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Potential roles of vitamin D binding protein in attenuating liver injury in sepsis

Military Medical Research 2022年第5期9卷 543-552页

作者： Kun Xiao Du-Chao Zhang Ye Hu Li-Cheng Song Jian-Qiao Xu wan-xue he Pan Pan Yu-Wei wang Li-Xin Xie Center of Pulmonary and Critical Care Medicine Chinese People's Liberation Army(PLA)General HospitalNo.28Fuxing StreetHaidian DistrictBeijing 100853China Department of Pulmonary and Critical Care Medicine Beijing Shijitan HospitalBeijing 100071China Medical School of Chinese People's Liberation Army(PLA) Chinese PLA General HospitalBeijing 100853China Department of Geriatric Comprehensive Surgery the Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalNo.28Fuxing StreetHaidian DistrictBeijing 100853China

Background:In sepsis,vitamin D binding protein(VDBP)has been shown to be *** current study examined the relationship between serum VDBP level and liver injury in sepsis patients,as well as in a mouse model for sepsis and in cultured liver epithelial cell line exposed to lipopolysaccharide(LPS).Methods:The human study included 78 sepsis patients and 50 healthy *** patients were categorized into sepsis survivor group(n=43)and sepsis non-survivor group(n=35)based on 28-day mortality for data *** male C57BL/6 mice were subjected to cecal ligation and puncture(CLP).Serum samples were collected on day 1,3,5 and 7 to determine the levels of VDBP,25-hydroxyvitamin D[25(OH)D_(3)],1,25-dihydroxyvitamin D[1,25(OH)_(2)D_(3)],interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α).Potential protective effects of VDBP overexpression against LPS-induced liver damage were examined in cultured THLE2 ***:Serum levels of VDBP,25(OH)D_(3),and 1,25(OH)_(2)D_(3)were significantly lower in sepsis patients *** healthy control(Phe sepsis non-survivor group *** sepsis survivor group(Pher Acute Physiology and Chronic health Evaluation(APAChe)II score(r=−0.2565,P=0.0234)and Sequential Organ Failure Assessment score(r=−0.3522,P=0.0016),but lower serum albumin(ALB,r=0.4628,Phere was a 5-day period of serum VDBP reduction,followed by return towards the baseline on day *** was also decreased in LPS-treated THLE2 cells(Phe c-Jun N-terminal kinase signaling ***:VDBP may be protective against sepsis-induced liver injury.

关键词： Vitamin D binding protein Sepsis Human Mouse Liver Injury c-Jun N-terminal kinase

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HPLC测定石榴健胃胶囊中的胡椒碱

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华西药学杂志 2011年第1期26卷 75-76页

作者：万雪荷王芳王进权嘉峪关市药品检验所甘肃嘉峪关735000 东格尔药业有限公司青海西宁810003

目的采用HPLC法测定石榴健胃胶囊中胡椒碱的含量。方法采用Waters C18柱(250 mm×4.6 mm,5μm),流动相为甲醇-0.2%磷酸溶液(70∶30),检测波长343 nm,柱温35℃,流速1.0 ***-1。结果胡椒碱进样量0.865～3.459μg(r=0.9996)与峰面积呈良好... 详细信息

目的采用HPLC法测定石榴健胃胶囊中胡椒碱的含量。方法采用Waters C18柱(250 mm×4.6 mm,5μm),流动相为甲醇-0.2%磷酸溶液(70∶30),检测波长343 nm,柱温35℃,流速1.0 ***-1。结果胡椒碱进样量0.865～3.459μg(r=0.9996)与峰面积呈良好的线性关系,平均回收率为99.47%(n=6)。结论所建方法简便、快速、准确,可用于制剂的质量控制。

关键词：石榴健胃胶囊胡椒碱高效液相色谱法含量测定

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国家队专项器材管理系统的研制与应用

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北京体育大学学报 2006年第2期29卷 145-148页

作者：刘扶民张立薛万和袁俊杰刘畅张春强国家体育总局体育经济司北京100763 国家体育总局体育信息中心北京100061 国家体育总局体育器材装备中心北京100763

为提高国家队专项器材管理效率,依据《国家队专项器材暂行管理办法》,在调研建立国家队专项器材配置标准基础上,利用COM+组件技术,开发研制了“国家队专项器材管理系统”软件,该软件在2004年的试用2、005年的全面推广应用中,取得了较好... 详细信息

为提高国家队专项器材管理效率,依据《国家队专项器材暂行管理办法》,在调研建立国家队专项器材配置标准基础上,利用COM+组件技术,开发研制了“国家队专项器材管理系统”软件,该软件在2004年的试用2、005年的全面推广应用中,取得了较好的效果,基本满足了国家体育总局经济司、16个运动项目管理中心、财务结算和审计中心、体育器材装备中心等部门在国家队专项器材预算、计划、审批、购置等方面的信息化工作需求,首次尝试性实现了国家体育总局系统内基于因特网技术的一站式服务,创新性地实现了多角色同步操作和管理者的实时监控工作局面,有力支持了国家队备战北京奥运会的保障工作。

关键词：管理信息系统运动器材国家队经费因特网

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Transgenic approaches for improving use efficiency of nitrogen, phosphorus and potassium in crops

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Journal of Integrative Agriculture 2017年第12期16卷 2657-2673页

作者： TENG wan he xue TONG Yi-ping State Key Laboratory for Plant Cell and Chromosome Engineering/Institute of Genetics and Developmental Sciences ChineseAcademy of Sciences Beijing 100101 P.R.China

The success of the Green Revolution largely relies on fertilizers, and a new Green Revolution is very much needed to use fertilizers more economically and efficiently, as well as with more environmental responsibility. The use efficiency of nitrogen, phosphorus, and potassium is controlled by complex gene networks that co-ordinate uptake, re-distribution, assimilation, and storage of these nutrients. Great progress has been made in breeding nutrient-efficient crops by molecularly engineering root traits desirable for efficient acquisition of nutrients from soil, transporters for uptake, redistribution and homeostasis of nutrients, and enzymes for efficient assimilation. Regulatory and transcription factors modulating these processes are also valuable in breeding crops with improved nutrient use efficiency and yield performance.

关键词： nutrient use efficiency nitrogen phosphorus potassium transgenic approach crop

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Enhanced inhibition of talc flotation using acidified sodium silicate and sodium carboxymethyl cellulose as the combined inhibitor

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International Journal of Minerals,Metallurgy and Materials 2023年第7期30卷 1310-1319页

作者： Jiwei xue Huazhen Tu Jin Shi Yanni An he wan Xianzhong Bu School of Resources Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Mineral Processing Beijing 100260China Northern Engineering&Technology Corporation Dalian 116600China

The flotation separation of chalcopyrite and talc is challenging due to their similar natural floatability ***,it is usually difficult to effectively inhibit talc by adding sodium carboxymethyl cellulose(CMC)alone during chalcopyrite ***,a combined inhibitor comprising acidified sodium silicate(ASS)and CMC was employed to realize effective flotation separation of chalcopyrite and talc,and the combined inhibition mechanism was further *** results showed that adding ASS strengthened the inhibitory effect of CMC on talc and improved the separation of chalcopyrite and *** zeta potential,Fourier transform infrared,and X-ray photoelectron spectroscopy analysis indicated that CMC was mainly adsorbed on the talc surface via hydroxyl and carboxyl ***,the addition of ASS improved the adsorption of carboxyl ***,the adsorption experiments and apparent viscosity measurements revealed that adding ASS dispersed the pulp well,which reduced the apparent viscosity,improved the adsorption amount of CMC on the talc surface,and enhanced the inhibition of talc in chalcopyrite flotation.

关键词： talc chalcopyrite flotation combined inhibitor apparent viscosity

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国家队专用器材配置现状及管理对策研究

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中国体育科技 2006年第3期42卷 137-139,143页

作者：刘扶民张立薛万和张春强刘畅袁俊杰李益群国家体育总局体育经济司北京100763 国家体育总局体育信息中心北京100061 国家体育总局体育器材装备中心北京100763 国家体育总局体育科学研究所北京100061

为搞好2008年奥运国家队专项器材配置、投入管理工作,通过全面深入14个运动项目管理中心、95支国家运动队组,运用实地走访、问卷调查、文献分析、数量统计等方法,研究了国家队专项器材的配置现状、结构,科学设计了国家队基本配置量和配... 详细信息

为搞好2008年奥运国家队专项器材配置、投入管理工作,通过全面深入14个运动项目管理中心、95支国家运动队组,运用实地走访、问卷调查、文献分析、数量统计等方法,研究了国家队专项器材的配置现状、结构,科学设计了国家队基本配置量和配置定额,为国家体育总局向财政部申报备战2008年北京奥运器材专项预算、制定安排年度器材配置经费提供参考依据。同时,所研究起草的《国家队专项器材暂行管理办法》以及据此开发的“国家队专项器材管理信息系统”,为科学申报、采购、管理国家队专项器材提供了有效手段。该项目成果在改变申报、审批、购置国家队专项器材的盲目性,防止国有资产流失等方面发挥了一定的作用,也为运动队了解存量、更新安排使用计划提供了方便,而一站式快速网络服务则较好地发挥了信息化的效率作用。

