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Microfluidic thermotaxic selection of highly motile sperm and in vitro fertilization

BIO-DESIGN AND MANUFACTURING 2024年第5期7卷 687-700页

作者： Chen, Sihan Chen, Jiemin Qin, Zihan wang, jibo wang, Yuwen Liu, Rong Zhao, Wen Zhang, Ming Zhang, Yuanzhen Luo, Mengcheng Chen, Pu Wuhan Univ TaiKang Med Sch Sch Basic Med Sci Dept Biomed EngnTissue Engn & Organ Mfg TEOM Lab Wuhan 430071 Peoples R China Wuhan Univ TaiKang Ctr Life & Med Sci Wuhan 430071 Peoples R China Wuhan Univ TaiKang Med Sch Sch Basic Med Sci Hubei Prov Key Lab Dev Originated Dis Wuhan 430071 Peoples R China Wuhan Univ Reprod Med Ctr Zhongnan Hosp Wuhan 430071 Peoples R China

The selection of the most motile and functionally competent sperm is an essential basis for in vitro fertilization (IVF) and normal embryonic development. Widely adopted clinical approaches for sperm sample processing intensely rely on centrifugation and wash steps that may induce mechanical damage and oxidative stress to sperm. Although a few microfluidic sperm sorting devices may avoid these adverse effects by exploiting intrinsic guidance mechanisms of sperm swimming, none of these approaches have been fully validated by clinical-grade assessment criteria. In this study, a microfluidic sperm sorting device that enables the selection of highly motile and functional sperm via their intrinsic thermotaxis is presented. Bioinspired by the temperature microenvironment in the fallopian tube during natural sperm selection, a microfluidic device with controllable temperature gradients along the sperm separation channel was designed and fabricated. This study investigated the optimal temperature conditions for human sperm selection and fully characterized thermotaxis-selected sperm with 45 human sperm samples. Results indicated that a temperature range of 35-36.5 degree celsius along the separation channel significantly improves human sperm motility rate ((85.25 +/- 6.28)% vs. (60.72 +/- 1.37)%; P=0.0484), increases normal sperm morphology rate ((16.42 +/- 1.43)% vs. (12.55 +/- 0.88)%; P<0.0001), and reduces DNA fragmentation ((7.44 +/- 0.79)% vs. (10.36 +/- 0.72)%; P=0.0485) compared to the nonthermotaxis group. Sperm thermotaxis is species-specific, and selected mouse sperm displayed the highest motility in response to a temperature range of 36-37.5 degree celsius along the separation channel. Furthermore, IVF experiments indicated that the selected sperm permitted an increased fertilization rate and improved embryonic development from zygote to blastocyst. This microfluidic thermotaxic selection approach will be translated into clinical practice to improve the IVF succe

关键词： Microfluidic device Thermotaxis Sperm sorting Assisted reproductive technology In vitro fertilization MECHANISM SYSTEM

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Microfluidic thermotaxic selection of highly motile sperm and in vitro fertilization

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Bio-Design and Manufacturing 2024年第05期 687-700页

作者： Sihan Chen Jiemin Chen Zihan Qin jibo wang Yuwen wang Rong Liu Wen Zhao Ming Zhang Yuanzhen Zhang Mengcheng Luo Pu Chen Tissue Engineering and Organ Manufacturing (TEOM) Lab Department of Biomedical Engineering TaiKang Medical School (School of Basic Medical Sciences) Wuhan University Hubei Provincial Key Laboratory of Developmentally Originated Disease TaiKang Medical School (School of Basic Medical Sciences) Wuhan University Reproductive Medicine Center Zhongnan Hospital of Wuhan University TaiKang Center for Life and Medical Sciences Wuhan University

The selection of the most motile and functionally competent sperm is an essential basis for in vitro fertilization(IVF) and normal embryonic development. Widely adopted clinical approaches for sperm sample processing intensely rely on centrifugation and wash steps that may induce mechanical damage and oxidative stress to sperm. Although a few microfluidic sperm sorting devices may avoid these adverse effects by exploiting intrinsic guidance mechanisms of sperm swimming, none of these approaches have been fully validated by clinical-grade assessment criteria. In this study, a microfluidic sperm sorting device that enables the selection of highly motile and functional sperm via their intrinsic thermotaxis is presented. Bioinspired by the temperature microenvironment in the fallopian tube during natural sperm selection, a microfluidic device with controllable temperature gradients along the sperm separation channel was designed and fabricated. This study investigated the optimal temperature conditions for human sperm selection and fully characterized thermotaxis-selected sperm with 45human sperm samples. Results indicated that a temperature range of 35–36.5 °C along the separation channel significantly improves human sperm motility rate((85.25±6.28)% vs.(60.72±1.37)%; P=0.0484), increases normal sperm morphology rate((16.42±1.43)% vs.(12.55±0.88)%; P<0.0001), and reduces DNA fragmentation((7.44±0.79)% vs.(10.36±0.72)%;P=0.0485) compared to the nonthermotaxis group. Sperm thermotaxis is species-specific, and selected mouse sperm displayed the highest motility in response to a temperature range of 36–37.5 °C along the separation channel. Furthermore, IVF experiments indicated that the selected sperm permitted an increased fertilization rate and improved embryonic development from zygote to blastocyst. This microfluidic thermotaxic selection approach will be translated into clinical practice to improve the IVF success rate for patients with oligozoospermia and asthenozoos

