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Understanding the role of PIN1 in hepatocellular carcinoma

2019年海峡两岸暨港澳青年科学家毒理学学术交流会

作者： Imran Khan 黄国鑫 Xiao-ang Li Weilin Liao wai kit leong Wenrui Xia Xiqing Bian Jianlin Wu W.L.Wendy Hsiao State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology 澳门科技大学-中药质量研究国家重点实验室

The incidence of colorectal cancer(CRC) is alarming among younger *** no effective chemopreventive drug available in the market,researchers have been searching for alternative strategies against CRC that are in ***,we tested the cancer-preventive properties of Ganoderma lucidum(Lingzhi) polysaccharides(GLP),along with the saponins extracted from Gynostemma pentaphyllum(GpS),an herbal tea with prebiotic-like ***,we report that saponins from Gynostemma pentaphyllum(GpS) and polysaccharides from Ganoderma lucidum(GLP together with GpS) profoundly improved the inflamed gut barrier of Apc mice by reducing polyps,shifting colonic M1 to M2 macrophages,positively reverting E-cadherin/N-cadherin ratio,and downregulating oncogenic signaling *** treatments also markedly promoted short-chain fatty acids(SCFAs)-producing bacteria and abridged sulfate-reducing bacteria in a time-dependent manner.G-protein coupled-receptors were significantly stimulated in the treated mice,accompanied by the modulated expressions of histone deacetylases,anti-cancer gut hormone PYY,and PPAPγ.These findings suggest that some of the herbal medicinal foods could modulate the relationship between the host and the GM to exert their beneficial properties to the *** study also implicates that these dietary mushroom polysaccharides and the Gp saponins have the potential to be developed as new preventive medicines against CRC.

关键词： Gut microbiota Saponins Polysaccharides SCFAs GPCRs ApcMin/+ mice

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World Journal of Gastroenterology 2016年第45期22卷 9921-9932页

作者： Chi-wai Cheng Ka-wai leong Eric Tse Department of Medicine The University of Hong Kong Queen Mary Hospital

PIN1 is a peptidyl-prolyl cis/trans isomerase that binds and catalyses isomerization of the specific motif comprising a phosphorylated serine or threonine residue preceding a proline(p Ser/Thr-Pro) in proteins. PIN1 can therefore induce conformational and functional changes of its interacting proteins that are regulated by proline-directed serine/threonine phosphorylation. Through this phosphorylation-dependent prolyl isomerization, PIN1 fine-tunes the functions of key phosphoproteins(e.g., cyclin D1, survivin, β-catenin and x-protein of hepatitis B virus) that are involved in the regulation of cell cycle progression, apoptosis, proliferation and oncogenic transformation. PIN1 has been found to be over-expressed in many cancers, including human hepatocellular carcinoma(HCC). It has been shown previously that overexpression of PIN1 contributes to the development of HCC invitro and in xenograft mouse model. In this review, we first discussed the aberrant transcription factor expression, miR NAs dysregulation, PIN1 gene promoter polymorphisms and phosphorylation of PIN1 as potential mechanisms underlying PIN1 overexpression in cancers. Furthermore, we also examined the role of PIN1 in HCC tumourigenesis by reviewing the interactions between PIN1 and various cellular and viral proteins that are involved in β-catenin, NOTCH, and PI3K/Akt/mT OR pathways, apoptosis, angiogenesis and epithelial-mesenchymal transition. Finally, the potential of PIN1 inhibitors as an anti-cancer therapy was explored and discussed.

关键词： Phosphorylation Hepatocellular carcinoma PIN1 Isomerization Hepatocarcinogenesis

Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection

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Neural Regeneration Research 2022年第12期17卷 2643-2648页

作者： Ling-Ping Cen Tsz Kin Ng wai kit Chu Chi Pui Pang Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Both inflammation and anti-inflammation are involved in the protection of retinal *** of the hypothalamic growth hormone-releasing hormone receptor(GHRHR)have been shown to possess potent anti-inflammatory properties in experimental disease models of various organs,some with systemic *** effects are also found in ocular inflammatory and neurologic injury *** experimental models of mice and rats,both growth hormone-releasing hormone receptor agonists and antagonists may alleviate death of ocular neural cells under certain experimental *** review explores the properties of growth hormone-releasing hormone receptor agonists and antagonists that lead to its protection against inflammatory responses induced by extrinsic agents or neurologic injures in ocular animal models.

