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Enterococcus faecalis provides protection during scavenging in carrion crow (Corvus corone)

Zoological Research 2024年第3期45卷 451-463页

作者： Bin Hu Jia-Min wang Qing-Xun Zhang Jing Xu ya-nan Xing Bo wang Shu-Yi Han Hong-Xuan He CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Beijing Milu Ecological Research Center Beijing 102600China Beijing Capital International Airport Co. Ltd.Beijing 101300China

The gut microbiota significantly influences host physiology and provides essential ecosystem *** diet can affect the composition of the gut microbiota,the gut microbiota can also help the host adapt to specific dietary *** carrion crow(Corvus corone),an urban facultative scavenger bird,hosts an abundance of pathogens due to its scavenging *** this,carrion crows infrequently exhibit illness,a phenomenon related to their unique physiological *** present,however,the role of the gut microbiota remains incompletely *** this study,we performed a comparative analysis using 16S rRNA amplicon sequencing technology to assess colonic content in carrion crows and 16 other bird species with different diets in Beijing,*** findings revealed that the dominant gut microbiota in carrion crows was primarily composed of Proteobacteria(75.51%)and Firmicutes(22.37%).Significant differences were observed in the relative abundance of Enterococcus faecalis among groups,highlighting its potential as a biomarker of facultative scavenging behavior in carrion ***,*** isolated from carrion crows was transplanted into model mice to explore the protective effects of this bacterial community against Salmonella enterica *** showed that *** down-regulated the expression of pro-inflammatory cytokines tumor necrosis factor alpha(TNF-α),interferon gamma(IFN-γ),and interleukin 6(IL-6),prevented *** colonization,and regulated the composition of gut microbiota in mice,thereby modulating the host’s immune regulatory ***,*** exerts immunoregulatory and anti-pathogenic functions in carrion crows engaged in scavenging behavior,offering a representative case of how the gut microbiota contributes to the protection of hosts with specialized diets.

关键词： Carrion crow Facultative scavenger Gut microbiota Enterococcus faecalis 16S rRNA sequencing

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泛素链的形成机理

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生物化学与生物物理进展 2021年第5期48卷 515-528页

作者：王亚楠赵博上海交通大学细胞工程和抗体药物教育部工程研究中心上海交通大学药学院上海200240

泛素化是真核细胞中重要的蛋白质翻译后修饰过程,通过靶向蛋白质降解或其他信号途径参与多种细胞功能.底物蛋白的多聚泛素化修饰是一个持续的过程,其中不仅涉及复杂泛素系统相关酶的参与,而且存在更为复杂的结构上相互作用与泛素链组装... 详细信息

泛素化是真核细胞中重要的蛋白质翻译后修饰过程,通过靶向蛋白质降解或其他信号途径参与多种细胞功能.底物蛋白的多聚泛素化修饰是一个持续的过程,其中不仅涉及复杂泛素系统相关酶的参与,而且存在更为复杂的结构上相互作用与泛素链组装机理.不同的泛素链修饰决定了底物蛋白下游的不同命运,泛素结合酶E2在泛素链形成中的重要作用受到越来越多的关注.对泛素链形成机理的深入研究与认识有利于发现与泛素系统相关的疾病靶点和利用泛素化调控方法进行治疗.本综述总结了E2和E3如何决定不同泛素链形成的机制和相关的结构信息,以及两种不同的泛素链组装机制.

关键词：泛素链泛素结合酶E2 泛素连接酶E3 泛素链特异性泛素链组装

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求解非线性回归问题的Newton算法

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计算机学报 2010年第5期33卷 841-846页

作者：韩敏王亚楠大连理工大学电子信息与电气工程学部辽宁大连116024

针对大规模非线性回归问题,提出基于静态储备池的Newton算法.利用储备池搭建高维特征空间,将原始问题转化成与储备池维数相关的线性支持向量回归问题,并应用Newton算法求解.鲁棒损失函数的应用可抑制异常点对预测结果的干扰.通过与SVR(S... 详细信息

针对大规模非线性回归问题,提出基于静态储备池的Newton算法.利用储备池搭建高维特征空间,将原始问题转化成与储备池维数相关的线性支持向量回归问题,并应用Newton算法求解.鲁棒损失函数的应用可抑制异常点对预测结果的干扰.通过与SVR(Support Vector Regression)及储备池Tikhonov正则化方法比较,验证了所提方法的快速性、较高的预测精度和较好的鲁棒性.