关键词：国家队器材配置管理经费预算信息系统

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Mechanical properties of dredged soil reinforced by xanthan gum and fibers

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第8期15卷 2147-2157页

作者： Dianzhi Feng Bing Liang Xingxing he Fu Yi Jianfei xue Yong wan Qiang xue School of Mechanics and Engineering Liaoning Technical UniversityFuxin123000China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing100084China

Biopolymers have become popular in geotechnical engineering as they provide a carbon-neutral alternative for soil *** gum(XG)and jute fiber(JF)were selected to solidify the Yellow River dredged *** mechanical behavior of solidified dredged soil(SDS)was investigated using a series of uniaxial compression and splitting tension tests at different XG and JF contents and fiber *** results indicate that on the 28th day,the unconfined compressive strength(UCS)values of SDS samples reached 2.83 MPa and splitting tensile strength(STS)of 0.763 MPa at an XG content of 1.5%.When the JF content was greater than 0.9%,the STS of the SDS samples *** is because that the large fiber content weakened the cementation ability of *** addition of JF can significantly increase the strain at peak strength of SDS *** is a linear relationship between the UCS and STS of the dredged soils solidified by XG and *** shows that the strength of SDS samples was improved mainly via the cementation of XG itself and the network structure formed by JF with soil *** dredged soil reinforced by XG and JF shows better mechanical performance and has great potential for application.

关键词： Solidified dredged soil(SDS) Xanthan gum(XG) Jute fiber(JF) Mechanical properties

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An easy route to exotic 9-epimers of 9-amino-(9-deoxy) cinchona alkaloids with(8S,9R) and(8R,9S)-configurations through two inversions of configuration

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Chinese Chemical Letters 2014年第4期25卷 557-560页

作者： Jing-Wei wan xue-Bing Ma Rong-Xing he Ming Li College of Chemistry and Chemical Engineering Southwest University

Four exotic chiral organocatalysts, 9-amino-（9-deoxy） cinchona alkaloids with （8S, 9R） and （8R, 9S）- configurations, were conveniently synthesized for the first time in 27-72% total yields through two conversion... 详细信息

关键词： Cinchona alkaloids 9-Amino-(9-deoxy) cinchona alkaloids Synthesis Inversion of configuration

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Secondary electron yield of air-exposed ALD-Al_(2)O_(3) coating on Ag-plated aluminum alloy

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Chinese Physics B 2024年第11期33卷 265-271页

作者： xue-Man wan Tian-Cun Hu Jing Yang Na Zhang Yun he wan-Zhao Cui National Key Laboratory of Science and Technology on Space Microwave China Academy of Space Technology (Xi'an)Xi'an 710100China

Secondary electron yield(SEY)of air-exposed metals tends to be increased because of air-formed oxide,hydrocarbon,and other *** enhances the possibility of secondary electron multipacting in high-power microwave systems,resulting in undesirable occurrence of discharge ***_(2)O_(3) coatings have been utilized as passive and protective layers on device packages to provide good environmental *** employed atomic layer deposition(ALD)to produce a series of uniform Al_(2)O_(3) coatings with appropriate thickness on Ag-plated aluminum *** secondary electron emission characteristics and their variations during air exposure were *** escape depth of secondary electron needs to exceed the coating thickness to some extent in order to demonstrate SEY of metallic *** on experimental and calculated results,the maximum SEY of Ag-plated aluminum alloy had been maintained at 2.45 over 90 days of exposure without obvious degradation by applying 1 nm Al_(2)O_(3) *** comparison,the peak SEY of untreated Ag-plated aluminum alloy grew from an initial 2.33 to 2.53,exceeding that of the 1 nm Al_(2)O_(3) *** ultra-thin ALDAl_(2)O_(3) coating substantially enhanced the SEY stability of metal materials,with good implications for the environmental dependability of spacecraft microwave components.

关键词： secondary electron yield(SEY) atomic layer deposition air exposure multipactor

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Atmospheric Particulate Matter 2.5(PM_(2.5))Induces Cell Damage and Pruritus in Human Skin

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Biomedical and Environmental Sciences 2024年第2期37卷 216-220页

作者： he Qiao xue wan Ting LI Li YI Fan LING Xiao GUO Miao Miao College of Chemistry and Materials Engineering Beijing Technology and Business UniversityBeijing 100048China China Light Industry Cosmetics Key Laboratory Beijing Technology and Business UniversityBeijing 100048China Beijing Lan Divine Technology Co.LTD Beijing 100872China

With the accelerated rate of urbanization in recent years,air pollution has become an environmental problem that requires urgent resolution,almost all of the world’s population exposed to pollution on a daily *** the... 详细信息

关键词： pollution Skin Human

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