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PointNetV3:feature extraction with position encoding

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Optoelectronics Letters 2024年第8期20卷 483-489页

作者： wang Jun wang xuefei ZHoU Boxiong GUO Dongyan College of Computer Science and Technology Zhejiang University of TechnologyHangzhou 310023China

Feature extraction of point clouds is a fundamental component of three-dimensional(3D)vision *** existing feature extraction networks primarily focus on enhancing the geometric perception abilities of networks and overlook the crucial role played by *** instance,though two airplane wings share the same shape,it demands distinct feature representations due to their differing *** this paper,we introduce a novel module called position aware module(PAM)to leverage the coordinate features of points for positional encoding,and integrating this encoding into the feature extraction network to provide essential positional ***,we embed PAM into the Point Net++framework,and design a novel feature extraction network,named Point Net *** validate the effectiveness of Point Net V3,we conducted comprehensive experiments including classification,object tracking and object detection on point *** results of remarkable improvement in three tasks demonstrate the exceptional performance achieved by Point Net V3 in point cloud processing.

关键词： Net Point exceptional

Development of RPA-Cas12a-fluorescence assay for rapid and reliable detection of human bocavirus 1

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Animal Models and Experimental Medicine 2024年第2期7卷 179-188页

作者： Weidong Qian xuefei wang Ting wang Jie Huang Qian Zhang Yongdong Li Si Chen School of Food and Biological Engineering Shaanxi University of Science and TechnologyXi'anP.R.China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenP.R.China Ningbo Municipal Center for Disease Control and Prevention NingboP.R.China Medical College of Shenzhen University ShenzhenP.R.China

Human bocavirus(HBoV)1 is considered an important pathogen that mainly affects infants aged 6–24 months,but preventing viral transmission in resource-limited regions through rapid and affordable on-site diagnosis of individuals with early infection of HBoV1 remains somewhat ***,we present a novel faster,lower cost,reliable method for the detection of HBoV1,which integrates a recombinase polymerase amplification(RPA)assay with the CRISPR/Cas12a system,designated the RPA-Cas12a-fluorescence *** RPA-Cas12a-fluorescence system can specifically detect target gene levels as low as 0.5 copies of HBoV1 plasmid DNA per microliter within 40 min at 37℃without the need for sophisticated *** method also demonstrates excellent specificity without cross-reactivity to non-target ***,the method was appraised using 28 clinical samples,and displayed high accuracy with positive and negative predictive agreement of 90.9%and 100%,***,our proposed rapid and sensitive HBoV1 detection method,the RPA-Cas12a-fluorescence assay,shows promising potential for early on-site diagnosis of HBoV1 infection in the fields of public health and health *** established RPA-Cas12a-fluorescence assay is rapid and reliable method for human bocavirus 1 *** RPA-Cas12a-fluorescence assay can be completed within 40 min with robust specificity and sensitivity of 0.5 copies/μl.

关键词： CRISPR-Cas12a detection human bocavirus 1 on-site diagnosis recombinase polymerase amplification

Computer-aided molecular design and optimization of potent inhibitors disrupting APC-Asef interaction

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2631-2645页

作者： xuefei wang Zeqian Du Yuegui Guo Jie Zhong Kun Song Junyuan wang Jianqiang Yu Xiuyan Yang Chen-Ying Liu Ting Shi Jian Zhang Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China Key Laboratory of Protection Development and Utilization of Medicinal Resources in Liupanshan AreaMinistry of EducationPeptide&Protein Drug Research CenterSchool of PharmacyNingxia Medical UniversityYinchuan 750004China State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Department of Colorectal and Anal Surgery Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Basic Science Research Center Base(Pharmaceutical Science) Yantai UniversityYantai 264005China Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Colorectal cancer(CRC)is the second leading cause of cancer mortality *** initial diagnosis,approximately 20%of patients are diagnosed with metastatic CRC(mCRC).Although the APC-Asef interaction is a well-established target for mCRC therapy,the discovery and development of effective and safe drugs for mCRC patients remains an urgent and challenging *** this study,we identified a novel structural scaffold based on MAI inhibitors,the first-in-class APC-Asef inhibitors we reported *** model-driven optimizations of the N-terminal cap and experimental evaluations of inhibitory activity were performed,and 24-fold greater potency was obtained with the best inhibitor compared to the parental *** addition,the cocrystal structure validated that the two-layerπ-πstacking interactions were essential for inhibitor stabilization in the bound ***,in vitro and in vivo studies have demonstrated that novel inhibitors suppressed lung metastasis in CRC by disrupting the APC-Asef *** results provide an intrinsic structural basis to further explore drug-like molecules for APC-Asef-mediated CRC therapy.

关键词： APC-Asef Peptidomimetic Computer-aided molecular design ONIOM model π-πstacking Metastatic colorectal cancer

Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial

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FRONTIERS OF MEDICINE 2024年第4期18卷 678-689页

作者： Zhao, Jun Zheng, Hui wang, Xin wang, xuefei Shi, Yunzhou Xie, Chaorong Tao, Qingfeng Li, Da Sun, Jingwen Tian, Junjian Gao, Junxia Liu, Huimin Shi, Suhua Ni, Jinxia Xue, Rongdan Hu, Hui Chen, Min Yu, Shuguang Li, Zhigang Beijing Univ Chinese Med Sch Acupuncture Moxibust & Tuina Beijing 100029 Peoples R China Sichuan Univ West China Hosp Dept Integrated Tradit & Western Med Chengdu Peoples R China Chengdu Univ Tradit Chinese Med Hosp 3 Acupuncture & Tuina Sch Chengdu 610000 Peoples R China Capital Med Univ Beijing Hosp Tradit Chinese Med Beijing 100010 Peoples R China Beijing Univ Chinese Med Dept Acupuncture & Moxibust Dongzhimen Hosp Beijing 100700 Peoples R China Beijing Univ Chinese Med Affiliated Hosp 3 Dept Rehabil Beijing 100029 Peoples R China Beijing Univ Chinese Med Dongfang Hosp Dept Acupuncture & Moxibust Beijing 100078 Peoples R China Hosp Chengdu Univ Tradit Chinese Med Anorectal Dis Dept Chengdu 610075 Peoples R China

Previous studies have confirmed that acupuncture for irritable bowel syndrome (IBS) provided an additional benefit over usual care alone. Therefore, we performed a multicenter, randomized, sham-controlled trial to assess the efficacy and safety of acupuncture versus sham acupuncture for refractory IBS in patients in the context of conventional treatments. Patients in the acupuncture and sham acupuncture groups received real or sham acupuncture treatment in 3 sessions per week for a total of 12 sessions. The primary outcome was a change in the IBS-Symptom Severity Scale (IBS-SSS) score from baseline to week 4. A total of 521 participants were screened, and 170 patients (85 patients per group) were enrolled and included in the intention-to-treat analysis. Baseline characteristics were comparable across the two groups. From baseline to 4 weeks, the IBS-SSS total score decreased by 140.0 (95% CI: 126.0 to 153.9) in the acupuncture group and 64.4 (95% CI: 50.4 to 78.3) in the sham acupuncture group. The between-group difference was 75.6 (95% CI: 55.8 to 95.4). Acupuncture efficacy was maintained during the 4-week follow-up period. There were no serious adverse events. In conclusion, acupuncture provided benefits when combined with treatment as usual, providing more options for the treatment of refractory IBS.

关键词： acupuncture functional gastrointestinal disorders irritable bowel syndrome clinical trial

早发性胃癌的发病趋势和治疗挑战及其未来思考

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中华胃肠外科杂志 2024年第5期27卷 425-429页

作者：汪学非孙益红复旦大学附属中山医院普通外科上海200032

早发性胃癌(EOGC)作为一种特殊类型的胃癌,近年来发病率逐渐上升,给社会和家庭带来了巨大的负面影响,也引起了社会的广泛关注。EOGC在临床表现上呈现出一系列特点,如女性患者较多、病理类型以低分化腺癌或未分化癌为主、Lauren分型多为... 详细信息

早发性胃癌(EOGC)作为一种特殊类型的胃癌,近年来发病率逐渐上升,给社会和家庭带来了巨大的负面影响,也引起了社会的广泛关注。EOGC在临床表现上呈现出一系列特点,如女性患者较多、病理类型以低分化腺癌或未分化癌为主、Lauren分型多为弥漫型,且更容易发生远处转移。然而,关于其病因和发病机制,目前尚未完全明确。值得注意的是,约有10%的EOGC病例存在家族聚集性,并发生Cadherin-1(CDH1)或α-1连环蛋白(CTNNA1)基因的胚系突变,被称为家族遗传性弥漫型胃癌(HDGC)。上述独特的临床特点给EOGC的诊疗带来了巨大的挑战,强疗效、保功能、促康复、回社会是EOGC的治疗目标,临床上需以多学科协作为基础、以综合治疗为方法,生理与心理并重,疗效与功能兼顾,造福于更多早发型胃癌患者。

关键词：胃肿瘤,早发性治疗发病趋势挑战

面向电化学转换和储能的中空金属有机框架及其衍生碳基纳米反应器构筑

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科学通报 2024年第16期69卷 2174-2184页

作者：王雪飞李海涛刘健内蒙古大学化学化工学院呼和浩特010021 School of Civil&Environmental Engineering University of Technology SydneySydney 2007Australia

模拟细胞的纳米反应器以其独特的物理化学特性在多相催化、能量储存和转化、环境修复和生物化学等领域引起了广泛的研究兴趣.这类纳米反应器为化学反应的发生提供了一个介于微观和宏观之间的受限空间.其中,具有多级中空或多级孔结构的... 详细信息

模拟细胞的纳米反应器以其独特的物理化学特性在多相催化、能量储存和转化、环境修复和生物化学等领域引起了广泛的研究兴趣.这类纳米反应器为化学反应的发生提供了一个介于微观和宏观之间的受限空间.其中,具有多级中空或多级孔结构的碳基纳米反应器,在碳材料的热力学稳定性高和导电性能好的基础上,还可以在纳米反应器效应(如微环境调控效应、空间限域效应和传质增强效应等)的作用下,进一步提升碳基材料在电化学转换与储能领域的性能.本文首先对金属有机框架材料衍生的碳基纳米反应器的合成策略进行了讨论,然后介绍了它们在电化学转换和储能领域的应用,重点介绍了其中的纳米反应器效应,最后对金属有机框架衍生的碳基纳米反应器的发展前景进行了展望.

关键词：纳米反应器多级中空结构多级孔结构碳基电催化剂金属有机框架

豫南地区小麦品质特性分析及其酥性饼干应用探究

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食品科技 2024年第1期49卷 154-161页

作者：张思颖王雪菲信阳农林学院旅游学院河南信阳464000 信阳农林学院食品科学与工程学院河南信阳464000

为探究豫南地区独特自然环境条件下培育的弱筋小麦对酥性饼干的品质影响,选用河南信阳地区弱筋小麦信麦79、信麦126、信麦129、信麦136为研究对象,通过湿面筋含量、粉质特性、理化分析及感官评定测定,评价小麦、小麦粉及酥性饼干的品质... 详细信息

为探究豫南地区独特自然环境条件下培育的弱筋小麦对酥性饼干的品质影响,选用河南信阳地区弱筋小麦信麦79、信麦126、信麦129、信麦136为研究对象,通过湿面筋含量、粉质特性、理化分析及感官评定测定,评价小麦、小麦粉及酥性饼干的品质特性。结果表明:信麦79、信麦129、信麦136为中筋小麦,信麦126为低筋小麦;通过面团微观结构和饼干品质特性分析综合表明,蛋白含量、湿面筋含量较低的面粉有助于酥性饼干质构特性和感官评价的提升。信麦126较为适宜制作酥性饼干,其制作的酥性饼干感官评分较高为95.53分,仅次于市售两款酥性饼干,具有外形完整,色泽均匀呈黄色,口感酥脆,甜而不腻的特点。通过相关性分析可知,小麦及小麦粉质特性中湿面筋含量、面筋指数、面团形成和稳定时间、最大阻力及延伸度对酥性饼干的品质影响较大。该研究为酥性饼干所用优质小麦品种的选育提供新选择,对豫南地区低筋小麦的种植和加速其工业化生产及应用有指导意义。

关键词：豫南地区弱筋小麦品质特性酥性饼干

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胃癌外科治疗的新进展及发展趋势

中国癌症杂志 2024年第3期34卷 250-258页

作者：汪学非周鹏唐兆庆复旦大学附属中山医院胃肠外科上海200032

胃癌严重威胁人类健康,尽管近年来化疗、靶向治疗和免疫治疗等新型药物研发不断取得突破,但根治性手术始终是胃癌诊疗的核心。随着标准胃癌根治手术的成型,以腹腔镜技术为代表的微创外科治疗技术的进步,进展期胃癌围手术期综合治疗模式... 详细信息

胃癌严重威胁人类健康,尽管近年来化疗、靶向治疗和免疫治疗等新型药物研发不断取得突破,但根治性手术始终是胃癌诊疗的核心。随着标准胃癌根治手术的成型,以腹腔镜技术为代表的微创外科治疗技术的进步,进展期胃癌围手术期综合治疗模式的确定,以及胃癌精准外科理念的形成和初步实践,胃癌手术治疗取得了巨大进步。个体化和精准化胃癌外科治疗理念深入人心。安全、有效、精准、微创始终是胃癌外科医师需牢牢把握的学科发展的内在规律。为帮助年轻医师更好的成长,本文总结胃癌诊疗的最新进展,并对未来的发展趋势进行展望。

关键词：胃癌外科治疗进展趋势

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不同改良剂对冷冻面团及面条品质的影响

食品与发酵工业 2024年第2期50卷 268-274页

作者：杜险峰周舟曹蒙王雪菲王宝刚哈尔滨商业大学旅游烹饪学院黑龙江哈尔滨150025 信阳农林学院食品学院河南信阳464000

该文以面条冷冻面团为实验对象,研究硬酯酰乳酸钠、黄原胶、谷朊粉、维生素C这4种添加剂的不同添加量对面条冷冻面团的可冻结水含量、稳态-流变学特性、析水率以及冷冻面团面条质构特性的影响。结果表明,添加不同量的改良剂能显著降低... 详细信息

该文以面条冷冻面团为实验对象,研究硬酯酰乳酸钠、黄原胶、谷朊粉、维生素C这4种添加剂的不同添加量对面条冷冻面团的可冻结水含量、稳态-流变学特性、析水率以及冷冻面团面条质构特性的影响。结果表明,添加不同量的改良剂能显著降低面条冷冻面团的可冻结水含量,增强面团的抗形变能力,小麦粉析水率在一定范围内显著降低,面条的硬度、弹性、咀嚼性均随着添加量的增加有显著的变化。结果显示通过添加一定量的改良剂能够较好地改善冷冻面团的品质以及最终产品冷冻面团面条的品质。

关键词：冷冻面团改良剂可冻结水稳态-流变学特性质构特性