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Effects of a combination of Japanese Raisin Tree Seed and Flower of Lobed Kudzuvine against acute alcohol-induced liver injury in mice

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Journal of Traditional Chinese Medical Sciences 2020年第1期7卷 59-67页

作者： wan xu Shaohong Chen Gansheng Zhong Haiyan Liu Linlin Xiu xue Yu Feng Chen Na Li Yanmin Lv School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China

Objective:The Flower of Lobed Kudzuvine[Pueraria lobata(Willd.)Ohwi;Gehua in Chinese;GH]and Japanese Raisin Tree Seed(Hovenia dulcis Thunnb.;Zhijuzi in Chinese;ZJZ)are herbs that have been used in China for the treatment of alcohol intoxication and liver *** aimed to evaluate the hepatoprotective potential of a combination of these in mice with acute alcohol-induced liver injury,and to elucidate the mechanisms ***:Male ICR mice were randomly allocated to six groups:a control group,an alcohol-administered group,and groups that were administered alcohol and one of silibinin,the GH,the ZJZ or a GH-ZJZ combination(at a ratio of 2:1).Animals were orally administered 56%alcohol(Er Guo-tou white spirit,0.12 mL/10 g/d)for 10 days and at the end of this period,hepatic biochemical indicators,antioxidant parameters,alcohol metabolic enzymes,and histopathologic changes were ***,the expression of the signaling molecules KEAP1,NRF2,and AQP9 were measured by qRT-PCR and western ***:Compared with the model group,GH-ZJZ(2:1)had lower serum ALT(12.15±0.39,P紏.003),AST(104.07±1.03,P紏.001),and ALP(148.09±2.55,P紏.010)activities,and lower TC(1.97±0.05,P紏.001)and TG(1.54±0.07,P?.002)***-ZJZ(2:1)also significantly increased the hepatic activities of SOD and GSH(4.24±0.25 and 1.57±0.06,respectively;both P<.01),reduced the ROS and MDA concentrations(97.50±3.00 and 2.39±0.19,respectively;both P<.01),and upregulated Nrf2 expression(P<.01).GH-ZJZ(2:1)significantly reduced the expression of KEAP1 and AQP9 in the liver,compared with alcohol-administered mice(P<.01).Importantly,the GH-ZJZ combination caused a more marked improvement in acute liver injury than GH or ZJZ ***:We have demonstrated protective effects of GH-ZJZ(2:1)against acute alcohol-induced hepatic injury,and shown that these effects may be associated with improvements in lipid and alcohol metabolism,antioxidant capacity,and lipid peroxidation.

关键词： GH-ZJZ combination Acute alcohol-induced liver injury Oxidative stress AQP9 KEAP1-NRF2-ARE

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Dynamics of maize grain drying in the high latitude region of Northeast China

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Journal of Integrative Agriculture 2022年第2期21卷 365-374页

作者： CHU Zhen-dong MING Bo LI Lu-lu xuE Jun ZHANG wan-xu HOU Liang-yu XIE Rui-zhi HOU Peng wanG Ke-ru LI Shao-kun Agricultural College Shihezi University/Key Laboratory of Oasis Eco-AgricultureXinjiang Production and Construction CropsShihezi 832000P.R.China Institute of Crop Sciences Chinese Academy of Agricultural Sciences/Key Laboratory of Crop Physiology and EcologyMinistry of Agriculture and Rural AffairsBeijing 100081P.R.China Heilongjiang Bayi Agricultural University Daqing 163000P.R.China

A high grain moisture content at harvest has been an important problem in the high latitude region of Northeast China, and it is closely related to the genotypes of varieties, local meteorological factors and planting management. However, delayed harvest at a low temperature could not effectively reduce the grain moisture content. In this study, we continuously observed the grain drying during the late stage of different maturing types of maize varieties in Daqing, Heilongjiang Province, China in 2016 and 2017. A two-segment linear model was used to analyze the different stages of the drying processes: 1) Twosegment linear model fitting can divide the grain drying process of all varieties into two separate linear drying processes with different slopes. 2) During the rapid drying stage, the drying was faster at a higher temperature. The rate of slow drying was influenced by air vapor pressure. 3) The moisture content and meteorological factors when the drying rate turns from one stage into the other were not consistent between varieties and years. After entering the frost period, temperatures below 0℃ will significantly reduce the rate of grain drying. 4) Due to the short growth period of early-maturing varieties, the drying time was prolonged, and the grain moisture content was lower than that of the mid-late maturing varieties. Local meteorological conditions do not allow the drying of mid-late maturing varieties to achieve a lower moisture content. When the temperature falls below 0℃, the drying rate of grain decreases markedly. Therefore, one feasible way to solve the problem of high moisture content is to replace the early-maturing varieties and implement the corresponding cultivation techniques.

