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Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： Zi-Bing Qian Jun-Feng Li wan-Yuan Xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic *** forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver *** general,more than one form of cell death pathways is responsible for the disease ***,it is particularly important to study the regulation and interaction of various cell death forms in liver *** sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver *** also used terms such as signal path,inducer,and inhibitor to supplement the query ***:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver ***:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

Sex-specific strategies of resource utilization and determining mechanisms of Hippophae rhamnoides in response to community succession

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Journal of Plant Ecology 2024年第4期17卷 114-130页

作者： Baoli Fan Pengfei Gao Tingting Tian Nana Ding Yongkuan wan Xianhui Zhou College of Life Science Northwest Normal UniversityLanzhou 730000China Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Lanzhou 730000China College of Ecology Lanzhou UniversityLanzhou 730000China

The dioecious plant,Hippophae rhamnoides,is a pioneer species in community succession on the Qinghai-Tibet Plateau(QTP),plays great roles in various ecosystem ***,the males and females of the species differ both in their morphology and physiology,resulting in a change in the ratio of male to female plants depending on the *** further explore the functional traits critical to this sex-based distinctive response in the alpine grassland,we have surveyed the sex ratios,measured their photosynthetic parameters,height,leaf area and biomass *** results showed that(i)The males had higher Pn,light saturation point,apparent quantum efficiency,A_(max) and lower water-use efficiency(WUE),which exhibited higher utilization efficiency or tolerance to strong light,while the females indicated higher utilization efficiency for low light and *** it showed sex-specific biomass allocation patterns.(ii)*** populations across the successional stages all showed a male-biased sexual allocation,which was closely related to sex-specific WUE,Pn,root biomass/total biomass and root-crown ratio.(iii)The leaf traits of *** changed from higher N_(area),P_(area) and leaf mass per area in the early and late to lower in the middle,which meant they moved their growth strategy from resource rapid acquisition to conservation as the succession progressed.(iv)The increasing soil total phosphorus mostly contributed to regulating the sex bias of populations and variations of traits during the *** results are vital for the management of grassland degradation and restoration due to shrub encroachment on the QTP.

关键词： dioecious sex ratio shrub encroachment functional traits physiological and ecological strategies

Monitoring cellular metabolism of 3T3 upon wild type E. coli infection by mapping NADH with FLIM

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Chinese Optics Letters 2010年第10期8卷 931-933页

作者： Tatyana Buryakina Pin-Tzu Su Vladimir Gukassyan wan-jr.syu Fu-Jen Kao Institute of Biophotonics National Yang-Ming University Institute of Microbiology and Immunology National Yang-Ming University Department of Photonics National Sun Yat-Sen University

Fluorescence lifetime imaging microscopy （FLIM） has gained popularity as a sensitive technique to monitor the functional/conformational states of reduced nicotinamide adenine dinucleotide （NADH）, one of the main compounds of oxidative phosphorylation. In this letter, we apply the technique to characterize the metabolic changes in mouse embryonic fibroblast 3T3 cells upon bacterial infection. A gradual shortening of the decaying time constants in both the short and the long lifetime components of NADH＇s autofluorescence is detected. The ratio of the short and the long lifetime components＇ relative contributions, however, shows a rapid increase, indicating the rise of cellular metabolic activity over the course of infection.

关键词： Amides Cell culture Phosphorylation Tissue

"Defective" mutations of hepatitis D viruses in chronic hepatitis D patients

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World Journal of Gastroenterology 2005年第11期11卷 1658-1662页

作者： Jaw-Ching Wu Sheng-Chieh Hsu Shen-Yung wang Yi-Hsiang Huang I-Jane Sheen Hsuan-Hui Shih wan-jr.syu Institute of Clinical Medicine Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan China Division of Gastroenterology School of Medicine National Yang-Ming University Taipei Taiwan China Institute of Microbiology and Immunology

