算,研究了氧化物夹杂的演变规律及机理。研究结果表明,在LF精炼后期的喂硫线工序,钢液存在二次氧化现象;精炼过程氧化物夹杂的演变规律为,纯Al_(2)O_(3)夹杂物→镁铝尖晶石和部分Al_(2)O_(3)-MgO-CaO复合夹杂物→钙处理后转变为Al_(2)O_(3)-MgO-CaO和Al_(2)O_(3)-CaO复合夹杂物→喂硫线后产生大量Al_(2)O_(3)-MgO-CaO-CaS和Al_(2)O_(3)-CaO-CaS类复合夹杂物。通过试验及热力学计算发现,现阶段的钙处理过程中钙含量略低于12CaO·7Al_(2)O_(3)(C12A7)的析出条件。为将Al_(2)O_(3)夹杂物尽可能变性成C12A7夹杂物,达到理想的钙处理效果,同时节约成本,钙处理过程所需钙质量分数应控制在0.00226%~0.00300%。喂硫线之后的钢液成分很容易满足CaS夹杂物的析出条件,生产过程应延长喂钙线与喂硫线之间的时间,在钙含量降低后再喂入硫线,后序可将喂硫线工序移至RH精炼中,以减少CaS夹杂物的生成。本研究为工业生产过程中提高含硫齿轮钢的洁净度提供了理论基础。

关键词： 20CrMnTiH齿轮钢非金属氧化物夹杂精炼全过程钙处理演变

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One-pot enantioselective construction of 3,4-dihydro-2H-1,4-oxazines over Ru/Au relay catalysis and its mechanistic serendipity

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Organic Chemistry Frontiers 2022年第1期9卷 102-108页

作者： Dongfeng Yang chengyi wang Yu wang Guohua Liu Tanyu Cheng Rui Liu Joint Laboratory of International Cooperation of Resource Chemistry of Ministry of Education Key Laboratory of Resource Chemistry of Ministry of Educationand Shanghai Key Laboratory of Rare Earth Functional MaterialsShanghai Normal UniversityShanghaiChina

The preparation of enantiomerically pure 1,4-oxazines remains a continuous challenge in synthetic chemistry because of their potential application in the total synthesis of morpholines.Herein,a one-pot asymmetric transfer hydrogenation/cyclization enantio-relay process catalyzed by Ru and Au bimetallic catalysts was developed.This enantio-relay process firstly allows the asymmetric transfer hydrogenation of alkynones to form chiral alkynols in the presence of(S,S)-mesityleneRuClTsDPEN(TsDPEN=N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine)and then the chiral alkynols could be converted into 3,4-dihydro-2H-1,4-oxazines in moderate to good yields with excellent enantioselectivity retention accompanied by AuCl(PPh_(3))/AgNTf_(2) and HCOOH.A series of sulfonamide-tethered alkynones were well tolerated in this process.Mechanistic studies indicated that the alkynols formed in the first step were initially transformed into a methylenemorpholine intermediate when AuCl(PPh_(3))/AgNTf_(2) and HCOOH were added,which can be further isomerized into chiral 3,4-dihydro-2H-1,4-oxazines with the addition of a second HCOOH.This protocol offers not only a practical method to access 3,4-dihydro-2H-1,4-oxazines from alkynones in an enantioselective version,but also enriches the arsenal of gold chemistry from a mechanistic point of view.

关键词： process chiral hydrogenation

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滋肾宁心胶囊联合替米沙坦治疗围绝经期高血压临床疗效观察

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药物流行病学杂志 2024年第1期33卷 52-59页

作者：王蓓杜明民王成益付达张晶王强石家庄市中医院心病科石家庄050000 河北省中医院脾胃一科石家庄050000 唐山市丰南区中医医院内一科河北唐山063000

目的观察滋肾宁心胶囊联合替米沙坦治疗围绝经期高血压的疗效,及对患者血压、生化指标、中医症状积分的影响。方法 300例围绝经期高血压患者随机分为对照组和观察组各150例。对照组给予替米沙坦治疗,观察组在对照组治疗基础上加用滋肾... 详细信息