关键词： grain drying maize Northeast China two-segment linear model

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高初速榴弹发射器动力学特性仿真研究

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南京理工大学学报 2006年第4期30卷 429-433页

作者：徐万和南京理工大学机械工程学院江苏南京210094

通过高初速榴弹发射器系统动力学特性的仿真分析,研究轻武器以低系统质量发射大威力弹药的技术问题。采用凯恩方法建立了系统动力学分析模型,针对多种设计方案进行了数值仿真,分析了主要运动件质量及复进簧刚度等有关设计参数对自动机... 详细信息

通过高初速榴弹发射器系统动力学特性的仿真分析,研究轻武器以低系统质量发射大威力弹药的技术问题。采用凯恩方法建立了系统动力学分析模型,针对多种设计方案进行了数值仿真,分析了主要运动件质量及复进簧刚度等有关设计参数对自动机运动特性的影响关系。给出了动力学综合特性匹配的结构方案,为该类武器的开发提供了理论依据。样机射击试验表明理论分析结果与实际有良好的吻合性。

关键词：榴弹发射器动力建模计算机仿真参数分析

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Experimental Studies of the Therapeutic Effect of Gypsophila Oldhamiana Gypsogenin on Lewis Lung Cancer in Mice

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Chinese Journal of Clinical Oncology 2008年第3期5卷 206-210页

作者： Guihong Tian Ling Zhou Ying Zhong wan xu Hong Bai Lu Liu Shuxiang Cui Institute of Materia Medica Shandong Academy of Medical Science Jinan 250062 Shandong Province China.

OBJECTIVE To observe the inhibitory effect of Gypsophila oldhamiana gypsogenin (GOG) on Lewis lung cancer growth,and to investigate the mechanism of its anti-tumor effect. METHODS A mouse model bearing Lewis lung cancer was *** 5 experimental groups were divided into a positive control (cis-diaminedichloroplatinum),a negative control,and high,medium and low-GOG dosage *** inhibitory action of GOG administration on the lung cancer was *** GOG treatment,the lungs were taken out and a lung coefficient *** expressions of VEGF,Bcl-2,Bax and P53 in the cancers were determined using immunohistochemical staining. RESULTS The tumor weight of the mice given various doses of GOG was significantly lower compared to the negative-control group (P<0.01),and the lung coefficient of the groups given high and low GOG doses was significantly lower compared to the negative-control group (P<0.01).Immunohistochemical results were shown as follows:i) The VEGF and Bcl-2 expressions in the GOG groups were significantly lower than that of the negative-control group (P<0.05);ii) Bax expression in the groups treated with high and medium GOG doses was significantly higher compared to the negative-control group (P<0.05);iii) The mutant P53 expression in the GOG-treated groups was significantly lower compared to the negative-control group (P<0.05).CONCLUSION GOG can inhibit the growth and metastasis of Lewis lung cancer,and may exert its mechanism of tumor control by inhibition of tumor angiogenesis and induction of apoptosis.

关键词： Gypsophila oldhamiana gypsogenin Lewis lungcancer tumor growth tumor metastasis.

