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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De zhang Jie Chen Hai-Di Fan wan wang Bin wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Cosmological constraints on the Undulant Universe

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Research in Astronomy and Astrophysics 2010年第11期10卷 1109-1118页

作者： Tian Lan Yan Gong Hao-Yi wan tong-Jie zhang Department of Astronomy Beijing Normal University Beijing 100875 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Business Office Beijing Planetarium Beijing 100044 China Center for High Energy Physics Peking University Beijing 100871 China

We use the redshift Hubble parameter H（z） data derived from relative galaxy ages, distant type Ia supernovae （SNe Ia）, the Baryonic Acoustic Oscillation （BAO） peak, and the Cosmic Microwave Background （CMB） shift parameter data, to constrain cosmological parameters in the Undulant Universe. We marginalize the like- lihood functions over h by integrating the probability density 19 ∝ e-x^2/2. By using a Markov Chain Monte Carlo （MCMC） technique, we obtain the best fitting results and give the confidence regions in the b - Ωm0 plane. Then we compare their constraints. Our results show that the H（z） data play a similar role with the SNe Ia data in cosmological study. By presenting the independent and joint constraints, we find that the BAO and CMB data play very important roles in breaking the degeneracy compared with the H（z） and SNe Ia data alone. Combined with the BAO or CMB data, one can remarkably improve the constraints. The SNe Ia data sets constrain Ωm0 much tighter than the H（z） data sets, but the H（z） data sets constrain b much tighter than the SNe Ia data sets. All these results show that the Undulant Universe approaches the ACDM model. We expect more H（z） data to constrain cosmological parameters in the future.

关键词： cosmology observations - dark matter

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BIFURCATION AND SPATIOTEMPORAL PATTERNS IN A HOMOGENEOUS DIFFUSION-COMPETITION SYSTEM WITH DELAYS

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International Journal of Biomathematics 2012年第6期5卷 19-41页

作者： JIA-FANG zhang wan-tong LI XIANG-PING YAN School of Mathematics and Information Sciences Henan University Kaifeng Henan 575001 P. R. China School of Mathematics and StatisticsLanzhou University Lanzhou Gansu 730000 P. R. China Department of MathematicsLanzhou Jiaotong University Lanzhou Gansu 730070 P. R. China

A competitive LotkaVolterra reactiondiffusion system with two delays subject to Neumann boundary conditions is considered. It is well known that the positive con stant steady state of the system is globally asymptotically stable if the interspecies competition is weaker than the intraspecies one and is unstable if the interspecies com petition dominates over the intraspecies one. If the latter holds, then we show that Hopf bifurcation can occur as the parameters （delays） in the system cross some critical val ues. In particular, we prove that these Hopf bifurcations are all spatially homogeneous if the diffusive rates are suitably large, which has the same properties as Hopf bifur cation of the corresponding delayed system without diffusion. However, if the diffusive rates are suitably small, then the system generates the spatially nonhomogeneous Hopf bifurcation. Furthermore, we derive conditions for determining the direction of spatially nonhomogeneous Hopf bifurcations and the stability of bifurcating periodic solutions. These results indicate that the diffusion plays an important role for deriving the complex spatiotemporal dynamics.

关键词： LotKa-Volterra competition system time delay spatial diffusion Hopf bifur-cation periodic solution.

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Entire Solutions for Nonlocal Dispersal Equations with Bistable Nonlinearity: Asymmetric Case

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Acta Mathematica Sinica,English Series 2019年第11期35卷 1771-1794页

作者： Li zhang wan tong LI Zhi Cheng wanG Yu Juan SUN School of Science Chang’an UniversityXi’an 710064P.R.China School of Mathematics and Statistics Lanzhou UniversityLanzhou 730000P.R.China ISN Laboratory Xidian UniversityXi’an 710071P.R.China

This paper mainly focuses on the entire solutions of a nonlocal dispersal equation with asymmetric kernel and bistable nonlinearity. Compared with symmetric case, the asymmetry of the dispersal kernel function makes more diverse types of entire solutions since it can affect the sign of the wave speeds and the symmetry of the corresponding nonincreasing and nondecreasing traveling *** divide the bistable case into two monostable cases by restricting the range of the variable, and obtain some merging-front entire solutions which behave as the coupling of monostable and bistable waves. Before this, we characterize the classification of the wave speeds so that the entire solutions can be constructed more clearly. Especially, we investigate the influence of the asymmetry of the kernel on the minimal and maximal wave speeds.

