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Experimental and numerical study regarding H-steel all-bolted connection steel frame with composite wall boards

Earthquake Engineering and Engineering Vibration 2024年第2期23卷 427-443页

作者： Fan Min Guo Hongchao Li Shen wang zhenshan wang Huaqiang School of Civil Engineering and Architecture Xi’an University of TechnologyXi’an 710048China State Key Laboratory Base of Eco-Hydraulic Engineering in Arid Area Xi’an University of TechnologyXi’an 710048China

H-steel all-bolted connection steel frame structures with heat preservation and decoration composite wall boards were investigated and the seismic performances of three scaled specimens were *** failure modes,hysteresis curves,bearing capacity,ductility,energy dissipation capacity,stiffness degradation and strain distribution were *** calculation method of structural theoretical internal force was *** results showed that the overall structural seismic performance was better,and the structural ductility met the demands of elastic-plastic inter-story drift angle for seismic *** H-steel weak-axis connection structure obtained better energy dissipation capacity,and its bearing capacity and stiffness were slightly different from the strong-axis *** heat preservation and decoration performance of composite wallboard and the all-bolted connection of the steel frame realized prefabrication during the whole construction *** plastic hinge of the steel beam can be moved outwards because of the L-angles,which effectively avoids stress concentration in joint areas and expands the plastic hinge *** errors between the theoretical structural capacity calculated by the plastic analysis method and the test results were within 2.44%.In addition,structural failure mechanisms and bearing capacities were verified by the finite element(FE)analysis,and the effects of the main parameters on the structures were *** FE verification results were the same as in the *** research results provide theoretical support and technical guidance for the application of thermal insulation and decorative composite wall panels in H-shaped steel all-bolted steel frames.

关键词： composite wall boards all-bolted steel frame H-steel low-cyclic loading failure modes

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Discrimination Between Broadband Underwater Target Echo and Reverberation Based on Signal Spectral Flatness Feature

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Chinese Journal of Electronics 2019年第3期28卷 542-550页

作者： CHEN Yunfei LI Sheng JIA Bing ZHANG Yang wang zhenshan LI Guijuan School of Naval Architecture Dalian University of Technology Science and Technology on Underwater Test and Control Laboratory

Reverberation is the major interference of active detection, discrimination between target echo and reverberation is difficult when the reverberation is very strong. For the distinguishing of underwater target echo with strong interference, the modulation feature of echo and reverberation spectrum are characterized by signal spectral flatness measure, and the relationship between signal spectral flatness and target physical properties are theoretically formed. A method of discrimination between broadband underwater target echo and reverberation that based on signal spectral flatness characteristics difference is proposed and studied. Sea experiment results of complex underwater target broadband acoustic scattering have shown that signal spectral flatness characteristics of underwater target broadband echo and reverberation have obvious differences. Target echo and reverberation can be well distinguished using the proposed method.

关键词： Echo Reverberation Signal spectral flatness Benchmark

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Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4246-4313页

作者： Shen wang Wujian Li zhenshan wang Wanying Yang Entao Li Xianzhu Xia Feihu Yan Sandra Chiu Key Laboratory of Jilin Province for Zoonosis Prevention and Control Changchun Veterinary Research InstituteChinese Academy of Agricultural SciencesChangchun130000China College of Veterinary Medicine Jilin UniversityChangchunJilinChina College of Veterinary Medicine Jilin Agricultural UniversityChangchunJilinChina Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei230027AnhuiChina Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases Hefei230027AnhuiChina Department of Laboratory Medicine the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina

To adequately prepare for potential hazards caused by emerging and reemerging infectious diseases, the WHO has issued a list of high-priority pathogens that are likely to cause future outbreaks and for which research and development (R&D) efforts are dedicated, known as paramount R&D blueprints. Within R&D efforts, the goal is to obtain effective prophylactic and therapeutic approaches, which depends on a comprehensive knowledge of the etiology, epidemiology, and pathogenesis of these diseases. In this process, the accessibility of animal models is a priority bottleneck because it plays a key role in bridging the gap between in-depth understanding and control efforts for infectious diseases. Here, we reviewed preclinical animal models for high priority disease in terms of their ability to simulate human infections, including both natural susceptibility models, artificially engineered models, and surrogate models. In addition, we have thoroughly reviewed the current landscape of vaccines, antibodies, and small molecule drugs, particularly hopeful candidates in the advanced stages of these infectious diseases. More importantly, focusing on global trends and novel technologies, several aspects of the prevention and control of infectious disease were discussed in detail, including but not limited to gaps in currently available animal models and medical responses, better immune correlates of protection established in animal models and humans, further understanding of disease mechanisms, and the role of artificial intelligence in guiding or supplementing the development of animal models, vaccines, and drugs. Overall, this review described pioneering approaches and sophisticated techniques involved in the study of the epidemiology, pathogenesis, prevention, and clinical theatment of WHO high-priority pathogens and proposed potential directions. Technological advances in these aspects would consolidate the line of defense, thus ensuring a timely response to WHO high priorit

