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Advances in Manufacturing 2023年第1期11卷 143-157页

作者： Hao Su Chuan-song wu MOE Key Lab for Liquid-Solid Structure Evolution and Materials Processing Institute of Materials JoiningShandong UniversityJinan250061People’s Republic of China

An accurate description of the contact condition between the tool and the workpiece material is one of the most important issues for expounding the underlying multi-physics coupled mechanism during friction stir welding(FSW)*** the present study,a novel asymmetrical boundary condition around the tool-workpiece contact interface is proposed for the FSW of AA2024-T4 alloy.A three-dimensional computational fluid dynamics model is employed for the comparison of the coupled thermal and plastic material flow behavior between asymmetrical and symmetrical boundary *** results of heat generation,temperature distribution,tunnel defect formation and material flow streamline during the welding process are quantitatively ***,various experimental measuring methods are utilized to obtain information about temperature,thermal cycle,tool torque and horizontal cross-section around the exiting *** is revealed that the modeling results of heat flux density and temperature distribution around the pin,as well as material flow characteristics all change significantly for the two models with different boundary ***,the asymmetrical boundary condition is more capable of predicting temperature fluctuation,plastic material flow along the vertical direction,as well as tunnel defect formation during ***,the superiority of the model with asymmetrical boundary condition over the symmetrical one during the numerical simulation of FSW is elucidated.

关键词： Friction stir welding(FSW) Numerical simulation Heat generation Plastic material flow Asymmetrical boundary condition

Thinning air-water films stabilized by bacterial particles

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Acta Mechanica Sinica 2021年第1期37卷 27-34,I0001页

作者： song wu Yuehua Yang Hongyuan Jiang Hefei National Laboratory for Physical Science at the Microscale CAS Key Laboratory of Mechanical Behavior and Design of MaterialsDepartment of Modern MechanicsCAS Center for Excellence in Complex System MechanicsUniversity of Science and Technology of ChinaHefei230026China

The ability of particles to stabilize liquid films has broad applications in many fields,such as drug delivery,biofuel catalysis,and crude-oil *** mechanism of particles to stabilize emulsions has been widely ***,how particles affect the stability of suspension films is still ***,the dynamics of bacterial particles on free liquid films during evaporation is obtained by direct microscopic *** find that the initial concentration of the bacterial solution affects the evolution of the shapes and stabilities of liquid *** liquid film with a low bacterial concentration exhibits a drainage and rupture process similar to pure water,and bacteria would be evacuated during the evaporation of liquid ***,when the bacterial concentration is high,bacteria form a single-layer array in the center of the film and greatly enhance the stability of the liquid *** demonstrate that these two distinct film evaporation dynamics are caused by the difference in the lateral capillary force of the particles at different positions on the liquid film,which is not affected by the active motility of ***,our research reveals the critical role of bacteria concentration in stabilizing suspension liquid film.

关键词： Bacterial concentration Evaporation dynamics Film stability Lateral capillary force

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Acta Mathematica Sinica,English Series 2014年第5期30卷 723-736页

作者： Jin song wu Wen Ming wu School of Mathematical Sciences University of Science and Technology of China Department of Mathematics Chongqing Normal University

In this paper, we will estimate an upper bound for the similarity degree of the crossed product of a hyperfinite finite von Neumann algebra by weakly compact action of an infinite discrete group. We will also improve ... 详细信息

关键词： Similarity degree von Neumann algebra weakly compact action compact action crossed product

Current status and future perspectives of immunotherapy in bladder cancer treatment

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Science China(Life Sciences) 2021年第4期64卷 512-533页

作者： Zhangsong wu Jinjian Liu Ruixiang Dai song wu Department of Urological Surgery.The Third Afiliated Hoaspital of Shenzhen Universiy Shenzhen University.Shenzhen 518000 China Shenzhen Following Precision Medical Institute The Third Afiliated Hospial of Shenzhen UniversityShenzhen UniversityShenzhen 518000China Deparment of Urological Surgery The First Afiliated Hospial of Guangzhou Medical UniversityGruangzhou Medical UniversityGuangzhou 510120China

The treatment strategy of bladder cancer has evolved not only through the traditional modalities of surgery and chemotherapy but also by immunotherapy over the past several *** such as intravesical Bacillus Calmette-Guérin(BCG)vaccines and immune checkpoint blockades(ICBs)are sometimes used for treating patients with bladder cancer,especially those who develop resistance to conventional first-line treatments such as surgery and ***,it is a limited number of individuals that see clinical benefits from this approach,and complicating matters more is that many of these patients suffer severe immune-related adverse events(ir AEs).If current momentum continues to result in improved response rates and managed ir AEs,immunotherapy could be poised to revolutionize the landscape of urothelial carcinoma therapeutics.

