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Reproductive toxicity of enrofloxacin in Caenorhabditis elegans involves oxidative stress-induced cell apoptosis

Journal of Environmental Sciences 2023年第5期127卷 726-737页

作者： Jiahao Huang Lizi Liao Guowei Wang Zhongkun Du zhengxing wu Key Laboratory of Molecular Biophysics Ministry of EducationCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China School of Environmental Ecology and Biological Engineering Wuhan Institute of TechnologyWuhan 430205China Key Laboratory of Green Chemical Engineering Process of Ministry of Education Wuhan 430205China College of Resources and Environment Shandong Agricultural UniversityTaian 271018China

Fluoroquinolone antibiotics(FQs)that persist and bioaccumulate in the environment have aroused people’s great ***,we studied the adverse effects of FQs in soil animals of Caenorhabditis elegans via food-chronically *** result shows *** exposed to FQs exhibited reproductive toxicity with small-brood size and low-egg *** study the underlying mechanism,we conduct a deep investigation of enrofloxacin(ENR),one of the most frequently detected FQs,on nematodes which is one of commonly used animal indicator of soil *** concentration-effect curves simulated by the Hill model showed that the half effect concentrations(EC50)of ENR were(494.3±272.9)μmol/kg and(107.4±30.9)μmol/kg for the brood size and the hatchability,*** gene expression between the control and the ENR-exposure group enriched with the oxidative stress and cell apoptosis *** results together with the enzyme activity in oxidative stress and the cell corpses suggested that ENR-induced reproductive toxicity was related to germ cell apoptosis under oxidative *** risk quotients of some soil and livestock samples were calculated based on the threshold value of EC10 for the egg hatchability(2.65μmol/kg).The results indicated that there was possible reproductive toxicity on the nematodes in certain agricultural soils for the *** study suggested that chronic exposure to FQs at certain levels in environment would induce reproductive toxicity to the nematodes and might reduce the soil sustainability,alarming the environment risks of antibiotics abuse.

关键词： Environmental toxicity Nematodes Chronic exposure Oxidative stress response Germ cell apoptosis

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A novel robotic visual perception framework for underwater operation

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Frontiers of Information Technology & Electronic Engineering 2022年第11期23卷 1602-1619页

作者： Yue LU Xingyu CHEN zhengxing wu Junzhi YU Li WEN State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China Ytech Kuaishou TechnologyBeijing 100085China State Key Laboratory for Turbulence and Complex Systems Department of Advanced Manufacturing and RoboticsCollege of EngineeringPeking UniversityBeijing 100871China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China

Underwater robotic operation usually requires visual perception(e.g.,object detection and tracking),but underwater scenes have poor visual quality and represent a special domain which can affect the accuracy of visual *** addition,detection continuity and stability are important for robotic perception,but the commonly used static accuracy based evaluation(i.e.,average precision)is insufficient to reflect detector performance across *** response to these two problems,we present a design for a novel robotic visual perception ***,we generally investigate the relationship between a quality-diverse data domain and visual restoration in detection *** a result,although domain quality has an ignorable effect on within-domain detection accuracy,visual restoration is beneficial to detection in real sea scenarios by reducing the domain ***,non-reference assessments are proposed for detection continuity and stability based on object ***,online tracklet refinement is developed to improve the temporal performance of ***,combined with visual restoration,an accurate and stable underwater robotic visual perception framework is ***-overlap suppression is proposed to extend video object detection(VID)methods to a single-object tracking task,leading to the flexibility to switch between detection and *** experiments were conducted on the ImageNet VID dataset and real-world robotic tasks to verify the correctness of our analysis and the superiority of our proposed *** codes are available at https://***/yrqs/VisPerception.

