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新生儿病理性黄疸光疗后胆红素又异常升高的研究

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医学检验与临床 2024年第1期35卷 1-4页

作者：杨冬钰吴晓萍马联卢嘉黎汝娟余永雄梧州市妇幼保健院检验科广西梧州543002 梧州市妇幼保健院新生儿科广西梧州543002 南宁市第四人民医院检验科广西南宁530023

目的:探讨新生儿病理性黄疸光疗停止后胆红素再次升高(反弹)的原因,给临床治疗和管理提供参考。方法:收集2018年1月1日-2022年12月31日这5年中在梧州市妇幼保健院新生儿科住院的诊断为病理性黄疸并进行光疗的患儿1013例,其中152例光疗... 详细信息

目的:探讨新生儿病理性黄疸光疗停止后胆红素再次升高(反弹)的原因,给临床治疗和管理提供参考。方法:收集2018年1月1日-2022年12月31日这5年中在梧州市妇幼保健院新生儿科住院的诊断为病理性黄疸并进行光疗的患儿1013例,其中152例光疗停止后胆红素出现反弹。通过病历资料和实验室检测结果进行原因分析,对单因素分析中差异有统计学意义的因素纳入多元Logistic回归分析。结果:152例光疗停止后胆红素出现反弹,反弹率为15.00%(152/1013),单方面因素分析显示,新生儿病理性黄疸光疗停止后胆红素出现反弹与性别、新生儿ABO溶血病、G-6PD缺乏和光疗前红细胞压积相关(P<0.05),但经过多元Logistic回归分析,新生儿病理性黄疸光疗停止后胆红素出现反弹与性别相关性不大。结论:新生儿病理性黄疸光疗停止后胆红素出现反弹与新生儿ABO溶血病和G-6PD缺乏症密切相关。

关键词：新生儿病理性黄疸胆红素光疗

三维并行高密度电法在六国化工磷石膏堆场场地勘察中的应用

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科学技术与工程 2024年第2期24卷 495-505页

作者：周官群崔颖梁希凯陈兴海岳明鑫王亚飞吴小平曹煜刘耀辉合肥工业大学资源与环境工程学院合肥230009 中国科学技术大学地球和空间科学学院合肥230026 安徽国科骄辉科技有限公司合肥230088 安徽惠洲地质安全研究院股份有限公司合肥231202

工程项目实施前,确定工区地下空间分布详情是不可缺少的工作内容。三维高密度电法观测系统的布设难度大,使用常规电法仪进行采集耗时较长,在真实复杂地质条件下,应用难度大。利用并行电法采集技术,可以达到高效采集数据的目的。为准确... 详细信息

工程项目实施前,确定工区地下空间分布详情是不可缺少的工作内容。三维高密度电法观测系统的布设难度大,使用常规电法仪进行采集耗时较长,在真实复杂地质条件下,应用难度大。利用并行电法采集技术,可以达到高效采集数据的目的。为准确查明某磷石膏堆场下部及周边可能形成渗漏管道的区域的三维形态,结合实际地质情况,采用并行电法进行数据采集,获取测区内真三维观测系统下的三维电法勘探数据体,然后对数据进行带地形三维反演处理和解释。结果表明:三维并行高密度电法探测场地地下空间分布具有一定的有效性和准确性。本次现场探测共圈定了5个异常区。与钻孔揭露资料吻合,为后期指导防渗帷幕施工提供准确依据.

关键词：并行电法地质异常渗漏管道三维成像

Effect of charge at an amino acid of basic fibroblast growth factor on its mitogenic activity

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Chinese Chemical Letters 2010年第4期21卷 468-471页

作者： wu, xiao ping Li, xiao Kun Jinan Univ Inst Tissue Transplantat & Immunol Guangzhou 510632 Guangdong Peoples R China Jinan Univ Natl Engn Res Ctr Gene Med Guangzhou 510632 Guangdong Peoples R China

The amino acid at the 119th position of human basic fibroblast growth factor(hbFGF),lysine(K119),is a critical component for its mitogenic ***,little is known about the effects of the characteristics of this residue including charge on the mitogenic activity of ***,this basic residue was replaced with neutral glutamine residue and acidic glutamic acid residue to construct mutants hbFGF^(K119Q) and hbFGF^(K119E),*** mutants were produced by BL21(DE3)/pET3c expression system...

