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Pollen and Resource Limitation in Veratrum nigrum L. （Liliaceae）, an Andromonoecious Herb

Journal of Integrative Plant Biology 2006年第12期48卷 1401-1408页

作者： wan-Jin liao qing-Fa Song Da-Yong Zhang Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering and Institute of Ecology Beijing Normal University Beijing 100875 China

Pollen limitation and resource limitation were invoked to account for the pattern that flowering plants produce more flowers and ovules than fruits and seeds. This study aimed to determine their relative importance in Veratrum nigrum, a self-compatible, perennial, andromonoecious herb. In order to determine whether female production was limited by pollen grains on stigmas or by available resources, we performed supplemental hand pollination in three populations, male-flower-bud removal in three other populations, and emasculation of hermaphroditic flowers in still another population, resulting in a total of seven populations experimentally manipulated. Across the three populations, supplemental hand pollination did not significantly increase fruit set, seed number per fruit, and total seed production per individual, nor did emasculation of hermaphroditic flowers. Taken together, our results suggest that pollen grains deposited on stigmas were abundant enough to fertilize all the ovules. Male-flower-bud removal significantly increased the mean size of hermaphroditic flowers in all three populations. Female reproductive success was increased in one population, but not in the other two populations possibly due to heavy flower/seed predation. We concluded that the female reproductive success of V. nigrum was not limited by pollen grains but by available resources, which is consistent with Bateman＇s principle. Furthermore, the female reproduction increase of male-flower-bud removal individuals might suggest a trade-off between male and female sexual functions.

关键词： andromonoecy pollen limitation resource limitation trade-off Veratrum nigrum

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XB130 inhibits healing of diabetic skin ulcers through the PI3K/Akt signalling pathway

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World Journal of Diabetes 2023年第9期14卷 1369-1384页

作者： Xin-Lin Zhu Dong-Ying Hu Zhao-Xiang Zeng Wei-Wei Jiang Tian-Yang Chen Tian-Cheng Chen wan-qing liao Wen-Zhi Lei Wen-Jie Fang Wei-Hua Pan Department of Dermatology Shanghai Key Laboratory of Medical MycologyChangzheng HospitalNaval Medical UniversityShanghai 200003China Department of Vascular Surgery Department of Vascular SurgeryChanghai HospitalNavy Medical UniversityShanghai 20003China

BACKGROUND Diabetic skin ulcers,a significant global healthcare burden,are mainly caused by the inhibition of cell proliferation and impaired ***130 is an adaptor protein that regulates cell proliferation and ***,the role of XB130 in the development of diabetic skin ulcers remains *** To investigate whether XB130 can regulate the inhibition of proliferation and vascular damage induced by high ***,we aim to determine whether XB130 is involved in the healing process of diabetic skin ulcers,along with its molecular *** We conducted RNA-sequencing analysis to identify the key genes involved in diabetic skin *** investigated the effects of XB130 on wound healing using histological *** addition,we used reverse transcription-quantitative polymerase chain reaction,Western blot,terminal deoxynucleotidyl transferasemediated dUTP nick end labeling staining,immunofluorescence,wound healing,and tubule formation experiments to investigate their effects on cellular processes in human umbilical vein endothelial cells(HUVECs)stimulated with high ***,we performed functional analysis to elucidate the molecular mechanisms underlying diabetic skin *** RNA-sequencing analysis showed that the expression of XB130 was up-regulated in the tissues of diabetic skin *** of XB130 promoted the healing of skin wounds in mice,leading to an accelerated wound healing process and shortened wound healing *** the cellular level,knockdown of XB130 alleviated high glucose-induced inhibition of cell proliferation and angiogenic impairment in *** of the PI3K/Akt pathway removed the proliferative effects and endothelial protection mediated by *** The findings of this study indicated that the expression of XB130 is up-regulated in high glucose-stimulated diabetic skin ulcers and *** of XB130 promotes cell proliferation and angiogenesis via the PI3K/Akt

关键词： XB130 Diabetes mellitus Diabetic skin ulcers PI3K/Akt signalling pathway

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X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway

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World Journal of Diabetes 2024年第6期15卷 1299-1316页

作者： Ming-Wei Du Xin-Lin Zhu Dong-Xing Zhang Xian-Zhen Chen Li-Hua Yang Jin-Zhou Xiao Wen-Jie Fang Xiao-Chun Xue Wei-Hua Pan wan-qing liao Tao Yang Institute of Cardiovascular Disease Shanghai Key Laboratory of Traditional Chinese Clinical MedicineShanghai University of Traditional Chinese MedicineShanghai 200120China Department of Dermatology Shanghai Key Laboratory of Molecular Medical MycologySecond Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Dermatology Dongshan HospitalMeizhou 514000Guangdong ProvinceChina Department of Dermatology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina Department of Emergency Naval Hospital of Eastern TheaterZhoushan 316000Zhejiang ProvinceChina Department of Pharmacy 905th Hospital of People’s Liberation Army of China(PLA)NavyShanghai 200052China

BACKGROUND Diabetic foot ulcers(DFU),as severe complications of diabetes mellitus(DM),significantly compromise patient health and carry risks of amputation and *** To offer new insights into the occurrence and development of DFU,focusing on the therapeutic mechanisms of X-Paste(XP)of wound healing in diabetic *** Employing traditional Chinese medicine ointment preparation methods,XP combines various medicinal ***-performance liquid chromatography(HPLC)identified XP’s main *** streptozotocin(STZ)-induced diabetic,we aimed to investigate whether XP participated in the process of diabetic wound ***-sequencing analyzed gene expression differences between XP-treated and control *** docking clarified XP’s treatment mechanisms for diabetic wound *** umbilical vein endothelial cells(HUVECs)were used to investigate the effects of Andrographolide(Andro)on cell viability,reactive oxygen species generation,apoptosis,proliferation,and metastasis in vitro following exposure to high glucose(HG),while NF-E2-related factor-2(Nrf2)knockdown elucidated Andro’s molecular *** XP notably enhanced wound healing in mice,expediting the healing ***-sequencing revealed Nrf2 upregulation in DM tissues following XP *** identified 21 primary XP components,with Andro exhibiting strong Nrf2 *** mitigated HG-induced HUVECs proliferation,metastasis,angiogenic injury,and inflammation *** alleviates HG-induced HUVECs damage through Nrf2/HO-1 pathway activation,with Nrf2 knockdown reducing Andro’s proliferative and endothelial protective *** XP significantly promotes wound healing in STZ-induced diabetic *** XP’s key component,Andro activates the Nrf2/HO-1 signaling pathway,enhancing cell proliferation,tubule formation,and inflammation reduction.

关键词： Words:Diabetes mellitus Wound healing NF-E2-related factor-2/HO-1 signaling pathway Andrographolide

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Dual roles of Annexin A2 on Host Blood-Brain-Barrier Invasion caused by Cryptococcus neoformans

Dual roles of Annexin A2 on Host Blood-Brain-Barrier Invasio...

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2016全国中西医结合皮肤性病学术年会

作者： Wei Fang Zhenzong Fa Junlin Gu Jiu Yi Chao Zhang Junjun Sang wan-qing liao Shanghai Key Laboratory of Molecular Medical Mycology Shanghai Institute of Medical MycologySecond Military Medical University PLA Key Laboratory of Mycosis Department of Dermatology and VenereologyChangzheng Hospital

*** is one of leading fungal pathogens worldwide,which primarily invades host centralnervous system(CNS)and causes fatal meningoencephalitis in both immunocompromised and immunocompetent *** transversal across the brain microvascular endothelial cells(BMECs)is the essential step for the development of CNS infection,but its molecular mechanisms are still not

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Pd@Ag nanosheets in combination with amphotericin B exert a potent cryptococcacidal effect

Pd@Ag nanosheets in combination with amphotericin B exert a ...