关键词： bladder cancer urothelial carcinoma immunotherapy predicative biomarkers adverse events

Numerical simulation of humping phenomenon in high speed gas metal arc welding

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Frontiers of Materials Science 2011年第2期5卷 90-97页

作者： Ji CHEN Chuan-song wu State Key Lab of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China Institute of Materials Joining Shandong University Jinan 250061 China

It is of great significance to obtain a thorough understanding of the physical mechanisms responsible for humping bead phenomenon in high speed gas metal arc welding （GMAW） in order to raise welding efficiency. Experiments were conducted to observe the weld pool behaviors in high speed GMAW, and it was found that both the severely deformed weld pool surface and strong backward flowing play a dominant role in humping bead formation. In this study, a mathematical model is developed to quantitatively analyze the forming mechanism of humping beads for high speed GMAW through considering both the momentum and heat content distribution of the backward flowing molten metal inside the weld pool. The transient development of temperature profiles in the weld pool with severe deformation demonstrates the humping bead forming process under some welding conditions. The predicted and measured humping bead dimensions are in agreement.

关键词： numerical simulation humping weld bead high-speed GMAW

NUMERICAL SIMULATION OF EFFECTS OF WALL THICKNESS AND CELL DENSITY ON THE THREE-WAY CATALYTIC CONVERTER PERFORMANCE

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Chinese Journal of Mechanical Engineering 2005年第4期18卷 617-622页

作者： wu Guojiang Tan song Huang Zhen School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200030 China

The transient symmetric mathematical model is established, and the effects of the wall thickness and cell density on the performance of a three-way catalytic converter are studied using numerical modeling. The conclusions show that the light-off time and the pressure drop through a converter are decreased, and the conversion efficiency during the warm-up period keeps almost invariant with reduction of the wall thickness of substrates, and that the pressure drop through a converter and a conversion efficiency during the warm-up state increases, and the light-off time almost keeps invariant when increasing cell density of substrates. Therefore, future catalytic converters should develop in the direction of thin wall thickness and high cell density substrates simultaneously.

关键词： Numerical simulations Advanced catalytic converter Emissions

Novel approaches towards conquering hepatitis B virus infection

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World Journal of Gastroenterology 2007年第6期13卷 830-836页

作者： Guo-Yi wu Hong-song Chen Hepatology Institute People's Hospital Peking University Beijing 100044 China

Currently approved treatments for hepatitis B virus （HBV） infection include the immunomodulatory agent, IFN-α, and nucleos（t）ide analogues. Their efficacy is limited by their side effects, as well as the induction of viral mutations that render them less potent. It is thus necessary to develop drugs that target additional viral antigens. Chemicals and biomaterials by unique methods of preventing HBV replication are currently being developed, including novel nucleosides and newly synthesized compounds such as capsid assembling and mRNA transcription inhibitors. Molecular therapies that target different stages of the HBV life cycle will aid current methods to manage chronic hepatitis B （CriB） infection. The use of immunomodulators and gene therapy are also under consideration. This report summarizes the most recent treatment possibilities for CHB infection. Emerging therapies and their potential mechanisms, efficacy, and pitfalls are discussed.