关键词： Human basic fibroblast growth factor Amino acid charge Expression Mitogenic activity Erk1/2 activation

超大城市流动老年人遭受童年欺凌经历与老年期孤独感的关系研究

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现代预防医学 2024年第5期51卷 904-909+915页

作者：刘娅婷姚丹郭娜李卓张继艳郑斐然吴小平洪晨璐王延涛罗雅楠北京大学护理学院北京市经济技术开发区疾控中心中国人口与发展研究中心清华大学社会科学学院中央民族大学民族学与社会学学院中国社会科学院大学国际政治经济学院北京大学公共卫生学院全球卫生学系司法部预防犯罪研究所

目的探索超大城市流动老年人遭受童年欺凌经历与老年期孤独感的关系。方法采用配额抽样方法，2022年在北京市大兴区青云店镇共完成1 000名≥60岁常住外来老年人的有效问卷调查，收集社会人口学、孤独感及童年欺凌等信息，采用单因素... 详细信息

目的探索超大城市流动老年人遭受童年欺凌经历与老年期孤独感的关系。方法采用配额抽样方法，2022年在北京市大兴区青云店镇共完成1 000名≥60岁常住外来老年人的有效问卷调查，收集社会人口学、孤独感及童年欺凌等信息，采用单因素分析和最小二乘回归（OLS）模型分析超大城市流动老年人遭受童年欺凌经历与老年期孤独感的关系及其调节因素，最后进行分样本回归。结果在调整人口学特征变量、社会经济地位变量、躯体健康变量、来京时长、普通话掌握程度和社会融入变量后，遭受过童年欺凌的超大城市流动老年群体孤独感得分平均提高5.616 (4.153～7.079)分，自评健康、普通话的掌握程度、婚姻关系满意度以及社会融入在“遭受童年欺凌-孤独感”中起调节作用，与模型1相比，模型2、3、4的β值(95%CI)由8.014 (6.580～9.447)变为7.498 (6.027～8.968)、7.402 (5.961～8.843)、5.616(4.153～7.079)。分样本回归表明在不同性别、年龄、户籍、婚姻与配偶流动情况中结果稳健（均P<0.01），但在受教育程度中结果存在差异。结论遭受过童年欺凌的超大城市流动老年人孤独感水平更高，自评健康、普通话的掌握程度、婚姻关系满意度以及社会融入有助于削弱上述关系。

关键词：孤独感童年欺凌流动老年人超大城市

Phase field modeling of grain stability of nanocrystalline alloys by explicitly incorporating mismatch strain

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Rare Metals 2024年第7期43卷 3370-3382页

作者： Min Zhou Hong-Hui wu Yuan wu Hui Wang Xiong-Jun Liu Sui-He Jiang xiao-Bin Zhang Zhao-ping Lu Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology Beijing Institute for Carbon Neutrality University of Science and Technology Institute of Materials Intelligent Technology Liaoning Academy of Materials

Ab st ra ct Nanocrystalline materials exhibit unique properties due to their extremely high grain boundary(GB) ***,this high-density characteristic induces grain coarsening at elevated temperatures,thereby limiting the widespread application of nanocrystalline *** experimental observations revealed that GB segregation and second-phase pinning effectively hinder GB migration,thereby improving the stability of nanocry stalline *** this study,a mouified phase-field model that integrates mismatch strain,solute segregation and precipitation was developed to evaluate the influence of lattice misfit on the thermal stability of nanocrystalline *** simulation results indicated that introducing a suitable mismatch strain can effectively enhance the microstructural stability of nanocrystalline *** synergizing precipitation with an appropriate lattice misfit,the formation of second-phase particles in the bulk grains can be suppressed,thereby facilitating solute segregation/precipitation at the *** concentrated solute segregation and precipitation at the GBs effectively hinders grain migration,thereby preventing grain *** findings provide a new perspective on the design and regulation of nanocrystalline alloys with enhanced thermal stability.

关键词： Phase field model Mismatch strain Second-phase precipitation Grain boundary segregation Nanocrystalline alloys

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市政道路路基施工裂缝产生机制及控制研究

工程建设与设计 2024年第15期 184-186页

作者：刘胜岩梅磊许兴龙刘冠垒王彦彬吴小平中建二局第二建筑工程有限公司广东深圳518000

针对市政道路路基施工易产生纵向裂缝的问题,研究利用裂缝产生机制模型对裂缝产生的原因进行了探讨,同时对施工裂缝的保养以及预防进行了研究。结果显示,裂缝产生机制模型与实测值之间产生的较大竖直位移误差为11.1%,产生的较大温度误差... 详细信息

针对市政道路路基施工易产生纵向裂缝的问题,研究利用裂缝产生机制模型对裂缝产生的原因进行了探讨,同时对施工裂缝的保养以及预防进行了研究。结果显示,裂缝产生机制模型与实测值之间产生的较大竖直位移误差为11.1%,产生的较大温度误差为2.0%。