AIM: To verify whether 'defective' mutations existed in hepatitis D virus (HDV).METHODS: Hepatitis delta antigen (HDAg)-codingsequences were amplified using Pfu DNA polymerases with proof-reading activities from sera of five patients with chronic hepatitis D. Multiple colonies were sequenced for each patient. Pfu analyzed a total of 270 HDV *** representative defective HDV clones were constructed in expression plasmids and transfected into a human hepatoma cell line. Cellular proteins were extracted and analyzed by Western ***: Four of five cases (80%) showed defective HDV genomes in their sera. The percentage of defective genomes was 3.7% (10/270). The majority (90%) of the defective mutations were insertions or deletions that resulted in frameshift and abnormal stop translation of the HDAg. The predicted mutated HDAg ranged from 45amino acids to ＞214 amino acids in length. Various domains of HDAg associated with viral replication or packaging were affected in different HDV isolates. Western blot analysis showed defected HDAg in predicted ***: 'Defective' viruses do exist in chronic HDV infected patients, but represented as minor strains. The clinical significance of the 'defected' HDV needs further study to evaluate.

关键词： Defective virus Hepatitis D virus Hepatitis B virus Polymerase chain reaction Hepatitis delta antigen

维奈克拉联合治疗急性髓系白血病的疗效和预后因素分析

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中国实验血液学杂志 2024年第1期32卷 104-111页

作者：任崇崇张婉婉吴庭恺刘蓓兰州大学第一临床医学院甘肃兰州730000 兰州大学第一医院血液内科甘肃兰州730000

目的:探讨维奈克拉(venetoclax,VEN)联合治疗急性髓系白血病(AML)的疗效和预后因素。方法:回顾性分析2020年3月至2023年4月在兰州大学第一医院接受VEN联合治疗的AML患者的临床资料,观察疗效及生存情况,分析其影响因素并评估安全性。结果... 详细信息

目的:探讨维奈克拉(venetoclax,VEN)联合治疗急性髓系白血病(AML)的疗效和预后因素。方法:回顾性分析2020年3月至2023年4月在兰州大学第一医院接受VEN联合治疗的AML患者的临床资料,观察疗效及生存情况,分析其影响因素并评估安全性。结果:本研究共纳入74例AML患者,其中初治AML 43例,复发难治性AML(R/R AML)31例。43例初治AML患者的中位年龄为65岁,复合完全缓解(cCR)率为67.4%(29/43),客观缓解率(ORR)为72.1%(31/43),中位总生存期(OS)为17.3个月。31例R/R AML患者中位年龄为51岁,cCR率为38.7%(12/31),ORR为58.1%(18/31),中位OS为7.1个月。性别、VEN治疗前血细胞计数、基因突变和预后分层与能否获得cCR有关。未获得cCR是患者死亡的独立危险因素。结论:VEN联合治疗AML安全有效,其疗效和生存受分子生物学、细胞遗传学等因素影响。

关键词：维奈克拉急性髓系白血病疗效生存

Involuntary Unemployment： An Expository Note

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2018年第1期13卷 83-92页

作者： Henry Y. wan jr. Department of Economics Comell University Ithaca NY 14853 USA

This note is an effort to view the research program of Brecher and his co-workers to deploy tax incentives against involuntary unemployment in the broader context; on both the equity-efficiency trade-off in political ... 详细信息

关键词： involuntary unemployment efficiency wage wage rigidity

Shape Selectivity of a Metallo Cavitand Host Allows Separation of n-Alkanes from Isooctane

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Chinese Journal of Chemistry 2021年第6期39卷 1498-1502页

作者： Yun-Hui wan Faiz-Ur Rahman Julius Rebek jr. Yang Yu Center for Supramolecular Chemistry&Catalysis and Department of Chemistry College of ScienceShanghai University99 Shang-Da RoodShanghai 200444China Skaggs Institute for Chemical Biology and Department of Chemistry The Scripps Research Institute10550 North Torrey Pines Roadio JolloCA 92037USA

The use of a metallo cavitand for the selective sequestration of n-alkanes from their mixtures with isooctane is *** experiments and NMR spectroscopy are used to show the preference of a water-soluble cavitand host for guests that are hydro-phobic and have narrow or flat *** host showed selectivity for trans 1,4-dimethylcyclohexane over the *** sep-arations of n-alkanes from isooctane by gas/liquid adsorption and a liquid/liquid extraction are detailed.