关键词： prevention epidemiology drugs

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Nanobodies with cross-neutralizing activity provide prominent therapeutic efficacy in mild and severe COVID-19 rodent models

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Virologica Sinica 2023年第5期38卷 787-800页

作者： Qiuxue Han Shen wang zhenshan wang Cheng Zhang Xinyue wang Na FengTiecheng wang Yongkun Zhao Hang Chi Feihu Yan Xianzhu Xia Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100021China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchun132122China Jiangsu Co-innovation Centre for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou225009China

The weakened protective efficacy of COVID-19 vaccines and antibodies caused by SARS-CoV-2 variants presents a global health emergency,which underscores the urgent need for universal therapeutic antibody intervention for clinical ***,we screened three alpacas-derived nanobodies(Nbs)with neutralizing activity from twenty RBD-specific *** three Nbs were fused with the Fc domain of human IgG,namely aVHH-11-Fc,aVHH-13-Fc and aVHH-14-Fc,which could specifically bind RBD protein and competitively inhibit the binding of ACE2 receptor to *** effectively neutralized SARS-CoV-2 pseudoviruses D614G,Alpha,Beta,Gamma,Delta,and Omicron sub-lineages BA.1,BA.2,BA.4,and BA.5 and authentic SARS-CoV-2 prototype,Delta,and Omicron BA.1,BA.2 *** mice-adapted COVID-19 severe model,intranasal administration of aVHH-11-Fc,aVHH-13-Fc and aVHH-14-Fc effectively protected mice from lethal challenges and reduced viral loads in both the upper and lower respiratory *** the COVID-19 mild model,aVHH-13-Fc,which represents the optimal neutralizing activity among the above three Nbs,effectively protected hamsters from the challenge of SARS-CoV-2 prototype,Delta,Omicron BA.1 and BA.2 by significantly reducing viral replication and pathological alterations in the *** structural modeling of aVHH-13 and RBD,aVHH-13 binds to the receptor-binding motif region of RBD and interacts with some highly conserved *** together,our study illustrated that alpaca-derived Nbs offered a therapeutic countermeasure against SARS-CoV-2,including those Delta and Omicron variants which have evolved into global pandemic strains.

关键词： COVID-19 SARS-CoV-2 Nanobody Broad-spectrum Therapeutic Rodent models

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Review on piezoelectric actuators:materials,classifications,applications,and recent trends

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Frontiers of Mechanical Engineering 2024年第1期19卷 5-33页

作者： Xuyang ZHOU Shuang WU Xiaoxu wang zhenshan wang Qixuan ZHU Jinshuai SUN Panfeng HUANG Xuewen wang Wei HUANG Qianbo LU Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi’an 710072China School of Automation Northwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China

Piezoelectric actuators are a class of actuators that precisely transfer input electric energy into displacement,force,or movement outputs efficiently via inverse piezoelectric effect-based electromechanical *** types of piezoelectric actuators have sprung up and gained widespread use in various applications in terms of compelling attributes,such as high precision,flexibility of stoke,immunity to electromagnetic interference,and structural *** paper systematically reviews the piezoelectric materials,operating principles,representative schemes,characteristics,and potential applications of each mainstream type of piezoelectric ***,we intend to provide a more scientific and nuanced perspective to classify piezoelectric actuators into direct and indirect categories with several *** addition,this review outlines the pros and cons and the future development trends for all kinds of piezoelectric actuators by exploring the relations and mechanisms behind *** rich content and detailed comparison can help build an in-depth and holistic understanding of piezoelectric actuators and pave the way for future research and the selection of practical applications.