关键词：支持向量回归静态储备池 Newton算法鲁棒性

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Fast X-ray imaging beamline at SSRF

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Nuclear Science and Techniques 2024年第9期35卷 68-81页

作者： Ke Li Hong-Lan Xie ya-nan Fu Fei-Xiang wang Guo-Hao Du Jian-Feng ji Biao Deng Ti-Qiao Xiao Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

The fast X-ray imaging beamline(BL16U2)at Shanghai Synchrotron Radiation Facility(SSRF)is a new beamline that provides X-ray micro-imaging capabilities across a wide range of time scales,spanning from 100 ps toμs and *** beamline has been specifically designed to facilitate the investigation of a wide range of rapid phenomena,such as the deformation and failure of materials subjected to intense dynamic *** addition,it enables the study of high-pressure and high-speed fuel spray processes in automotive *** light source of this beamline is a cryogenic permanent magnet undulator(CPMU)that is cooled by liquid *** CPMU can generate X-ray photons within an energy range of 8.7-30 *** beamline offers two modes of operation:monochromatic beam mode with a liquid nitrogen-cooled double-crystal monochromator(DCM)and pink beam mode with the first crystal of the DCM out of the beam *** X-ray imaging methods were implemented in BL16U2:single-pulse ultrafast X-ray imaging,microsecond-resolved X-ray dynamic imaging,millisecond-resolved X-ray dynamic micro-CT,and high-resolution quantitative ***,BL16U2 is equipped with various in situ impact loading systems,such as a split Hopkinson bar system,light gas gun,and fuel spray *** the completion of the final commissioning in 2021 and subsequent trial operations in 2022,the beamline has been officially available to users from 2023.

关键词： Multiple time-scale X ray imaging Single-pulse X ray imaging Dynamic 2D imaging Dynamic micro-CT

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Assessment of ecological civilization construction from the perspective of environment and health in China

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Eco-Environment & Health 2024年第3期3卷 281-289页

作者： ya'nan Guo Linsheng yang Li wang Hairong Li Quansheng Ge Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

This study innovatively evaluated ecological civilization in China from the perspective of environment and health.A Composite Environmental Health Index(CEHI)was constructed based on the Driving force-Pressure-State-Impact-Response(DPSIR)and Coupling Coordination Degree(CCD)*** showed that significant and sustained improvements were observed in the ecological environment after ecological civilization,while economic development continued to progress at a steady ***,the advancement in population health(impact subsystem),exhibited comparatively modest progress,potentially linked to issues such as demographic aging and the enduring consequences of past exposure to environmental *** the provincial level,the regional development was *** CEHI performance was highest in the eastern regions,followed by the central regions,with the western regions showing the least ***,Guangdong,Jiangsu,Shanghai,and Zhejiang emerged as top performers with higher CEHI scores,which can be attributed to their favorable geographical positioning and the response ***,northeastern regions(Heilongjiang,Jilin,and Liaoning)and northwestern regions(Shaanxi,Gansu,Ningxia,and Qinghai)experienced limited advancements in post-ecological civilization *** these underperforming regions,there is a pressing need to intensify efforts aimed at enhancing their response *** summary,China's pursuit of ecological civilization has yielded significant successes,potentially offering valuable insights for other nations striving for sustainable *** ecological civilization model's integration of ecological environmental protection into economic,political,cultural,and social constructs may serve as a meaningful reference for the sustainable development of other countries.

关键词： Ecological civilization Environment and health Driving force-Pressure-State-Impact-Response Coupling Coordination Degree Model

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Mitigated reaction kinetics between lithium metal anodes and electrolytes by alloying lithium metal with low-content magnesium

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Journal of Energy Chemistry 2024年第8期95卷 644-650,I0014页

作者： yang-yang wang ya-nan wang nan yao Shu-Yu Sun Xiao-Qing Ding Chen-Xi Bi Qian-Kui Zhang Zhao Zheng Cheng-Bin Jin Bo-Quan Li Xue-Qiang Zhang Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018ZhejiangChina

Lithium(Li)metal is regarded as a promising anode candidate for high-energy-density rechargeable ***,Li metal is highly reactive against electrolytes,leading to rapid decay of active Li metal ***,alloying Li metal with low-content magnesium(Mg)is proposed to mitigate the reaction kinetics between Li metal anodes and *** atoms enter the lattice of Li atoms,forming solid solution due to the low amount(5 wt%)of *** atoms mainly concentrate near the surface of Mg-alloyed Li metal *** reactivity of Mg-alloyed Li metal is mitigated kinetically,which results from the electron transfer from Li to Mg atoms due to the electronegativity *** on quantitative experimental analysis,the consumption rate of active Li and electrolytes is decreased by using Mgalloyed Li metal anodes,which increases the cycle life of Li metal batteries under demanding ***,a pouch cell(1.25 Ah)with Mg-alloyed Li metal anodes delivers an energy density of 340 Wh kg^(-1)and a cycle life of 100 *** work inspires the strategy of modifying Li metal anodes to kinetically mitigate the side reactions with electrolytes.

