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Role of [18F] fludeoxyglucose positron emission tomography in the selection of liver transplantation candidates in patients with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2017年第3期16卷 257-263页

作者： Yu-Fu Ye Wei wang Ting wang Jun Yu Lei Geng Song-Feng Yu Sheng Yan Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases Hangzhou 310003 China

BACKGROUND： The Milan criteria are widely accepted among many centers. However, patients with hepatocellular carcinoma beyond the Milan criteria might still benefit from liver transplantation （lt） when tumor itself is not aggressive. [18F] fluorodeoxyglucose positron emission tomography/computed tomography imaging could provide useful information of tumor behaviors, which is helpful to predict the prognosis for many tumors. METHOD： In order to determine its role in candidate selection for lt, we therefore retrospectively analyzed 103 recipients with preoperative positron emission tomography （PET） findings. RESUltS： Positive PET findings （PET＋） were significantly associated with tumor nodule numbers （P=0.013）, tumor grade （P=0.025）, macro- （P=0.002） and micro-vascular invasion （P=0.002）, as well as the Milan criteria （P=0.018）. PET＋ patients had significantly increased risk of tumor recurrence post-lt compared to PET negative （PET-） patients （P=0.007）. The 1-, 3-, and 5-year overall survival rate of PET- patients were 96.0%, 87.2% and 76.2%, compared to 74.7%, 55.4% and 49.9% in PET＋ patients, respectively （P〈0.05）. The 1-, 3-, and 5-year recurrence-free survival rate of PET- patients were 91.8%,81.9% and 76.0%, compared to 70.1%, 39.3% and 21.9% in PET＋ patients, respectively （P〈0.05）. Recipients within the Milan criteria showed comparable 1-, 3-, and 5-year survival rates in comparison with those beyond the Milan criteria with a PET- findings （1-, 3-, and 5-year overall survival rates, 97.5%, 83.3%, and 83.3% vs 90.0%, 80.0%, and 66.7%, P= 0.123; 1-, 3-, and 5-year recurrence-free survival rates, 95.1%, 73.1%, and 73.1% vs 90.0%, 78.8%, and 65.6%, P=0.148）. CONCLUSIONS： Certain patients with hepatocellular carcinoma and negative PET findings, who have exceeded the Milan criteria, are also eligible candidates for lt. Preoperative PET/CT imaging is an important marker, which should be incorporated in extended candidate selection criteria for lt.

关键词： liver transplantation hepatocellular carcinoma positron emission tomography/computed tomography ,prognostic factors

Asynchronism of the spreading dynamics underlying the bursty pattern

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Chinese Physics B 2020年第5期29卷 586-592页

作者： Tong wang Ming-Yang Zhou Zhong-Qian Fu Department of Electronic Science and Technology University of Science and Technology of ChinaHefei 230027China Guangdong Province Key Laboratory of Popular High Performance Computers College of Computer Science and Software EngineeringShenzhen UniversityShenzhen 518060China Department of Physics University of FribourgChemin du Mus´ee 3FribourgCH-1700Switzerland

The potential mechanisms of the spreading phenomena uncover the organizations and functions of various ***,due to the lack of valid data,most of early works are limited to the simulated process on model *** this paper,we track and analyze the propagation paths of real spreading events on two social networks:Twitter and *** empirical analysis reveals that the spreading probability and the spreading velocity present the explosive growth within a short period,where the spreading probability measures the transferring likelihood between two neighboring nodes,and the spreading velocity is the growth rate of the information in the whole ***,we observe the asynchronism between the spreading probability and the spreading *** explain the interesting and abnormal issue,we introduce the time-varying spreading probability into the susceptible-infected(SI)and linear threshold(lt)*** the analytic and experimental results reproduce the spreading phenomenon in real networks,which deepens our understandings of spreading problems.

关键词： social network information diffusion spreading probability asynchronism

Liver fibrosis in biliary atresia

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World Journal of Pediatrics 2019年第2期15卷 117-123页

作者： Wen-Jun Shen Gong Chen Min wang Shan Zheng Department of Pediatric Surgery Children's Hospital of Fudan University399 Wanyuan RoadMinhang DistrictShanghai 201102China

Background Biliary atresia (BA) is the most common cause of obstructive jaundice in *** the Kasai procedure has greatly improved the progno sis,most patients still need liver transplantation (lt) for long-term *** pathogenesis of BA has not been fully clarified,and liver fibrosis in BA is far beyond biliary obstructive *** sources Literature reviews were underwent through *** inflammation,immune response,biliary epithelial-mesenchymal transition,matrix deposition,decompensated angiogenesis,and unique biliary structure development all contribute to the fibrosis *** evidences in such fields have been collected and form the backbone of this *** Interactions of the multiple pathways accelerate this *** Understanding the mechanisms of the liver fibrosis in BA may pave the way to improved survival after the Kasai procedure.

