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Three-dimensional stability calculation method for high and large composite slopes formed by mining stope and inner dump in adjacent open pits

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International Journal of Mining Science and Technology 2024年第4期34卷 507-520页

作者： Zuchao Liang Dong wang Guanghe Li Guangyu Sun Mingyu Yu Dong Xia Chunjian Ding College of Mining Engineering Liaoning Technical UniversityFuxin 123000China Inner Mongolia Pingxi Baiyinhua Coal Industry Co. Ltd.Xilingol League 026000China Guoneng Baorixile Energy Co. Ltd.Hulunbuir 021008China

The 2D limit equilibrium method is widely used for slope stability ***,with the advancement of dump engineering,composite slopes often exhibit significant 3D mechanical ***,it is of significant importance to develop an effective 3D stability calculation method for composite slopes to enhance the design and stability control of open-pit slope *** the composite slope formed by the mining stope and inner dump in Baiyinhua No.1 and No.2 open-pit coal mine as a case study,this research investigates the failure mode of composite slopes and establishes spatial shape equations for the sliding *** integrating the shear resistance and sliding force of each row of microstrip columns onto the bottom surface of the strip corresponding to the main sliding surface,a novel 2D equivalent physical and mechanical parameters analysis method for the strips on the main sliding surface of 3D sliding masses is ***,a comprehensive 3D stability calculation method for composite slopes is developed,and the quantitative relationship between the coordinated development distance and its 3D stability coefficients is *** analysis reveals that the failure mode of the composite slope is characterized by cutting-bedding sliding,with the arc serving as the side interface and the weak layer as the bottom interface,while the destabilization mechanism primarily involves shear *** spatial form equation of the sliding mass comprises an ellipsoid and weak plane *** analysis revealed that when the coordinated development distance is 1500 m,the error rate between the 3D stability calculation result and the 2D stability calculation result of the composite slope is less than 8%,thereby verifying the proposed analytical method of equivalent physical and mechanical parameters and the 3D stability calculation method for composite ***,the3D stability coefficient of the composite slope exhibits an exponential co

关键词： Composite slope Destabilization mechanism 3D mechanical effect Three-dimensional stability Coordinated development distance

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Lift system optimization for hover-capable flapping wing micro air vehicle

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Frontiers of Mechanical Engineering 2024年第3期19卷 61-75页

作者： Shengjie XIAO Yongqi SHI Zemin wang Zhe NI Yuhang ZHENG Huichao DENG Xilun DING Department of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China

A key challenge is using bionic mechanisms to enhance aerodynamic performance of hover-capable flapping wing micro air vehicle(FWMAV).This paper presented a new lift system with high lift and aerodynamic efficiency,which use a hummingbird as a bionic *** new lift system is able to effectively utilize the high lift mechanism of hummingbirds,and this study innovatively utilizes elastic energy storage elements and installs them at the wing root to help improve aerodynamic performance.A flapping angle of 154°is achieved through the optimization of the flapping mechanism *** optimized wing shape and parameters are obtained through experimental studies on the ***,the max net lift generated is 17.6%of the flapping wing vehicle’s ***,energy is stored and released periodically during the flapping cycle,by imitating the musculoskeletal system at the wing roots of hummingbirds,thereby improving the energy utilization rate of the FWMAV and reducing power consumption by 4.5%under the same ***,strength verification and modal analyses are conducted on the flapping mechanism,and the weight of the flapping mechanism is reduced through the analysis and testing of different *** results show that the lift system can generate a stable lift of 31.98 g with a wingspan of 175 mm,while the lift system weighs only 10.5 g,providing aerodynamic conditions suitable for high maneuverability flight of FWMAVs.