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2016全国中西医结合皮肤性病学术年会

作者： Chao Zhang Mei Chen Wei Fang Chen Ye Hanhua Hu Zhenzong Fa Jiu Yi wan-qing liao Shanghai Key Laboratory of Molecular Medical Mycology Shanghai Institute of Medical MycologySecond Military Medical University PLA Key Laboratory of Mycosis Department of Dermatology and VenereologyChangzheng Hospital State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Centre of Chemistry for Energy Materials and Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen University Department of Urology Changhai HospitalSecond Military Medical University UEM department Xinjiang Medical university

Silver nanoparticles have received considerable interest as new nanoantibiotics" with the potential to kill drug-resistant ***,a class of new core-shell nanostructures,Pd@Ag nanosheets(Pd@Ag NSs),were created using deposition techniques and demonstrated excellent inhibitory effects on various bacteria in *** this study,we evaluated the antifungal activity of Pd@Ag NSs against common invasive fungal *** these organisms,Cryptococcus neoformans complex species was most susceptible to Pd@Ag NSs,which exhibited potent antifungal activity against various molecular types or sources of cryptococcal strains including fluconazole-resistant *** anticryptococcal activity of Pd@Ag NSs was significantly greater than fluconazole and similar to that of amphotericin B(AmB).At relatively high concentrations,Pd@Ag NSs exhibited fungicidal activity against Cryptococcus spp.,which can likely be attributed to the disruption of cell integrity,intracellular protein synthesis,and energy ***,Pd@Ag NSs also exhibited strong synergistic cryptococcacidal effects at low concentrations in combination with AmB but exhibited much better safety in erythrocytes than AmB,even at the minimal fungicidal ***,Pd@Ag NSs may be a promising adjunctive agent for treating cryptococcosis,and further investigation for clinical applications is required.

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Deubiquitinase Ubp5 is required for the growth and pathogenicity of Cryptococcus gattii

Deubiquitinase Ubp5 is required for the growth and pathogeni...

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2016全国中西医结合皮肤性病学术年会

作者： Yunfang Meng Chao Zhang Jiu Yi Zhaojing Zhou Zhenzong Fa Jingyu Zhao Yali Yang Wei Fang Yan wang wan-qing liao Shanghai Key Laboratory of Molecular Medical Mycology Shanghai Institute of Medical MycologySecond Military Medical University Department of Dermatology Shandong Provincial Hospital Affiliated to Shandong University PLA Key Laboratory of Mycosis Department of Dermatology and VenereologyChangzheng Hospital Shanghai Dermatology Hospital Department of Pharmacology School of PharmacySecond Military Medical University

Cryptococcus gattii is a resurgent fungal pathogen that primarily infects immunocompetent ***,it poses an increasingly significant impact on global public health;however,the mechanisms underlying its pathogenesis remain largely *** conducted a detailed characterization of the deubiquitinase Ubp5 in the biology and virulence of ***,and defined its properties as either

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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The development of many tumor supresssor genes and the expression in the carcinoma of tongue

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中国口腔颌面外科杂志 2008年第B5期6卷 134-134页

作者： wan Chang-qing liao Gui-qing Zhang Tong-han Ou De- ming Fahmha Numan wang Qin Department of Oral and Maxillofacial Surgery Guanghua Schoolof Stomatology Sun Yat-sen University Guangzhou 510055China

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian wan Yu-Ming wang Han-Zhou Li Wei-Quan Xu Jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Phase selection and performance of Mg–Cu–Y amorphous composite with different Mg/Cu ratios

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Rare Metals 2014年第1期33卷 91-94页

作者： Di-qing wan School of Mechanical and Electronical Engineering East China Jiaotong University

In this article, Mg-Cu-Y alloys with two dif- ferent Mg/Cu ratios （in at%） were prepared using a water- cooled copper mold. Scanning electron microscopy and X-ray diffraction were applied to analyze the microstructure and phase composition. Moreover, corrosion resistance and wear resistance were studied systematically. The results show that both Mg65Cu25Ylo and Mg60Cu30Ylo alloys could form a composition of crystalline and amorphous phases. Although the microstructure of Mg65Cu25Ylo con- sists of an amorphous phase and ：t-Mg, Mg2Cu, and Cu2Y crystalline phases, the microstructure of Mg60Cu30Ylo alloy mainly consists of the amorphous phase and ：t-Mg, Mg2Cu. With reducing Mg/Cu ratio, the alloys have better corrosion resistance and wear resistance. The mechanism has also been discussed in detail.

关键词： Mg-Cu-Y alloy Amorphous composites Corrosion resistance Wear resistance

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