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具有位置相关权重的工期分配排序问题研究

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工程数学学报 2024年第2期41卷 377-385页

作者：吕丹阳王吉波沈阳航空航天大学机电工程学院沈阳110136 沈阳航空航天大学理学院沈阳110136

针对具有位置相关权重的工期分配排序问题进行了研究,其目标是在共同工期分配/松弛工期分配两种模式下,找到最优的工件加工序列以极小化工件工期与工件延误的线性加权和,其中权重是与位置相关的权重。通过证明一系列性质得到工期的计算... 详细信息

针对具有位置相关权重的工期分配排序问题进行了研究,其目标是在共同工期分配/松弛工期分配两种模式下,找到最优的工件加工序列以极小化工件工期与工件延误的线性加权和,其中权重是与位置相关的权重。通过证明一系列性质得到工期的计算方法,进而将所要研究的两类工期分配问题转换为与工件加工时间有关的函数。根据每个工件对应的系数来给出具体求解算法从而得到最优的工件序列,以及对应的最优共同工期/最优松弛工期。通过具体的算例验证了此算法可在多项式时间内求解。

关键词：位置相关权重排序共同/松弛工期延误

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多共同工期分配调度问题算法研究

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重庆师范大学学报（自然科学版） 2024年第1期41卷 8-13页

作者：包晗吕丹阳王吉波沈阳航空航天大学理学院沈阳110136

为确定所有工件的多个共同工期以及工件的最优调度序列,最小化提前惩罚、延误惩罚和公共工期分配的加权和,利用位置权重与处理时间的匹配过程来获得最优解。对此问题给出了最优解满足的性质,当分配给共同工期的工件个数为给定常数时该... 详细信息

为确定所有工件的多个共同工期以及工件的最优调度序列,最小化提前惩罚、延误惩罚和公共工期分配的加权和,利用位置权重与处理时间的匹配过程来获得最优解。对此问题给出了最优解满足的性质,当分配给共同工期的工件个数为给定常数时该问题可解。该问题是多项式可解的,并给出了具体求解算法。

关键词：调度提前/延误惩罚多项式时间算法单机多共同工期

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Electronic characteristic,tensile cracking behavior and potential energy surface of TiC(111)/Ti(0001)interface:A first principles study

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中国航空学报:英文版 2023年第9期36卷 451-463页

作者： Silong ZHANG jibo wang Lixiang RAO Qizhen HE Xiaolei XING Yefei ZHOU Qingxiang YANG State Key Lab of Metastable Materials Science&Technology Hebei Key Lab for Optimizing Metal Product Technology and PerformanceCollege of Materials Science&EngineeringYanshan UniversityQinhuangdao 066004China College of Physics and Mechanical&Electrical Engineering Longyan UniversityLongyan 364012China College of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China

The preparation of TiC coating on Ti alloy surface to improve the wear resistance has attracted attention from researchers in aerospace *** service life of TiC coating is related to the interfacial adhesion properties between TiC coating and Ti alloy ***,it is difficult to explain its interfacial adhesion mechanism by experimental *** on the termination of atoms on the TiC surface,two TiC/Ti interface models named as the C-terminated-TiC(111)/Ti(0001) and Ti-terminated-TiC(11)/Ti(0001) interface were constructed by *** interfacial electronic characteristic of C-Ti bond is a mixture of polar covalent and metal bonds,and that of Ti-Ti bond is the metal *** tensile strains of both C-terminated-TiC(111)/Ti(0001) and Ti-terminated-TiC(111)/Ti(0001) interface in the fracture stage are ranged from 12% to 14%.Their maximum tensile stresses are 16.201 GPa and 15.590GPa,*** sliding potential energy surface maximum of C-terminated-TiC(111)/Ti(0001) and Ti-terminated-TiC(111)/Ti(0001) interface are 5.387 J/m^(2) and 0.271 J/m^(2),*** the sliding potential barriers on the minimum energy path are 2.094 J/m2and 0.136 J/m^(2) with an ideal shear strength of 20.32 GPa and 1.61 GPa,*** summary,the interfacial adhesion property of C-terminated-TiC(111)/Ti(0001) interface is better than that of Ti-terminated-TiC(111)/Ti(0001) interface.