关键词： Liver fibrosis Biliary atresia Children

Chemoselective hydrogenation of α,β-unsaturated aldehydes with modified Pd/C catalyst

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Chinese Chemical Letters 2012年第7期23卷 773-776页

作者： Wen Qiang Du Ze Ming Rong Yan Liang Yong wang Xin Yi Lu Yi Fan wang Lian Hai Lu State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalian 116024China

Selective hydrogenation of α, β-unsaturated aldehydes with modified Pd/C catalyst was *** reduction of C=O bond could be efficiently inhibited by the addition of carbonates,and high selectivity to the corresponding saturated aldehydes was achieved under mild *** protocol provides an alternative for efficient preparation of saturated aldehydes.

关键词： Pd/C catalyst α,β-Unsaturatcd aldehydes Hydrogenation Selectivity

Modulation of electronic state in copper-intercalated 1T-TaS_(2)

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Nano Research 2022年第5期15卷 4327-4333页

作者： Wenhao Zhang Degong Ding Jingjing Gao Kunliang Bu Zongxiu Wu Li wang Fangsen Li Wei wang Xuan Luo Wenjian Lu Chuanhong Jin Yuping Sun Yi Yin Zhejiang Province Key Laboratory of Quantum Technology and Device Department of PhysicsZhejiang UniversityHangzhou 310027China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China Vacuum Interconnected Nanotech Workstation(Nano-X) Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123China High Magnetic Field Laboratory HFIPSChinese Academy of SciencesHefei 230031China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Intercalation is an effective method to modify physical properties and induce novel electronic states of transition metal dichalcogenide(TMD)***,it is difficult to reveal the microscopic electronic state evolution in the intercalated *** we successfully synthesize the copper-intercalated 1T-TaS_(2) and characterize the structural and electronic modification combining resistivity measurements,atomic-resolution scanning transmission electron microscopy(ADF-STEM),and scanning tunneling microscopy(STM).The intercalated Cu atom is determined to be directly below the Ta atom and suppresses the commensurate charge density wave(CCDW)*** specific electronic modulations are discovered in the near-commensurate(NC)CDW phase:the electron doping state near the defective star of Davids(SDs)in metallic domains and the spatial evolution of the Mott gap in insulating *** modulations reveal that intercalated Cu atoms act as a medium to enhance the interaction between intralayer SDs,in addition to the general charge transfer *** also solidifies the Mott foundation of the insulating gap in pristine *** intriguing electronic evolution in Cu-intercalated 1T-TaS_(2) will motivate further exploration of novel electronic states in the intercalated TMD materials.

关键词： intercalation scanning tunneling microscopy Mott insulator charge transfer electron doping

Observation of multiple charge density wave phases in epitaxial monolayer 1T-VSe_(2) film

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Chinese Physics B 2022年第10期31卷 137-145页

作者： Junyu Zong Yang Xie Qinghao Meng Qichao Tian wang Chen Xuedong Xie Shaoen Jin Yongheng Zhang Li wang Wei Ren Jian Shen Aixi Chen Pengdong wang Fang-Sen Li Zhaoyang Dong Can wang Jian-Xin Li Yi Zhang National Laboratory of Solid State Microstructure School of PhysicsNanjing UniversityNanjing 210093China Vacuum Interconnected Nanotech Workstation(Nano-X) Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123China Department of Applied Physics Nanjing University of Science and TechnologyNanjing 210094China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

As a special order of electronic correlation induced by spatial modulation, the charge density wave(CDW) phenomena in condensed matters attract enormous research interests. Here, using scanning-tunneling microscopy in various temperatures, we discover a hidden incommensurate stripe-like CDW order besides the(■) CDW phase at low-temperature of 4 K in the epitaxial monolayer 1T-VSe_(2) film. Combining the variable-temperature angle-resolved photoemission spectroscopic(ARPES) measurements, we discover a two-step transition of an anisotropic CDW gap structure that consists of two parts △_(1) and△_(2). The gap part ?1 that closes around ~ 150 K is accompanied with the vanish of the(√7×√3) CDW phase. While another momentum-dependent gap part △_(2) can survive up to ~ 340 K, and is suggested to the result of the incommensurate CDW phase. This two-step transition with anisotropic gap opening and the resulted evolution in ARPES spectra are corroborated by our theoretical calculation based on a phenomenological form for the self-energy containing a two-gap structure △_(1) +△_(2), which suggests different forming mechanisms between the(√7×√3) and the incommensurate CDW phases. Our findings provide significant information and deep understandings on the CDW phases in monolayer 1T-VSe_(2) film as a two-dimensional(2D) material.