关键词： neuroprotection ocular inflammation optic nerve injury retinal ganglion cells uveitis

Seroprevalence of Pteropine orthoreovirus (PRV) Infection among Outpatients in a Clinic in Rembau, Malaysia

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Biomedical and Environmental Sciences 2022年第8期35卷 755-759页

作者： leong wai Jing VOON Kenny WONG Siew Tung TENG Cheong Lieng leong Pooi Pooi WANG Linfa School of Medicine International Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia School of Pharmacy University of Nottingham MalaysiaSemenyih 43500SelangorMalaysia Faculity of Medicine and Health Sciences Universiti Tunku Abdui RahmanKajang 43000SelangorMalaysia Programme in Emerging Infectious Diseases Duke-NUS Medical School169857 Singapore

Pteropine orthoreovirus(PRV)is an emerging zoonotic respiratory virus with the potential to spill over from fruit bats to *** belongs to the family Reoviridae,whose name is derived from an abbreviation of"respiratory enteric orphan".This family of viruses was initially not believed to cause diseases in humans and therefore was named an"orphan virus".PRV infections in humans are characterized by symptoms ranging from mild influenza-like illness to severe acute respiratory distress.

关键词： PRV abbreviation initially

Anesthetic Management of Pheochromocytoma in Pediatric Patient—Case Report

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Open Journal of Anesthesiology 2021年第6期11卷 175-183页

作者： Lam wai Teng Siu Man kit Chan Si wai leong Fai Department of Anesthesiology Centro Hospitalar Conde de S?o Januário Macao Special Administrative Region China

Background: Pediatric pheochromocytoma is very rare, accounting for only about 1% of pediatric hypertension. Case Presentation: We presented a case of pediatric pheochromocytoma in a 12-year-old girl undergoing laparoscopic adrenalectomy, with the aim of highlighting an anesthetic challenge. Conclusion: Preoperative screening of hereditary conditions, investigations for end-organ dysfunction, preoperative blood pressure optimization, intensive intraoperative hemodynamic management and good communication with surgeons were the cornerstones for this successful surgery.

关键词： Anesthesia Hemodynamic Pediatrics Pheochromocytoma

Investigation on the Consumption Values of Hong Kong People on Tie Products

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Journal of Donghua University(English Edition) 2004年第2期21卷 52-59页

作者： Sarah Mei-yi Leung Alice wai-ching Chu kit-lun Yick Institute of Textiles & Clothing The Hong Kong Polytechnic University Hung Hom Kowloon Hong KongDrInstitute of Textiles & Clothing The Hong Kong Polytechnic University Hung Hom Kowloon Hong KongInstitute of Textiles & Clothing The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong

This study aims at investigating the consumption values of Hong Kong people on necktie. Based on the Sheth-Newman-Gross Model of consumption values on consumers’ choice decision as conceptual framework, results from the focus group interview, a questionnaire was designed and adopted for conducting the survey. Data collected from 245 respondents were analysed using the Factor Analysis to review the important elements of consumers’ decision of purchasing tie products. Implications on the results on the Functional value were reviewed and discussed in details. Interesting elements such as fabric hand-feel were also identified as influential associated in Hong Kong consumers’ selection of necktie. Since, both fibre content and fabric handle were also found as major selection criteria for fabric materials, the study was focused on the analysis of functional value of the product and further extended to study the handle preference for Hong Kong customers, in which a subjective handle assessment of a wide range of tie fabrics being newly developed and introduced in the market was conducted and objective fabric physical and mechanical properties were measured. Important fabric handle attributes that influence the consumers’ preference on tie fabrics were identified and their objective translation by fabric physical and mechanical properties were also obtained. The investigation provides decision support to necktie manufacturers and retailers through scientific and quantitative recommendations for product development of tie products and material selection.

关键词： Necktie Hand-feel Consumption Values and Consumer Behaviour

hale gas reservoir modeling and production evaluation considering complex gas transport mechanisms and dispersed distribution of kerogen

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Petroleum Science 2021年第1期18卷 195-218页

作者： Jie Zeng Jishan Liu wai Li Yee-Kwong leong Derek Elsworth Jianchun Guo School of Engineering The University of Western Australia35 Stirling HighwayPerthWA 6009Australia Department of Energy and Mineral Engineering G3 Center and Energy InstituteThe Pennsylvania State UniversityUniversity ParkPA 16802USA State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

Stimulated shale reservoirs consist of kerogen,inorganic matter,secondary and hydraulic *** dispersed distribution of kerogen within matrices and complex gas flow mechanisms make production evaluation *** we establish an analytical method that addresses kerogen-inorganic matter gas transfer,dispersed kerogen distribution,and complex gas flow mechanisms to facilitate evaluating gas *** matrix element is defined as a kerogen core with an exterior inorganic *** most previous models,we merely use boundary conditions to describe kerogen-inorganic matter gas transfer without the instantaneous kerogen gas source *** is closer to real inter-porosity flow conditions between kerogen and inorganic *** diffusion,surface diffusion,adsorption/desorption,and slip corrected flow are involved in matrix gas ***-fracture coupling is realized by using a seven-region linear flow *** model is verified against a published model and field *** reveal that inorganic matrices serve as a major gas source especially at early *** provides limited contributions to production even under a pseudo-steady *** properties’influence starts from the late matrix-fracture inter-porosity flow regime,while inorganic matter properties control almost all flow regimes except the early-mid time fracture linear flow *** contribution of different linear flow regions is also documented.