关键词： lift optimization flapping wing elastic energy hovering flapping mechanism

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Presence of a long nuclear-localization signal sequence in homeodomain transcription factor Nkx 1.2

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Journal of Oceanology and Limnology 2024年第2期42卷 620-626页

作者： Xinyi LI Lihui CHEN Xinyuan wang Chen SUN Guangdong JI Guobin HU Zhenhui LIU College of Marine Life Science and Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdao 266003China Laoshan Laboratory Qingdao 266237China

Homeodomains,a 60-amino acid sequence encoded by 180 nucleotides,are highly conserved DNA-binding motifs that are present in a variety of transcription factors in species ranging from yeast to *** NKX proteins belong to the homeodomain(HD)-containing transcription factor *** play vital roles in the regulation of ***1-2 is one member of the NKX *** present,information about its nuclear localization signal(NLS)sequence is *** studied the NLS sequence of zebrafish Nkx1.2 by introducing sequence changes such as deletion,mutation,and truncation,and identified an NLS motif(QNRRTKWKKQ)that is localized at the C-terminus of the ***,the deletion of two amino acid residues(RR)in this NLS motif prevents Nkx1.2 from entering the nucleus,indicating that the two amino acids are essential for Nkx1.2 nuclear ***,the NLS motif alone is unable to target cytoplasmic protein glutathione S-transferase(GST)to the *** intact homeodomain is necessary for mediating the complete nuclear transport of cytoplasmic *** most nuclear import proteins with short NLS sequences,a long NLS is present in zebrafish *** also demonstrated that the sequences of homeodomain of NKX1.2 are well conserved among different *** study is informative to verify the function of the NKX1.2 protein.

关键词： NKX1.2 NKX protein homeodomain nuclear localization signal(NLS) nuclear transport

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Targeting the Warburg effect:A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

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Acta Pharmaceutica Sinica B 2024年第3期14卷 953-1008页

作者： Minru Liao Dahong Yao Lifeng Wu Chaodan Luo Zhiwen wang Jin Zhang Bo Liu Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China School of Pharmaceutical Sciences Shenzhen Technology UniversityShenzhen 518118China School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China Department of Psychology University of Southern CaliforniaLos AngelesCA 90089USA

Cancer reprogramming is an important facilitator of cancer development and survival,with tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation,even under sufficient oxygen supply *** metabolic alteration,known as the Warburg effect,serves as a significant indicator of malignant tumor *** Warburg effect primarily impacts cancer occurrence by influencing the aerobic glycolysis pathway in cancer *** enzymes involved in this process include glucose transporters(GLUTs),HKs,PFKs,LDHs,and ***,the expression of transcriptional regulatory factors and proteins,such as FOXM1,p53,NF-κB,HIF1a,and c-Myc,can also influence cancer ***,lncRNAs,miRNAs,and circular RNAs play a vital role in directly regulating the Warburg ***,gene mutations,tumor microenvironment remodeling,and immune system interactions are closely associated with the Warburg ***,the development of drugs targeting the Warburg effect has exhibited promising potential in tumor *** comprehensive review presents novel directions and approaches for the early diagnosis and treatment of cancer patients by conducting in-depth research and summarizing the bright prospects of targeting the Warburg effect in cancer.

关键词： Warburg effect Cancer Regulatory factor LncRNAs miRNAs Traditional Chinese medicine Small-molecule drug Drug resistance

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Effects of potassium lactate on sensory attributes,bacterial community succession and biogenic amines formation in Rugao ham

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Food Science and Human Wellness 2024年第1期13卷 198-210页

作者： Renyong Liao Ying wang Qiang Xia Changyu Zhou Fang Geng Daodong Pan Jinxuan Cao State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Key Laboratory of Animal Protein Food Processing Technology of Zhejiang ProvinceNingbo UniversityNingbo 315211China Meat Processing Key Laboratory of Sichuan Province School of Food and Biological EngineeringChengdu UniversityChengdu 610106China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China

To deepen the understanding in the effect of potassium lactate on the sensory quality and safety of Rugao ham,sensory attributes,physicochemical parameters,total volatile basic nitrogen(TVBN),microorganism community and biogenic amines of Rugao ham manufactured with different potassium lactate levels(0%,0.5%,1%,2%)were investigated;the relationship between microbial community and the formation of TVBN and biogenic amines was further *** the increase of potassium lactate from 0%to 2%,the increased sensory scores and the decreased total aerobic bacterial count and TVBN were observed;the abundance of Staphylococcus increased,while the content of Halomonas *** effect size(LEf Se)and correlations analysis showed that Staphylococcus equorum and Lactobacillus fermentum could be the key species to improve sensory scores and decrease biogenic amines and *** pathway analysis further showed that amino acids metabolism and nitrogen metabolism were mainly involved in decreasing TVBN and biogenic amines in the treatment of 2%potassium lactate.

