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Ultrasound-guided percutaneous catheter drainage in early treatment of severe acute pancreatitis

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World Journal of Emergency Medicine 2010年第1期1卷 45-48页

作者： Xin-bo Ai Xiao-ping Qian Wen-sheng Pan jun Xu, Liang-qing Wu wan-jun zhang An wang Department of Gastroenterology Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou 310009 China Department of Gastroenterology Zhuhai People's Hospital Third Affiliated Hospital of Jinan University School of Medicine Zhuhai 519000 China Department of Radiology Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou 310009 China Department of Ultrasonography Second Affiliated Hospital of Zhejiang University School of Medicme Hangzhou 310009 China

Percutaneous catheter drainage （PCD） is a minimally invasive intervation for severe acute pancreatitis （SAP）. This study was undertaken to compare the results of surgery and ultrasound-guided PCD in the treatment of 32 patients with SAP, and to direct clinicians to the most optimal approach for SAP. In the 32 patients, 19 were proved to have deteriorated clinical signs or symptoms, extensive fluid exudation, and necrosis confirmed by computed tomography （CT） and they underwent operative debridement and drainage. For extensive fluid exudation or necrosis, complete liquefaction and safe catheter implantation, the other 13 patients were given PCD. The mortality rate of the surgery group was 26.3%, much higher than that of the PCD group （0%）. There was a significant difference between the two groups （P=0.044）. The mean time for recovery of the serum C-reactive protein （CRP） level was 43.8 days in the surgery group, which was significantly longer than that of the PCD group （23.8 days）（P=0.034）. Early PCD guided by ultrasound could decrease the mortality of patients with severe acute pancreatitis, alleviate life-threatening inflammatory complications, and avoid unnecessary emergency operation.

关键词： Percutaneous catheter drainage Operation Severe acute pancreatitis Clinicalefficacy

An all-round Al-Chemist with a scientific mind

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National Science Review 2022年第10期9卷 158-168页

作者： Qing Zhu Fei zhang Yan Huang Hengyu Xiao Lu Yuan Zhao Xu Chun zhang Tao Song Xin Sheng Tang Xiang Li Guo He Bao Chen Chong jun Yi Zhou Yi Han zhang Baicheng zhang Jia Qi Cao Man Luo Song wang Gui Lin Ye wan jun zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou Wei Wei Shang jun Jiang Yi Luo Hefei National Research Center for Physical Sciences at the Microscale School of Chemistry and Materials Science University of Science and Technology of China School of Information Science and Technology University of Science and Technology of China Hefei Ji Shu Quantum Technology Co.Ltd Hefei National Laboratory University of Science and Technology of China

The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI) *** AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains ***,we present an all-round AI-Chemist e quipped with scientific data intelligence that is capable of performing basic tasks generally re quired in chemical *** on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans *** can control a mobile robot in-house or online to automatically execute the complete experimental process on 14workstations,including synthesis,characterization and performance *** experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be *** competence of the AI-Chemist has been scrutinized by three different chemical *** the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory.

关键词： AI-Chemist computational brain mobile robot machine reading all-round research

氯化两面针碱对胃癌细胞株SGC7901凋亡的影响及初步机制

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世界华人消化杂志 2017年第14期25卷 1248-1254页

作者：张婉君陈阳张娜台州恩泽医疗中心(集团)路桥医院药剂科浙江省台州市318050

目的探讨氯化两面针碱对胃癌细胞株SGC7901凋亡的影响,并研究其可能的初步机制.方法MTT法检测不同浓度氯化两面针碱(0、5、10、20和40?mol/L)对胃癌细胞株SGC7901存活率的影响;Hoechst染色观察SGC7901细胞的形态学;Annexin V-FITC/PI双... 详细信息

目的探讨氯化两面针碱对胃癌细胞株SGC7901凋亡的影响,并研究其可能的初步机制.方法MTT法检测不同浓度氯化两面针碱(0、5、10、20和40?mol/L)对胃癌细胞株SGC7901存活率的影响;Hoechst染色观察SGC7901细胞的形态学;Annexin V-FITC/PI双染法检测SGC7901细胞的凋亡;JC-1单标法检测细胞内线粒体膜电位变化;免疫印迹法检测caspase-3剪切体、caspase-9剪切体和PARP剪切体与其各自未激活体的蛋白表达变化.结果S G C 7 9 0 1的存活率随着氯化两面针碱浓度的增加而逐渐下降,并与时间呈正相关;Hoechst染色与Annexin V-FITC/PI双染法结果分别显示氯化两面针碱干预后SGC7901细胞的凋亡特征更显著,细胞凋亡率明显增多;经过氯化两面针碱处理后,SGC7901细胞线粒体膜电位显著下降,caspase-3剪切体、caspase-9剪切体和PARP剪切体蛋白表达水平显著上升,其未激活体蛋白表达明显下降.结论氯化两面针碱呈浓度依赖性抑制SGC7901细胞的存活率,增加细胞凋亡率,可能是通过激活内源性线粒体通路有关.