关键词： Analytical solution Shale gas reservoir Well performance Kerogen and inorganic matter

Genetically modified foods in China and the United States:A primer of regulation and intellectual property protection

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Food Science and Human Wellness 2016年第3期5卷 124-140页

作者： Alice Yuen-Ting Wong Albert wai-kit Chan Albert wai-kit Chan Intellectual Property Limited Hong Kong Special Administrative Region United States-China Intellectual Property Institute New YorkUSA Law Offices of Albert wai-kit Chan PLLCNew YorkUSA

Food is a basic and personal necessity to *** of food is a prime factor to consider apart from nutrition,quality and *** modified(GM)foods first came on the market in *** safety,transparency and traceability ofGMfoods are still under hot ***,the market of GM foods is huge and *** affairs and intellectual property(IP)are two critical factors affecting the development and commercial success of a food *** article will take a look at the GM food technology and regulatory framework for GM foods in China and the United *** article will also discuss the unique patent issues and non-patent IP tools for safeguarding the technology in these two countries.

关键词： property modified attractive

Spatial memory enhances the evacuation efficiency of virtual pedestrians under poor visibility condition

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Chinese Physics B 2018年第3期27卷 560-567页

作者： Yi Ma Eric wai Ming Lee Meng Shi Richard Kwok kit Yuen Institute for Disaster Management and Reconstruction Sichuan University Chengdu 610207 China Department of Architecture and Civil Engineering City University of Hong Kong Kowloon Hong Kong China

Spatial memory is a critical navigation support tool for disoriented evacuees during evacuation under adverse environ-mental conditions such as dark or smoky conditions. Owing to the complexity of memory, it is challenging to understand the effect of spatial memory on pedestrian evacuation quantitatively. In this study, we propose a simple method to quan- titatively represent the evacuee＇s spatial memory about the emergency exit, model the evacuation of pedestrians under the guidance of the spatial memory, and investigate the effect of the evacuee＇s spatial memory on the evacuation from theoretical and physical perspectives. The result shows that （i） a good memory can significantly assist the evacuation of pedestrians under poor visibility conditions, and the evacuation can always succeed when the degree of the memory exceeds a threshold （φ〉 0.5）; （ii） the effect of memory is superior to that of ＂follow-the-crowd＂ under the same environmental conditions; （iii） in the case of multiple exits, the difference in the degree of the memory between evacuees has a significant effect （the greater the difference, the faster the evacuation） for the evacuation under poor visibility conditions. Our study provides a new quantitative insight into the effect of spatial memory on crowd evacuation under poor visibility conditions.

关键词： crowd evacuation memory visibility social force model

Ineffective esophageal motility is associated with acute rejection after lung transplantation independent of gastroesophageal reflux

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World Journal of Gastroenterology 2023年第21期29卷 3292-3301页

作者： wai-kit Lo Brent Hiramoto Hilary J Goldberg Nirmal Sharma Walter W Chan Division of Gastroenterology Hepatology and EndoscopyBrigham and Women's HospitalBostonMA 02115United States Division of Pulmonary and Critical Care Medicine Brigham and Women's HospitalBostonMA 02115United States

BACKGROUND Gastroesophageal reflux is associated with poorer outcomes after lung transplant,likely through recurrent aspiration and allograft *** prior studies have demonstrated a relationship between impedance-pH results and transplant outcomes,the role of esophageal manometry in the assessment of lung transplant patients remains debated,and the impact of esophageal dysmotility on transplant outcomes is *** particular interest is ineffective esophageal motility(IEM)and its associated impact on esophageal *** To assess the relationship between pre-transplant IEM diagnosis and acute rejection after lung *** This was a retrospective cohort study of lung transplant recipients at a tertiary care center between 2007 and *** with pre-transplant anti-reflux surgery were *** and reflux diagnoses were recorded from pre-transplant esophageal function ***-to-event analysis using Cox proportional hazards model was applied to evaluate outcome of first episode of acute cellular rejection,defined histologically per International Society of Heart and Lung Transplantation *** not meeting this endpoint were censored at time of post-transplant anti-reflux surgery,last clinic visit,or ***’s exact test for binary variables and student’s t-test for continuous variables were performed to assess for differences between *** Of 184 subjects(54%men,mean age:58,follow-up:443 person-years)met criteria for *** pulmonary fibrosis represented the predominant pulmonary diagnosis(41%).During the follow-up period,60 subjects(33.5%)developed acute *** all-cause mortality was 16.3%.Time-to-event univariate analyses demonstrated significant association between IEM and acute rejection[hazard ratio(HR):1.984,95%CI:1.03-3.30,P=0.04],confirmed on Kaplan-Meier *** multivariable analysis,IEM remained independently associated with acute rejection,even after c

关键词： Ineffective esophageal motility Esophageal hypomotility Esophageal manometry Gastroesophageal reflux disease Lung transplantation Acute rejection