关键词： Rugao ham Potassium lactate Biogenic amines Microbial community Metabolic pathways

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Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1230-1243页

作者： Jun Zhou Jiaqi Liu Bingjing wang Nan Li Juan Liu Yanmei Han Xuetao Cao Institute of Immunology Zhejiang University School of MedicineHangzhou 310058China National Key Laboratory of Immunity and Inflammation Institute of ImmunologyNaval Medical UniversityShanghai 200433China Department of Immunology Center for ImmunotherapyInstitute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100005China Institute of Immunology College of Life SciencesNankai UniversityTianjin 300071China

Memory CD8+T cell generation is crucial for pathogen elimination and effective vaccination against *** cellular and molecular circuitry that underlies the generation of memory CD8+T cells remains *** can modulate inflammatory allergic responses and interact with lymphocytes to regulate their functions in immune *** we report that eosinophils are required for the generation of memory CD8+T cells by inhibiting CD8+T cell ***-deficient mice display significantly impaired memory CD8+T cell response and weakened resistance against Listeria monocytogenes(L.m.)***,eosinophils secrete interleukin-4(IL-4)to inhibit JNK/Caspase-3 dependent apoptosis of CD8+T cells upon *** in ***,active eosinophils are recruited into the spleen and secrete more IL-4 to suppress CD8+T cell apoptosis during early stage of *** in *** transfer of wild-type(WT)eosinophils but not IL-4-deficient eosinophils into eosinophil-deficient mice could rescue the impaired CD8+T cell memory ***,our findings suggest that eosinophil-derived IL-4 promotes the generation of CD8+T cell memory and enhances immune defense against *** study reveals a new adjuvant role of eosinophils in memory T cell generation and provides clues for enhancing the vaccine potency via targeting eosinophils and related cytokines.

关键词： impaired immunity spleen

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Theoretical Epidemiology Needs Urgent Attention in China

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China CDC weekly 2024年第21期6卷 499-502页

作者： Yao wang Zeyu Zhao Jia Rui Tianmu Chen State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen CityFujian ProvinceChina

The mathematical method to which theoretical epidemiology belongs is one of the three major methodologies in *** is of great value in diagnosing infectious disease epidemic trends and evaluating the effectiveness of prevention and control *** paper aims to summarize the brief history of the development of theoretical epidemiology,common types of mathematical models,and key steps to develop a mathematical *** also provides some thoughts and perspectives on the development and application of theoretical epidemiology in China.

关键词： epidemiology prevention China.

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The protective role of prebiotics and probiotics on diarrhea and gut damage in the rotavirus-infected piglets

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1424-1448页

作者： Heng Yang Xiangqi Fan Xiangbing Mao Bing Yu Jun He Hui Yan Jianping wang Institute of Animal Nutrition Sichuan Agricultural UniversityKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationKey Laboratory of Animal Disease-Resistant Nutrition and Feed of China Ministry of Agriculture and Rural AffairsKey Laboratory of Animal Disease-Resistant Nutrition of Sichuan ProvinceNo.211Gongpinghuimin RoadWenjiang DistrictChengduSichuan Province 611130People’s Republic of China

Rotavirus is one of the pathogenic causes that induce diarrhea in young animals, especially piglets, worldwide. However, nowadays, there is no specific drug available to treat the disease, and the related vaccines have no obvious efficiency in some countries. Via analyzing the pathogenesis of rotavirus, it inducing diarrhea is mainly due to disturb enteric nervous system, destroy gut mucosal integrity, induce intracellular electrolyte imbalance, and impair gut microbiota and immunity. Many studies have already proved that prebiotics and probiotics can mitigate the damage and diarrhea induced by rotavirus infection in hosts. Based on these, the current review summarizes and discusses the effects and mechanisms of prebiotics and probiotics on rotavirus-induced diarrhea in piglets. This information will highlight the basis for the swine production utilization of prebiotics and probiotics in the prevention or treatment of rotavirus infection in the future.