关键词： Entire solution traveling wave solution nonlocal dispersal asymmetry

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Production of functional sperm from in vitro-cultured premeiotic spermatogonia in a marine fish

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Zoological Research 2022年第4期43卷 537-551页

作者： Hong zhang wan-wan zhang Cheng-Yu Mo Meng-Dan Dong Kun-tong Jia Wei Liu Mei-Sheng Yi School of Marine Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiGuangdong 519000China Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering GuangzhouGuangdong 510000China

In vitro production of functional gametes can revolutionize reproduction by reducing generation intervals and accelerating genetic breeding in aquaculture,especially in fish with relatively long ***,functional sperm production from in vitro-cultured spermatogonia remains a challenge in most aquaculture *** this study,we isolated and characterized premeiotic spermatogonia from marine four-eyed sleepers(Bostrychus sinensis),which are prone to ovotesticular or sterile testicular development,and induced the differentiation of the spermatogonia into flagellated sperm in a three-dimensional(3D)culture *** insemination indicated that the in vitro-derived sperm were capable of fertilizing mature oocytes to develop into normal ***,melatonin significantly promoted spermatogonia proliferation and differentiation through the ERK1/2 signaling pathway,and thus increased the efficiency in functional sperm *** 3D culture system and resulting functional sperm hold great promise for improving the genetic breeding of aquaculture fish.

关键词： In vitro spermatogenesis 3D culture model Spermatogonia Four-eyed sleeper Melatonin Genetic breeding

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Synthetic Features and Mechanism for the Preparation of Vinyl Chloride-co-Butyl Acrylate-co-Vinyl Acetate Terpolymer via Precipitation Polymerization

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Chinese Journal of Polymer Science 2023年第11期41卷 1714-1724,I0006页

作者： Chang-tong Song Xian-Hong zhang Dong Chen Yu-Hong Ma wan-Tai Yang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China College of Material Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China

Without any type of su rfactant or dispersing agent,precipitation polymerization has great superiorities in both polymer synthesis and *** the present work,the polymerization of vinyl chloride(VC),n-butyl acrylate(BA),and vinyl acetate(VAc)are conducted in the precipitation polymerization system and series of their random terpolymers poly(vinyl chloride-co-n-butyl acrylate-co-vinyl acetate)(PCBV)are synthesized *** effects of various polymerization conditions,including solvent polarity,temperature,initiator concentration,and monomer feed ratios on the polymerization kinetics,number-average molecular weight(M_(n)),and terpolymer composition are investigated *** solvent and the monomer feed ratio are crucial factors not only for the polymer morphology,but also for the reaction *** the non-polar solvent such as n-hexane,the PCBV displays particle morphology when the composition of BA ratio lower than 10 wt%.Otherwise,the PCBV forms a uniform polymer phase and precipitates out from the *** the polar solvent,e.g.,dimethyl carbonate(DMC)and ethanol,the PCBV polymer maintains a slurry state either in low or in high monomer feed ***,VC based ternary copolymer that obtained in n-hexane has much lower M_(n)(40 wt%)compared with emulsion and suspension ***,the terpolymer can be easily sepa rated by simple centrifugation.

关键词： Precipitation polymerization Copolymerization Vinyl chloride Low molecular weight

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High-efficiency preparation of multifunctional conjugated electrospun graphene doped PVDF/CF yarns for energy harvesting and human movement monitoring in TENG textile

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Nano Research 2024年第5期17卷 4478-4488页

作者： Ting Yang Chengwei wan Xiaoyu zhang tong Liu Li Niu Jian Fang Yuqing Liu College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China

Portable power is an effective solution to realize self-powered sensors for wearable devices,promoting future sustainable ***-based triboelectric nanogenerators(M-TENGs)have emerged as a promising technology for harvesting biomechanical energy from human motion owing to their advantages,such as simple structure,lightweight design,and efficient energy ***,the poor durability,low adaptability,and un-washability of two-dimensional membrane materials have largely hindered their application in wearable *** this study,we propose a sheath-core polyvinylidene fluoride(PVDF)/graphene(G)-carbon fiber(CF)yarn fabricated via conjugate electrospinning,comprising a commercial CF core and an electrospun graphene-doped PVDF sheath,which improves the fatigue resistance of electrospun nanofiber films under prolonged friction and keeps a high degree of *** resulting electronic textile,woven with the large-scale electrospun PVDF/G-CF yarn,demonstrates a remarkable power density of 25.5 mW·m^(-2).The tight distribution of PVDF/G nanofibers on the textile surface ensures excellent softness,washability,and ***,the electrospun PVDF/G-CF textile exhibits significant potential in pressure sensing,self-powered operation,and motion detection,making it highly suitable for wearable electronics applications.

