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Pretreatment can alleviate programmed cell death in mesenchymal stem cells

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World Journal of Stem Cells 2024年第8期16卷 773-779页

作者： Xin-Xing wan Xi-Min Hu Qi zhang Kun xiong Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Anatomy and Neurobiology Central South UniversityChangsha 410000Hunan ProvinceChina Department of Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 410013Hunan ProvinceChina

In this editorial,we delved into the article titled“Cellular preconditioning and mesenchymal stem cell ferroptosis.”This groundbreaking study underscores a pivotal discovery:Ferroptosis,a type of programmed cell death,drastically reduces the viability of donor mesenchymal stem cells(MSCs)after engraftment,thereby undermining the therapeutic value of cell-based ***,the article proposes that by manipulating ferroptosis mechanisms through preconditioning,we can potentially enhance the survival rate and functionality of MSCs,ultimately amplifying their therapeutic *** the crucial role ferroptosis plays in shaping the therapeutic outcomes of MSCs,we deem it im-perative to further investigate the intricate interplay between programmed cell death and the therapeutic effectiveness of MSCs.

关键词： Mesenchymal stem cells Programmed cell death Apoptosis Autophagy Ferroptosis

Analysis of thermal management and anti-mechanical abuse of multi-functional battery modules based on magneto-sensitive shear thickening fluid

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 529-542页

作者： Yang xiong Bo LU Yicheng SONG Junqian zhang Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Zhejiang Laboratory Hangzhou 311100China

Electric vehicles(EVs)have garnered significant attention as a vital driver of economic growth and environmental ***,ensuring the safety of high-energy batteries is now a top priority that cannot be overlooked during large-scale *** paper proposes an innovative active protection and cooling integrated battery module using smart materials,magneto-sensitive shear thickening fluid(MSTF),which is specifically designed to address safety threats posed by lithium-ion batteries(LIBs)exposed to harsh mechanical and environmental *** theoretical framework introduces a novel approach for harnessing the smoothed-particle hydrodynamics(SPH)methodology that incorporates the intricate interplay of non-Newtonian fluid behavior,capturing the fluid-structure coupling inherent to the *** approach is further advanced by adopting an enhanced Herschel-Bulkley(H-B)model to encapsulate the intricate rheology of the MSTF under the influence of the magnetorheological effect(MRE)and shear thickening(ST)*** simulation results show that in the case of cooling,the MSTF is an effective cooling medium for rapidly reducing the *** terms of mechanical abuse,the MSTF solidifies through actively applying the magnetic field during mechanical compression and impact within the battery module,resulting in 66%and 61.7%reductions in the maximum stress within the battery jellyroll,and 31.1%and 23%reductions in the reaction force,*** mechanism effectively lowers the risk of short-circuit *** groundbreaking concepts unveiled in this paper for active protection battery modules are anticipated to be a valuable technological breakthrough in the areas of EV safety and lightweight/integrated design.

关键词： magneto-sensitive shear thickening fluid(MSTF) battery module impact protection temperature control integrated design

ON THE EMPTY BALLS OF A CRITICAL OR SUBCRITICAL BRANCHING RANDOM WALK

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Acta Mathematica Scientia 2024年第5期44卷 2051-2072页

作者： Shuxiong zhang Jie xiong School of Mathematics and Statistics Anhui Normal UniversityWuhu241002China Department of Mathematics and SUSTech International Center for Mathematics Southern University of Science and TechnologyShenzhen518055China

Let{Z_(n)}_(n)≥0 be a critical or subcritical d-dimensional branching random walk started from a Poisson random measure whose intensity measure is the Lebesugue measure onℝ^(d).Denote by R_(n):=sup{u>0:Z_(n)({x∈ℝ^(... 详细信息

关键词： empty ball dimension branching random walk super-Brownian motion

Self-separation ionic liquid catalyst for the highly effective conversion of H2S by α,β-unsaturated carboxylate esters under mild conditions

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Green Energy & Environment 2024年第9期9卷 1440-1448页

作者： Wenjie xiong Xiaomin zhang Xingbang Hu Youting Wu Key Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical Engineering Nanjing University The Institute of Green Chemistry and Engineering School of Chemistry and Chemical Engineering Nanjing University

The deep-processing utility of pure hydrogen sulfide （H2S） is a significant direction in natural gas chemical ***,a brand-new strategy of H2S conversion by a,β-unsaturated carboxylate esters into thiols or thioethers using task-specific carboxylate ionic liquids （ILs） as catalyst has been developed,firstly accomplishing the phase separation of product and catalyst without introducing the third *** can be considered as a cascade reaction in which the product selectivity can be controlled by adjusting the molar ratio of H2S to a,β-unsaturated carboxylate ***,the effects of ILs with different anions and cations,intermittent feeding operations,as well as pressure-time kinetic behaviors on cascade reaction were ***,the proposed interaction mechanism of H2S conversion using butyl acrylate catalyzed by[Emim][Ac]was revealed by DFT-based theoretical *** approach enables the self-phase separation promotion of catalyst and product and achieves 99%quantitative conversion under mild conditions in the absence of solvent,making the entire process ecologically ***-efficiency reaction activity can still be maintained after ten cycles of the ***,the good results,combined with its simplicity of operation and the high recyclability of the catalyst,make this green method environmentally friendly and *** is anticipated that this self-separation method mediated by task-specific ILs will provide a feasible strategy for H2S utilization,which will guide its application on an industrial scale.

