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Prediction and Regulation of Delamination at Flexible Film/Finite-Thickness-Substrate Structure Interfaces

Acta Mechanica Solida Sinica 2024年第2期37卷 238-251页

作者： Yutang Zhou Yunlong Xu Haoran Gong chenyu wang Department of Engineering Mechanics Northwestern Polytechnical UniversityXi’an710072China School of Instrumentation Science and Opto-Electronics Engineering Beihang UniversityBeijing100191China

Regulating the surface instability of thin film/substrate structures has been successfully applied to prepare new ductile electronic ***,such electronic devices need to be subjected to external loads during operation,which can easily induce delamination of the thin-film electronic device from the *** study aims to investigate the instability characteristics of hard films on flexible substrate surfaces from theoretical analysis and numerical simulation *** finite-thickness substrates,this paper establishes theoretical models for pure bending,bent wrinkle,partial delamination,and total delamination buckling of film/substrate structures based on the nonlinear Euler–Bernoulli beam theory and the principle of minimum energy;then the effects of material and geometric parameters of the structure,interfacial adhesion strength,and pre-strain on the evolutionary path of the four patterns are *** study results show that:the greater Young’s modulus of the substrate is,the larger the parameter region where partial delamination of the film/substrate structure occurs,and the smaller the parameter region where bent wrinkle *** varying Young’s modulus,thickness of the film and substrate,interfacial adhesion coefficient,and pre-strain,the buckling pattern of the structure can be predicted and *** parametric design intervals for each pattern are summarized in the phase *** results of this paper provide theoretical support for the design and reliability evaluation of flexible electronic devices.

关键词： Thin film/finite-thickness-substrate structure Delamination Surface instability Pattern evolution

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Bioinspired 4D Printing Shape-Memory Polyurethane Rhinoplasty Prosthesis for Dynamic Aesthetic Adjustment

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Journal of Bionic Engineering 2024年第3期21卷 1397-1411页

作者： Jiaqi Liu Guiwei Li He Liu Jincheng wang Hui wang Xue Gao Qingping Liu chenyu wang Department of Plastic and Reconstructive Surgery The First Hospital of Jilin UniversityChangchun130021China Department of Orthopaedics The Second Hospital of Jilin UniversityChangchun130041China Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchun130022China

The disparity between the postoperative outcomes of rhinoplasty and the expected results frequently necessitates secondary or multiple surgeries as a compensatory measure,greatly diminishing patient ***,there is renewed optimism for addressing these challenges through the innovative realm of Four-Dimensional(4D)*** groundbreaking technology enables three-dimensional objects with shape-memory properties to undergo predictable transformations under specific external ***,implants crafted using 4D printing offer significant potential for dynamic *** by worms in our research,we harnessed 4D printing to fabricate a Shape-Memory Polyurethane(SMPU)for use as a nasal augmentation *** choice of SMPU was guided by its Glass Transition Temperature(Tg),which falls within the acceptable temperature range for the human *** attribute allowed for temperature-responsive intraoperative self-deformation and postoperative *** chosen animal model for experimentation was *** into account the anatomical structure of the rabbit nose,we designed and produced nasal augmentation prostheses with superior *** prostheses were then surgically implanted in a minimally invasive manner into the rabbit ***,they exhibited successful temperature-controlled in-surgery self-deformation according to the predetermined shape and non-invasive remodeling within a mere 9 days *** histological evaluations confirmed the practical viability of these prostheses in a living *** research findings posit that worm-inspired 4D-printed SMPU nasal prostheses hold significant promise for achieving dynamic aesthetic adjustments.

关键词： 4D printing Shape memory polyurethane Rhinoplasty Self-deformation Dynamic aesthetic adjustment

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Evolution and spatiotemporal analysis of earthquake public opinion based on social media data

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Earthquake Science 2024年第5期37卷 387-406页

作者： chenyu wang Yanjun Ye Yingqiao Qiu Chen Li Meiqing Du School of Earth Science and Engineering Hebei University of EngineeringHandan 056038China China Coal Geology Group Co.LTD Beijing 100040China Key Laboratory of Agricultural Water Resources Hebei Key Laboratory of Water-Saving AgricultureCenter for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyCASShijiazhuang 050021China University of Chinese Academy of Sciences Beijing 100049China Shandong Zhengyuan Digital City Construction Co. Ltd.Yantai 264670China Yantai Smart City and Internet of Facilities Engineering Research Center Yantai 264670China

