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Hepatic and renal effects of oral stingless bee honey in a streptozotocin-induced diabetic rat model

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World Journal of Experimental Medicine 2024年第1期14卷 113-123页

作者： Suriati mohd Nasir Anis Farihan Ismail Tuan Salwani Tuan Ismail wan Faiziah wan abdul rahman wan Amir Nizam wan Ahmad Tengku Ahmad Damitri Al-Astani Tengku Din Kuttulebbai Nainamohammed Salam Sirajudeen Department of Chemical Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Endocrinology Laboratory Department of Chemical PathologySchool of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Biomedicine Program School of Health SciencesHealth CampusUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Basic Medical Sciences Kuliyyah of MedicineInternational Islamic University MalaysiaBandar Indera MahkotaKuantan 25200PahangMalaysia

BACKGROUND Diabetes is known damage the liver and kidney,leading to hepatic dysfunction and kidney *** is believed to help in lowering the blood glucose levels of diabetic patients and reducing diabetic ***,the effect of stingless bee honey(SBH)administration in relieving liver and kidney damage in diabetes has not been *** To investigate the effect of SBH administration on the kidney and liver of streptozotocin-induced(STZ;55 mg/kg)diabetic Sprague Dawley *** The rats were grouped as follows(n=6 per group):non-diabetic(ND),untreated diabetic(UNT),metformin-treated(MET),and SBH+metformin-treated(SBME)*** successful diabetic induction,ND and UNT rats were given normal saline,whereas the treatment groups received SBH(2.0 g/kg and/or metformin(250 mg/kg)for 12 *** biochemical parameters and histological changes using hematoxylin and eosin(H&E)and periodic acid–Schiff(PAS)staining were *** On H&E and PAS staining,the ND group showed normal architecture and cellularity of Bowman’s capsule and tubules,whereas the UNT and MET groups had an increased glomerular cellularity and thickened basement *** SBH-treated group showed a decrease in hydropic changes and mild cellularity of the glomerulus vs the ND group based on H&E staining,but the two were similar on PAS ***,the SBME-treated group had an increase in cellularity of the glomerulus on H&E staining,but it was comparable to the SBH and ND groups on PAS *** diabetic rats had tubular hydropic tubules,which were smaller than other *** fatty vacuole formation and dilated blood sinusoids in liver tissue were seen in the SBH ***,the UNT group had high glucose levels,which subsequently increased MDA levels,ultimately leading to liver *** treatment reduced this damage,as evidenced by having the lowest fasting glucose,serum alanine transaminase,aspartate transaminase,and alkaline phosphatase l

关键词： Diabetes Streptozotocin Stingless bee honey Hematoxylin and eosin Periodic acid-Schiff Liver Kidney

Relationship between Parent-Child Attachment and Problem Behaviors among Chinese Firstborn Children in Family Transitions: A Meta-Analysis

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International Journal of Mental Health Promotion 2023年第11期25卷 1161-1172页

作者： Cong Liu mohd nazri abdul rahman Nur Eva Education Faculty University MalayaKuala Lumpur50603Malaysia Psychological Education Faculty Universitas Negeri MalangMalang65145Indonesia

The implementation of China’s three-child fertility policy has led to a notable increase in multiple-child ***,ﬁrstborn children experience a signiﬁcant transition from being an only child to a non-only *** transition is associated with problematic behaviors,affecting their social adjustment,sibling relationships,and family *** several studies have examined the relationship between parent-child attachment and problem behaviors exhibited byﬁrstborn children during family transitions,theﬁndings have been ***,a meta-analytic study was undertaken to elucidate the inconsistencies in this relationship and explore the moderating factors that may contribute to these *** a systematic literature retrieval and screening method,12 effect sizes were derived from the 10 eligible articles,encompassing a sample size of *** meta-analysis demonstrated a low negative association between parent-child secure attachment and problem behaviors exhibited byﬁrstborn children during family ***,the present study investigates potential moderator factors,such as children’s age and geographic region,to gain a more nuanced understanding of the ***,the establishment of parent-child attachment relationships has the potential to mitigate problem behaviors observed inﬁrst-born children during family *** implications of theseﬁndings indicate that parents can nurture secure attachment bonds with their children by demonstrating sensitive responsiveness,employing positive parenting practices,and fostering emotional *** efforts contribute to the cultivation of secure internal working models and positive behavioral manifestations withinﬁrst-born children,which in turn affect their relationships with siblings.

