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Intricacies of TGF-βsignaling in Treg and Th17 cell biology

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Cellular & Molecular Immunology 2023年第9期20卷 1002-1022页

作者： Junying wang Xingqi Zhao yisong y.wan Lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Microbiology and Immunology University of North Carolina at Chapel HillChapel HillNC 27599USA

Balanced immunity is pivotal for health and ***4+helper T(Th)cells are central to the balance between immune tolerance and immune *** cells adopt distinct functions to maintain tolerance and clear *** of Th cell function often leads to maladies,including autoimmunity,inflammatory disease,cancer,and *** T(Treg)and Th17 cells are critical Th cell types involved in immune tolerance,homeostasis,pathogenicity,and pathogen *** is therefore critical to understand how Treg and Th17 cells are regulated in health and *** are instrumental in directing Treg and Th17 cell *** evolutionarily conserved TGF-β(transforming growth factor-β)cytokine superfamily is of particular interest because it is central to the biology of both Treg cells that are predominantly immunosuppressive and Th17 cells that can be proinflammatory,pathogenic,and immune *** TGF-βsuperfamily members and their intricate signaling pathways regulate Treg and Th17 cell function is a question that has been intensely investigated for two ***,we introduce the fundamental biology of TGF-βsuperfamily signaling,Treg cells,and Th17 cells and discuss in detail how the TGF-βsuperfamily contributes to Treg and Th17 cell biology through complex yet ordered and cooperative signaling networks.

关键词： TGF-beta regulatory T cell Th17 cell Treg

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An y.Bai O.Bakina I.Balossino y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen y.B.Chen y.Q.Chen Z.J.Chen Z.y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang y.Fang y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu y.W.Fu H.Gao y.N.Gao yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding y.Ding y.Ding J.Dong L.y.Dong M.y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu y.T.Gu C.y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz y.K.Heng C.Herold T.Holtmann P.C.Hong G.y.Hou X.T.Hou y.R.Hou Z.L.Hou B.y.Hu H.M.Hu J.F.Hu T.Hu y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji y.y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.y.Li y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

A method for analyzing on-line video images of crystallization at high-solid concentrations

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Particuology 2008年第1期6卷 9-15页

作者： Jian wan Cai y. Ma Xue Z. wang Institute of Particle Science and Engineering School of Process Environmental and Materials Engineering University of Leeds Leeds LS2 9JT UK

Recent research has demonstrated that on-line video imaging is a very promising technique for monitoring crystallization processes. The bottleneck in applying the technique for real-time closed-loop control is considered as image analysis that needs to be robust, fast and able to handle varied image qualities due to temporal variations of operating conditions such as mixing and solid concentrations. Image analysis at highsolid concentrations turns out to be extremely challenging because crystals tend to overlap or attach to each other and the boundaries between the crystals are usually ambiguous. This paper presents an image segmentation algorithm that can effectively deal with images taken at high-solid concentrations. The method segments crystals attached to each other along the mostly related concave points on the contours of crystal blocks. The detailed procedure is introduced with application to crystallization of L-glutamic acid in a hot-stage reactor.

关键词： Crystallization High-solid concentrations Image processing Multi-scale segmentation Watershed segmentation Crystal size distribution

An essential role for TAK1 in the contact hypersensitivity response

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Cellular & Molecular Immunology 2011年第4期8卷 315-324页

作者： yan G Zhao yunqi wang Weidong Hao yisong y wan Department of Toxicology School of Public HealthPeking UniversityBeijingChina Department of Microbiology and Immunology Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel HillNCUSA

Contact hypersensitivity(CHS)is a delayed-type hypersensitivity that can be induced by haptens,such as 2,4-dinitrofluorobenzene(DNFB).Innate and adaptive immunities are both important for the development of *** treat CHS-related diseases,such as allergic contact dermatitis,a disease prevalent in industrialized countries,ways of interfering with improper immune function during CHS responses need to be *** growth factor-b-activated kinase-1(TAK1),a member of mitogen-activated protein kinase kinase kinase family,is important for both innate and adaptive *** thus hypothesized that the CHS response could be inhibited by interfering with TAK1 *** a mouse model in which TAK1 deletion can be locally induced,we observed that TAK deficiency led to an impaired CHS response and was associated with defective T-cell expansion,activation and interferon(IFN)-c *** addition,we investigated the effect of deleting TAK1 specifically in dendritic cells(DC)on the CHS *** found that when TAK1 is deficient in DC,the CHS response was abolished and hapten-elicited T-cell responses were ***,this study demonstrates an essential role of TAK1 in the induction of CHS and suggests that targeting TAK1 could be a viable approach to treat CHS.

