检索结果-南通市图书馆

N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2/MYC axis

Genes & Diseases 2023年第2期10卷 554-567页

作者： wan-xin peng Fei Liu Jia-Hong Jiang Hang Yuan Ziqiang Zhang Liu Yang Yin-Yuan Mo Department of Surgical Oncology The Children's HospitalZhejiang University School of MedicineNational Research Center for Child HealthHangzhouZhejiang 310052China Cancer Center and Research Institute University of Mississippi Medical CenterJacksonMS 39216USA Department of Nephrology The Children's HospitalZhejiang University School of MedicineNational Research Center for Child HealthHangzhouZhejiang 310052China Department of Medical Oncology Zhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical CollegeHangzhouZhejiang 310014China Department of Colorectal Surgery Zhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical CollegeHangzhouZhejiang 310014China Department of Pulmonary Medicine Tongji HospitalTongji UniversityShanghai 200065China Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province Zhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical CollegeHangzhouZhejiang 310014China Department of Pharmacology/Toxicology University of Mississippi Medical CenterJacksonMS 39216USA

Accumulating evidence indicates that RNA methylation at N6-methyladenosine(m6A)plays an important regulatory role in gene expression and aberrant mRNA m6A modification is often associated with a variety of ***,little is known whether and how m6A-modification impacts long non-coding RNA(lncRNA)and lncRNA-mediated tumorigenesis,particularly in pancreatic ductal adenocarcinoma(PDAC).In the present study,we report that a previously uncharacterized lncRNA,LINC00901,promotes pancreatic cancer cell growth and invasion and moreover,LINC00901 is subject to m6A modification which regulates its *** this regard,YTHDF1 serves as a reader for the m6A modified LINC00901 and downregulates the LINC00901 ***,two conserved m6A sites in LINC00901 are critical to the recognition of LINC00901 by ***,RNA sequencing(RNA-seq)and gene function analysis revealed that LINC00901 positively regulates MYC through upregulation of IGF2BP2,a known RNA binding protein that can enhance MYC mRNA ***,our results suggest that there is a LINC00901-IGF2BP2-MYC axis through which LINC00901 promotes PDAC progression in an m6A dependent manner.

关键词： IGF2BP2 LINC00901 MYC N6-methyladenosine modification(m6A) PDAC YTHDF1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Corrigendum to“N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2/MYC axis”[Genes&Diseases 10(2023)554–567]

引用

Genes & Diseases 2024年第6期11卷 541-542页

[This corrects the article DOI: 10.1016/***.2022.02.014.].

关键词：

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children:analysis of 571 patients

引用

World Journal of Pediatrics 2024年第3期20卷 250-258页

作者： Min He Jia-Bin Cai Xuan Wu Yin-Bing Tang Jin-Yan wang Jun-Qin Mao Ji-Jun Chen Li-Feng Zhang Zhong-Hai Guan Jie-Ni Xiong wan-xin peng Jin-Hu wang Ting Tao Pediatric Cancer Research Center National Clinical Research Center for Child HealthHangzhouChina Department of Surgical Oncology Children's HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityNo.3333 Binsheng RodeHangzhouChina

Background Surgery plays an important role in the treatment of *** complications may impact the course of neuroblastoma *** date,comprehensive analyses of complications and risk factors have been *** Patients with retroperitoneal neuroblastoma undergoing tumor resection were retrospectively analyzed between 2014 and *** data collected included clinical characteristics,operative details,operative complications and postopera-tive *** factors for perioperative complications of retroperitoneal neuroblastoma were *** A total of 571 patients were enrolled in this *** complications were observed in 255(44.7%)*** leakage(28.4%),diarrhea(13.5%),and injury(vascular,nerve and organ;7.5%)were the most frequent *** were three operation-related deaths(0.53%):massive hemorrhage(n=1),biliary tract perforation(n=1)and intestinal necrosis(n=1).The presence of image-defined risk factors(IDRFs)[odds ratio(OR)=2.09,P<0.01],high stage of the International Neuroblastoma Risk Group staging system(INRGSS)(OR=0.454,P=0.04),retroperitoneal lymph node metastasis(OR=2.433,P=0.026),superior mesenteric artery encasement(OR=3.346,P=0.003),and inferior mesenteric artery encasement(OR=2.218,P=0.019)were identified as independent risk factors for perioperative *** Despite the high incidence of perioperative complications,the associated mortality rate was quite ***-perative complications of retroperitoneal neuroblastoma were associated with IDRFs,INRGSS,retroperitoneal lymph node metastasis and vascular *** with high-risk factors should receive more serious attention during surgery but should not discourage the determination to pursue total resection of neuroblastoma.

关键词： Complication Neuroblastoma Risk factors Surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

引用

Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da wan Shuwei Tang Shulin Bai Xiaodong Li peng Ai wanrong Guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

引用

Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan wan wang Bin wang Ju-Yun Ma peng-peng Li Hai-Wei Pu xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

引用

Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo Feng Chongbo Liu xin Li Guangsheng Luo Naixin Zhai Ruizhe Hu Jing Lin Jinbin peng Yuhui peng Renchao Che Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Early Growth Response 1(Egr-1)Gene can Protect Microtubules from Disassembly:A Function Not Related with Its Transcriptional Factor Characteristics

The Early Growth Response 1(Egr-1)Gene can Protect Microtubu...

引用

中国细胞生物学学会第九次会员代表大会暨青年学术大会

作者： wan-xin peng Yi-Qian wang Xiao-Jin Liu Yan Qian Jun Yuan Chao-Jun Li (Key Laboratory of Molecular and Medical Biotechnology,Life Sciences College Nanjing Normal University,Nanjing 210046,China)

Oxygen deprivation can cause aberrant modifications of signaling pathways and their downstream transcrip- tion *** hypoxia-sensitive mammalian transcription factors have been described,including hypoxia- inducible transcription factor-1(HIF-1), nuclear factor κB(NF-κB),c-Fos and c-Jun(AP-1)and *** early growth response 1(Egr-1)gene is a transcription factor that acts as both tumor suppressor and tumor ***

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

甘肃省非公有制经济发展中的制度性问题探析

引用

科学．经济．社会 2008年第2期26卷 6-10页

作者：辛万鹏吕志祥李振宇兰州理工大学人文学院甘肃兰州730050

非公有制经济因其产权明晰而具有的原发创造力、极强的渗透力和高度的灵活性,为中国经济的发展增添了无穷的活力。事实表明,非公有制经济的发展状况显示了一个省份经济发展的活跃程度,甘肃省经济发展落后的原因之一就在于非公有制经济... 详细信息

非公有制经济因其产权明晰而具有的原发创造力、极强的渗透力和高度的灵活性,为中国经济的发展增添了无穷的活力。事实表明,非公有制经济的发展状况显示了一个省份经济发展的活跃程度,甘肃省经济发展落后的原因之一就在于非公有制经济没有发展起来。甘肃省的非公有制经济为何发展滞后?又如何发展?本文试图从制度的层面予以探讨。

关键词：甘肃省非公有制经济软环境制度创新

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

One-step synthesis of FeO(OH)nanoparticles by electric explosion of iron wire underwater

引用

Defence Technology（防务技术） 2022年第1期18卷 133-139页

作者： Hao Yin xin Gao peng-wan Chen Insitute of Systems Engineering China Acaderry of Engineering PhysicsMianyang.Sichuan 612900.China State Key Laboratory of Explosion Science and Technology Beijing Ins titute of Technology Beijing100081.China

In this study,we investigated electric explosion of iron wire in distilled water with different energy input adjusted by charging *** as-prepared samples were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM)and X-ray photoelectron spectroscopy(XPS),showing the presence of iron and multiple iron-based compounds oxides with contents influenced by the experimental *** particular,pure FeO(OH)nanoparticles were obtained using electric explosion of iron wire with energy input of 1125 J at charging voltage of 15 *** of discharge current and resistive voltage data indicate that the high energy input induced bystrong plasma discharge at high charging voltage is a key factor to form FeO(OH).This study presents a one-step method to synthesize FeO(OH)nanoparticles using electric explosion of iron wire.

关键词： Electric wire explosion Plasma tunnel Nanopartides FeO(OH)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental and numerical investigations of interface properties of Ti6Al4V/CP-Ti/Copper composite plate prepared by explosive welding

引用

Defence Technology（防务技术） 2021年第5期17卷 1592-1601页

作者： Yasir Mahmood peng-wan Chen I.A.Bataev xin Gao State Key Lab of Explosion Science and Technology Beijing Institute of Technology100081PR China Novosibirsk State Technical University K.Marks 20630073NovosibirskRussia

Explosive welding technique is widely used in many *** technique is useful to weld different kinds of metal alloys that are not easily welded by any other welding *** plays an important role to improve the welding quality and control energy loss during the collision *** this paper,the Ti6Al4V plate was welded with a copper plate in the presence of a commercially pure titanium *** details of welded composite plate were observed through optical and scanning electron ***-base plate interface morphology showed a wavy structure with solid melted regions inside the ***,the energy dispersive spectroscopy analysis in the interlayer-base interface reveals that there are some identified regions of different kinds of chemical equilibrium phases of CueTi,***,Cu_(2)Ti,CuTi_(2),Cu_(4)Ti,*** study the mechanical properties of composite plates,mechanical tests were conducted,including the tensile test,bending test,shear test and Vickers hardness *** simulation of explosive welding process was performed with coupled Smooth Particle Hydrodynamic method,Euler and Arbitrary Lagrangian-Eulerian *** multi-physics process of explosive welding,including detonation,jetting and interface morphology,was observed with ***,simulated plastic strain,temperature and pressure profiles were analysed to understand the welding *** results show that the interlayer base plate interface was created due to the high plastic deformation and localized melting of the parent *** the collision point,both alloys behave like fluids,resulting in the formation of a wavy morphology with vortices,which is in good agreement with the experimental results.

关键词： Explosive welding Ti6Al4V/CP-Ti/Cu Smooth particle hydrodynamic(SPH) Microstructure Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：