关键词：市政道路路基施工纵向裂缝产生机制道路保养

To improve robustness of mechanical properties of semi-solid cast A356 alloy using taguchi design method

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China Foundry 2024年第2期21卷 175-184页

作者： Yi-wu Xu Hong-yi Zhan Wei Tong Jin-ping Li Le-peng Zhang De-jiang Li xiao-qin Zeng School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China China Science Lab General Motors Global Research&DevelopmentShanghai 201206China General Motors(China)Investment Co. Ltd.Shanghai 201206China China International Intellectech Corporation(CIIC) Beijing 100004China

Mechanical properties of semi-solid casting are dependent on multiple processing parameters,and improper processing parameters will not only reduce mean data but also increase *** present study investigated the impact of parameters in slurry preparation and heat treatment on the yield strength and ductility of T6 heat-treated A356 Al-Si alloy using rapid slurry forming(RSF)semi-solid *** focus was primarily on the robustness of mechanical properties based on Taguchi design *** analyzing signal-to-noise ratio and minimum value calculated from-3S,the optimum slurry preparation parameters and heat treatment parameters were determined to be no quench,enthalpy exchange material(EEM)temperature of 140℃,EEM-to-melt ratio of 6mass%,stirring time of 18 s,solution heat treated at 520℃ for 2 h,and ageing heat treated at 190℃ for 6 *** a small batch validation,the-3S yield strength and-3S elongation reach 256.1 MPa and 5.03% respectively,showing a satisfactory *** hardness and microstructure of heat-treated samples with the best and worst properties were characterized to gain insight into the underlying mechanisms affecting the mean value and variations of mechanical properties.

关键词： semi-solid casting taguchi design method signal-to-noise ratio mechanical property microstructure

Analysis of China's Electricity Price and Electricity Burden of Basic Industries under the Carbon Peak Target before 2030

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 481-491页

作者： Yue Qiu Suyang Zhou Wei Gu xiao-ping Zhang School of Electrical Engineering Southeast UniversityNanjingChina School of Electronic Electrical and System EngineeringUniversity of BirminghamU.K.

The Chinese government is deepening reformation of electricity prices during the 14th Five Year Plan period and has set a carbon emission reduction target of reaching carbon peak before *** this context,will the carbon emission target influence electricity pricing and will electricity price influence competitiveness of Chinese main industries are two questions needing to be *** paper compares China's electricity price level with the selected major countries in the world,and four typical industries are selected to evaluate their electricity burden ***,the correlation between residential electricity price and industrial electricity price and the influencing factors is analyzed,from the perspectives of scale,structure and *** to the model obtained by regression analysis,the electricity price level and corresponding residential and industrial electricity burden in 2025 and 2030 are *** Terms-Electricity burden,industrial electricity price,regression analysis,residential electricity price.

关键词： Electricity burden industrial electricity price regression analysis residential electricity price

Comparison of biliary protein spectrum in gallstone patients with obesity and those with normal body weight

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 385-392页

作者： Min-Zhi Chen ping Xie xiao-Chang wu Zhen-Hua Tan Hai Qian Zhi-Hong Ma Xing Yao Department of Hepatopancreatobiliary Surgery Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhou 313000China Huzhou Key Laboratory of Molecular Medicine Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhou 313000China

Background: Obesity is a common public health issue and is currently deemed a disease. Research has shown that the risk of gallstones in individuals with obesity is elevated. This study aimed to explore the bile proteomics differences between cholelithiasis patients with obesity and normal body weight. Methods: Bile samples from 20 patients(10 with obesity and 10 with normal body weight) who underwent laparoscopic cholecystectomy at our center were subjected to tandem mass tag labeling(TMT) and liquid chromatography-tandem mass spectrometry(LC-MS/MS), followed by further bioinformatic analysis. Results: Among the differentially expressed proteins, 23 were upregulated and 67 were downregulated. Bioinformatic analysis indicated that these differentially expressed proteins were mainly involved in cell development, inflammatory responses, glycerolipid metabolic processes, and protein activation cascades. In addition, the activity of the peroxisome proliferator-activated receptor(PPAR, a subfamily of nuclear receptors) signaling pathway was decreased in the Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analysis. Two downregulated proteins in the PPAR signaling pathway, APO A-Ⅰ and APO A-Ⅱ, were confirmed using enzyme-linked immunosorbent assay. Conclusions: The PPAR signaling pathway may play a crucial role in the development of cholelithiasis among patients with obesity. Furthermore, biliary proteomics profiling of gallstones patients with obesity is revealed, providing a reference for future research.

关键词： Proteome profiling Gallstones Obesity-associated gallstones Tandem mass tag labeling PPAR signaling