关键词：氯化两面针碱胃癌细胞株SGC7901 凋亡线粒体

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu jun Shen Xin zhang Lingcong Chao Liang Chen Ding zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

miR-15a-5p靶向PD-L1对食管癌进展、预后与肿瘤免疫反应的影响

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世界华人消化杂志 2024年第9期32卷 678-685页

作者：林亭呈张婉君浙江省台州医院药剂科浙江省台州市318050

背景微核糖核酸(microRNA,miR)-15a-5p与细胞程序性死亡蛋白配体1(programmed death-ligand 1,PD-L1)在多种肿瘤进展、治疗与预后中发挥重要作用,但其在食管癌中的作用尚不完全清楚.目的研究miR-15a-5p与PD-L1表达对食管癌进展与预后的... 详细信息

背景微核糖核酸(microRNA,miR)-15a-5p与细胞程序性死亡蛋白配体1(programmed death-ligand 1,PD-L1)在多种肿瘤进展、治疗与预后中发挥重要作用,但其在食管癌中的作用尚不完全清楚.目的研究miR-15a-5p与PD-L1表达对食管癌进展与预后的影响,并分析二者的靶向关系以及二者调控食管癌细胞生物学行为的机制.方法用癌症基因组图谱数据库、基因表达综合数据库和RNA相互作用组百科全书泛癌分析数据库分析食管癌中miR-15a-5p和PD-L1基因的表达,通过Kaplan-Meier生存分析研究miR-15a-5p和PD-L1的表达与食管癌无病生存期以及总生存期的关系.信息学和荧光活性实验检测miR-15a-5p与PD-L1的靶向关系.体外培养食管癌细胞,转染miR-15a-5p mimics或miR-NC后,分别用Western blot、流式细胞术、免疫荧光实验检测PD-L1表达.将转染miR-15a-5p mimics或miR-NC的食管癌细胞与CD8+T细胞共培养,流式细胞术检测干扰素-γ(interferon-γ,INF-γ)阳性CD8+T细胞比例,ELISA检测共培养体系中上清液中INF-γ和白细胞介素(interleukin,IL)-2含量.结果miR-15a-5p在食管癌组织中表达水平较癌旁非癌变组织降低(P<0.05).以miR-15a-5p表达水平的中位数为分界线,随T分期和肿瘤大小增加和淋巴结转移,miR-15a-5p低表达率增加(P<0.05);相比于miR-15a-5p低表达的食管癌患者,miR-15a-5p高表达显示出较长的无病生存期和总生存期(P<0.05),miR-15a-5p高表达同时PD-L1低表达的无病生存期和总生存期更长(P<0.05).在miR-15a-5p高表达的食管癌患者中PD-L1 mRNA多呈低表达.PD-L1为miR-15a-5p的靶基因.过表达miR-15a-5p抑制食管癌细胞中总PD-L1及膜PD-L1表达(P<0.05).在食管癌细胞中过表达miR-15a-5p可促进共培养体系中CD8+T细胞的激活(即:共培养体系中INF-γ阳性CD8+T细胞比例以及共培养体系中上清液中INF-γ和IL-2含量增加).结论miR-15a-5p可通过靶向PD-L1增强食管癌细胞的肿瘤免疫反应,且miR-15a-5p/PD-L1可作为食管癌诊断及预后生物标记物.

关键词： miR-15a-5p 食管癌 PD-L1 预后肿瘤免疫反应

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei wan Xiuqin Rao Yue Lin Gen Wei jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun zhang Shengtao Gao Xingzhao zhang Dacheng Ma Chuanlei Zhu jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

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视觉量子目标跟踪方法

软件学报 2016年第11期27卷 2961-2984页

作者：姜文涛刘万军袁姮张海涛辽宁工程技术大学软件学院辽宁葫芦岛125105 辽宁工程技术大学研究生院辽宁葫芦岛125105

为了解决变结构目标跟踪过程中目标失跟率较高的问题,提出了一种基于视觉量子(vision quantum,简称VQ)的目标跟踪方法.该方法首先在图像内自上而下地辐射视觉量子采集灰度信息,统计量子内部概率密度较大的灰度级和分布区域;然后计算视... 详细信息

为了解决变结构目标跟踪过程中目标失跟率较高的问题,提出了一种基于视觉量子(vision quantum,简称VQ)的目标跟踪方法.该方法首先在图像内自上而下地辐射视觉量子采集灰度信息,统计量子内部概率密度较大的灰度级和分布区域;然后计算视觉量子的量子频率,归一化量子频率系数,滤除系统噪音和杂波干扰,利用频率阶跃不变性移动视觉量子至平衡状态,将达到量子平衡状态的视觉量子组成量子簇;最后,以该量子簇作为候选目标信息,采用极大似然估计预测运动目标状态,以预测结果作为下一帧图像中视觉量子移动的参考值,并进一步验证移动后的视觉量子是否达到量子平衡状态,以确保目标跟踪有效性.该方法抓住了变结构运动目标前景与背景交界处具有量子频率阶跃不变性的特点,继而将阶跃不变特征采用具有独立性和约束性的视觉量子进行描述,可以有效地消除形状变化、尺度变化等变结构因素对运动目标跟踪的影响,失跟率较低.同时,由于视觉量子数据量较小,计算复杂度较低,其跟踪实时性较高.大量实验测试结果表明,该方法对变结构目标跟踪具有很好的适应性、实时性和鲁棒性.

关键词：视觉量子频率阶跃量子平衡量子簇目标跟踪

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le wang Wenwu zhang Gang Li Xing Cheng Peiqiang Su Yong wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury