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Dynamic response of mountain tunnel,bridge,and embankment along the Sichuan-Tibet transportation corridor to active fault based on model tests

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Journal of Mountain Science 2024年第1期21卷 182-199页

作者： HUANG Beixiu QIAO sijia CHEN Xulei LI Lihui QI Shengwen Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong *** extensive studies have individually explored the effect of active faults and strong earthquakes on different engineering structures,their combined effect remains *** research employed multiple physical model tests to investigate the dynamic response of various engineering structures,including tunnels,bridges,and embankments,under the simultaneous influence of cumulative earthquakes and stick-slip misalignment of an active *** prototype selected for this study was the Kanding No.2 tunnel,which crosses the Yunongxi fault zone within the Sichuan-Tibet transportation *** results demonstrated that the tunnel,bridge,and embankment exhibited amplification in response to the input seismic wave,with the amplification effect gradually decreasing as the input peak ground acceleration(PGA)*** PGAs of different engineering structures were weakened by the fault rupture ***,the misalignment of the active fault may decrease the overall stiffness of the engineering structure,leading to more severe damage,with a small contribution from seismic ***,the seismic vibration effect might be enlarged with the height of the engineering structure,and the tunnel is supposed to have a smaller PGA and lower dynamic earth pressure compared to bridges and embankments in strong earthquake zones crossing active *** findings contribute valuable insights for evaluating the dynamic response of various engineering structures crossing an active fault and provide an experimental reference for secure engineering design in the challenging conditions of the Sichuan-Tibet transportation corridor.

关键词： Dynamic response Engineering structure Sichuan-Tibet transportation corridor Active fault Earthquake Model test

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Puerariae Radix protects against ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation

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Food Science and Human Wellness 2024年第4期13卷 2266-2276页

作者： Yu Ga Yuanyuan Wei Qingyu Zhao Yimeng Fan Yannan Zhang Zhifang Zhang sijia Hao Lixia wang Zhifen wang Jinlong Han Shuang Wu Zhihui Hao Innovation Centre of Chinese Veterinary Medicine College of Veterinary MedicineChina Agricultural UniversityBeijing 100086China National Center of Technology Innovation for Medicinal Function of Food National Food and Strategic Reserves AdministrationBeijing 100193China Inner Mongolia Medical University Hohhot 010059China China Agricultural University Yantai Institute Yantai 264670China Shandong Academy of Agricultural Sciences Jinan 250100China

Ulcerative colitis(UC)is a common inflammatory disease of the gastrointestinal *** Chinese medicine(TCM)has long been used in Asia as a treatment for UC and Puerariae Radix(PR)is a reliable anti-diarrheal *** aims of this study were to investigate the protective effect of PR using the dextran sulfate sodium salt(DSS)-induced UC model in mice and identify molecular mechanisms of PR *** chemical constituents of PR via ultra-performance liquid chromatography/tandem mass spectrometry and identified potential PR and UC targets using a network pharmacology(NP)approach were obtained to guide mouse experiments.A total of 180 peaks were identified from PR including 48 flavonoids,46 organic acids,14 amino acids,8 phenols,8 carbohydrates,7 alkaloids,6 coumarins and 43 other *** results showed that caspase-1 was the most dysregulated of the core genes associated with UC.A PR dose of 0.136 mg/g administered to DSS treated mice reversed weight loss and decreased colon lengths found in UC *** also alleviated intestinal mucosal shedding,inflammatory cell infiltration and mucin *** treatment suppressed upregulation of NOD-like receptor protein 3(NLRP3),cysteinyl aspartate-specific proteases-1(caspase-1),apoptosis-associated speck-like(ASC)and gasdermin D(GSDMD)at both the protein and m RNA expression *** addition of a small molecule dual-specificity phosphatase inhibitor NSC 95397 inhibited the positive effects of *** results indicated that PR exerts a protective effect on DSS-induced colitis by inhibiting NLRP3 inflammasome activation in mice.

关键词： Puerariae Radix Ulcerative colitis Molecular mechanisms Pyroptosis NOD-like receptor protein 3 inflammasome

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Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait

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Journal of Genetics and Genomics 2016年第12期43卷 702-704页

作者： Manfei Zhang Sijie Wu Juan Zhang Yajun Yang Jingze Tan Haijuan Guan Yu Liu Kun Tang Jean Krutmann Shuhua Xu Li Jin Yaqun Guan Hui Li sijia wang Ministry of Education Key Laboratory of Contemporary Anthropology Collaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan UniversityShanghai 200438China Chinese Academy of Sciences Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Fudan-Taizhou Institute of Health Sciences Taizhou 225300China IUF-Leibniz Research Institute for Environmental Medicine Dusseldorf 40225Germany School of Life Science and Technology Shanghai Tech UniversityShanghai 200031China Department of Biochemistry and Molecular Biology Preclinical Medicine CollegeXinjiang Medical UniversityUrumqi 830011China

Petaloid toenail, or accessory nail of the fifth toe, is a physical trait characterized by the presence of an additional tiny toenail on the small toe. Since it can occasionally cause disfigurement and tenderness while wearing tight shoes or walking, standard surgical matricectomy is often carried out to repair the petaloid toenail （Chi and wang, 2004）. Chinese legends recorded petaloid toenails as a trait unique to Han Chinese （Gao, 2010）, but population- based studies are largely absent.

关键词： meta mode than

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Real-time Model Identification for Beam Stabilization in Laser Pointing Systems

Real-time Model Identification for Beam Stabilization in Las...

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第三十九届中国控制会议

作者： Xiaochu wang Changhao Sun Lei wang sijia wang Qingrui Zhou Qian Xuesen Laboratory of Space Technology China Academy of Space Technology

This paper investigates the problem of model identification in laser pointing systems, which is one of the most important issues to guarantee beam stabilization. This problem is essentially challenging in view of that misalignments always exist among individual optical components and result in uncertain modeling errors. Focusing on this problem, the structure of propagation equation of the laser beam is derived, and a filtering estimation algorithm is then proposed to identify the undetermined parameters. With this approach, a high-precision model can be estimated in real time for control laws. Finally, an illustrative example is simulated to substantiate the efficacy of the proposed approach.

关键词： Parameter identification Beam stabilization Attitude transformation Kalman filter

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Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction

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Journal of Genetics and Genomics 2018年第8期45卷 419-432页

作者： Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan sijia wang Shuhua Xu Kun Tang Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology (PICB) Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences CAS Shanghai 200031 China State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai 200433 China Fudan-Taizhou Institute of Health Sciences Taizhou 225300 China Department of Neurology The First People's Hospital of Chenzhou Hunan 423000 China Collaborative Innovation Center of Genetics and Development Shanghai 200438 China Department of Biochemistry and Molecular Biology Preclinical Medicine College Xinjiang Medical University Urumqi 830011 China Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming 650223 China School of Life Science and Technology ShanghaiTech University Shanghai 201210 China

It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics, Genome-wide associ- ation studies （GWAS） were conducted on a discovery panel of Uyghurs, Six significant loci were iden- tified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios.

关键词： Genome-wide association study Dense 3D facial image Ancestry-divergent phenotypes Face prediction Forensic scenario

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Recent advances in living cell nucleic acid probes based on nanomaterials for early cancer diagnosis

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 22-40页

作者： Xuyao Liu Qi Shi Peng Qi Ziming wang Tongyue Zhang sijia Zhang Jiayan Wu Zhaopei Guo Jie Chen Qiang Zhang Department of Thyroid Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The early diagnosis of cancer is vital for effective treatment and improved prognosis. Tumor biomarkers, which can be used for the early diagnosis, treatment, and prognostic evaluation of cancer, have emerged as a topic of intense research interest in recent years. Nucleic acid, as a type of tumor biomarker, contains vital genetic information, which is of great significance for the occurrence and development of cancer. Currently, living cell nucleic acid probes, which enable the in situ imaging and dynamic monitoring of nucleic acids, have become a rapidly developing field. This review focuses on living cell nucleic acid probes that can be used for the early diagnosis of tumors. We describe the fundamental design of the probe in terms of three units and focus on the roles of different nanomaterials in probe delivery.

关键词： Nucleic acid Nanomaterials In situ detection Living cell Early cancer diagnosis

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Measurement of left ventricular fluid dynamic parameters in healthy Chinese adults based on echocardiographic vector flow mapping

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Chinese Medical Journal 2023年第5期136卷 616-618页

作者： sijia wang Lixue Yin Anguo Luo Zhengyang wang Shan wang Geqi Ding Xiuzhang Lyu Yunyou Duan Qing Zhou Mei Zhang Di Xu Jiawei Tian Hong Tang Guang Zhi Yunchuan Ding Xianhong Shu Mingxing Xie Ying Yang Jun Zhang Tiangang Zhu Yuhong Feng Ultrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Cardiology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Ultrasound Diagnostics Tangdu HospitalAir Force Medical UniversityXi’anShaanxi 710032China Department of Ultrasonography Renmin Hospital of Wuhan UniversityWuhanHubei 430060China The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineDepartment of CardiologyQilu Hospital of Shandong UniversityJinanShandong 250012China Department of Ultrasound The First Affiliated Hospital with Nanjing Medical UniversityNanjingJiangsu 210029China Department of Ultrasound The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China Department of Cardiology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Cardiology Chinese PLA General HospitalChinese PLA Medical SchoolBeijing 100080China Department of Ultrasound Yan’an Hospital of Kunming Medical UniversityKunmingYunnan 650051China Division of Echocardiography and the Division of Cardiology Zhongshan Hospital of Fudan UniversityShanghai 200032China Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiovascular Disease Peking University First HospitalBeijing 100034China Xijing Hypertrophic Cardiomyopathy Center Department of UltrasoundXijing HospitalAir Force Medical UniversityXi’anShaanxi 710032China Department of Cardiology Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial InfarctionCenter for Cardiovascular Translational Resear

To the Editor:As we concerdered that there was barely any widely representative,recognized,and standardized echocardiographic vector flow mapping(VFM)method has been established for the observation and measurement of the blood flow in cardiac cavities in clinical practice,and there were no commonly accepted normal reference values for Chinese adults have been obtained till now,hindering the further promotion and application of this technology in clinical *** normal reference values for echocardiographic VFM that can be widely accepted in clinical practice is of great significance for determining the normal or abnormal fluid dynamic status in the left ventricle(LV)chamber.

关键词： flow mapping dynamic

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Remote estimates of suspended particulate matter in global lakes using machine learning models

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International Soil and Water Conservation Research 2024年第1期12卷 200-216页

作者： Zhidan Wen Qiang wang Yue Ma Pierre Andre Jacinthe Ge Liu sijia Li Yingxin Shang Hui Tao Chong Fang Lili Lyu Baohua Zhang Kaishan Song Northeast Institute of Geography and Agroecology CASChangchunJilin130102China Department of Geology Indiana University∼Purdue UniversityIndianapolisIN44602USA University of Chinese Academy of Sciences Beijing100100China College of Geography and Urban Planning Liaocheng UniversityLiaochengChina

Suspended particulate matter(SPM)in lakes exerts strong impact on light propagation,aquatic ecosystem productivity,which co-varies with nutrients,heavy metal and micro-pollutant in *** lakes,SPM exerts strong absorption and backscattering,ultimately affects water leaving signals that can be detected by satellite *** regression models based on specific band or hand ratios have been widely used for SPM estimate in the past with moderate *** are still rooms for model accuracy improvements,and machine learning models may solve the non-linear relationships between spectral variable and SPM in *** assembled more than 16,400 in situ measured SPM in lakes from six continents(excluding the Antarctica continent),of which 9640 samples were matched with Landsat overpasses within±7 *** machine learning algorithms and two simple regression methods(linear and partial least squares models)were used to estimate SPM in lakes and the performance were *** overcome the problem of imbalance datasets in regression,a Synthetic Minority Over-Sampling technique for regression with Gaussian Noise(SMOGN)was adopted in this *** comparison,we found that gradient boosting decision tree(GBDT),random forest(RF),and extreme gradient boosting(XGBoost)models demonstrated good spatiotemporal transferability with SMOGN processed dataset,and has potential to map SPM at different year with good quality of Landsat land surface reflectance *** all the tested modeling approaches,the GBDT model has accurate calibration(n=6428,R^(2)=0.95,MAPE=29.8%)from SPM collected in 2235 lakes across the world,and the validation(n=3214,R^(2)=0.84,MAPE=38.8%)also exhibited stable ***,the good performances were also exhibited by RF model with calibration(R^(2)=0.93)and validation(R^(2)=0.86,MAPE=24.2%)*** applied GBDT and RF models to map SPM of typical lakes,and satisfactory result was *** addition,the GBDT model was evaluated b

关键词： Landsat imagery Remote estimation SPM Transferability

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A novel multi-threshold coupling InAlN/GaN double-channel HEMT for improving transconductance flatness

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Science China(Information Sciences) 2024年第1期67卷 314-315页

作者： Sirui AN Minhan MI Pengfei wang sijia LIU Qing ZHU Meng ZHANG Zhihong CHEN Jielong LIU Siyin GUO Can GONG Xiaohua MA Yue HAO School of Microelectronics Xidian University School of Advanced Materials and Nanotechnology Xidian University Hubei Jiufengshan Laboratory

GaN-based HEMTs have significant advantages, making them a prime choice for high-frequency, high-power switching [1]. However, the inherent poor linearity of GaN HEMT has yet to be solved, which can be reflected by the nonlinearity of the transconductance (Gm) profile [2]. This makes it hard to achieve high data transmission efficiency and less signal distortion in the wireless communication system [3].

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氨水沉淀法由含钛滤液提取二氧化钛

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化工学报 2012年第10期63卷 3345-3349页

作者：张悦王思佳薛向欣东北大学材料与冶金学院辽宁沈阳110819 沈阳化工研究院有限公司农药研究所辽宁沈阳110021

以含钛高炉渣为原料,经硫酸铵熔融法得到含钛滤液,然后以氨水为沉淀剂,控制pH值使钛水解,水解产物经600℃煅烧2h得到二氧化钛。考察了螯合剂的加入量、溶液pH值和反应时间对钛沉淀率的影响,实验结果表明:反应过程中铁与钛发生共沉淀,造... 详细信息

以含钛高炉渣为原料,经硫酸铵熔融法得到含钛滤液,然后以氨水为沉淀剂,控制pH值使钛水解,水解产物经600℃煅烧2h得到二氧化钛。考察了螯合剂的加入量、溶液pH值和反应时间对钛沉淀率的影响,实验结果表明:反应过程中铁与钛发生共沉淀,造成二氧化钛产物中的铁含量过高。EDTA几乎完全抑制了铁的沉淀,明显降低了二氧化钛产物的全铁含量;2-羟基丙烷-1,2,3-三羧酸的加入降低了产物中二氧化硅的含量,提高了产物中二氧化钛的含量。当2-羟基丙烷-1,2,3-三羧酸与硅的摩尔比为1,EDTA与铁的摩尔比为3,pH值为2.0,反应时间为90min时产物中二氧化钛的含量为96.35%。

关键词：含钛高炉渣二氧化钛水解沉淀

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