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Lamivudine therapy for children with chronic hepatitis B

World Journal of Gastroenterology 2006年第15期12卷 2412-2416页

作者： Anna Liberek Anna Szaflarska-Poplawska Maria Korzon Gra(?)yna (?)uczak Magdalena Góra-Gebka Ewa (?)o(s|')-Rycharska wanda bako Mieczyslawa Czerwionka-Szaflarska Department of Pediatrics Pediatric Gastroenterology and Oncology Medical University of Gda(n|')sk Poland

AIM： To assess the effectiveness and side-effects of lamivudine therapy for children with chronic hepatitis B （CHB） who fail to respond to or have contraindications to interferon-α （IFN-α） therapy. METHODS： Fifty-nine children with CHB were treated with 100 mg lamivudine tablets given orally once daily for 12 too. Alanine aminotransferase （ALT） activity was evaluated monthly during the therapy and every 3 months after its discontinuation. HBe antigen, antiHBe antibodies, HBV DNA level in serum were evaluated at baseline and every six months during and after the lamivudine therapy. Sustained viral response （SVR） to lamivudine therapy was defined as permanent （not shorter than 6 mo after the end of the therapy）, namely ALl＂ activity normalization, seroconversion of HBeAg to anti-HBe antibodies, and undetectable viral HBV-DNA in serum （lower than 200 copies per mL）. The analysis of the side-effects of the lamivudine treatment was based upon interviews with the patients and their parents using a questionnaire concerning subjective and objective symptoms, clinical examinations, and laboratory tests performed during clinical visits monthly during the therapy, and every 3 mo after the therapy. RESULTS： ALT normalisation occurred in 47 （79.7%） patients between the first and 11^th mo of treatment （mean 4.4±2.95 mo, median 4.0 mo）, and in 18 （30.5%） of them after 2 mo of the therapy. There was no correlation between the time of ALT normalization and the children＇s age, the age of HBV infection, the duration of HBV infection, inflammation activity score （grading）, staging, ALT activity before treatment, serum HBV DNA level, and lamivudnie dose per kg of body weight. HBeAg/anti HBe seroconversion was achieved in 27.1% of *** higher rate of seroconversion was connected with lower serum HBV DNA level and longer duration of HBV infection. There was no connection between HBeAg/ anti HBeAb seroconversion and the children＇s age, age of HBV infection, grading, staging, ALT activ

关键词： Chronic hepatitis B Children Lamivudine

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Evaluation of media for simultaneous enumeration of total coliform and Escherichia coli in drinking water supplies by membrane filtration techniques

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Journal of Environmental Sciences 2008年第3期20卷 273-277页

作者： WANG Dunling FIESSEL wanda Centre for Sustainable Infrastructure Research Institute for Research in Construction National Research Council Suite 3016 Research Drive Regina S4S 7J7 Saskatchewan Canada Environmental Services Saskatchewan Disease Control Laboratory Saskatchewan Health 3211 Albert Street Regina S4S 5W6 Saskatchewan Canada

This study evaluated three different dehydrated media for simultaneous detection and enumeration of total coliform （TC） and Escherichia coil in drinking water samples with a standard membrane filtration procedure. The experiment indicated that the differential coliform agar （DCA） medium was the most effective among the tested media in enumerating TC and E. coil, without the need for extensive accompanying confirmation tests. The results for DCA medium were highly reproducible for both TC and E. coil with standard deviation of 6.0 and 6.1, respectively. A high agreement （82%） was found between DCA and m-Endo media on 152 drinking water samples in terms of TC positive. The DCA medium also reduced concealment of background bacteria.

关键词： drinking water differential coliform agar (DCA) total coliform (TC) E. coli membrane filtration (MF)

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Self-assembly as a route to one-dimensional lanthanum(Ⅲ) salicylaldimine coordination polymer

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Journal of Rare Earths 2010年第S1期28卷 51-55页

作者： wanda Radecka-Paryzek Izabela Pospieszna-Markiewicz Maciej Kubicki Faculty of Chemistry Adam Mickiewicz University

The self-assembled formation of a one-dimensional lanthanum salicylald imine coordination polymer was proved by the X-ray diffraction analysis of new l anthanum(Ⅲ) nitrate complex containing N,N’-bis(salicylidene)-1,5-pentanediami ne ligand(H2L) . It was obtained in situ in a one-step,metal-templated condensa tion of salicylaldehyde with 1,5-pentanediamine(cadaverine,biogenic polyamine) and characterized by microanalysis and spectroscopic(IR,ESI-MS,UV-Vis,and 1 H NMR) data. The [La(NO3) 3(μ-H2L) 2]∞ complex displayed 10-coordinate distorted bicapped dodecahedron geometry with unusual coordination pattern of undeprotonat ed salicylaldimines which acted as μ-bridging ditopic ligands using exclusivel y the oxygens as donor atoms with the nitrogen atoms not being involved in the c oordination environment.

关键词： self assembly lanthanum salicylaldimine crystal structure coordina tion polymer rare earths

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Viscoelastic Immersed Boundary Methods for Zero Reynolds Number Flow

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Communications in Computational Physics 2012年第7期12卷 462-478页

作者： wanda Strychalski Robert D.Guy Department of Mathematics University of CaliforniaDavis CA 95616USA

The immersed boundary method has been extensively used to simulate the motion of elastic structures immersed in a viscous *** some applications,such as modeling biological materials,capturing internal boundary viscosity is *** present numerical methods for simulating Kelvin-Voigt and standard linear viscoelastic structures immersed in zero Reynolds number *** find that the explicit time immersed boundary update is unconditionally unstable above a critical boundary to fluid viscosity ratio for a Kelvin-Voigt *** also show there is a severe time step restriction when simulating a standard linear boundary with a small relaxation time scale using the same explicit update.A stable implicit method is presented to overcome these computation challenges.

关键词： Stokes flow viscoelastic structures fluid-structure interaction numerical instability

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Three-Dimensional Modeling of Shallow Shear-Wave Velocities for Las Vegas, Nevada, Using Sediment Type

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Journal of China University of Geosciences 2009年第3期20卷 555-562页

作者： Barbara Luke Helena Murvosh wanda Taylor Jeff Wagoner University of Nevada Las Vegas Las Vegas NV USA Stanley Consultants Inc. Las Vegas NV USA Lawrence Livermore National Laboratory Livermore CA USA

A three-dimensional model of near-surface shear-wave velocity in the deep alluvial basin underlying the metropolitan area of Las Vegas, Nevada （USA）, is being developed for earthquake site response projections. The velocity dataset, which includes 230 measurements, is interpolated across the model using depth-dependent correlations of velocity with sediment type. The sediment-type database contains more than 1 400 well and borehole logs. Sediment sequences reported in logs are assigned to one of four units. A characteristic shear-wave velocity profile is developed for each unit by analyzing closely spaced pairs of velocity profiles and well or borehole logs. The resulting velocity model exhibits reasonable values and patterns, although it does not explicitly honor the measured shear-wave velocity profiles. Site response investigations that applied a preliminary version of the velocity model support a two-zone ground-shaking hazard model for the valley. Areas in which clay predominates in the upper 30 m are predicted to have stronger ground motions than the rest of the basin.

关键词： shear-wave velocity earthquake site response site amplification microzonation sediment type.

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A combination of climate,tree diversity and local human disturbance determine the stability of dry Afromontane forests

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Forest Ecosystems 2021年第2期8卷 207-222页

作者： Hadgu Hishe Louis Oosterlynck Kidane Giday wanda De Keersmaecker Ben Somers Bart Muys KU Leuven Department of Earth and Environmental SciencesDivision ForestNature and LandscapeCelestijnenlaan 200EP.O.Box 24113001 LeuvenBelgium Department of Land Resource Management and Environmental Protection Mekelle UniversityCollege of Dryland Agriculture and Natural ResourcesP.O.Box 231MekelleTigrayEthiopia Laboratory of Geo-Information Science and Remote Sensing Wageningen University6708 PB WageningenThe Netherlands

Background:Anthropogenic disturbances are increasingly affecting the vitality of tropical dry *** future condition of this important biome will depend on its capability to resist and recover from these *** far,the temporal stability of dryland forests is rarely studied,even though identifying the important factors associated with the stability of the dryland forests could serve as a basis for forest management and ***:In a degraded dry Afromontane forest in northern Ethiopia,we explored remote sensing derived indicators of forest stability,using MODIS satellite derived NDVI time series from 2001 to *** and resistance were measured using the anomalies(remainders)after time series decomposition into seasonality,trend and remainder *** stability was calculated using the integral of the undecomposed NDVI *** NDVI derived stability indicators were then related to environmental factors of climate,topography,soil,tree species diversity,and local human disturbance,obtained from a systematic grid of field inventory plots,using boosted regression trees in ***:Resilience and resistance were adequately predicted by these factors with an R^(2) of 0.67 and 0.48,respectively,but the model for growth stability was *** of the wettest month,distance from settlements and slope were the most important factors associated with resilience,explaining 51%of the ***,temperature seasonality and humus accumulation were the significant factors associated with the resistance of the forest,explaining 61%of the overall effect.A positive effect of tree diversity on resilience was also important,except that the impact of species evenness declined above a threshold value of 0.70,indicating that perfect evenness reduced the resilience of the *** of the wettest month was the most important factor explaining 43.52%of the growth stability ***:A combination of clima

关键词： Climate Dryland Disturbance Restoration Tigray Growth stability Biodiversity function

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G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis

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World Journal of Gastroenterology 2019年第30期25卷 4092-4104页

作者： Damian Jacenik Ellen J Beswick wanda M Krajewska Eric R Prossnitz Department of Cytobiochemistry Faculty of Biology and Environmental ProtectionUniversity of LodzLodz 90-236Poland Department of Internal Medicine School of Medicineand UNM Comprehensive Cancer CenterUniversity of New MexicoAlbuquerqueNM 87131United States Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineSchool of MedicineUniversity of UtahSalt Lake CityUT 84132United States

Estrogens play important roles in the development and progression of multiple tumor *** evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast,endometrium and ovary,but also in the development of colorectal cancer(CRC).The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen receptorsαandβ,as well as the membranebound G protein-coupled estrogen receptor(GPER).The roles of GPER in CRC development and progression,however,remain poorly *** on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases,such as Crohn’s disease and ulcerative *** is also involved in cell cycle regulation,endoplasmic reticulum stress,proliferation,apoptosis,vascularization,cell migration,and the regulation of fatty acid and estrogen metabolism in CRC ***,multiple lines of evidence suggest that GPER may play an important role in colorectal *** this review,we present the current state of knowledge regarding the contribution of GPER to colon function and CRC.

关键词： G protein-coupled estrogen receptor Colorectal cancer Proliferation Migration Colonic motility Inflammatory bowel disease

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Colon cancer stem cells:Controversies and perspectives

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World Journal of Gastroenterology 2013年第20期19卷 2997-3006页

作者： Maria Ausiliatrice Puglisi Valentina Tesori wanda Lattanzi Giovanni Battista Gasbarrini Antonio Gasbarrini Department of Internal Medicine and Gastroenterology Gemelli Hospital00168 RomeItaly Institute of Anatomy and Cell Biology Università Cattolica del Sacro Cuore00168 RomeItaly Fondazione Ricerca in Medicina ONLUS 40123 BolognaItaly

Tumors have long been viewed as a population in which all cells have the equal propensity to form new tumors,the so called conventional stochastic *** cutting-edge theory on tumor origin and progression,tends to consider cancer as a stem cell *** cells are actively involved in the onset and maintenance of colon *** review is intended to examine the state of the art on colon cancer stem cells(CSCs),with regard to the recent achievements of basic research and to the corresponding translational *** prominence is given to the hypothesized origin of CSCs and to the methods for their *** growing understanding of CSC biology is driving the optimization of novel anti-cancer targeted drugs.

关键词： Colon cancer stem cells Colorectal cancer CD133 Therapy Chemoresistance

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Update on small intestinal stem cells

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World Journal of Gastroenterology 2013年第29期19卷 4671-4678页

作者： Valentina Tesori Maria Ausiliatrice Puglisi wanda Lattanzi Giovanni Battista Gasbarrini Antonio Gasbarrini Department of Internal Medicine and Gastroenterology Università Cattolica del Sacro Cuore Rome Largo A. Gemelli 8 00197 Rome Italy Department of Internal Medicine Gemelli Hospital 00168 Rome Italy Institute of Anatomy and Cell Biology Università Cattolica del Sacro Cuore 00168 Rome Italy Medical Research Foundation ONLUS Galleria Falcone Borsellino 2 40123 Bologna Italy

Among somatic stem cells, those residing in the intestine represent a fascinating and poorly explored research field. Particularly, somatic stem cells reside in the small intestine at the level of the crypt base, in a constant balance between self-renewal and differentiation. Aim of the present review is to delve into the mechanisms that regulate the delicate equilibrium through which intestinal stem cells orchestrate intestinal architecture. To this aim, special focus will be addressed to identify the integrating signals from the surrounding niche, supporting a model whereby distinct cell populations facilitate homeostatic vs injury-induced regeneration.

关键词： Intestinal stem cells Organoids Intestinal regeneration Lgr5 Niche

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A Clinical Observation of Functional Abdominal Pain Syndrome in Patients Treated by Traditional Chinese Spinal Orthopedic Manipulation

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Chinese Journal of Integrative Medicine 2018年第2期24卷 140-146页

作者： QU Liu-xin XING Li-yang wanda Norman CHEN Hong LI Ming-ju GAO Song LI Ping Department of Chinese Orthopedics and Traumatology Zhongda Hospital School of Medicine Southeast UniversityNanjing 210009 China Department of Acupuncture and Moxibustion Zhongda Hospital School of Medicine Southeast University Nanjing 210009 China Acupuncturist at Gateway Sports Medicine Portland OR 97216 USA Department of Gastroenterology Zhongda Hospital School of Medicine Southeast University Naniina 210009. China

Objective： To evaluate the clinical effect of traditional Chinese spinal orthopedic manipulation（TCSOM） in treating patients with functional abdominal pain syndrome（FAPS） in comparison with Pinaverium Bromide（Dicetel, PBD）, and to assess a possible cause for FAPS. Methods： Eighty patients with FAPS were randomly and equally assigned to the TCSOM group and PBD group according to the random number table. All patients in the TCSOM group were treated with a maximum of 5 times of spinal manipulations. Patients in the PBD group were instructed to take 50 mg 3 times a day, consistently for 2 weeks. The symptoms of pre-and post-treatment were assessed on a visual analog scale（VAS） pain score. A symptom improvement rating（SIR） was implemented to evaluate the effects of the treatments. Results： The symptoms of 27 cases of the TCSOM group were relieved soon after the first TCSOM treatment and 9 cases were significantly improved. The VAS pain scores in the TCSOM group were significantly lower than those in the PBD group after 2 weeks treatment. According to the SIR based on VAS, the TCSOM group included 30 cases with excellent results, 7 cases with good, and 3 cases with poor. Adverse events to the treatment were not reported. Based on VAS, the PBD group reported 8 cases with excellent results, 10 cases with good and 22 cases with poor. There was a significant difference between the two groups（P〈0.01）. Conclusions： The displacement of intervertebral discs and/or vertebra in the thoracic or lumbar region seems to be a contributing factor in the symptoms of FAPS. TCSOM is an effective treatment for FAPS.

关键词： functional abdominal pain syndrome spinal manipulation orthopedic Jiaji(EX-B2) Back-Shu acupoints visual analog scale

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