关键词： yarn-based triboelectric nanogenerator(TENG) graphene polyvinylidene fluoride(PVDF) conjugated-electrospinning multifunctional

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Influence on Cellular Signal Transduction Pathway in Dairy Cow Mammary Gland Epithelial Cells by Galactopoietic Compound Isolated from Vaccariae segetalis

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Agricultural Sciences in China 2011年第4期10卷 619-630页

作者： wan Zhong-ying tong Hui-li LI Qing-zhang GAO Xue-jun Key Laboratory of Dairy Science Ministry of Education~Northeast Agricultural University Harbin 150030 P.R.China

The galactopoietic mechanism of Vaccaria segetalis is still unknown. Understanding dibutyl phthalate （DBP） separated from Vaccaria segetalis on the expression of lactation signal transduction genes of mammary gland epithelial cells, including prlr, erα, akt1, socs2, pparγ and elf5, will be helpful to reveal the molecular mechanism. Western blot and qRT- PCR were used to study the change of prlr, erα, akt, socs2, pparγ, and elf5 expression at mRNA and protein level. Co- localization expression of prolactin receptor （PRLR） and estrogen receptor α （ERα） was observed by immunofluorescence; the expression changes of miRNAs （21, 125b, 143, and 195） and the secretion of β-casein and lactose were detected by qRT-PCR and RP-HPLC. The results showed that Vaccaria segetalis active compound had similar fuctions as estrogen and/or prolactin （PRL） in dairy cow mammary gland epithelial cells （DCMECs）, increased the expressions of prlr, erα, akt1, and elf5 genes, while repressed pparγ expressions. DBP promoted socs2 mRNA expression, but its protein expressions were repressed. Furthermore, both DBP and PRL could repress the expressions of miRNA-125b, miRNA-143 and miRNA- 195 in DCMECs. DBP could repress the expression of miRNA-21, while the influence of PRL on miRNA-21 was not certain. DBP could promote the lactation ability of DCMECs by regulating the ER and PRLR cellular signal transduction pathway.

关键词： Vaccaria segetalis DBP dairy cow mammary gland epithelial cells signal transduction miRNAs

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Concept of scientific wildlife conservation and its dissemination

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Zoological Research 2016年第5期37卷 270-274页

作者： Xue-Hong ZHOU Xiao-tong wan Yu-Hui JIN Wei zhang College of Wildlife Resources Northeast Forestry University

In recent years, wildlife conservation has attracted great public attention. However, substantial distinctions can be found in the prevailing concepts of wildlife conservation, particularly with the recent notion that emphasizes animal rights. Wildlife welfare and wildlife rights are not synonymous, with welfare more compatible with the reasonable and legal utilization of wildlife. The key to scientific wildlife conservation is the appropriate awareness and appreciation of the relationship between wildlife conservation and utilization and the theoretical basis of holism. Nevertheless, rational biases regarding the public＇s understanding of wildlife conservation and the spread of information via social media still exist. As such, expansion of the concept of scientific wildlife conservation requires the application of several measures. Wildlife conservation researchers should be regarded as the most important disseminators of scientifically-based information, with education in schools and universities of growing importance. Furthermore, the media should shoulder the social responsibility for the accurate dissemination of conservation information.

关键词： Wildlife conservation scientific concept Media Dissemination.

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Positive Solutions for Second-Order m-Point Boundary Value Problems on Time Scales

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1797-1804页

作者： wan tong LI Hong Rui SUN School of Mathematics and Statistics Lanzhou University Lanzhou 730000 P. R. China

Let T be a time scale such that 0, T ∈ T. By means of the Schauder fixed point theorem and analysis method, we establish some existence criteria for positive solutions of the m-point boundary value problem on time scales where α ∈ Ctd（（O,T,[0,∞））,f∈ Ckd（[0,∞）×[0,∞））,β,γ ∈[0,∞）,ξi ∈（0,p（T）.b,ai∈ （0,∞）（for i = 1,..., m - 2） are given constants satisfying some suitable hypotheses. We show that this problem has at least one positive solution for sufficiently small b 〉 0 and no solution for sufficiently large b. Our results are new even for the corresponding differential equation （T = R） and difference equation （T = Z）.

关键词： time scales positive solution Schauder fixed point theorem

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