Effect of cholesterol lowering on stiffness of aortic and femoral arterial walls in rabbits on a high fat diet

作     者：XUE Li XU Wan-hai XU Jin-zhi ZHANG Tong BI Hong-yuan SHEN Bao-zhong 

作者机构：Department of Carctiology Center of Vascular Diseases Fouth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Urinary Surgery Fouth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Cardiac Surgery Fouth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Imaging Fouth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2009年第122卷第12期

页      面：1444-1448页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：ultrasonography vascular stiffness abdominal aorta femoral artery rabbits 

摘      要：Background Researches in arterial elasticity have increased over the past few years. We investigated the effects of simvastatin on vascular stiffness in fat fed rabbits by ultrasonography. Methods Thirty rabbits were assigned randomly to 3 groups： normal control group （A）, the cholesterol group （B）, simvastatin group （C： high fat diet for 4 weeks and high fat diet ＋ simvastatin for further 4 weeks）. Stiffness coefficient, pressure strain elastic modulus and velocity of pulse waves in abdominal aorta and femoral artery were measured by ultrasonographic echo tracking at the end of the 4th and the 8th weeks. Results At the end of the 4th week, stiffness coefficient, pressure strain elastic modulus and pulse wave velocity of femoral artery were significantly increased in group B compared with those in group A. Similarly, at the end of the 8th week, the same parameters of abdominal aorta were significantly increased in group B compared with those in group A. In contrast, stiffness coefficient, pressure strain elastic modulus and pulse wave velocity of femoral artery were significantly decreased in group C compared with those in group B, however, there was no significant difference in parameters of abdominal aorta between groups B and C. Conclusion Short term administration of simvastatin can improve the elasticity of femoral artery but not abdominal aorta.