关键词： Parent-child attachment problem behaviors ﬁrstborn children meta-analysis moderation effect

Phytocompounds of Anonna muricata leaves extract and cytotoxic effects on breast cancer cells

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Asian Pacific Journal of Tropical Medicine 2018年第12期11卷 659-665页

作者： Husna Syakirah Ab rahman wan Suriyani wan-Ibrahim Norzila Ismail Tuan Nadrah Naim Tuan Ismail Siti Farhanah mohd-Salleh Michael Pak-Kai Wong mohd Ridzuan abdul Samad mohd Nizam Md Hashim Department of Surgery School of Medical Sciences Universiti Sains Malaysia Department of Pharmacology School of Medical Sciences Universiti Sains Malaysia School of Dental Sciences Universiti Sains Malaysia

Objective: To identify the phytochemical compounds from Annona muricata(A. muricata) and to determine their in vitro anti-proliferative activities against breast cancer cells, MCF7 and MDA-MB-231. Methods: A. muricata leaves were successively extracted by soxhlet method using n-hexane, ethyl acetate and methanol, and decocted with water. Each extract was analysed by gas chromatography mass spectrometry(GCMS) and characterized with Wiley and NIST library searches. Anti-proliferative activity of each extract was evaluated on MCF7 and MDA-MB-231 breast cancer cells using MTT assay. Results: The GCMS analysis of different solvent extracts of A. muricata leaves showed presence of different chemical groups of compounds such as steroids, terpenoids, phenolic compounds, sugars, sugars alcohol and others including vitamin E. Ethyl acetate leaves extract exhibited the lowest IC_(50) value on the MDA-MB-231 breast cancer cell and n-hexane leaves extract showed the the lowest IC_(50) value on the MCF-7 breast cancer cell. Conclusion: Steroids and phenolic compounds were the main phytocompound groups identified from all A. muricata leaves extracts. The antiproliferative activity of n-hexane and ethyl acetate extract towards breast cancer MCF7 and MDA-MB-231 respectively might be due to the presence of biologically active compounds in the extracts, hence, providing some scientific evidences of the effectiveness of its traditional usages.

关键词： Annona muricata GCMS Anti-proliferative Breast cancer Graviola

Nutritional Status and Physical Activities among Army Trainees in Public Institutions of Higher Education in Malaysia

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Food and Nutrition Sciences 2011年第6期2卷 511-520页

作者： Zulaikha mohd Rashid Suriah Abd rahman Zalifah mohd Kasim wan Aida wan Mustapha mohd Hazali Mohamed Halip Zulmadi Arifin Ummul Fahri abdul Rauf 不详

This study was conducted to evaluate the nutritional status and physical activities of university students that enrolled in military training with the age range of 20 - 34 years. Nutritional status assessment was based on eating habit questionnaires, anthropometric measurements with body mass index (BMI) and waist-to-hip ratio (WHR), food intake records for three days and also food frequency questionnaire (FFQ). Assessment of physical activities was carried out using physical activities records. Food intake and physical activities data were analyzed using the Nutri-Antro Web (NAW) software. Generally, the subjects were found to have good nutrition knowledge and food intake habits, except for having an irregular meal time (85.0%). Based on BMI studies, 80.0% of male subjects and 78.6% of female subjects were within normal range with the average of 22.94 ± 2.97 kg/m2 and 21.40 ± 3.06 kg/m2 respectively. None of the subjects had WHR above the cut-off point of 1.0 for men and 0.85 for women. The average energy intake for male and female was 2589 ± 687 kcal and 1959 ± 460 kcal respectively. Overall, nutrient intake of both genders fulfilled Malaysia Recommended Nutrient Intake 2005 (RNI) except for the average energy intake of the female subjects. The daily physiccal activities patterns revealed that 73.6% was used for light activities, 19.7% for moderate while 7.4% for heavy activities. The average daily energy expenditure for male subjects (3161 ± 444 kcal) was higher than the female subjects (2492 ± 388 kcal). Both male and female subjects have negative energy balance of -572 kcal and -533 kcal respecttively. Majority of the subjects were categorized as physically active (77.9%). Pearson correlation test showed that physical activities were positively correlated (p < 0.05) with BMI, WHR and nutrient intakes except for the intake of vitamin C. In conclusion, nutritional status and physical activity level of subjects were satisfactory.