关键词： piezoelectric actuator piezoelectric effect amplified piezoelectric actuator ultrasonic actuator stepping actuator piezoelectric polymer

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Establishment and application of a surrogate model for human Ebola virus disease in BSL-2 laboratory

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Virologica Sinica 2024年第3期39卷 434-446页

作者： Wanying Yang Wujian Li Wujie Zhou Shen wang Weiqi wang zhenshan wang Na Feng Tiecheng wang Ying Xie Yongkun Zhao Feihu Yan Xianzhu Xia Hebei Key Lab of Laboratory Animal Science Department of Laboratory Animal ScienceHebei Medical UniversityShijiazhuang050017China Key Laboratory of Jilin Province for Zoonosis Prevention and Control Changchun Veterinary Research InstituteChinese Academy of Agricultural SciencesChangchun130122China College of Veterinary Medicine Jilin UniversityChangchun130062China College of Veterinary Medicine Jilin Agricultural UniversityChangchun130118China

The Ebola virus(EBOV)is a member of the Orthoebolavirus genus,Filoviridae family,which causes severe hemorrhagic diseases in humans and non-human primates(NHPs),with a case fatality rate of up to 90%.The development of countermeasures against EBOV has been hindered by the lack of ideal animal models,as EBOV requires handling in biosafety level(BSL)-4 ***,accessible and convenient animal models are urgently needed to promote prophylactic and therapeutic approaches against *** this study,a recombinant vesicular stomatitis virus expressing Ebola virus glycoprotein(VSV-EBOV/GP)was constructed and applied as a surrogate virus,establishing a lethal infection in *** infection with VSV-EBOV/GP,3-week-old female Syrian hamsters exhibited disease signs such as weight loss,multi-organ failure,severe uveitis,high viral loads,and developed severe systemic diseases similar to those observed in human EBOV *** animals succumbed at 2–3 days post-infection(dpi).Histopathological changes indicated that VSV-EBOV/GP targeted liver cells,suggesting that the tissue tropism of VSV-EBOV/GP was comparable to wild-type EBOV(WT EBOV).Notably,the pathogenicity of the VSV-EBOV/GP was found to be species-specific,age-related,gender-associated,and challenge ***,equine anti-EBOV immunoglobulins and a subunit vaccine were validated using this ***,this surrogate model represents a safe,effective,and economical tool for rapid preclinical evaluation of medical countermeasures against EBOV under BSL-2 conditions,which would accelerate technological advances and breakthroughs in confronting Ebola virus disease.

关键词： Ebola virus(EBOV) Recombinant vesicular stomatitis virus Pathogenicity Syrian hamster Surrogate models Vaccine evaluation and drug screening

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Neural substrates for regulating self-grooming behavior in rodents

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第10期25卷 841-856页

作者： Guanqing LI Chanyi LU Miaomiao YIN Peng wang Pengbo ZHANG Jialiang WU Wenqiang wang Ding wang Mengyue wang Jiahan LIU Xinghan LIN Jian-Xu ZHANG zhenshan wang Yiqun YU Yun-Feng ZHANG State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100101China School of Life Sciences Hebei UniversityBaoding 071002China State Key Laboratory of Molecular Development Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Department of Rehabilitation Medicine Tianjin Huanhu HospitalTianjin 300350China Medical Center for Human Reproduction Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100101China Department of Gastrointestinal Surgery the People’s Hospital of Zhaoyuan CityZhaoyuan 265400China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Department of Otolaryngology EyeEarNose&Throat HospitalFudan UniversityShanghai 200031China Ear Nose&Throat InstituteEyeEarNose&Throat HospitalFudan UniversityShanghai 200031China Clinical and Research Center for Olfactory Disorders EyeEarNose&Throat HospitalFudan UniversityShanghai 200031China

Grooming,as an evolutionarily conserved repetitive behavior,is common in various animals,including humans,and serves essential functions including,but not limited to,hygiene maintenance,thermoregulation,de-arousal,stress reduction,and social *** rodents,grooming involves a patterned and sequenced structure,known as the syntactic chain with four phases that comprise repeated stereotyped movements happening in a cephalocaudal progression style,beginning from the nose to the face,to the head,and finally ending with body *** context-dependent occurrence of grooming behavior indicates its adaptive *** review briefly summarizes the neural substrates responsible for rodent grooming behavior and explores its relevance in rodent models of neuropsychiatric disorders and neurodegenerative diseases with aberrant grooming *** further emphasize the utility of rodent grooming as a reliable measure of repetitive behavior in neuropsychiatric models,holding promise for translational ***,we mainly focus on rodent ***(grooming being applied on one animal by its conspecifics via licking or carefully nibbling)and heterogrooming(a form of grooming behavior directing towards another animal,which occurs in other contexts,such as maternal,sexual,aggressive,or social behaviors)are not covered due to space constraints.