关键词： Metallo cavitand Shape selectivity eceptor Alkane separation Host-guest system

骨髓增生异常综合征患者基因突变与临床特征相关性及预后

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中国实验血液学杂志 2024年第1期32卷 176-183页

作者：张婉婉张雅丽任崇崇吴庭恺刘蓓甘肃省兰州大学第一临床医学院兰州大学第一医院血液内科甘肃兰州730000

目的:探索骨髓增生异常综合征(MDS)基因突变与临床特征的相关性及预后分析。方法:收集兰州大学第一医院2015年6月至2023年2月期间131例MDS患者的临床资料,随访期间其中19例进展为继发性急性髓系白血病(sAML)。利用二代测序技术检测MDS... 详细信息

目的:探索骨髓增生异常综合征(MDS)基因突变与临床特征的相关性及预后分析。方法:收集兰州大学第一医院2015年6月至2023年2月期间131例MDS患者的临床资料,随访期间其中19例进展为继发性急性髓系白血病(sAML)。利用二代测序技术检测MDS疾病相关基因突变类型并绘制突变谱,结合患者临床资料分析其之间相关性及预后。结果:131例MDS患者中位年龄58(17-86)岁,男女比例约为1.3∶1。131例中共检测出148个基因突变、25种突变类型,其中U2AF1、ASXL1常与其它基因发生共突变,且分别与20q-和正常核型伴随出现。SETBP1和SRSF2多见于60岁以上患者,NPM1和WT1常见于60岁以下患者,老年患者的基因突变数目多于年轻患者。男性SF3B1和RUNX1基因突变发生率高于女性,女性DNMT3A基因突变发生率高于男性。MDS进展为sAML患者组的基因突变数目高于MDS组(1.8 vs 1.0个,P=0.006)。单因素、多因素分析结果显示,IPSS-R预后评分≥3.5分和TP53是MDS患者预后不良的危险因素。单等位基因TP53突变和野生型TP53患者OS优于双等位基因突变型(P=0.003);未转白患者OS优于sAML患者(P=0.01);移植患者OS明显优于未移植患者(P=0.036)。结论:基因突变与细胞遗传学指标和临床特征(外周血细胞数、性别、年龄)密切相关。IPSS-R预后评分、TP53是影响MDS患者OS的危险因素。

关键词：骨髓增生异常综合征共突变细胞遗传学临床表型预后

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融合韵律特征的诗歌生成模型

计算机工程与应用 2024年第13期60卷 162-170页

作者：吴林东何向真万福成西北民族大学语言与文化计算教育部重点实验室兰州730030

诗歌生成中的韵律规范和主题一致性一直以来都是自然语言生成领域的研究热点。为提升诗歌生成中的韵律规范,提出了基于Transformer结合韵律特征的诗歌生成模型(Transformer and prosodic features poetry generation model,TPPG)。根据... 详细信息

诗歌生成中的韵律规范和主题一致性一直以来都是自然语言生成领域的研究热点。为提升诗歌生成中的韵律规范,提出了基于Transformer结合韵律特征的诗歌生成模型(Transformer and prosodic features poetry generation model,TPPG)。根据韵律特征建立平仄韵律词库和平声韵脚词库,在Transformer编码器中引入平仄韵律编码,模型训练过程中可以捕获更多平仄韵律特征的信息,学习到多种诗歌韵律;最终根据建立的平声韵脚词库规范诗歌生成韵脚,运用极大后验概率对于候选的诗歌选择当前赋有韵律特征规范的最优诗句,整体提升诗歌规范性和流畅性。实验结果表明TPPG模型生成的诗歌能够很好地符合韵律,在人工评价和机器评价中均有提高。

关键词：诗歌生成韵律库韵律编码韵律特征