关键词： Underwater operation Robotic perception Visual restoration Video object detection

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Development and Control of Underwater Gliding Robots:A Review

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IEEE/CAA Journal of Automatica Sinica 2022年第9期9卷 1543-1560页

作者： Jian Wang zhengxing wu Huijie Dong Min Tan Junzhi Yu the State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 the School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China the State Key Laboratory for Turbulence and Complex System Department of Mechanics and Engineering ScienceBIC-ESATCollege of EngineeringPeking UniversityBeijing 100871China

As one of the most effective vehicles for ocean development and exploration,underwater gliding robots(UGRs)have the unique characteristics of low energy consumption and strong ***,by borrowing the motion principles of current underwater robots,a variety of novel UGRs have emerged with improving their maneuverability,concealment,and environmental friendliness,which significantly broadens the ocean *** this paper,we provide a comprehensive review of underwater gliding robots,including prototype design and their key *** the perspective of motion characteristics,we categorize the underwater gliding robots in terms of traditional underwater gliders(UGs),hybrid-driven UGs,bio-inspired UGs,thermal UGs,and ***,their buoyancy driven system,dynamic and energy model,and motion control are concluded with detailed ***,we have discussed the current critical issues and future *** review offers valuable insight into the development of next-generation underwater robots well-suited for various oceanic applications,and aims to gain more attention of researchers and engineers to this growing field.

关键词： Buoyancy driven motion control oceanic applications system development underwater gliding robots

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Palladium-Catalyzed Long-Range Isomerization of Aryl Olefins

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Chinese Journal of Chemistry 2022年第19期40卷 2269-2275页

作者： Qianyi Ge Jingjie Meng Huikang Liu Zehua Yang zhengxing wu Wanbin Zhang Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research Institute of Pharmacy&Pharmacology School of Pharmaceutical ScienceHengyang Medical SchoolUniversity of South ChinaHengyangHunan421001 China Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai200240 China

Long-range olefin isomerization could lead to the remote functionalization of hydrocarbon chains,which is advantageous with regards to atom-,step-,and redox ***,present methodologies for long-range olefin isomerization are mainly focused on heteroatom directed remote olefin migration;studies using aryl groups as the directing group are *** limited examples either utilize aryl olefins with special substituted groups on a benzene ring,or use elaborately optimized ligands or co-catalysts to accelerate the isomerization.A more simple catalytic system for general aryl olefins,without the need for special ligands or co-catalysts,was to be ***,we report a Pd-catalyzed long-range olefin isomerization(up to 15 units)for general aryl olefins via a 1,2-hydrogen shift *** methodology provides a simple pathway to long-range olefin isomerization without the participation of special ligands or co-catalysts.

关键词： Palladium/Long-range Isomerization Arylolefin/1,2-Hydrogenshift

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耐药肺结核患者密切接触者结核分枝杆菌潜伏感染危险因素分析

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中国防痨杂志 2024年第5期46卷 525-530页

作者：叶新春刘赛朵程芳蒋贤高宁洪叶吴正兴周月影邱超超潘宁施伎蝉温州医科大学定理临床医院/温州市中心医院感染科温州325000

目的:探究耐药肺结核患者密切接触者结核分枝杆菌潜伏感染(latent tuberculosis infection,LTBI)情况及危险因素。方法:采用前瞻性研究方法,选取2020年7月至2022年1月于温州市中心医院收治的154例耐药肺结核(包括单耐利福平肺结核、耐... 详细信息