关键词： Ionic liquid Cascade reaction Self-separation H 2 S conversion Catalysis

Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： Zi-Bing Qian Jun-Feng Li wan-Yuan xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic *** forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver *** general,more than one form of cell death pathways is responsible for the disease ***,it is particularly important to study the regulation and interaction of various cell death forms in liver *** sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver *** also used terms such as signal path,inducer,and inhibitor to supplement the query ***:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver ***:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

Performance evaluation of HY-2 series satellites in marine gravity field recovery

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Geodesy and Geodynamics 2024年第4期15卷 397-403页

作者： Ruijie Hao Xiaoyun wan Keyan zhang School of Land Science and Technology China University of Geosciences(Beijing)Beijing100083China School of Geospatial Engineering and Science Sun Yat-Sen UniversityZhuhai519082China

China has successfully launched four Haiyang-2(HY-2)series altimetry ***-2A has attracted significant attention in gravity field recovery,but the performance of other HY-2 series satellites,including HY-2B/C/D,is seldom *** study evaluated the performance of all the HY-2 series satellites in recovering marine gravity ***,the crossover discrepancies in sea surface height of the four satellites,HY-2A,HY-2B,HY-2C,and HY-2D,were analyzed to assess their altimetry *** was found that HY-2B had the best altimetry quality,followed by ***,different combina-tions of altimetry data were used to calculate vertical deflections and gravity anomalies in the South China Sea(112°E-119°E,12°N-20°N).The results showed that combining data from HY-2B,HY-2C,and HY-2D improved the inversion accuracy of gravity anomalies by 0.3 mGal compared to using HY-2A data ***-2C and HY-2D contributed to enhancing the accuracy of the east component of vertical deflections.

关键词： Satellite altimetry HY-2 Sea surfaceheight Marinegravityfield

A Spleen Tyrosine Kinase’s Sky in Neuronal Degeneration

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Neuroscience Bulletin 2024年第2期40卷 273-276页

作者： wan-Yun zhang Sen Lin Department of Neurology Xinqiao HospitalThe Second Afliated HospitalArmy Medical UniversityChongqing 400042China Chongqing Institute for Brain and Intelligence Guangyang Bay LaboratoryChongqing 400064China

With the growing elderly population,neurodegenerative disorders like Alzheimer's disease(AD)are emerging as a significant public health *** is widely acknowledged in the scientific community that the accumulation of neurotoxic aggregates,such as amyloid beta(Aβ),within the central nervous system is a major factor in the development of these ***,human genome-wide association studies have identified mutations in microglial receptors that may be linked to a number of neurodegenerative diseases[1].

关键词： Aβ Spleen Alzheimer

Hybrid Dynamic Variables-Dependent Event-Triggered Fuzzy Model Predictive Control

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 723-733页

作者： xiongbo wan Chaoling zhang Fan Wei Chuan-Ke zhang Min Wu IEEE the School of Automation China University of Geosciencesthe Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systemsand the Engineering Research Center of Intelligent Technology for Geo-ExplorationMinistry of EducationWuhan 430074China

This article focuses on dynamic event-triggered mechanism(DETM)-based model predictive control(MPC) for T-S fuzzy systems.A hybrid dynamic variables-dependent DETM is carefully devised,which includes a multiplicative dynamic variable and an additive dynamic *** addressed DETM-based fuzzy MPC issue is described as a “min-max” optimization problem(OP).To facilitate the co-design of the MPC controller and the weighting matrix of the DETM,an auxiliary OP is proposed based on a new Lyapunov function and a new robust positive invariant(RPI) set that contain the membership functions and the hybrid dynamic variables.A dynamic event-triggered fuzzy MPC algorithm is developed accordingly,whose recursive feasibility is analysed by employing the RPI *** the designed controller,the involved fuzzy system is ensured to be asymptotically *** examples show that the new DETM and DETM-based MPC algorithm have the advantages of reducing resource consumption while yielding the anticipated performance.

关键词： Dynamic event-triggered mechanism(DETM) hybrid dynamic variables model predictive control(MPC) robust positive invariant(RPI)set T-S fuzzy systems

Multiple pretreatments can effectively improve the functionality of mesenchymal stem cells

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World Journal of Stem Cells 2024年第2期16卷 58-63页

作者： Xin-Xing wan Xi-Min Hu Kun xiong Department of Endocrinology Third Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 410013Hunan ProvinceChina

In this editorial,we offer our perspective on the groundbreaking study entitled“Hypoxia and inflammatory factor preconditioning enhances the immunosup-pressive properties of human umbilical cord mesenchymal stem cells”,recently published in World Journal of Stem *** over three decades of research on the clinical application of mesenchymal stem cells(MSCs),only a few therapeutic products have made it to clinical use,due to multiple preclinical and clinical challenges yet to be *** study proved the hypoxia and inflammatory factor preconditioning led to higher immunosuppressive effects of MSCs without damaging their biological characteristics,which revealed the combination of inflammatory factors and hypoxic preconditioning offers a promising approach to enhance the function of *** we delve deeper into the intricacies of pretreat-ment methodologies,we anticipate a transformative shift in the landscape of MSC-based therapies,ultimately contributing to improved patient outcomes and advancing the field as a whole.

关键词： Mesenchymal stem cells Inflammatory factor Hypoxia Pretreatment