关键词： Hepatitis B virus Antiviral drugs Drugevaluation Immunomodulatory agents Gene therapy

Chemical looping gasification of maceral from low-rank coal: Products distribution and kinetic analysis on vitrinite

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Chinese Journal of Chemical Engineering 2021年第8期34卷 233-241页

作者： Bo Zhang Bolun Yang Wei Guo song wu Jie Zhang Zhiqiang wu Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an710049China

The product distribution and kinetic analysis of low-rank coal vitrinite were investigated during the chemical looping gasification(CLG)*** acid washing method was used to treat low-rank coal,and the density gradient centrifugation method was adopted to obtain the coal *** combining thermogravimetric analysis and online mass spectrometry,the influence of the heating rate and oxygen carrier(Fe2O3)blending ratio on product distribution was *** macroscopic kinetic parameters were solved by the Kissinger-Akahira-Sunose(KAS)method,and the main gaseous product formation kinetic parameters were solved by the iso-conversion *** results of vitrinite during slow heating chemical looping gasification showed that the main weight loss interval was 400–600℃,and the solid yield of sample vitrinite-Fe-10 at different heating rates was 64.30%–69.67%.When b=20℃·min^(-1),the maximum decomposition rate of vitrinite-Fe-10 was 0.312%*** addition of Fe2O_(3)reduced the maximum decomposition rate,but by comparing the chemical looping conversion characteristic index,it could be inferred that the chemical looping gasification of vitrinite might produce volatile substances higher than the pyrolysis process of vitrinite *** average activation energy of the reaction was significantly reduced during chemical looping gasification of vitrinite,which was lower than the average activation energy of 448.69 kJ·mol^(-1) during the pyrolysis process of vitrinite *** gaseous products were mainly CO and CO_(2).When the heating rate was 10℃·min^(-1),the highest activation energy for CH4 formation was 21.353 kJ·mol^(-1),and the lowest activation energy for CO formation was 9.7333 kJ·mol^(-1).This study provides basic data for exploring coal chemical looping gasification mechanism and reactor design by studying the chemical looping gasification process of coal macerals。

关键词： Coal Vitrinite Chemical looping process Gasification Products distribution Reaction kinetics

Receptivity of hypersonic boundary layer due to fast-slow acoustics interaction

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Acta Mechanica Sinica 2015年第6期31卷 899-909页

作者： Jun Gao Ji-Sheng Luo Xue-song wu Department of Mechanics Tianjin University Department of Mathematics Imperial College London

The objective of receptivity is to investigate the mechanisms by which external disturbances generate unsta- ble waves. In hypersonic boundary layers, a new receptivity process is revealed, which is that fast and slow acoustics through nonlinear interaction can excite the second mode near the lower-branch of the second mode. They can generate a sum-frequency disturbance though nonlinear interaction, which can excite the second mode. This receptivity process is generated by the nonlinear interaction and the nonparal- lel nature of the boundary layer. The receptivity coefficient is sensitive to the wavenumber difference between the sumfrequency disturbance and the lower-branch second mode. When the wavenumber difference is zero, the receptivity coefficient is maximum. The receptivity coefficient decreases with the increase of the wavenumber difference. It is also found that the evolution of the sum-frequency disturbance grows linearly in the beginning. It indicates that the forced term generated by the sum-frequency disturbance resonates with the second mode.

关键词： Hypersonic boundary layer · Receptivity·Nonlinear interaction · Acoustic

The era of personalized treatments:Updates on immunotherapy within urothelial of bladder cancer

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Current Urology 2022年第3期16卷 117-120页

作者： Zhang-song wu song wu Medical College Shenzhen UniversityShenzhenChina The Huanan Affiliated Hospital of Shenzhen University Shenzhen UniversityShenzhen518000China School of Life Sciences Chinese University of Hong Kong(Shenzhen)ShenzhenChina

Bladder cancer is a complex disease of the urinary system with high morbidity and ***,the introduction of immunother-apies such as immune checkpoint inhibitors(eg,programmed cell death protein 1/programmed death-ligand 1)has proven to be a re-liable means of improving survival outcomes,including patients with limited response to conventional ***,difficult questions remain in clinical practice,such as how to select appropriate patients for personalized treatment,how to predict and assess therapeutic efficacy in advance,and how to enhance the therapeutic benefits of immunotherapy *** issues require urgent ***,we describe recent clinical applications of immune checkpoint inhibitors in bladder cancer therapy,examine underlying mechanisms for treatment failure in a subset of patients,and discuss potential approaches to improve their therapeutic effects.

关键词： Bladder cancer Combination strategies Immune checkpoint inhibitors Molecular subtypes Predictive biomarkers