Update on small intestinal stem cells

作     者：Valentina Tesori Maria Ausiliatrice Puglisi Wanda Lattanzi Giovanni Battista Gasbarrini Antonio Gasbarrini 

作者机构：Department of Internal Medicine and Gastroenterology Università Cattolica del Sacro Cuore Rome Largo A. Gemelli 8 00197 Rome Italy Department of Internal Medicine Gemelli Hospital 00168 Rome Italy Institute of Anatomy and Cell Biology Università Cattolica del Sacro Cuore 00168 Rome Italy Medical Research Foundation ONLUS Galleria Falcone Borsellino 2 40123 Bologna Italy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第29期

页      面：4671-4678页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Intestinal stem cells Organoids Intestinal regeneration Lgr5 Niche 

摘      要：Among somatic stem cells, those residing in the intestine represent a fascinating and poorly explored research field. Particularly, somatic stem cells reside in the small intestine at the level of the crypt base, in a constant balance between self-renewal and differentiation. Aim of the present review is to delve into the mechanisms that regulate the delicate equilibrium through which intestinal stem cells orchestrate intestinal architecture. To this aim, special focus will be addressed to identify the integrating signals from the surrounding niche, supporting a model whereby distinct cell populations facilitate homeostatic vs injury-induced regeneration.