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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang He Lingzi Shi Ran Sun Lianfei ding Mukun He Jiaming Li hua Guo Tiande Gao Panbo Liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption

Retrospective study on the efficacy and safety of quinacrine sterilization

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Asian Journal of Andrology 2001年第2期3卷 158-158页

作者： Ju-Hong ding Wei-Qun LU wan-hua ding Hong ZHU Jian-Sun TONG Jiangsu Family Planning Institute,Najing 210029,China Guizhou Family Planning Institute,Guiyang 550001,China

Aim: To observe the efficacy and safety of quinacrine ***: This retrospective study was to evaluate the efficacy and safetyof quinacrine sterilization in 572 cases in Jiangsu and Guizhou Provincesfrom 1993 to 1997. A total of 588 cases of surgical sterilization performed atthe same time served as the controls. Results: Two groups had similardemographic and gynecological characteristics. The multiple decrement lifetable analysis showed that the 12th month gross cumulative failure rate forquinacrine sterilization was 3.13% . Serious side effects occurred in 2 cases(0.35%); one is ectopic pregnancy (20 months after treatment) and theother, allergy reaction (10 minutes after the second insertion). The liverand renal functions were all normal in both groups. No cance cells/suspect-ed cancer cells were found. In the quinacrine group, the acceptability was99.6% . Conclusions: The quinacrine method has a high acceptability,but the efficacy is relatively low. It is a safe method of contraception inshort-term study, while the long-term safety warrants further investigation.

关键词： quinacrine non-surgical sterilization liver function renal function cervical smear retrospective study

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan wan wang Bin wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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CAN总线的分布式温度监控网络

湘潭师范学院学报（自然科学版） 2004年第3期26卷 46-48页

作者：万静华丁亚军湖南师范大学计算机部湖南长沙410006

介绍了一种基于多路DS16 2 1数字温度传感器和CAN总线的分布式温度检测网络设计。

关键词：数字温度传感器 12C总线 80C592 CAN总线温度监控网络电路

Three-dimensional Construction and Omni-directional Rolling Analysis of a Novel Frame-like Lattice Modular Robot

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 691-701页

作者： ding wan WU Jianxu YAO Yan'an School of Mechanical Electronic and Control Engineering Beijing Jiaotong University

Lattice modular robots possess diversity actuation methods, such as electric telescopic rod, gear rack, magnet, robot arm, etc. The researches on lattice modular robots mainly focus on their hardware descriptions and reconfiguration algorithms. Meanwhile, their design architectures and actuation methods perform slow telescopic and moving speeds, relative low actuation force verse weight ratio, and without internal space to carry objects. To improve the mechanical performance and reveal the locomotion and reconfiguration binary essences of the lattice modular robots, a novel cube-shaped, frame-like, pneumatic-based reconfigurable robot module called pneumatic expandable cube（PE-Cube） is proposed. The three-dimensional（3D） expanding construction and omni-directional rolling analysis of the constructed robots are the main focuses. The PE-Cube with three degrees of freedom（Do Fs） is assembled by replacing the twelve edges of a cube with pneumatic cylinders. The proposed symmetric construction condition makes the constructed robots possess the same properties in each supporting state, and a binary control strategy cooperated with binary actuator（pneumatic cylinder） is directly adopted to control the PE-Cube. Taking an eight PE-Cube modules＇ construction as example, its dynamic rolling simulation, static rolling condition, and turning gait are illustrated and discussed. To testify telescopic synchronization, respond speed, locomotion feasibility, and repeatability and reliability of hardware system, an experimental pneumatic-based robotic system is built and the rolling and turning experiments of the eight PE-Cube modules＇ construction are carried out. As an extension, the locomotion feasibility of a thirty-two PE-Cube modules＇ construction is analyzed and proved, including dynamic rolling simulation, static rolling condition, and dynamic analysis in free tipping process. The proposed PE-Cube module, construction method, and locomotion analysis enrich the family of the la

关键词： modular robot pneumatic expandable cube pneumatic actuation omni-directional rolling binary control strategy