关键词： Grooming Repetitive behavior Syntactic chain Cephalocaudal progression Neuropsychiatric disorders

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基于合作视角的企业委托贷款与科技创新

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会计研究 2021年第7期 113-126页

作者：王晶王振山东北财经大学金融学院 116025

现有研究认为企业基于投机目的发放委托贷款会导致实体企业"脱实向虚",并抑制企业创新活动。与此不同,本文利用手工搜集的基于合作目的发放委托贷款的上市公司数据,考察了发放合作性质委托贷款对企业创新的影响及其作用机制。研究结论发... 详细信息

现有研究认为企业基于投机目的发放委托贷款会导致实体企业"脱实向虚",并抑制企业创新活动。与此不同,本文利用手工搜集的基于合作目的发放委托贷款的上市公司数据,考察了发放合作性质委托贷款对企业创新的影响及其作用机制。研究结论发现,企业基于合作目的发放委托贷款能够显著促进企业创新。机制检验发现,贷款企业通过发放合作性质委托贷款,促进技术知识等创新所需资源的共享交换,并通过提高客户质量、增加销售现金流,最终提升企业创新。进一步,在风险承担水平低、受到融资约束、投资机会较多以及无政治关联的公司,合作性质委托贷款对创新的促进作用也更显著。本文扩展了企业委托贷款问题的研究视野,丰富了企业合作与创新机制的研究文献。

关键词：委托贷款企业合作企业创新

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Broadband underwater target echo detection based on signal spectral irregularity feature

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Journal of Southeast University(English Edition) 2018年第2期34卷 147-155页

作者： Chen Yunfei Li Sheng Jia Bing wang zhenshan Li Guijuan School of Naval Architecture Dalian University of TechnologyDalian 116024China Science and Technology on Underwater Test and Control Laboratory Dalian 116013China

For the detection of underwater target echo under strong interferences,the modulation feature of direct echo signal and reverberation spectrum are characterized by the signal spectral irregularity feature,and the relationship between signal spectral irregularity and target physical properties is theoretically formed.A novel method of broadband underwater target echo detection under reverberation based on the signal spectral irregularity characteristics is *** proposed method has the capability of discriminating between the direct target echo signal from *** results of complex underwater target broadband acoustic scattering show that the echo can be detected even with the signal to reverberation ratio(SRR)below-10 dB by the proposed method based on the spectral irregularity(SI)*** corresponding sea experimental results also show that echo can be detected when the SRR is below 0 *** effectiveness and correctness of the proposed method are verified both in simulated data and in real data in sea experiment.

关键词： echo reverberation signal spectral irregularity

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股票投机、信息发现与权益成本——对股权融资偏好的再讨论

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经济评论 2018年第2期 103-118页

作者：王振山王秉阳东北财经大学金融学院

我国股市的过度投机与上市公司的股权融资偏好存在着内在的关联。本文以2006-2013年我国沪深A股主板市场上市公司为样本,研究了股票投机交易对权益成本的影响,以及信息发现机制在其中发挥的调节作用。结果表明,在控制了内生性和样本选... 详细信息

我国股市的过度投机与上市公司的股权融资偏好存在着内在的关联。本文以2006-2013年我国沪深A股主板市场上市公司为样本,研究了股票投机交易对权益成本的影响,以及信息发现机制在其中发挥的调节作用。结果表明,在控制了内生性和样本选择偏误之后,市场投机和个股投机都能够显著地降低权益成本;对于盈余预期更高的"好公司",投机交易对权益成本的影响更弱,支持了信息发现的"替代效应"假说。进一步的分析发现,再融资公司的权益成本与控制组相比显著更低,与上年相比也存在着明显的下降,成本偏低确实是股权融资偏好的重要原因。本文的研究充实了中国实践背景下的资本结构理论的相关成果,同时为推进资本市场健康发展、抑制市场非理性行为提供了证据支持。

关键词：股票投机信息发现机制权益成本股权融资偏好

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