关键词： Electronic First-principles Potential energy surface Tensile TiC/Ti interface

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Bionic Hand Motion Control Method Based on Imitation of Human Hand Movements and Reinforcement Learning

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Journal of Bionic Engineering 2024年第2期21卷 764-777页

作者： jibo Bai Baojiang Li Xichao wang Haiyan wang Yuting Guo The School of Electrical Engineering Shanghai DianJi UniversityShanghai201306China

Bionic hands are promising devices for assisting individuals with hand disabilities in rehabilitation *** primarily by bioelectrical signals such as myoelectricity and EEG,these hands can compensate for lost hand ***,developing model-based controllers for bionic hands is challenging and time-consuming due to varying control parameters and unknown application *** address these challenges,we propose a model-free approach using reinforcement learning(RL)for designing bionic hand *** method involves mimicking real human hand motion with the bionic hand and employing a human hand motion decomposition technique to learn complex motions from simpler *** approach significantly reduces the training time *** utilizing real human hand motion data,we design a multidimensional sampling proximal policy optimization(PPO)algorithm that enables efficient motion control of the bionic *** validate the effectiveness of our approach,we compare it against advanced baseline *** results demonstrate the quick learning capabilities and high control success rate of our method.

关键词： Bionic hand Reinforcement learning Motion decomposition Multidimensional sampling PPO algorithm

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基于提问与对话的互动教学对批判性思维培养的探索

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基础医学教育 2024年第6期26卷 528-532页

作者：杨瑞孙虹霞夏嫱廖业王吉博遵义医科大学珠海校区基础医学院病原生物学教研室珠海519041 遵义医科大学珠海校区第二临床学院

以学生为中心的互动教学强调询问、分析、评估、解决问题和批判性思维等技能,这需要学生借助高质量问题进行互动并参与课堂对话。文章重点关注“提问”和“对话”在互动教学中的核心作用,阐述和制定相关的原则和策略,强调互动教学在培... 详细信息

以学生为中心的互动教学强调询问、分析、评估、解决问题和批判性思维等技能,这需要学生借助高质量问题进行互动并参与课堂对话。文章重点关注“提问”和“对话”在互动教学中的核心作用,阐述和制定相关的原则和策略,强调互动教学在培养批判性思维方面的潜力。通过将提问和对话的力量作为一种学习工具,创造一个充满活力和包容性的学习环境,鼓励开放式提问,促进更深层次的思考,激发丰富而有意义的讨论,从简单的掌握知识转变为批判及创新性思维能力的培养,推进高校教育教学改革和高质量发展。

关键词：高等教育互动教学批判性思维对话提问教学改革

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Study on Dynamic Mechanical Behavior of Al-Mg-Si Alloy

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 454-462页

作者：陶小旺 LIU jibo LIU Xianbin CHEN Jianbin wang Yonggang 汪小锋 Key Laboratory of Impact and Safety Engineering Ministry of EducationNingbo UniversityNingbo 315211China Ningbo Zhanci New Material Co. Ltd.Ningbo 315338China

The dynamic mechanical behavior of Al-Mg-Si alloy was investigated under different strain rates by mechanical property and microstructure characterization,constitutive behavior analysis and numerical simulation in the present *** the strain rate increases,the yield strength,ultimate tensile strength and elongation increase first,then remain almost constant,and finally *** alloy always exhibits a typical ductile fracture mode,not depending on the strain ***,as the strain rate increases,the number of dimples gradually *** deformation can refine grains,however,the grain structure is slightly affected by the strain *** optimized Johnson-Cook constitutive equation was used to describe the mechanical behavior and obtained by fitting the true stress-strain *** parameter C was described by a function related to the strain *** fitting true stress-strain curves by the JC model agree very well with the experimental true stress-strain *** true stress-strain curves calculated by the finite element numerical simulation agree well with the experimental true stress-strain curves.

关键词： Al-Mg-Si alloy strain rate mechanical property microstructure Johnson-Cook model finite element simulation

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A highly reliable encoding and decoding communication framework based on semantic information

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Digital Communications and Networks 2024年第3期10卷 509-518页

作者： Yichi Zhang Haitao Zhao Kuo Cao Li Zhou Zhe wang Yueling Liu jibo Wei College of Electronic Science and Technology National University of Defense TechnologyChangsha 410073China

Increasing research has focused on semantic communication,the goal of which is to convey accurately the meaning instead of transmitting symbols from the sender to the *** this paper,we design a novel encoding and decoding semantic communication framework,which adopts the semantic information and the contextual correlations between items to optimize the performance of a communication system over various *** the sender side,the average semantic loss caused by the wrong detection is defined,and a semantic source encoding strategy is developed to minimize the average semantic *** further improve communication reliability,a decoding strategy that utilizes the semantic and the context information to recover messages is proposed in the *** simulation results validate the superior performance of our strategies over state-of-the-art semantic coding and decoding policies on different communication channels.

关键词： Semantic information Semantic encoding method Context-based decoding method

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Journal of Applied Mathematics and Physics 2016年第1期4卷 21-27页

作者： jibo wang Chou-Jung Hsu School of Science Shenyang Aerospace University Shenyang China Department of Industrial Management Nan Kai University of Technology Taiwan

In this paper, we consider scheduling problems with general truncated job-dependent learning effect on unrelated parallel-machine. The objective functions are to minimize total machine load, total completion (waiting) time, total absolute differences in completion (waiting) times respectively. If the number of machines is fixed, these problems can be solved in time respectively, where m is the number of machines and n is the number of jobs.

关键词： Scheduling Unrelated Parallel Machines Truncated Job-Dependent Learning

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