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Journal of Rare Earths 1999年第2期17卷 52-56页

作者： Liu, y yang, XG wu, y Chinese Acad Sci Changchun Inst Appl Chem Changchun 130022 Peoples R China

Two series of layered mixed oxides La4BaCu5-xMxO13+(M=Mn, Co, x=05) were prepared and characterized by means of XRD, XPS, O2TPD and chemical analysis. The results show that their structures are 5layered ABO3 perovskite, and the XPS and O2TPD investigation confirms that there exists synergistic effect between Cu ion and M when M ion is doped into the lattice of La4BaCu5O13+, and the synergistic effect between Mn and Cu is stronger than that of CuCo.

关键词： Rare earths Layered mixed oxides Synergistic effect Active oxygen species

Synthesis of an Anti-1,3-Diol Type Chiral Building Block

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Chinese Chemical Letters 1998年第11期9卷 987-988页

作者： wu, y Guan, M W China Univ Med Sci Sch Pharm Chengdu 610041 Peoples R China W China Univ Med Sci Hosp 1 Chengdu 610041 Peoples R China

A chiral building block, anti-1,3-diol 2, has been synthesized in 7 steps, starting from readily available and inexpensive D-(+)-xylose.

关键词： chiral building block anti-1,3-Diol D(+)-xylose

Mathematical modelling of axonal microtubule bundles under dynamic torsion

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Applied Mathematics and Mechanics(English Edition) 2018年第6期39卷 829-844页

作者： J.y.wu Hong yUAN L.y.LI MOE Key Laboratory of Disaster Forecast and Control in Engineering Institute of Applied MechanicsJinan University School of Engineering University of Plymouth

Owing to its viscoelastic nature, axon exhibits a stress rate-dependent me- chanical behavior. An extended tension-shear chain model with Kelvin-Voigt viscoelas- ticity is developed to illustrate the micromechanical behavior of the axon under dynamic torsional conditions. Theoretical closed-form expressions are derived to predict the de- formation, stress transfer, and failure mechanism between microtubule （MT） and tau protein while the axon is sheared dynamically. The results obtained from the present an- alytical solutions demonstrate how the MT-tau interface length, spacing between the tau proteins, and loading rate affect the mechanical properties of axon. Moreover, it is found that the MTs are more prone to rupture due to the contributions from the viscoelastic effects. Under the torsional force, the MTs are so long that the stress concentrates at the loaded end where axonal MTs will break. This MT-tau protein dynamics model can help to understand the underlying pathology and molecular mechanisms of axonal injury. Additionally, the emphasis of this paper is on the micromechanical behavior of axon, whereas this theoretical model can be equally applicable to other soft or hard tissues, owning the similar fibrous structure.

关键词： torsion biocomposite diffuse axonal injury (DAI) Kelvin-Voigt viscoelas-tic model dynamic response tension-shear chain model

Tongue as a first-line immune organ?

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Protein & Cell 2021年第3期12卷 162-164页

作者： Jane y.wu Department of Neurology Center for Genetic MedicineLurie Cancer CenterNorthwestern University Feinberg School of MedicineChicagoUSA

The tongue is an organ strategically situated at the beginning of the gastrointestinal(Gl)system,yet it has been remarkably *** only there is no separate subspecialty dedicated to the tongue,it is even excluded from 27 human organs/tissues thoroughly archived in the NCBI gene expression *** none of my physician colleagues in Western medicine have paid attention to it,except a few who study tongue *** tongue is typically described as a muscular organ important for taste,mastication,speech and *** than its development,anatomy/gross structural analyses and taste function(for recent reviews,see Roper and Chaudhari,2017),the human tongue is poorly studied in Western medicine,in particular,in terms of its roles in systemic *** traditional Chinese medicine(TCM),however,the tongue holds a special *** the“tongue coating”,"tongue body”and morphological features is one of the most critical skills that TCM doctors have relied on for disease diagnoses for thousands of years before the advent of Western Medicine.

关键词： anatomy sensation organs

Pathogenesis of Thrombocytopenia in Chronic HCV Infection:A Review

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Journal of Clinical and Translational Hepatology 2020年第2期8卷 184-191页

作者： Sarah Rawi George y wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

A large proportion of patients with chronic hepatitis C have associated thrombocytopenia (TCP). Due to bleeding risks, TCP, when severe, can limit diagnostic and therapeutic procedures, treatments, and increases risk of complications, especially excessive bleeding. It is important to understand the mechanisms that cause TCP in order to manage it. In general, TCP can be due to increased destruction or decreased production. Proposed mechanisms of increased destruction include autoantibodies to platelets and hyper-splenism with sequestration. Proposed mechanisms of de-creased production include virus-induced bone marrow suppression and decreased TPO production. Autoantibodies directed against platelet surface antigens have demonstrated an inverse correlation with platelet counts. Hypersplenism with sequestration involves the interaction of portal hyper-tension, splenomegaly, and platelet destruction. Decreased production mechanisms involve appropriate and inappropri-ate levels of TPO secretion. There is limited evidence to support viral-induced bone marrow suppression. In contrast, there is strong evidence to support low levels of TPO in liver failure as a major cause of TCP. TPO-agonists, specifically eltrombopag, have been shown in hepatitis C patients to increase platelet counts without reducing portal hypertension or splenomegaly. We conclude that TCP in hepatitis C virus-induced liver disease is often multifactorial, but an under-standing of the mechanisms can lead to judicious use of new drugs for treatment.