目的:探究耐药肺结核患者密切接触者结核分枝杆菌潜伏感染(latent tuberculosis infection,LTBI)情况及危险因素。方法:采用前瞻性研究方法,选取2020年7月至2022年1月于温州市中心医院收治的154例耐药肺结核(包括单耐利福平肺结核、耐多药肺结核)患者的306名密切接触者作为研究对象。收集研究对象社会人口学特征、卡介苗接种史、疾病史,以及与指示病例的接触情况等信息;并进行HIV抗体筛查、胸部CT扫描、结核感染T细胞斑点试验和(或)结核菌素皮肤试验(PPD试验)等。调查研究对象LTBI情况,并采用logistic回归模型分析其发生LTBI的影响因素。结果:研究对象结核分枝杆菌潜伏感染率为18.6%(57/306)。多因素分析结果表明,年龄≥40岁、女性、体力劳动者、指示病例为复治患者,以及指示病例有咳嗽、咳痰等临床症状的密切接触者发生LTBI的风险更高[OR(95%CI)值分别为6.501(1.371~30.827)、2.961(1.472~5.956)、2.716(1.368~5.391)、3.100(1.278~7.521)、3.065(1.336~7.031)];而家庭月收入≥5000元是密切接触者发生LTBI的保护因素[OR(95%CI)=0.308(0.156~0.607)]。结论:耐药肺结核患者密切接触者结核分枝杆菌潜伏感染率较高,高龄、女性、体力劳动者、低收入,以及与复治耐药肺结核患者和具有咳嗽、咳痰等临床症状耐药肺结核患者的密切接触者是发生LTBI的高危人群。

关键词：结核,肺抗药性,细菌接触者追踪感染因素分析,统计学

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Hybridization-mediated quasiparticle and phonon dynamics in single crystal cerium films

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 146-153页

作者： Yunhe Pei Yi wu Kai Hu zhengxing Wei YiFeng Yang Yang Liu Jingbo Qi State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 611731China Center for Correlated Matter and Department of Physics Zhejiang UniversityHangzhou 310058China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

We report the ultrafast optical pump-probe spectroscopy measurements on the single-crystal cerium *** experimental results of temperature-dependent quasiparticle dynamics reveal development of the hybridization between localized f moments and conduction electrons,i.e.,evolving from fluctuating hybridization to collective *** phonon renormalization is discovered to appear at the emerging temperature(T^(+))of fluctuating hybridization apart from its known presence at the coherent temperature(T^(*)),and can hardly be explained by the mean-field *** quasiparticle relaxation at high temperatures indicates coexistence of nonthermal electron-electron scattering and inelastic Kondo scattering,while its behavior at low temperatures suggests onset ofαphase in theγ-phase dominated *** also extract the indirect gap below T^(*),representing the appearance of collective *** findings provide novel information about the hybridization and phase evolution in the heavy fermion systems.

关键词： cerium quasiparticle dynamics hybridization phonon renormalization

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Controlling the depth of a gliding robotic dolphin using dual motion control modes

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Science China(Information Sciences) 2020年第9期63卷 217-230页

作者： Jian WANG zhengxing wu Min TAN Junzhi YU State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory for Turbulence and Complex System Department of Mechanics and Engineering ScienceBIC-ESAT College of Engineering Peking University

This paper investigates the performance of the dual mode, namely flipper mode and central pattern generator(CPG) mode, for controlling the depth of a gliding robotic dolphin. Subsequent to considering the errors in dynamic models, we propose a depth control system that combines the line-of-sight(LOS)method with an adaptive control approach(ACA) to deal with uncertainties in the model parameters. First,we establish a full-state dynamic model to conduct simulations and optimize the parameters used in later aquatic experiments. Then, we use the LOS method to transform the control target from the depth to the pitch angle and employ the ACA to calculate the control signal. In particular, we optimize the ACA’s control parameters using simulations based on our dynamic model. Finally, our simulated and experimental results demonstrate not only that we can successfully control the robotic dolphin’s depth, but also that its performance was better than that of the CPG-based control, thus indicating that we can achieve three-dimensional motion by combining flipper-based and CPG-based control. The results of this study suggest valuable ideas for practical applications of gliding robotic dolphins.