关键词： Anthropometry Energy Military Training Nutritional Status Physical Activities

马来西亚智慧学校项目及其对我国教师教育的启示

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世界教育信息 2022年第2期35卷 53-59页

作者：刘聪 [马来西亚]莫哈末·纳兹里马来亚大学教育学院

马来西亚智慧学校项目实施20余年,经历了试点、后试点、全面智慧化、巩固和稳定四个阶段。根据智慧学校资格标准评价结果,马来西亚采取融合企业和社区多方资金支持、鼓励开展教学一线调查研究、保障智慧教师培训连贯性等政策工具对项目... 详细信息

马来西亚智慧学校项目实施20余年,经历了试点、后试点、全面智慧化、巩固和稳定四个阶段。根据智慧学校资格标准评价结果,马来西亚采取融合企业和社区多方资金支持、鼓励开展教学一线调查研究、保障智慧教师培训连贯性等政策工具对项目进行优化升级。其中,智慧学校教师培养的优化策略为信息化时代我国师范生培养、新教师入职培训、教师在职研修三个阶段的智慧教师教育提供借鉴。

关键词：马来西亚智慧学校项目优化策略教师教育

Factors influencing COVID-19 vaccination intention among university students:A cross-sectional study in Malaysia

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Biosafety and Health 2023年第1期5卷 37-44页

作者： Chee Yin Wong Jen Sern Tham Chai Nien Foo Foong Leng Ng Saleha Shahar mohd Nizam Zahary mohd nazri Ismail Cheng Siang Tan Boon Peng Hoh Subbiah Vijay Kumar Yang Mooi Lim Center for Cancer Research Universiti Tunku Abdul RahmanKajang 43000Malaysia M.Kandiah Faculty of Medicine&Health Sciences Universiti Tunku Abdul RahmanKajang 43000Malaysia Department of Communication Faculty of Modern Languages and CommunicationUniversiti Putra MalaysiaSerdang 43400Malaysia UPM-UNICEF C4D Faculty of Modern Languages and CommunicationUniversiti Putra MalaysiaSerdang 43400Malaysia Faculty of Science Universiti Teknologi MalaysiaJohor Bahru 81310Malaysia Faculty of Health Sciences Universiti Sultan Zainal AbidinKuala Nerus 21300Malaysia Analytical Biochemistry Research Centre Universiti Sains MalaysiaBayan Lepas 11900Malaysia Faculty of Medicine and Health Sciences Universiti Malaysia SarawakKota Samarahan 94300Malaysia Faculty of Medicine and Health Sciences UCSI UniversityCheras 56000Malaysia Biotechnology Research Institute Universiti Malaysia SabahKota Kinabalu 88400Malaysia

Vaccination is crucial in controlling the spread of the coronavirus disease 2019(COVID-19)that triggered the pandemic,but herd immunity can only work with high vaccination coverage in the *** study aims to measure the COVID-19 knowledge level and determine the factors influencing COVID-19 vaccination intention among university students in Malaysia.A cross-sectional online survey was carried out with 1,274 Malaysian university students in July *** and multivariate analyses were employed to examine the relationships between the study *** showed that the majority of university students had an acceptable level of knowledge of *** knowledge,risk perception of COVID-19,social norms,and perceived benefit of COVID-19 vaccination were positively associated with vaccination ***,perceived trust in information sources of COVID-19 vaccination and the government's response to COVID-19 did not affect the university students’desire to receive the *** findings are essential for health policymakers and healthcare providers to implement evidence-based interventions to increase COVID-19 vaccination uptake among university students.

关键词： Behavioral intention COVID-19 Influencing factor SARS-CoV-2 University student Vaccination