目的观察滋肾宁心胶囊联合替米沙坦治疗围绝经期高血压的疗效,及对患者血压、生化指标、中医症状积分的影响。方法 300例围绝经期高血压患者随机分为对照组和观察组各150例。对照组给予替米沙坦治疗,观察组在对照组治疗基础上加用滋肾宁心胶囊,两组疗程均为8周。观察比较两组患者治疗前后24 h动态血压及其变异系数(24 h平均收缩压及其变异系数、24 h平均舒张压及其变异系数)、性激素水平(血清雌二醇、促卵泡生成素、睾酮、孕酮)、血脂(三酰甘油、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)、肾素和超敏C反应蛋白水平,以及中医症状积分变化,评价两组疗效。结果治疗后,两组患者的24 h平均收缩压及其变异系数、24 h平均舒张压及其变异系数,性激素、血脂、肾素和超敏C反应蛋白水平,以及中医症状积分等指标均较前明显改善(P 0.05)。结论滋肾宁心胶囊联合替米沙坦治疗围绝经期高血压临床疗效显著,可有效降低血压、缓解症状,改善性激素、血脂、肾素和超敏C反应蛋白水平。

关键词：滋肾宁心胶囊替米沙坦围绝经期高血压

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民办高校药学实验教学中安全教育探索

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科教导刊 2024年第3期 26-28页

作者：宋桂先王成义宋京松贵州医科大学神奇民族医药学院贵州贵阳550004 贵州博成科技有限公司贵州贵阳550000

药学是一门实践性很强的学科,实验教学贯穿于药学本科教学的全过程,而安全教育则是实验教学开展和顺利进行的首要条件。实施实验安全教育、创建平安校园、杜绝实验安全事故的发生,是高校稳定发展的基本保障。本文根据我院实际情况,介绍... 详细信息

药学是一门实践性很强的学科,实验教学贯穿于药学本科教学的全过程,而安全教育则是实验教学开展和顺利进行的首要条件。实施实验安全教育、创建平安校园、杜绝实验安全事故的发生,是高校稳定发展的基本保障。本文根据我院实际情况,介绍了药学实验教学中安全教育的探索与实践。我们着重从实验室安全意识的培养、实验安全技能的掌握、实验安全制度的建立等三方面着手,探索出适合我院发展的药学实验安全教育体系。为培养高素质创新型药学人才提供安全保障,为进一步完善高校药学实验室安全教育提供参考。

关键词：药学实验教学安全教育探索

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A ratiometric fluorescent probe for hypoxanthine detection in aquatic products based on the enzyme mimics and fluorescence of cobalt-doped carbon nitride

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Food Science and Human Wellness 2024年第2期13卷 879-884页

作者： Xin wang chengyi Hong Zhengzhong Lin Zhiyong Huang College of Ocean Food and Biological Engineering Jimei UniversityXiamen 361021China

A ratiometric fluorescent probe for hypoxanthine(Hx)detection was established based on the mimic enzyme and fluorescence characteristics of cobalt-doped graphite-phase carbon nitride(Co doped g-C_(3)N_(4)).In addition to emitting strong fluorescence,the peroxidase activity of Co doped g-C_(3)N_(4)can catalyze the reaction of O-phenylenediamine and H_(2)O_(2)to produce diallyl phthalate which can emit yellow fluorescence at 570 nm.Through the decomposition of Hx by xanthine oxidase,Hx can be indirectly detected by the generating hydrogen peroxide based on the measurement of fluorescent ratio I(F_(570)/F_(370)).The linear range was 1.7-272.2 mg/kg(R^(2)=0.997),and the detection limit was 1.52 mg/kg(3σ/K,n=9).The established method was applied to Hx detection in bass,grass carp,and shrimp,and the data were verified by HPLC.The result shows that the established probe is sensitive,accurate,and reliable,and can be used for Hx detection in aquatic products.

关键词： Co doped g-C_(3)N_(4) Ratiometric fluorescent probe Hypoxanthine Freshness Aquatic products

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