关键词： CHS DC 2,4-dinitrofluorobenzene(DNFB) TAK1

Determination of the number ofψ(3686)events taken at BESⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An y.Bai O.Bakina I.Balossino y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen H.y.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen y.B.Chen y.Q.Chen Z.J.Chen Z.y.Chen S.K.Choi G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding X.X.Ding y.Ding y.Ding J.Dong L.y.Dong M.y.Dong X.Dong M.C.Du S.X.Du y.y.Duan Z.H.Duan P.Egorov y.H.Fan J.Fang J.Fang S.S.Fang W.X.Fang y.Fang y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng y.T.Feng M.Fritsch C.D.Fu J.L.Fu y.W.Fu H.Gao X.B.Gao y.N.Gao yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu y.T.Gu C.y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han F.Hanisch X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz y.K.Heng C.Herold T.Holtmann P.C.Hong G.y.Hou X.T.Hou y.R.Hou Z.L.Hou B.y.Hu H.M.Hu J.F.Hu S.L.Hu T.Hu y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang y.P.Huang T.Hussain F.Hölzken N.Hüsken N.in der Wiesche J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji y.y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li Ke Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Z.Li Xi Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

The number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BESⅢdetector

Involuntary Unemployment： An Expository Note

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2018年第1期13卷 83-92页

作者： Henry y. wan Jr. Department of Economics Comell University Ithaca NY 14853 USA

This note is an effort to view the research program of Brecher and his co-workers to deploy tax incentives against involuntary unemployment in the broader context; on both the equity-efficiency trade-off in political ... 详细信息

关键词： involuntary unemployment efficiency wage wage rigidity

Targeting gut microbiota in hepatocellular carcinoma: probiotics as a novel therapy

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Hepatobiliary Surgery and Nutrition 2018年第1期7卷 11-20页

作者： Murphy L.y.wan Hani El-Nezami School of Biological Sciences Faculty of ScienceThe University of Hong KongPokfulamHong KongChina Institute of Public Health and Clinical Nutrition University of Eastern FinlandKuopioFinland

Hepatocellular carcinoma(HCC),the most common primary liver cancer,is one of the dreaded complications of chronic liver *** experimental and clinical studies have revealed that the alteration of gut-liver axis plays a pivotal role in the onset of chronic liver diseases,including *** gut microbiota and endotoxemia are increasingly recognized as critical components in promoting the progression of chronic liver diseases to *** have been suggested as a novel,safe and cost-effective approach to prevent or treat *** by which probiotics exerts their anti-cancer effects include their ability to bind carcinogens,modulation of gut microbiota,improvement of intestinal barrier function,and *** review summarizes the literature findings of the changes in gut microbiota linked to HCC,and discusses the possible therapeutic implications of probiotics for HCC.

关键词： Endotoxemia gut-liver axis gut microbiota hepatocellular carcinoma(HCC) probiotics

Growth of RB Population in the Conversion Phase of Chlamydia Life Cycle

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Communications on Applied Mathematics and Computation 2024年第1期6卷 90-112页

作者： Frederic y.M.wan Department of Mathematics University of CaliforniaIrvineCA92697-3875USA

Upon infecting a host cell,the reticulate body(RB)form of the Chlamydia bacteria simply proliferates by binary fission for an extended *** data show only RB units in the infected cells 20 hours post infection(hpi),spanning nearly half way through the development *** data collected every 4 hpi,conversion to the elementary body(EB)form begins abruptly at a rapid rate sometime around 24 *** modeling proliferation and conversion as simple birth and death processes,it has been shown that the optimal strategy for maximizing the total(mean)EB population at host cell lysis time is a bang-bang control qualitatively replicating the observed conversion ***,the simple birth and death model for the RB proliferation and conversion to EB deviates in a significant way from the available data on the evolution of the RB population after the onset of RB-to-EB *** working with a more refined model that takes into account a small size threshold eligibility requirement for conversion noted in the available data,we succeed in removing the deficiency of the previous models on the evolution of the RB population without affecting the optimal bang-bang conversion strategy.

关键词： Chlamydia Life cycle Optimal control Maximal infectious spread Specie competitive survival

Effects of nano thickener deposited film on the behaviour of starvation and replenishment of lubricating greases

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Friction 2016年第4期4卷 313-323页

作者： Lu HUANG Dan GUO Xiang LIU Guoxin XIE George T y wan Shizhu WEN National Institute of Metrology Beijing 100029 ChinaState Key Laboratory of Tribology Tsinghua University Beijing 100086 China State Key Laboratory of Tribology Tsinghua University Beijing 100086 China

The mechanism of grease replenishment in and around a starved point contact was studied in this *** made of different thickeners and same base oil were tested and *** and re-formation of a dynamic grease reservoir during operation revealed that grease bled oil to replenish ***,the replenishment process was slow because of the presence of grease fingers along the track and thickener-deposited film inside the *** contact angles of base oil on the chromium-coated surface and thickener-deposited surfaces were *** proved that the contact angle on the deposited film remarkably increased compared with that on the chromium-coated surface from 25° to more than 40°.However,the deposited film could be consumed with continuous rolling,and replenishment was then enhanced.

关键词： grease starvation thickener deposited film replenishment contact angle