关键词： charge density waves VSe_(2) band structures STM ARPES

Effect of nocistatin in pain modulation

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Chinese Science Bulletin 2000年第8期45卷 716-720页

作者： ZHAO Chengshui SUN Ruiqing LI Bingshan wang Yun LUO Fei wang Xiaomin CHANG Jaokang HAN Jisheng Neuroscience Research Institute Beijing Medical UniversityBeijing 100083China Phoenix Pharmaceutical Inc.Mountain View CAUSA

Using tail-flick latency as the nociceptive index and von Frey hair to measure the mechanical allodynia, the aim of the present study is to determine whether nocistatin, injected intracerebroventricularly (i.c.v.), would reverse the anti-morphine effect of orphanin FQ (OFQ), and, injected i.c.v. or intrathecally (i.t.), would inhibit the mechanical allodynia in a L5 and L6 spinal nerve ligation model of neuropathic pain in rats. The results show that i.c.v. injection of nocistatin produces no significant changes in the TFL, nor does it affect morphine analgesia. in addition, i.c.v. or i.t. nocistatin produces no significant changes in withdrawal threshold of the nerve-lesioned hind paw. However, nocistatin significantly reverses the antagonistic effect of OFQ on morphine analgesia when it was coinjected i.c.v. with OFQ. The results suggest that nocistatin can reverse the anti-morphine effect of OFQ in rat brain, but cannot inhibit the mechanical allodynia of neuropathic pain in rat brain and spinal cord.

关键词： morphine nociceptin nocistatin hyperalgesia allodynia neuropathic pain.

Effects of Maternal Marginal Iodine Deficiency on Interactions between Cerebellar Bergmann Glia Cells and Purkinje Cells in Rat Offspring

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Biomedical and Environmental Sciences 2017年第12期30卷 932-937页

作者： YU Ye DONG Jing wang Yuan wang Yi MIN Hui SHAN Zhong Yan TENG Wei Ping CHEN Jie Department of Occupational and Environmental Health School of Public Health China Medical University Department of Endocrinology and Metabolism Liaoning Provincial Key Laboratory of Endocrine Diseases the First Hospital of China Medical University

Iodine deficiency （ID） during early pregnancy has an adverse effect on children＇s psychomotor and motor function but the mechanism has not been clarified. Therefore, our aim was to study the effect of maternal marginal ID on cerebellar neurodevelopment and the underlying mechanism. After obtaining marginal ID rats, we examined interactions between Bergmann gila cells （BGs） and Purkinje cells （PCs） using immunofluorescence and expression of the glutamate transporter and receptor by western blot. Our results showed that marginal ID reduced the number of contacted points between BGs and PCs,

关键词： Effects of Maternal Marginal Iodine Deficiency Cerebellar Bergman Purkinje Cells

Therapeutic applications of bone marrow-derived stem cells in liver transplantation for end-stage liver diseases

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Chinese Science Bulletin 2007年第18期52卷 2449-2456页

作者： LUO HaiYing wang YunFang KONG Wei PEI XueTao Department of Stem Cell and Regenerative Medicine Beijing Institute of Transfusion Medicine Beijing 100850 China College of Life Science Jilin University Changchun 130062 China

Today, liver transplantation (lt) is the only established treatment for end-stage liver diseases. The de- velopment of lt, including Olt, cadaveric lt, split lt, living donor lt (LDlt), brings hopes to patients with these diseases. However, increasing donor shortage, rejection and life-long immunosuppression with its side effects are the major limitations of this therapy strategy. Bone marrow-derived stem cells (BMDSCs) are capable of differentiating into hepatocyte-like cells and contribute to liver injury repair. The microenvironment of liver injury caused by rejection, ischemia/reperfusion, loss of liver mass, recurrence of HCV and "small-for-size syndrome" after lt can attract a variety of bone marrow-derived stem cell population to the peripheral circulation and then migration to the injury liver to promote the hepatic function restoration. Additionally, BMDSCs can also take part in the functional regeneration of living donor liver after LDlt. This participation in liver regeneration may be associated to the interac- tion between SDF-1and its receptor CXCR4, involving HGF, IL-8, MMP9, and VEGF/VEGFR-2. BMDSC with its bio-characteristics could maintain the allograft tolerance from different angles and in different ways. In conclusion, BMDSCs transplantation, as a new assistant therapeutic method for lt, will ex- pand the space of lt, and provide more survival opportunities for the patients suffering liver diseases in the future.

关键词：肝移植骨髓干细胞晚期肝病治疗肝功能重建