关键词： Thrombocytopenia Chronic hepatitis Autoantibodies Hypersplenism Thrombopoietin

AN IN-SITU STUDy ON DISLOCATION BEHAVIOR OF CRACK-TIP IN Ti_3Al-Nb ALLOy

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中国有色金属学会会刊：英文版 1997年第3期7卷 31-37页

作者： wu, y Zhen, L yang, DZ Liang, W HARBIN INST TECHNOL SCH MAT SCI & ENGN HARBIN 150001 PEOPLES R CHINA TAIyUAN UNIV TECHNOL DETECTING CTR TAIYUAN 030024 PEOPLES R CHINA

ＡＮＩＮＳＩＴＵＳＴＵＤＹＯＮＤＩＳＬＯＣＡＴＩＯＮＢＥＨＡＶＩＯＲＯＦＣＲＡＣＫＴＩＰＩＮＴｉ３ＡｌＮｂＡＬＬＯＹ①ＷｕＹｉｎｇ，ＺｈｅｎＬｉａｎｇ，ＹａｎｇＤｅｚｈｕａｎｇＳｃｈｏｏｌｏｆＭａｔｅｒｉａｌｓ... 详细信息

ＡＮＩＮＳＩＴＵＳＴＵＤＹＯＮＤＩＳＬＯＣＡＴＩＯＮＢＥＨＡＶＩＯＲＯＦＣＲＡＣＫＴＩＰＩＮＴｉ３ＡｌＮｂＡＬＬＯＹ①ＷｕＹｉｎｇ，ＺｈｅｎＬｉａｎｇ，ＹａｎｇＤｅｚｈｕａｎｇＳｃｈｏｏｌｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｒ...

关键词： Ti 3Al Nb alloy tensile deformation crack propagation dislocation

ELECTRON TRANSFER BETWEEN Eu￣(3+) AND Ce￣(3+) IN SrMgF_4 MATRIX

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Chinese Chemical Letters 1995年第5期6卷 449-452页

作者： wu, y Shi, CS Chinese Acad Sci Changchun Inst Appl Chem Lab Rare Earth Chem & Phys Changchun 130022 Peoples R China

Emissions of europium (Ⅱ ) and europium (Ⅲ) have been observed in SrMgF4: Eu and SrMgF4: Eu, Ce phosphors which are synthesized in Ar flow, It is notable that the intensity of the ESR peaks eorresponding to Eu3+ is... 详细信息

关键词： ELECTRON TRANSFER BETWEEN Eu AND Ce IN SrMgF4 MATRIX

Autism, an area that needs public attention and investment

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Science China(Life Sciences) 2015年第10期58卷 931-932页

作者： Jane y.wu Department of Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School of Medicine State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences

I would like to dedicate this special issue to children and adults who are affected by autism or related developmental disorders, as well as to their families and friends. I am indebted to the clinicians and care providers who have made tremendous effort in supporting these patients. They have inspired me to invest a significant amount of my energy to adventure into this area. I greatly appreciate all the contributing authors around the world whose hard work made this special issue possible.

关键词：自闭投资公众成年人

Primary Sclerosing Cholangitis and Primary Biliary Cirrhosis Overlap Syndrome:A Review

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 336-346页

作者： Sheena Mago George y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Primary sclerosing cholangitis(PSC)and primary biliary cirrhosis(PBC)are slow progressive diseases which have been increasing in *** pathogeneses of PBC and PSC are incompletely understood but the underlying mechanisms appear to be fundamentally autoimmune in *** PBC and PSC appear to be separate entities,overlap has been *** depends on a combination of serological markers,imaging,and pathological *** mainstay of treatment has been ursodeoxycholic acid and in some cases of extrahepatic biliary obstruction and overlap disorder,endoscopic retrograde cholangiopancreatography has been useful.

关键词： Primary sclerosing cholangitis Primary biliary cirrhosis Overlap syndrome

HEV and HBV Dual Infection:A Review

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 313-321页

作者： Myra Nasir George y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Hepatitis E virus(HEV)is a global health problem,affecting about 20 million people *** is significant overlap of hepatitis B virus(HBV)and HEV endemicity in many Asian countries where dual infections with HEV and HBV can *** the clinical course of HEV is largely self-limited,HEV superinfection in patients with chronic hepatitis B(CHB)can result in acute exacerbation of underlying *** superinfection in patients with CHB-related cirrhosis has been identified as a risk factor for decompensated cirrhosis and an independent predictor of *** acute HEV infection in pregnancy can cause fulminant liver failure,the few studies on pregnant patients with dual HBV and HEV infection have shown a subclinical *** is a risk factor for the development of chronic HEV infection,which can be managed by decreasing the dose of immune-suppressants and administering *** for HEV has been developed and is in use in China but its efficacy in patients with CHB has yet to be established in the *** this review,we appraise studies on dual infection with HEV and HBV,including the effect of HEV superinfection and coinfection in CHB,management strategies used and the role of active vaccination in the prevention of HEV.

关键词： Hepatitis B Hepatitis E Coinfection Superinfection Chronic hepatitis B