Thermodynamic analysis of β → α(α_2) phase transformation temperature in a Ti-Al-H alloy system

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Rare Metals 2010年第3期29卷 298-301页

作者： ding hua HAO Shiming School of Materials and Metallurgy Northeastern University Shenyang 110004 China

The T0 face equation of a Ti-Al-H alloy system was set up by the regular solution model,and the relationship between the β phase stabilizing parameter of hydrogen and the equilibrium phase compositions was *** to the T0 face equation and the thermodynamic parameters from literature,the effect of hydrogen on the β→α（α2） transformation temperature was *** calculated results were in a better consistence with the measured ones.

关键词： temary alloy system thermodynamics phase transformation transformation temperature regular solution model

Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-hua wan Hong-Wei Zhang Xiao Guo hua Guo Shou-Feng Jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

Iptakalim,an ATP-sensitive potassium channel opener,confers neuroprotection against cerebral ischemia/reperfusion injury in rats by protecting neurovascular unit cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第10期12卷 835-845页

作者： Yu-hua RAN Hai wan Institute of Health and Environmental Medicine Academy of Military Medical Sciences Beijing 100850 China Thadweik Academy of Medicine Beijing 100039 China

Objective:To investigate the role of iptakalim,an ATP-sensitive potassium channel opener,in transient cerebral ischemia/reperfusion (I/R) injury and its involved ***:Intraluminal occlusion of middle cerebral artery (MCAO) in a rat model was used to investigate the effect of iptakalim at different time *** volume was measured by staining with 2,3,5-triphenyltetrazolium chloride,and immunohistochemistry was used to evaluate the expressions of Bcl-2 and *** vitro,neurovascular unit (NVU) cells,including rat primary cortical neurons,astrocytes,and cerebral microvascular endothelial cells,were cultured and underwent oxygen-glucose deprivation (OGD).The protective effect of iptakalim on NVU cells was investigated by cell viability and injury assessments,which were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and release of lactate ***-3,Bcl-2 and Bax mRNA expressions were evaluated by real-time polymerase chain reaction (PCR).Results:Administration of iptakalim 0 or 1 h after reperfusion significantly reduced infarct volumes,improved neurological scores,and attenuated brain edema after cerebral I/R *** treatment (0 h after reperfusion) also reduced caspase-3 expression and increased the ratio of Bcl-2 to Bax by *** inhibited OGD-induced cell death in cultured neurons and astrocytes,and lactate dehydrogenase release from cerebral microvascular endothelial *** reduced mRNA expression of caspase-3 and increased the ratio of Bcl-2 to Bax in NVU ***:Iptakalim confers neuroprotection against cerebral I/R injury by protecting NVU cells via inhibiting of apoptosis.

关键词： Neurovascular unit Cerebral ischemia/reperfusion (I/R) injury ATP-sensitive potassium channel opener Neuroprotection Apoptosis

Torsional vibration of a pipe pile in transversely isotropic saturated soil

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Earthquake Engineering and Engineering Vibration 2016年第3期15卷 509-517页

作者： Zheng Changjie hua Jianmin ding Xuanming College of Civil Engineering Chongqing University Key Laboratory of New Technology for Construction of Cities in Mountain Area (Chongqing University) Ministry of Education

This study considers the torsional vibration of a pipe pile in a transversely isotropic saturated soil layer. Based on Biot＇s poroelastic theory and the constitutive relations of the transversely isotropic medium, the dynamic governing equations of the outer and inner transversely isotropic saturated soil layers are derived. The Laplace transform is used to solve the governing equations of the outer and inner soil layers. The dynamic torsional response of the pipe pile in the frequency domain is derived utilizing 1D elastic theory and the continuous conditions at the interfaces between the pipe pile and the soils. The time domain solution is obtained by Fourier inverse transform. A parametric study is conducted to demonstrate the influence of the anisotropies of the outer and inner soil on the torsional dynamic response of the pipe pile.

关键词： torsional vibration saturated soil pipe pile transversely isotropic medium