关键词： Lithium metal anodes Alloying Anode/electrolyte interface Reaction kinetics Pouch cell

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一种基于特征融合的恶意代码快速检测方法

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电子学报 2023年第1期51卷 57-66页

作者：王硕王坚王亚男宋亚飞空军工程大学防空反导学院陕西西安710051

随着恶意代码对抗技术的发展,恶意攻击者通过加壳、代码混淆等技术繁衍大量恶意代码变种,而传统恶意代码检测方法难以对其进行有效检测.基于恶意代码可视化的恶意代码检测方法被证明是一种能够有效识别恶意代码及其变种的新方法 .针对... 详细信息

随着恶意代码对抗技术的发展,恶意攻击者通过加壳、代码混淆等技术繁衍大量恶意代码变种,而传统恶意代码检测方法难以对其进行有效检测.基于恶意代码可视化的恶意代码检测方法被证明是一种能够有效识别恶意代码及其变种的新方法 .针对目前研究仅着眼于提升模型分类准确率而忽略了恶意代码检测的时效性,本文提出了一种基于特征融合的恶意代码快速检测方法 .该方法以深度神经网络为框架,采取模块化设计思想,将多尺度恶意代码特征融合与通道注意力机制结合,增强关键特征表达,并使用数据增强技术改善数据集类别不平衡问题.通过实验证明本文方法分类准确率高且参数量小、检测时效性高,优于目前的恶意代码检测技术.

关键词：恶意代码深度神经网络特征融合通道注意力机制数据增强技术恶意代码可视化

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硫代硫酸钠对排硫硫杆菌固碳能力的影响及其作用机制

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环境科学 2017年第6期38卷 2496-2501页

作者：李欢王磊王亚楠同济大学环境科学与工程学院污染控制与资源化研究国家重点实验室上海200092

通过测定不同浓度Na_2S_2O_3·5H_2O培养时排硫硫杆菌(DSM 505)菌液的总有机碳浓度(TOC),分析Na_2S_2O_3·5H_2O对排硫硫杆菌固碳能力的影响,并结合各浓度Na_2S_2O_3·5H_2O条件下固碳关键酶Rubis CO编码基因cbb的转录特性和胞外游离有... 详细信息

通过测定不同浓度Na_2S_2O_3·5H_2O培养时排硫硫杆菌(DSM 505)菌液的总有机碳浓度(TOC),分析Na_2S_2O_3·5H_2O对排硫硫杆菌固碳能力的影响,并结合各浓度Na_2S_2O_3·5H_2O条件下固碳关键酶Rubis CO编码基因cbb的转录特性和胞外游离有机碳浓度(EFOC),阐明Na_2S_2O_3·5H_2O影响排硫硫杆菌固碳能力的作用机制.结果表明,适当范围内增加Na_2S_2O_3·5H_2O的浓度能显著提高排硫硫杆菌的固碳能力,降低胞外游离有机碳在总有机碳中所占的比例.cbb基因转录特性分析结果表明,Na_2S_2O_3·5H_2O浓度对cbb基因的转录效率和表达模式均无显著影响.因此推测Na_2S_2O_3·5H_2O影响排硫硫杆菌固碳能力的作用机制可能是作为电子供体提供能量,促进细胞骨架合成,从而削弱胞外游离有机碳对排硫硫杆菌自养过程的抑制作用,进而增强固碳能力.

关键词： CO2同化电子供体有机碳抑制核酮糖-1,5-二磷酸羧化酶/加氧酶

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基于储备池主成分分析的多元时间序列预测研究

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控制与决策 2009年第10期24卷 1526-1530页

作者：韩敏王亚楠大连理工大学电信学院辽宁大连116024

提出一种基于回声状态网络储备池的非线性PCA方法,并将其应用于多元时间序列的预测中.由于多维输入变量间的相关性会影响建模效果,通过储备池将输入在原空间的非线性特征转化成高维空间的线性特征.在其中运用线性PCA技术寻找输入在储备... 详细信息

提出一种基于回声状态网络储备池的非线性PCA方法,并将其应用于多元时间序列的预测中.由于多维输入变量间的相关性会影响建模效果,通过储备池将输入在原空间的非线性特征转化成高维空间的线性特征.在其中运用线性PCA技术寻找输入在储备池空间的最大方差方向,提取有效的多元变量综合信息.经储备池主成分分析处理后的输入与预测点呈动态线性映射,可使用线性方法建模.仿真结果表明了该方法的有效性.

关键词：储备池主成分分析回声状态网络多元时间序列预测

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Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

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Chinese Journal of Integrative Medicine 2024年第2期30卷 171-180页

作者： ZHAO Wen-xiao wang Tong ZHANG ya-nan CHEN Qian wang Yuan XING yan-qing ZHENG Jun DUAN Chen-chen CHEN Lijun ZHAO Hai-jun wang Shijun School of Nursing Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJi'nan(250355)China Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula Shandong University of Traditional Chinese MedicineJi'nan(250355)China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan(250355)China

The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver *** extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and *** alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides *** addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut *** review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.

关键词： Chinese medicine polysaccharides gut microbiota short-chain fatty acids lipopolysaccharides gut-organaxis synergistic actions

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