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Effect of cholesterol lowering on stiffness of aortic and femoral arterial walls in rabbits on a high fat diet

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Chinese Medical Journal 2009年第12期122卷 1444-1448页

作者： xuE Li xu wan-hai xu Jin-zhi ZHANG Tong BI Hong-yuan SHEN Bao-zhong Department of Carctiology Center of Vascular Diseases Fouth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Urinary Surgery Fouth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Cardiac Surgery Fouth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Imaging Fouth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

Background Researches in arterial elasticity have increased over the past few years. We investigated the effects of simvastatin on vascular stiffness in fat fed rabbits by ultrasonography. Methods Thirty rabbits were assigned randomly to 3 groups： normal control group （A）, the cholesterol group （B）, simvastatin group （C： high fat diet for 4 weeks and high fat diet ＋ simvastatin for further 4 weeks）. Stiffness coefficient, pressure strain elastic modulus and velocity of pulse waves in abdominal aorta and femoral artery were measured by ultrasonographic echo tracking at the end of the 4th and the 8th weeks. Results At the end of the 4th week, stiffness coefficient, pressure strain elastic modulus and pulse wave velocity of femoral artery were significantly increased in group B compared with those in group A. Similarly, at the end of the 8th week, the same parameters of abdominal aorta were significantly increased in group B compared with those in group A. In contrast, stiffness coefficient, pressure strain elastic modulus and pulse wave velocity of femoral artery were significantly decreased in group C compared with those in group B, however, there was no significant difference in parameters of abdominal aorta between groups B and C. Conclusion Short term administration of simvastatin can improve the elasticity of femoral artery but not abdominal aorta.

关键词： ultrasonography vascular stiffness abdominal aorta femoral artery rabbits

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Three new physalins from Physalis alkekengi var. franchetii

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Natural Products and Bioprospecting 2013年第3期3卷 103-106页

作者： wan-xuan xu Jian-Chao CHEN Jie-Qing LIU Lin ZHOU Yi-Fen wanG Ming-Hua QIU State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Three new physalin steroids,physalin Ⅲ(1),physalin IV(2),3-O-methylphysalin X(3),together with five known physalins(4-8)were isolated from the 80%EtOH extract of calyces of Physalis alkekengi *** structures of the ne... 详细信息

关键词： Physalis alkekengi var.franchetii steroid physalin neophysalin

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Does nitrogen application rate affect the moisture content of corn grains?

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Journal of Integrative Agriculture 2021年第10期20卷 2627-2638页

作者： ZHANG Yuan-meng xuE Jun ZHAI Juan Zhang Guo-qiang ZHANG wan-xu wanG Ke-ru MING Bo HOU Peng XIE Rui-zhi LIU Chao-wei LI Shao-kun Key Laboratory of Oasis Eco-Agriculture Xinjiang Production and Construction Corps/Agricultural CollegeShihezi UniversityShihezi 832000P.R.China Institute of Crop Sciences Chinese Academy of Agricultural Sciences/Key Laboratory of Crop Physiology and EcologyMinistry of Agriculture and Rural AffairsBeijing 100081P.R.China

Nitrogen fertilizer application is an important measure to obtain high and stable corn yield,and the moisture content of corn grains is an important factor affecting the quality of mechanical grain *** this study,four different nitrogen fertilizer treatments from 0 to 450 kg ha^(–1) pure nitrogen were set for a planting density of 12.0×10^(4) plants ha^(–1) in 2017 and 2018,and 18 different nitrogen fertilizer treatments from 0 to 765 kg ha^(–1) pure nitrogen were set for planting densities of 7.5×10^(4) and 12.0×10^(4) plants ha^(–1) in 2019,to investigate the effect of nitrogen application rate on the moisture content of corn *** each treatment,the growth of corn,leaf area index(LAI)of green leaves,grain moisture content,and grain dehydration rate were *** results showed that,as nitrogen application increased from 0 to 765 kg ha^(–1),the silking stage was delayed by about 1 day,the maturity stage was delayed by about 1–2 days,and the number of physiologically mature green leaves and LAI *** and after physiological maturity,the extreme difference in grain moisture content between different nitrogen application rates was 1.9–4.0%.As the amount of nitrogen application increased,the corn grain dehydration rate after physiological maturity decreased,but it did not reach statistical significance between nitrogen application rate and grain dehydration *** significant correlation was observed between LAI at physiological maturity and grain dehydration rate after physiological *** short,nitrogen application affected the grain moisture content of corn at and after physiological maturity,however,the difference in grain moisture content among different nitrogen application rates was *** results suggest that the effect of nitrogen application on the moisture content of corn grains should not be considered in agricultural production.