As critical conduits for the dissemination of online public opinion,social media platforms offer a timely and effective means for managing emergencies during major disasters,such as *** study focuses on the analysis of online public opinions following the Maduo M7.4 earthquake in Qinghai Province and the Yangbi M6.4 earthquake in Yunnan *** collecting,cleaning,and organizing post-earthquake Sina Weibo(short for Weibo)data,we employed the Latent Dirichlet Allocation(LDA)model to extract information pertinent to public opinion on these *** analysis included a comparison of the nature and temporal evolution of online public opinions related to both *** emotion analysis,utilizing an emotion dictionary,categorized the emotional content of post-earthquake Weibo posts,facilitating a comparative study of the characteristics and temporal trends of online public emotions following the *** findings were visualized using Geographic Information System(GIS)*** analysis revealed certain commonalities in online public opinion following both ***,the peak of online engagement occurred within the first 24 hours post-earthquake,with a rapid decline observed between 24 to 48 hours *** variation in popularity of online public opinion was linked to aftershock *** for population factors,online engagement in areas surrounding the earthquake sites and in Sichuan Province was significantly *** dominated by feelings of“fear”and“surprise”,the public sentiment shifted towards a more positive outlook with the onset of rescue ***,distinctions in the online public response to each earthquake were also *** the Yangbi earthquake,Yunnan Province reported the highest number of Weibo posts nationwide;in contrast,Qinghai Province ranked third post-Maduo earthquake,attributable to its smaller population size and extensive damage to communication ***

关键词： internet public opinion topic clustering emotional analysis psychological crisis intervention

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Identification of a novel MYO1D variant associated with laterality defects,congenital heart diseases,and sperm defects in humans

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Frontiers of Medicine 2024年第3期18卷 558-564页

作者： Zhuangzhuang Yuan Xin Zhu Xiaohui Xie chenyu wang Heng Gu Junlin Yang Liangliang Fan Rong Xiang Yifeng Yang Zhiping Tan Department of Cardiovascular Surgery The Second Xiangya Hospital of Central South UniversityChangsha410011China Clinical Center for Gene Diagnosis and Therapy The Second Xiangya Hospital of Central South UniversityChangsha410011China Department of Cell Biology School of Life SciencesCentral South UniversityChangsha410013China Department of Gynecology and Obstetrics Xiangya Hospital of Central South UniversityChangsha410008China

The establishment of left–right asymmetry is a fundamental process in animal *** with this process leads to a range of disorders collectively known as laterality defects,which manifest as abnormal arrangements of visceral *** patients with laterality defects,congenital heart diseases(CHD)are *** multiple model organisms,extant research has established that myosin-Id(MYO1D)deficiency causes laterality *** study investigated over a hundred cases and identified a novel biallelic variant of MYO1D(NM_015194:c.1531G>A;p.D511N)in a consanguineous family with complex CHD and laterality *** examination of the proband revealed asthenoteratozoospermia and shortened ***,the effects of the D511N variant and another known MYO1D variant(NM_015194:c.2293C>T;p.P765S)were *** assessment showed that both enhance the interaction withβ-actin and ***,this study revealed the genetic heterogeneity of this rare disease and found that MYO1D variants are correlated with laterality defects and CHD in ***,this research established a connection between sperm defects and MYO1D *** offers guidance for exploring infertility and reproductive health *** findings provide a critical basis for advancing personalized medicine and genetic counseling.

关键词： MYO1D laterality defect congenital heart disease sperm defect β-actin SPAG6

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Naked-eye visualization of lymph nodes using fluorescence nanoprobes in non-human primate-animal models

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Nano Research 2024年第8期17卷 7404-7414页

作者： Xiaoyuan Ji Binbin Chu Xiaofeng Wu Zhiming Xia Airui Jiang chenyu wang Zhiming Chen Danni Zhong Qiaolin Wei Bin Song Wanlin Li Yiling Zhong Houyu wang Fenglin Dong Min Zhou Yao He Suzhou Key Laboratory of Nanotechnology and Biomedicine Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesInstitute of Functional Nano and Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025China Zhejiang University-University of Edinburgh Institute(ZJU-UoE Institute) Zhejiang UniversityHaining 314400China Department of Ultrasound the First Affiliated Hospital of Soochow UniversitySuzhou 215006China State Key Laboratory(SKL)of Biobased Transportation Fuel Technology Zhejiang UniversityHangzhou 310027China School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China Macao Translational Medicine Center Macao University of Science and TechnologyTaipa 999078MacaoChina Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyTaipa 999078MacaoChina

Despite sufficient studies performed in non-primate animal models,there exists scanty information obtained from pilot trials in non-human primate animal models,severely hindering nanomaterials moving from basic research into clinical *** herein present a pioneering demonstration of nanomaterials based optical imaging-guided surgical operation by using macaques as a typical kind of non-human primate-animal ***,taking advantages of strong and stable fluorescence of the small-sized(diameter:~5 nm)silicon-based nanoparticles(SiNPs),lymphatic drainage patterns can be vividly visualized in a real-time manner,and lymph nodes(LN)are able to be sensitively detected and precisely excised from small animal models(e.g.,rats and rabbits)to non-human primate animal models(e.g.,cynomolgus macaque(Macaca fascicularis)and rhesus macaque(Macaca mulatta)).Compared to clinically used invisible near-infrared(NIR)lymphatic tracers(i.e.,indocyanine green(ICG);etc.),we fully indicate that the SiNPs feature unique advantages for naked-eye visible fluorescence-guided surgical operation in long-term *** toxicological analysis in macaque models further provides confirming evidence of favorable biocompatibility of the SiNPs *** expect that our findings would facilitate the translation of nanomaterials from the laboratory to the clinic,especially in the field of cancer treatment.

关键词： fluorescent silicon nanoparticles lymph node real-time naked-eye visualization macaque models

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PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton,modulating emotional behavior

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Zoological Research 2024年第3期45卷 535-550页

作者： Laidong Yu Fangfang Zeng Mengshu Fan Kexuan Zhang Jingjing Duan Yalu Tan Panlin Liao Jin Wen chenyu wang Meilin wang Jialong Yuan Xinxin Pang Yan Huang Yangzhou Zhang Jia-Da Li Zhuohua Zhang Zhonghua Hu Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China MOE Key Lab of Rare Pediatric Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China Department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China

Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain *** abnormalities,such as defects in the density and morphology of postsynaptic dendritic spines,underlie the pathology of various neuropsychiatric *** 17(PCDH17)is associated with major mood disorders,including bipolar disorder and ***,the molecular mechanisms by which PCDH17 regulates spine number,morphology,and behavior remain *** this study,we found that PCDH17 functions at postsynaptic sites,restricting the number and size of dendritic spines in excitatory *** overexpression of PCDH17 in the ventral hippocampal CA1 results in spine loss and anxiety-and depression-like behaviors in ***,PCDH17 interacts with actin-relevant proteins and regulates actin filament(F-actin)***,PCDH17 binds to ROCK2,increasing its expression and subsequently enhancing the activity of downstream targets such as LIMK1 and the phosphorylation of cofilin serine-3(Ser3).Inhibition of ROCK2 activity with belumosudil(KD025)ameliorates the defective F-actin organization and spine structure induced by PCDH17 overexpression,suggesting that ROCK2 mediates the effects of PCDH17 on F-actin content and spine ***,these findings reveal a novel mechanism by which PCDH17 regulates synapse development and behavior,providing pathological insights into the neurobiological basis of mood disorders.

关键词： Synapse development Dendritic spine Mood disorder Actin cytoskeleton Animal behavior

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Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles

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Bone Research 2024年第1期12卷 137-152页

作者： Weicheng Lu Jianfei Yan chenyu wang Wenpin Qin Xiaoxiao Han Zixuan Qin Yu Wei Haoqing Xu Jialu Gao Changhe Gao Tao Ye Franklin R.Tay Lina Niu Kai Jiao Department of Stomatology Tangdu Hospital&State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina The Dental College of Georgia Augusta UniversityAugustaGAUSA

Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting pathogens to initiate secondary ***-related proteins encapsulated in brain-derived extracellular vesicles can cross the blood‒brain barrier to reach distal *** proteins initiate inflammatory dysfunction,such as neurogenic heterotopic *** recurrent condition is highly debilitating to patients because of its relatively unknown pathogenesis and the lack of effective prophylactic intervention ***,a rat model of neurogenic heterotopic ossification induced by combined traumatic brain injury and achillotenotomy was developed to address these two *** examination of the injured tendon revealed the coexistence of ectopic calcification and fibroblast *** relationships among brain-derived extracellular vesicles,fibroblast pyroptosis and ectopic calcification were further investigated in vitro and in *** injection of the pyroptosis inhibitor Ac-YVAD-cmk reversed the development of neurogenic heterotopic ossification in *** present work highlights the role of brain-derived extracellular vesicles in the pathogenesis of neurogenic heterotopic ossification and offers a potential strategy for preventing neurogenic heterotopic ossification after traumatic brain injury.

关键词： neurogenic ossification pathogenesis

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基于多度量多模型图像投票的织物表面瑕疵检测方法

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纺织学报 2024年第6期45卷 89-97页

作者：朱凌云王晨宇赵悦莹重庆理工大学计算机科学与工程学院重庆400054 重庆理工大学两江国际学院重庆401135

为解决自动化生产线上织物表面瑕疵检测准确率低和计算速度慢的问题,利用织物表面具有周期纹理的特性提出了一种改进的RANSac检测方法,即多度量多模型图像投票。首先将输入图像裁剪为尺寸一致的子图,计算出子图多维度量的输出值矩阵;然... 详细信息

为解决自动化生产线上织物表面瑕疵检测准确率低和计算速度慢的问题,利用织物表面具有周期纹理的特性提出了一种改进的RANSac检测方法,即多度量多模型图像投票。首先将输入图像裁剪为尺寸一致的子图,计算出子图多维度量的输出值矩阵;然后与改进RANSac计算出的无瑕疵背景的多维度量标准值分别对应作差,采用投票得出每张子图的基础分;再将其在4个记数模型下得到的综合评分排序,根据顺序和偏移量在输出端得到外点所代表的瑕疵子图。实验结果表明:在自采样的织物瑕疵数据集上,选择单度量和单模型的预测精度平均可达到90.9%,平均预测时间达到0.139 s,综合多度量多模型投票的平均预测精度可达到92.7%。该算法不需要大量前期数据进行训练,适用于纯色和条纹状织物的实时表面缺陷检测。

关键词：目标检测周期纹理织物表面瑕疵检测零斜率RANSac 多度量多模型图像投票

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STEMI患者的再灌注策略:药物介入策略与直接PCI对比研究的进展

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中华心血管病杂志 2024年第3期52卷 295-299页

作者：张紫薇王晨宇何奔上海交通大学医学院附属胸科医院心血管内科上海200030

虽然直接经皮冠状动脉介入治疗(PCI)仍是急性ST段抬高型心肌梗死(STEMI)的首选再灌注策略,然而,每年仍有大量的新发STEMI患者无法于最佳时间窗内接受直接PCI治疗。近年来,学界开始越来越重视先溶栓再进行PCI治疗的“药物介入”策略,以... 详细信息

虽然直接经皮冠状动脉介入治疗(PCI)仍是急性ST段抬高型心肌梗死(STEMI)的首选再灌注策略,然而,每年仍有大量的新发STEMI患者无法于最佳时间窗内接受直接PCI治疗。近年来,学界开始越来越重视先溶栓再进行PCI治疗的“药物介入”策略,以及该策略与直接PCI在疗效和安全性方面的比较。近来的一些临床研究证据逐渐表明,药物介入策略对STEMI患者安全有效,特别是当确诊后无法于120 min内进行直接PCI治疗时,选择药物介入策略不亚于直接PCI。该文复习了近来这两大策略的对比研究,对STEMI患者的再灌注策略选择提出了新的建议。

关键词： ST段抬高型心肌梗死经皮冠状动脉介入治疗药物介入策略

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基于时空结合的道路交通事故的黑点判别方法

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汽车安全与节能学报 2024年第3期15卷 321-328页

作者：陈春王晨宇张道文重庆交通大学生态人居与绿色交通研究中心重庆400074 重庆交通大学交通运输学院重庆400074 西华大学汽车与交通学院成都610039 汽车测控与安全四川省重点实验室成都610039 四川省新能源汽车智能控制与仿真测试技术工程研究中心成都610039

为精准识别道路交通事故黑点,辅助交通事故的防控,提出了一种基于时空结合的交通事故黑点判别方法。以时空重叠率,来衡量道路危险程度;用双曲正切函数拟合时空重叠率的累积频率;将拟合函数最小曲率半径对应的点,规定为临界值;以大于临... 详细信息

为精准识别道路交通事故黑点,辅助交通事故的防控,提出了一种基于时空结合的交通事故黑点判别方法。以时空重叠率,来衡量道路危险程度;用双曲正切函数拟合时空重叠率的累积频率;将拟合函数最小曲率半径对应的点,规定为临界值;以大于临界值的时空复合点,来判别为事故黑点;对成南(成都—南充)高速第二辖区交警大队收集的交通事故数据,进行实例研究。利用本时空结合的判别方法,从64例有效案例中,共判别出13个事故黑点。结果表明:事故频率法、累积频率曲线法、核密度分析法、时空重叠率法的碰撞预测准确率指标(CPAI)值分别为2.29、2.03、2.03、2.29,这意味着:时空重叠率法具有良好的判别准确性。时空重叠率法同时结合空间和时间维度,增加了黑点判别的可靠性。

关键词：道路交通事故交通安全事故黑点黑点判别方法时空重叠率

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