关键词： Diarrhea Piglet Prebiotics Probiotics Rotavirus

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Loyal wingman task execution for future aerial combat:A hierarchical prior-based reinforcement learning approach

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Chinese Journal of Aeronautics 2024年第5期37卷 462-481页

作者： Jiandong ZHANG Dinghan wang Qiming YANG Zhuoyong SHI Longmeng JI Guoqing SHI Yong WU School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China

In modern Beyond-Visual-Range(BVR)aerial combat,unmanned loyal wingmen are pivotal,yet their autonomous capabilities are *** study introduces an advanced control algorithm based on hierarchical reinforcement learning to enhance these capabilities for critical missions like target search,positioning,and relay *** on a dual-layer model,the algorithm’s lower layer manages basic aircraft maneuvers for optimal flight,while the upper layer processes battlefield dynamics,issuing precise navigational *** approach enables accurate navigation and effective reconnaissance for lead ***,our Hierarchical Prior-augmented Proximal Policy Optimization(HPE-PPO)algorithm employs a prior-based training,prior-free execution method,accelerating target positioning training and ensuring robust target *** paper also improves missile relay guidance and promotes the effective *** integrating this system with a human-piloted lead aircraft,this paper proposes a potent solution for cooperative aerial *** experiments demonstrate enhanced survivability and efficiency of loyal wingmen,marking a significant contribution to Unmanned Aerial Vehicles(UAV)formation control *** advancement is poised to drive substantial interest and progress in the related technological fields.

关键词： Beyond-visual-range Loyal wingmen Hierarchical prior-augmented proximal policy optimization Unmanned aerial vehicles Warfare

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Impact of transcranial electrical stimulation on serum neurotrophic factors and language function in patients with speech disorders

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World Journal of Clinical Cases 2024年第10期12卷 1742-1749页

作者： Li Sun Kai Xiao Xiao-Yan Shen Shu wang Department of Rehabilitation Medicine General Hospital of the Yangtze River ShippingWuhan 430010Hubei ProvinceChina

BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of *** treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and patient *** electrical stimulation(TES)has emerged as a promising non-invasive treatment to improve neurological ***,its effectiveness in enhancing language functions and serum neurofactor levels in individuals with speech disorders requires further *** To investigate the impact of TES in conjunction with standard therapies on serum neurotrophic factor levels and language function in patients with speech *** In a controlled study spanning from March 2019 to November 2021,81 patients with speech disorders were divided into a control group(n=40)receiving standard speech stimulation and psychological intervention,and an observation group(n=41)receiving additional *** study assessed serum levels of ciliary neurotrophic factor(CNTF),glial cell-derived neurotrophic factor(GDNF),brainderived neurotrophic factor(BDNF),and nerve growth factor(NGF),as well as evaluations of motor function,language function,and development quotient *** After 3 wk of intervention,the observation group exhibited significantly higher serum levels of CNTF,GDNF,BDNF,and NGF compared to the control ***,improvements were noted in motor function,cognitive function,language skills,physical abilities,and overall development quotient *** is worth mentioning that the observation group also displayed superior perfor CONCLUSION This retrospective study concluded that TES combined with traditional speech and psychotherapy can effectively increase the levels of neurokines in the blood and enhance language function in patients with speech *** results provide a promising avenue for integrating TES into standard treatment methods for speech disorders.

关键词： Transcranial electrical stimulation Serum neurofactor levels Developmental level Language features

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