关键词： nitrogen corn grain moisture content leaf area index physiological maturity

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Multiorgan dysfunction syndrome due to high-dose cantharidin poisoning:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2074-2078页

作者： wan-Ling xu Wen-Jing Tang Wei-Ying Yang Li-Chao Sun Ze-Qun Zhang Wei Li Xiu-Xian Zang Department of Emergency Medicine First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Chinese Traditional Medicine First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with high-dose cantharidin poisoning and multiorgan dysfunction syndrome(MODS).Particular emphasis is placed on the comprehensive elucidation of the clinical manifestations of high-dose cantharidin poisoning,the intricate path to diagnosis,and the exploration of potential underlying *** SUMMARY A patient taking 10 g of cantharidin powder orally subsequently developed *** patient was treated with supportive care,fluid hydration and antibiotics,and hemoperfusion and hemofiltration therapy for 24 h and successfully recovered 8 d after hospital *** poisoning can cause lifethreatening MODS and is rare *** case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt *** This article has reported and analyzed the clinical data,diagnosis,treatment,and prognosis of a case of high-dose cantharidin poisoning resulting in MODS and reviewed the relevant literature to improve the clinical understanding of this rare condition.

关键词： Cantharidin Poisoning Multiorgan dysfunction syndrome Clinical treatment and management Case report

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Facile synthesis of dendrimer-like star-branched poly(isopropylacrylamide) via combination of click chemistry and atom transfer radical polymerization

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Science China Chemistry 2010年第12期53卷 2520-2527页

作者： wan xueJuan,xu Jian & LIU ShiYong CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering,Hefei National Laboratory for Physical Sciences at the Microscale,University of Science and Technology of China,Hefei 230026,China CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Hefei China

We report a facile synthesis method of dendrimer-like star-branched poly(N-isopropylacrylamide) (PNIPAM) via the combination of click chemistry and atom transfer radical polymerization (ATRP) by employing the arm-first ***,the α-azido-ω-chloro-heterodifunctionalized building block,N3-PNIPAM-Cl (G0-Cl),was synthesized via ATRP by 3-azidopropyl 2-chloropropionate as the *** advantage of click chemistry,the first generation (G1) of dendrimer-like star-branched PNIPAM,G1-(Cl)3,was facilely prepared via the click coupling reaction between G0-Cl and *** the construction of second generation (G2) dendrimer-like star-branched PNIPAM,G2-(Cl)6,terminal chloride moieties of G1-(Cl)3 were first converted to azide,and then reacted with excess tripropargylamine to give G1-(alkynyl)6 ;G2-(Cl)6 was subsequently prepared via click reaction between G1-(alkynyl) 6 and *** permeation chromatography (GPC) and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry were employed to confirm the successful construction of dendrimer-like star-branched *** unique thermal phase transition behavior of this dendrimer-like star-branched polymer in aqueous solutions was further investigated by turbidimetry and micro-differential scanning calorimetry (Micro-DSC).

关键词： dendrimer-like branched ATRP click chemistry

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Preparation and Photochemical Behavior of a Cationic Azobenzene Dye-Montmorillonite Intercalation Compound

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Journal of Wuhan University of Technology(Materials Science) 2007年第3期22卷 466-469页

作者：万涛 College of Materials and Chemistry & Chemical Engineering Chengdu University of Technology

Montmorillonite/cationic azobenzene dye（p-（δ-triethylammoniobutoxy）-p＇-methyl- azobenzene bromide） intercalation compounds were prepared by the conventional ion exchange method. As compared with that of pure cationic azo-dye, the thermal stability of the intercalated dye was greatly enhanced, and the absorption band corresponding to azobenzene group in intercalated dye shifted towards longer wave length by 38 nm. This could be ascribed to the strong conjugation of cationic azo-dye supramolecular order structure（J cluster） confined in a nanoscale space of montmorillonite interlayer gallery. UV/vis spectra data show that the intercalated azo dye in the montmorillonite interlayer space exhibited reversible trans-to-cis photoisomerization and daylight cis-to-trans back reaction. FTIR indicates the successful intercalation of cationic azo-dye into the montmorillonite interlayer.

关键词： Na-montmorillonite azobenzene intercalation photoisomerization

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