关键词： gliding robotic dolphin depth control dual motion adaptive control approach

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Hydrodynamic Analysis and Verification of an Innovative Whale Shark-like Underwater Glider

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Journal of Bionic Engineering 2020年第1期17卷 123-133页

作者： Huijie Dong zhengxing wu Min Tan Junzhi Yu State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceBIC-ESATCollege of EngineeringPeking UniversityBeijing 100871China

This paper presents an innovative design for a biomimetic whale shark-like underwater glider aiming at the combination of high maneuverability and long *** a hybrid of the underwater glider and the robotic fish,its pectoral fins and tail can serve as not only the external control surfaces for attitude regulation during gliding but also the propellers for agile fish-like swimming *** verify the gliding capability of the whale shark-like glider and prepare for future dynamic analysis,the hydrodynamic coefficients,including drag,lift,sliding force,and corresponding moments are estimated through computational fluid dynamics *** addition,the hydrodynamic analyses of the proposed glider and an equivalent conventional glider during steady gliding motion are executed for *** experiments are performed to verify the downward gliding *** results reveal that the whale shark-like glider has less drag as well as higher lift-to-drag ratio and a markable gliding capability in *** may offer important inspiration for improving the gliding efficiency and performance of an underwater glider in biomimetic shape design.

关键词： biomimetic robot CFD hydrodynamic analysis underwater glider

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Kinematic Comparison of Forward and Backward Swimming and Maneuvering in a Self-Propelled Sub-Carangiform Robotic Fish

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Journal of Bionic Engineering 2014年第2期11卷 199-212页

作者： zhengxing wu Junzhi Yu Min Tan Jianwei Zhang State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing 100190 P. R. China Department of Informatics University of Hamburg Hamburg Germany

We make a thorough kinematic comparison of forward and backward swimming and maneuvering on a self-propelled robot platform that uses sub-carangifbrm swimming as the primary propulsor. An improved Central Pattern Generator （CPG） model allowing free adjustment of phase relationship and directional bias is employed to achieve flexible swimming and smooth transition. Considering the characteristics of forward swimming in carangiform fish and backward swimming in anguilliform fish, various backward swimming patterns for the sub-carangiform robotic fish are suitably created by reversing the direction of propagating propulsive waves. Through a combined use of the CPG control and closed-loop swimming direction control strategy, flexible and precise turning maneuvers in both forward and backward swimming are implemented and compared. By contrast with forward swimming, backward swimming requires a higher frequency or an increased lateral displacement to reach the same relative swimming speed. Noticeably, the phase difference shows a greater impact on forward swimming than on backward swimming. Our observations also indicate that the robotic fish achieves a larger turning rate in forward maneuvering than in backward maneuvering, yet these two maneuvers display comparable turning precision.

关键词： robotic fish backward swimming Central Pattern Generator (CPG) swimming locomotion control

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Precise planar motion measurement of a swimming multi-joint robotic fish

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Science China(Information Sciences) 2016年第9期59卷 183-197页

作者： Jun YUAN Junzhi YU zhengxing wu Min TAN State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of Sciences

This paper presents a method for planar motion measurement of a swimming multi-joint robotic fish. The motion of the robotic fish is captured via image sequences and a proposed tracking scheme is employed to continuously detect and track the robotic fish. The tracking scheme initially acquires a rough scope of the robotic fish and thereafter precisely locates it. Historical motion information is utilized to determine the rough scope, which can speed up the tracking process and avoid possible ambient interference. A combination of adaptive bilateral filtering and k-means clustering is then applied to segment out color markers accurately. The pose of the robotic fish is calculated in accordance with the centers of these markers. Further, we address the problem of time synchronization between the on-board motion control system of the robotic fish and the motion measurement system. To the best of our knowledge, this problem has not been tackled in previous research on robotic fish. With information about both the multi-link structure and motion law of the robotic fish, we convert the problem to a nonlinear optimization problem, which we then solve using the particle swarm optimization(PSO) algorithm. Further, smoothing splines are adopted to fit curves of poses versus time, in order to obtain a continuous motion state and alleviate the impact of noise. Velocity is acquired via a temporal derivative operation. The results of experiments conducted verify the efficacy of the proposed method.

关键词： motion measurement robotic fish time synchronization visual tracking localization

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