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Endovascular treatment for acute ischaemic stroke due to medium vessel occlusion:data from ANGEL-ACT registry

Stroke & Vascular Neurology 2023年第1期8卷 51-58页

作者： Dapeng Sun Raynald Xiaochuan Huo Baixue Jia Xu Tong anxin wang Gaoting Ma Ning Ma Feng Gao Dapeng Mo Zhongrong Miao 无 Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Beijing Fengtai You anmen HospitalBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalBeijingChina on behalf of the ANGEL-ACT Study Group

Objectives To investigate the safety and efficacy of endovascular treatment(EVT)for acute medium vessel occlusion(MeVO)in the anterior circulation and to explore the independent predictors of the 90-day good outcome for such *** Data from ANGEL-ACT Registry were analysed in our *** outcomes,such as the modified Rankin Scale(mRS)at 90 days,successful recanalisation rate and symptomatic intracranial haemorrhage(SICH)rate,were compared between MeVO and acute large vessel occlusions(LVO).Then,the independent predictors of the good outcome at 90 days in MeVO patients were determined by the logistic regression *** We included 1032 subjects in the analysis,of which,147 were MeVO and 885 were *** at 90 days distribution(3(0-4)vs 3(0-5),common odds ratio(OR)=1.00,95%confidence interval(CI)0.73 to 1.38,p=0.994),SICH rate(4.8%vs 8.9%;OR=0.59,95%CI 0.26 to 1.34,p=0.205)and successful recanalisation rate(89.8%vs 89.7%;OR=1.0095%CI 0.51 to 1.93,p=0.992)were similar between the MeVO and LVO groups after adjusting for the *** identified that baseline neutrophil-to lymphocyte ratio≤4.1(OR=2.13,95%CI 1.14 to 3.99,p=0.019),baseline National Institutes of Health Stroke Scale≤14(OR=1.96,95%CI 1.02 to 3.80,p=0.045)and mechanical thrombectomy passes≤1(OR=2.16,95%CI 1.14 to 4.11,p=0.021)were independent predictors of the 90-day good outcome in MeVO patients undergoing *** Patients with MeVO achieved similar 90-day mRS,SICH rate and successful recanalisation rate after EVT compared with patients with *** independent predictors of 90-day good outcome in MeVO patients undergoing EVT were determined,which should be highly considered in MeVO stroke management.

关键词： acute occlusion treatment

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Analytical validation of GMEX rapid point- of care CYP2C19 genotyping system for the CHANCE-2 trial

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Stroke & Vascular Neurology 2021年第2期6卷 274-279页

作者： Xia Meng anxin wang Guojun Zhang Siying Niu Wei Li Sifei Han Fang Fang Xingquan Zhao Kehui Dong Zening Jin Huaguang Zheng Kelin Chen Hao Li Chengyuan Yang Yongjun wang China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Clinical Diagnosis Laboratory Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Biomedical and Health Informatics The Children's Hospital of PhiladelphiaPhiladelphiaPennsylvaniaUSA Department of Cardiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose Rapid genotyping is useful for guiding early antiplatelet therapy in patients with high-risk nondisabling ischaemic cerebrovascular events(HR-NICE).Conventional genetic testing methods used in CYP2C19 genotype-guided antiplatelet therapy for patients with HR-NICE did not satisfy the needs of the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events(CHANCE)-2 ***,we developed the rapid-genotyping GMEX(point-of care)system to meet the needs of the CHANCE-2 *** Healthy individuals and patients with history of cardiovascular diseases(n=408)were enrolled from six centres of the CHANCE-2 *** compared the laboratory-based genomic test results with Sanger sequencing test results for accuracy ***,we demonstrated the accuracy,timeliness and clinical operability of the GMEX system compared with laboratory-based technology(YZY Kit)to verify whether the GMEX system satisfies the needs of the CHANCE-2 *** Genotypes reported by the GMEX system showed 100%agreement with those determined by using the YZY Kit and Sanger sequencing for all three CYP2C19 alleles(*2,*3 and*17)*** average result’s turnaround times for the GMEX and YZY Kit methods were 85.0(IQR:85.0-86.0)and 1630.0(IQR:354.0-7594.0)min(p<0.001),*** Our data suggest that the GMEX system is a reliable and feasible point-of care system for rapid CYP2C19 genotyping for the CHANCE-2 trial or related clinical and research applications.

关键词： CYP2C19 Acute system

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The efficacy and safety of nimodipine in acute ischemic stroke patients with mild cognitive impairment: a double-blind, randomized,placebo-controlled trial

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Science Bulletin 2019年第2期64卷 101-107页

作者： Huaguang Zheng Yilong wang anxin wang Hao Li David wang Xingquan Zhao Penglian wang Haipeng Shen Lijun Zuo Yuesong Pan Zixiao Li Xia Meng Xianwei wang Weixiong Shi Yi Ju Liping Liu Kehui Dong Chunxue wang Rubo Sui Rong Xue Xiaoping Pan Xiaoyua Niu Benyan Luo Yi Sui Huali wang Tao Feng Yongjun wang Beijing Tiantan Hospital Capital Medical University China National Clinical Research Center for Neurological Diseases OSF Saint Francis Medical Center Peoria Faculty of Business and Economics University of Hong Kong The First Hospital Liao Ning Medical College The General Hospital Tianjin Medical University Guangzhou First People’s Hospital School of Medicine South China University of Technology The First Hospital of Shanxi Medical University The First Hospital Zhejiang Medical University Shenyang First People’s Hospital Shenyang Medical College Dementia Care & Research Center Peking University Institute of Mental Health

Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remains to be established. In this multicenter, double-blind trial, we randomly assigned 654 eligible patients to nimodipine 30 mg three times a day or placebo. The primary outcome was any cognitive decline defined by the changes on the Mini-Mental State Examination(DMMSE à3) or vascular AD assessment scale cognitive subscale(DADAS-cog ! 4) at 6 months. Secondary outcomes included any distribution shift of DADAS-cog, DMMSE or cognitive improvement defined by DADAS-cog à2, or DMMSE ! 0. The primary outcome in the nimodipine group and placebo group were similar for DMMSE à3(4.18% and 7.22%, respectively, P = 0.15) and DADAS-cog ! 4(8.36% and 8.93% respectively,P = 0.88). The distribution shift of DADAS-cog and DMMSE differed significantly between the two groups(P = 0.03 and P = 0.05 respectively). Cognitive improvement occurred in 55.4% in the nimodipine group and 43.6% in the placebo group measured by DADAS-cog à2(Odds Ratio, 1.54; 95% confidence interval[CI] 1.10–2.14, P < 0.01) or 84.0% and 74.6% respectively by DMMSE ! 0(Odds Ratio, 1.79; 95% CI 1.18–2.70, P < 0.01). Nimodipine was associated with better cognitive function in the memory domain. The adverse events rate was similar in two groups. This study is registered with ***,NCT01220622. Nimodipine did not show benefit to prevent cognitive decline in AIS patients with VaMCI, but improved cognition moderately, especially measured in the memory domain.

关键词： Nimodipine Acute ischemic stroke Mild cognitive impairment Cognitive decline Prevention

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Ambulatory blood pressure profile and stroke recurrence

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Stroke & Vascular Neurology 2021年第3期6卷 352-358,I0006-I0008页

作者： Jie Xu Fei Jiang anxin wang Hui Zhi Yuan Gao Junping Tian Jinglin Mo Zimo Chen An-Ding Xu Benyan Luo Bo Hu Yuqing Zhang Xingquan Zhao Yilong wang Hao Li Haipeng Shen Yongjun wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases(NCRCND) Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Statistics and Actuarial Sciences University of Hong KongHong KongChina Biostatistics and Clinical Research Methodology Unit Faculty of MedicineUniversity of Hong KongHong KongChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Cardiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology and Stroke Center The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdongChina Department of Neurology and Brain Medical Centre The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Division of Hypertension National Center for Cardiovascular Disease ChinaFuwai HospitalBeijingChina Faculty of Business and Economics University of Hong KongHong KongChina

Objectives To establish a new ambulatory blood pressure(ABP)parameter(24-hour ABP profile)and evaluated its performance on stroke outcome in ischaemic stroke(IS)or transient ischaemic attack(TIA)*** The prospective cohort consisted of 1996 IS/TIA patients enrolled for ABP monitoring and a 3-month follow-up for stroke recurrence as *** groups of systolic blood pressure(SBP)were identified via an advanced functional clustering method,and the associations of the profile groups and conventional ABP parameters with stroke recurrence were examined in a Cox proportional hazards *** Three discrete profile groups(n=604,781 and 611 in profiles 1,2 and 3,respectively)in 24-hour ambulatory SBP were *** 1 resembled most to the normal diurnal blood pressure pattern;profile 2 also dropped at night,but climbed earlier and with higher morning surge;while profile 3 had sustained higher nocturnal SBP without significant nocturnal SBP *** incidence of stroke recurrence was 2.9%,3.9%and 5.5%in profiles 1,2 and 3,*** adjustment for covariates,profile 3 was significantly associated with higher risk of stroke recurrence with profile 1 as reference(HR 1.76,95%CI:1.00 to 3.09),while no significant difference was observed between profiles 2 and 1(HR 1.22,95%CI:0.66 to 2.25).None of conventional ABP parameters showed significant associations with the *** Ambulatory 24-hour SBP profile is associated with short-term stroke *** of ABP may help improve identification of stroke recurrence by capturing the additive effects of individual ABP parameters.

关键词： sustained Profiles recurrence

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Development of BPM feedthroughs for the High Energy Photon Source

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Radiation Detection Technology and Methods 2022年第4期6卷 460-469页

作者： Yong Li Jun He Yanfeng Sui anxin wang Lin wang Dechong Zhu Ying Zhao Di Yin Qiang Ye Shujun Wei Taoguang Xu Junhui Yue Jianshe Cao Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China

Purpose Based on the requirements of the High Energy Photon Source(HEPS),the key components for strip-type and button-type beam position monitors(BPMs)and feedthroughs are designed and *** The mechanical structure of the feedthroughs is designed according to the Computer Simulation Technology(CST)simulation *** Small batches of feedthroughs are manufactured,and the structure is optimized based on mechanical,vacuum,electromagnetic,and other characteristic test *** performance improved signiﬁcantly owing to optimization through batch product testing,and quality control-related information from several manufacturers is obtained,which provide a foundation for the development of BPMs for HEPS.

关键词： High Energy Photon Source BPM Feedthroughs Quality control

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Mechanical thrombectomy with combined stent retriever and contact aspiration versus stent retriever alone for acute large vessel occlusion:data from ANGEL-ACT registry

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Stroke & Vascular Neurology 2023年第4期8卷 318-326页

作者： Xiaochuan Huo Dapeng Sun Mingkai Hu Raynald Baixue Jia Xu Tong Gaoting Ma anxin wang Ning Ma Feng Gao Dapeng Mo Zhongrong Miao the ANGEL-ACT Study group Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose An analysis of the ASTER 2 trial revealed similar final recanalisation levels and clinical outcomes in acute large vessel occlusion(LVO)stroke between stent retrieval(SR)alone as a first-line mechanical thrombectomy(MT)technique(SR alone first-line)and concomitant use of contact aspiration(CA)plus SR as a first-line MT technique(SR+CA first-line).The purpose of the present study was to compare the safety and efficacy of SR+CA first-line with those of SR alone first-line for patients with LVO in *** We conducted the present study by using the data from the ANGEL-ACT *** divided the selected patients into SR+CA first-line and SR alone first-line *** performed logistic regression and generalised linear models with adjustments to compare the angiographic and clinical outcomes,including successful/complete recanalisation after the first technique alone and all procedures,first-pass successful/complete recanalisation,number of passes,90-day modified Rankin Scale,procedure duration,rescue treatment and intracranial haemorrhage within 24 *** Of the 1233 enrolled patients,1069(86.7%)received SR alone first-line,and 164(13.3%)received SR+CA ***+CA first-line was associated with more thrombectomy passes(3(2-4)vs 2(1-2);β=1.77,95%CI=1.55 to 1.99,p0.05)between the two *** Patients undergoing SR+CA first-line had more thrombectomy passes and longer procedure duration than patients undergoing SR alone ***,we suggested that SR+CA first-line was not superior to SR alone first-line in final recanalisation level,first-pass recanalisation level and 90-day clinical outcomes in the Chinese population.

关键词： throm alone occlusion

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Dual antiplatelet therapy may increase the risk of non-intracranial haemorrhage in patients with minor strokes: a subgroup analysis of the CHANCE trial

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Stroke & Vascular Neurology 2016年第2期1卷 29-36页

作者： David wang Li Gui Yi Dong Hao Li Shujuan Li Huaguang Zheng anxin wang Xia Meng Li-Ping Liu Yi-Long wang Guangyao wang Jing Jing Zixiao Li Xing-Quan Zhao Yong-Jun wang on behalf of the investigators for the CHANCE trial Illinois Neurological Institute Stroke Network Sisters of the Third Order of St.Francis Healthcare SystemUniversity of Illinois College of MedicinePeoriaIllinoisUSA Southwest Hospital Stroke Center Third Military University of Medical SciencesChongqingChina Department of Neurology Huashan HospitalFudan UniversityShanghaiChina China National Clinical Research Center for Neurological Diseases BeijingChina Chaoyang Hospital Neurology Department Capital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalTiantan Clinical Trial and Research Center for StrokeCapital Medical UniversityBeijingChina Neurological Intensive Care Unit Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalVascular NeurologyCapital Medical UniversityBeijingChina 不详

Aim:The aim of this study was to explore the difference between haemorrhagic events among those patients on either aspirin or aspirin plus clopidogrel who were enrolled in the Clopidogrel in High-Risk Patients with Acute Non-disabling Ischemic Cerebrovascular Events(CHANCE)***:This was an ad hoc analysis of the CHANCE trial;data on all patients with any haemorrhagic event were reviewed and *** proportional hazards regression was used to determine factors association with any ***:In the CHANCE trial,there were a total of 101(2%)haemorrhagic events reported from 50 different *** clopidogrel–aspirin group had 60(2.3%)cases and the aspirin group had 41(1.6%,p=0.09).Moderate or severe haemorrhagic events occurred in 7 patients(0.3%)in the clopidogrel–aspirin group and in 8(0.3%)in the aspirin group(p=0.73).Of 36(0.7%)cases of intracranial haemorrhages,20(0.4%)were in the clopidogrel–aspirin group and 16(0.3%)in the aspirin *** group had 8(0.3%)cases of symptomatic haemorrhagic *** common haemorrhagic events included 24(0.5%)cases of skin bruises,13(0.3%)gastrointestinal haemorrhages,9(0.2%)gum haemorrhages and 8(0.2%)intraocular ***:There was no overall significant difference in haemorrhagic events(p=0.29),especially in the rate of intracranial haemorrhages between the 2 treatment ***,patients enrolled with minor strokes had an increased risk of haemorrhagic events regardless of treatment group,not seen in patients with high-risk transient ischaemic *** elderly,of male gender and with a history of aspirin or proton pump inhibitor usage were associated with increased risk of *** with higher body mass index had lower risk of haemorrhagic events.

关键词： patients intracranial analysis

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Thermal Hall effect and the Wiedemann–Franz law in Chern insulator

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中国物理B:英文版 2023年第10期32卷 579-584页

作者：王安新秦涛 School of Physics and Optoelectronics Engineering Anhui UniversityHefei 230601China

Thermal Hall effect, where a transverse temperature difference is generated by implementing a longitudinal temperature gradient and an external magnetic field in the perpendicular direction to systems, is a useful tool to reveal transport properties of quantum materials. A systematic study of the thermal Hall effect in a Chern insulator is still lacking. Here,using the Landauer–Büttiker formula, we investigated the thermal Hall transport of the Harper–Hofstadter model with flux φ= 1/2 and its generalizations. We demonstrated that the Wiedemann–Franz law, which states that the thermal Hall conductivity is linearly proportional to the quantum Hall conductivity in the low temperature limit, is still valid in this Chern insulator, and that the thermal Hall conductivity can be used to characterize the topological properties of quantum materials.

关键词： thermal Hall effect quantum Hall effect Chern insulator Landauer–Büttike formula

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A Comparative Study on Conceptual Metaphors of “SHEN” and “QIAN”

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International Journal of Technology Management 2016年第6期 14-16页

作者： Xu Xiaojia Yang Yuanyuan Peng Lujiao wang anxin Wuhan Donghu College Wuhan 430212

This thesis is a comparative discussion of conceptual metaphors of “SHEN” and “QIAN”, carried out within the framework of conceptual metaphor from the perspective of cognitive linguistics. Both qualitative and quantitative analyses are adopted in this research. The metaphorical extensions of Chinese “SHEN”/“QIAN” and DEEP/SHALLOW concepts in English have been compared quantitatively. The statistic results show in each projected domain, which further indicates the similarities of peoples’ modes of thinking in different cultures.

关键词： SHEN / DEEP QIAN / SHALLOW conceptual metaphor cultural universality cultural differences

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Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics

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Stroke & Vascular Neurology 2021年第2期6卷 291-297页

作者： Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong wang Xia Meng anxin wang Xinying Huang Zhimin wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina Department of Neurology The First people's Hospital of TaizhouTaizhouChina Department of Neurology Wuhan First HospitalWuhanChina Department of Neurology The First People's Hospital of Xi'anXi'anChina Department of Neurology The Second People’s Hospital of JinzhongJinzhongChina Department of Neurology WuYuan County People’s HospitalBayannurChina Department of Neurology Qiqihar City Rongjian Stroke Prevention and Treatment InstituteQiqiharChina Department of Neurology Peking University Shenzhen HospitalShenzhenChina Department of Neurology Luoyang Central HospitalLuoyangChina Department of Neurology Qinghai Provincial People's HospitalXiningChina Department of Neurology Tianjin Huanhu HospitalTianjinChina Department of Neurology Pingdingshan First People's HospitalPingdingshanChina Department of Neurology Changzhi People's HospitalChangzhiChina Department of Neurology Zhejiang Provincial People's HospitalHangzhouChina Department of Neurology Xinjiang Uygur Autonomous Region People's HospitalUrumqiChina

Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively *** here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were *** was extracted from white blood cells of *** are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 *** average depth is intended to be greater than 30×for each ***,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and *** each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same *** copy number variations and structural variations are also called for each *** of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public *** The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were *** of the baseline clinical characteristics of the 10914 and the excluded patients were *** The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke.

关键词： patients transient characteristics

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